The Gary Null Show - 06.30.21

The Gary Null Show - 06.29.21

The Gary Null Show - 06.28.21

The Woke Culture: A Pathology of Post-Modern Tribalism

The Woke Culture: A Pathology of Post-Modern Tribalism

Richard Gale and Gary Null PhD

Progressive Radio Network, June 28, 2021

In a recent article, “Critical Race Theory [CRT] is Worse than Marxism, the social thinker and author, Prof. Paul Gottfried, breaks ranks from his Alt-Right compatriots to argue that CRT “has nothing to do with traditional Marxism.”  “The swear words “Marxist” and “revolutionary,” Gottfried writes, “are thrown around by conservatives, such as those at Heritage, the New York Post and Fox News, with the same abandon with which the left speaks about “human rights”…” Rather than being truly revolutionary, based upon the history of past revolutionary movements, CRT “is an instrument of repression brandished by those in power against those whom it is feared might resist them.”  Yet most important, to label CRT as Marxist desecrates good ol’ Marx’s tomb. 

In fact, at the time Critical Theory emerged from the German Frankfurt School in the 1930s, its most adamant opponents were the traditional card-carrying Marxists and Communists. The School’s intention was to actually re-write classical Marxism and to prolong the internal fallacies launched during the Enlightenment era. Perhaps its most redeeming value is its efforts to define and explain the phenomenology of social power and aggression. Its primary early proponents, such as Max Horkheimer, were also harsh critics of the rise of metaphysical realism and scientific dogmatism that today has turned modern science, especially the biological sciences and medicine, into a fundamentalist ideology or religion. But this is where Critical Theory’s contributions end. Critical theory has more in common with Freudian sexual repression and psychoanalysis than Marx. One of the 20^th century’s great philosophers Karl Popper criticized the Frankfurt School for offering no viable and realistic pathway to improve society.  Unlike Marx, who reasonably condemned capitalist society’s unfairness, he did offer a vision for a better future. On the other hand, Critical Theory for Popper, was “vacuous and irresponsible” for omitting a promised future altogether. Remarkably, modern Critical Theory’s leading spokespersons, such as Robin DiAngelo, are exemplars of the very manifestation of dysfunctional biases that Critical Theory rebukes. This may be a reason why those who embrace tribal wokeness are simply angry, maladjusted adolescents in adult bodies. 

The 21^st century woke generations appear to have entered a coma.  Its characteristic qualia of ADHD would likely prevent them from getting through 20 pages of Das Capital let alone making any sense from it. The most recent incarnation of wokeness is not an awakening of either conscientiousness or a higher conscious awareness that directly experiences the sacredness of all life, other humans, and the animal and plant kingdoms. It veered from its origins within the Black community in the 20^th century when it was used to refer to a social and political awareness for racial and social injustices. In fact its first modern expression might be traced back to a 1962 New York Times article by the Black author William Melvin Kelly in referring to being “well informed, up to date.”  To be authentically woke requires critical thought and discernment, and also an intuitive knowing to distinguish the cobra from the rope when groping in the dark. Now the term has been adopted by two entire generations, regardless of race, and politically weaponized with almost an ontological unease to conquer and divide. Hence to be woke is anti-woke. 

Througout human history there have been those who have held hierarchical power to control those who are subject and dependent upon that power, such as the rule of kings, emperors and authoritarian tyrants. And for having our daily needs met and securing financial ease there are the landowners, merchants and bankers. In all of these power relationships, equity is always on the side of those who hold power. At this moment our nation has reached an impasse where only a tiny group of individuals control and govern the dictates of the lives of the many. 

The Canadian philosopher Marshall McLuhan wrote, “In a culture like ours, long accustomed to splitting and dividing all things as a means of control, it is sometimes a bit of a shock to be reminded that, in operational and practical fact, the medium is the message.”  What McLuhan was suggesting is that the masses have the tendency to focus on what is most obvious and consequently miss or ignore the deeper and more subtle changes happening over a period of time.  In other words, what may seem to be correct and just on the surface eventually brings forth deleterious or “unintended” consequences. McLuhan was writing long before the internet. Now, presidential campaigns and federal laws, public health policies, the mainstream media and the films and music are the conduits for how we define ourselves and establish the options of dogmatic beliefs that we ultimately identify with. But all of these narratives are controlled by a handful of power players, including the social media platforms such as Google, Facebook, YouTube and Wikipedia. Succumbing to the siren’s call of this illusion is being woke with closed eyes.

There is a saying that if you do not know the product being advertised you are the product; and this is certainly true for how millions of Americans are persuaded to purchase junk they have no need for, including the honor of wearing a “woke” badge. Our personal realities thereby are reduced to millions of bits of algorithmic data that know more about us than we know about ourselves.  We are sold on the promises of 5G technology despite the media never mentioning its serious dangers to human health and the environment. The risks of genetically modified foods and the lack vaccine science to prove their safety and efficacy are censored from public discourse. Federal agencies that started small and were believed to be temporary, such as Homeland Security, became permanent and unstoppable leviathans that encroach into every corner of our lives. 

At this moment, we are being lectured like children to get vaccinated against the SARS-2 virus so life can return to normal. In principle, this sounds reasonable. However, to accomplish this there lurks under this message’s surface the hidden intention to bypass or trash essential regulatory protective measures to assure the safety of these products.  If you get vaccinated, you are now “woke.” If you remain cautious or hesitant because nobody has even a vague idea about the Covid-19 vaccine’s long-term adverse effects, you should be hermetically sealed away from the society, branded, canceled and censored. 

Conventional medical voices who refuse to be misled by Biden’s, Anthony Fauci’s and Bill Gate’ Ministry of Truth are also being canceled and censored from society by Silicon Valley and social media. So too are professors who have spoken out against student demands for personal entitlement and the anti-woke White Fragility diatribe that condemns genetic whiteness as racist. Students would prefer college to be sanitized of critical thought, a pleasant, non-intrusive and safe environment filled with teddy bears and psychologists next door to drug their episodes of existential angst and purposelessness in life. 

As the pandemic hijacks our attention, global warming increases. But federal experts tell us we have time. Biden tells us the economy is recovering and flourishing and a herd of lemmings believe this message despite 20 percent of Americans who will go to sleep hungry tonight. Those with cancer, heart disease, diabetes and dementia are told to just hang on a bit longer; a big pharmaceutical cure is just around the corner.  But for decades, this carrot has been dangled before us and has yet to come to fruition. 

Everything today is its opposite. The blue and red pills have been pulverized together. Only a purple pill laced with the strychnine of lies and half-truths is offered by an unduly legislative system run by technocrats and their private financial handlers. Woke and anti-woke are indistinguishable since both are born from similarly delusional worldviews isolated from reality. Neither is capable of observing the preciousness and fragility of human life. What should be a condemnation of the class and economic struggle against the elites’ persecution of everyone else has degenerated into hate-filled identity war, both on the Left and the Right. It is only the rare authentic progressive who has transcended this divide and can observe wisely the battlefields orchestrated by politically motivated ideologues, aristocrats and the media. 

As the US spins further into a controlled dystopia, it is difficult to imagine that the trajectory towards social decay can be easily reversed. Arthur Miller said, “an era can be said to end when its basic illusions are exhausted.”  Therefore, we still have a long way to go and it may require a full system-failure at all economic and social levels before a viable and realistic effort can restore what has been lost from the ethical wasteland left in its wake. It took Rome several centuries to collapse but we are on course to accomplish this feat within a decade. To remain optimistic, therefore, requires a rejection of the dominant Social Darwinism and the specter of what Thomas Huxley called the Church Scientific that now informs both parties and that has shackled us into a fatalist purgatory or worse Dante’s hedonic hells of lust, gluttony and greed. The evangelical Christian Right, as science’s counterrevolutionary reactive response, is equally a major contributor to the dumbing down of the nation’s sanity with fairy tales and superstition. 

Our indoctrination into scientific materialism, our surrendering our autonomy and divine freedoms to political and corporate regimes, and the clashes over political correctness, that disempower us from believing we can change our conditions, has resulted in a sense of hopelessness in life and growing existential despair. It is contributing to the unbridled frenzy of anger in the streets, again from both the Left and Right.  Ideological beliefs become dogmas founded upon our mental afflictions, which in turn hold rule over our emotions, fears and hatreds and reactions. No wonder that pessimism is on the rise and optimism is in decline. 

Only a personal encounter with a deeper purpose and meaning in life, which cuts through the tyranny of our false sense of the self or ego, can ultimately guide us to rise above the turmoil and crises facing us. This does not imply a detached disinterest, an ascetic renunciation, from the plights of our neighbors and humanity. In fact, only by discovering authentic kindness and compassion through a personal introspective inquiry into ourselves and our connection with the others can an authentic sense of well-being and genuine happiness emerge.  It is a commitment to finding our interconnection, in fact our interdependence, with others in the spirit of selflessness and service. 

Yet to be left alone with only your own mind to keep you company terrifies the vast majority of people, including those who might be characterized as “normal.” This was observed in literally “shocking” experiments. In a University of Virginia study, hundreds of student participants would sit alone in an empty lab room for 15 minutes. No mobile phones, books, paper or anything was permitted. Just themselves and the cacophony of static in their own minds. However, there was a button they could push if they felt so inclined that would give a moderately painful electric shock. The results? Sixty-seven percent of men and 25 percent of women chose to find amusement to occupy their minds by shocking themselves rather than sit quietly and have peaceful time for self-reflection. This was despite all of the participants stating prior to the experiment that they would pay money to avoid being shocked with electricity. 

So if modern American society relies solely upon mental and emotional distraction to survive, clearly there is no hope for constructive solutions to emerge to confront climate change, racism, identity politics, inequality, etc. Nor will society evolve beyond that of primates if we can only function from our reptilian and limbic brains. Obviously not everyone will discover the same purpose to his or her life’s meaning. It is an individual quest that is largely entwined with each of our unique gifts, skills, passions and talents that we have brought into this incarnation. Those who disagree that one can discover meaning in life are the dogmatists of materialism and should be shunned as deranged scientific fanatics. Logic and reason alone will not satisfy this discovery, although developing skills in critical thought and discernment is more often than not necessary. It is only the rare person who has immediate intuitive knowledge about herself and the world around her. 

For the remainder of us, we need to reeducate ourselves to create a roadmap, develop a discerning eye, and engage in deep introspection into ourselves to find a genuine well-being that transcends power player’s board game to manufacture social strife, division and hatred. It is an individual journey that begins deep within ourselves and ends by embracing others in community despite all differences. However this is not an exercise in reason, but a direct experience within the depths of ourselves. When we touch on that space that can only be reached by subjective introspection new horizons of opportunities and possibilities open up. Then we can understand the words of the great jazz artist John Coltrane, “I know that there are bad forces, forces that bring suffering to others and misery to the world, but I want to be the opposite force. I want to be the force which is truly for good.” In that honoring of our inherent goodness, genuine well-being and happiness is found and only then can our illusions and dogmatic beliefs be broken down. 

The Gary Null Show - 06.25.21

Please keep in mind that these two write-ups represent only the "tip of the iceberg," and for everything that is recorded here, there are literally dozens of other examples that I could give.

My information is NOT included in John Lauritsen's book on AZT, simply because neither of us had heard of each other at that time (although I wish we had!). His book documents information related to the Phase II studies of AZT, whereas I was involved with the Phase III studies (ACTG 019). But it was all the same kinds of shocking nonsense, incompetence and fraud.

In addition to ACTG 019 (which was the major study at that time), I also worked on other studies of AZT and ddI (ACTG 002, 016, 020, 081, 116, 117 and 118). Some of these studies included other drugs, such as pentamidine.

I was somewhat young (and naive) at the time, and didn't quite know what to make of what I was witnessing, or what to do with the information that I had documented, having NEVER witnessed anything even remotely similar. In fact, at that point in my life, I didn't even realize that human beings were even CAPABLE of this kind of corrupt, insane, self-motivated behavior. If I had known then what I know now, I would have been much more persistent in my attempts to report this information to the NIH. I don't even have a single letter – my communication with them was done entirely over the phone. Which means they could simply deny that these phone conversations ever took place. All I have to offer as evidence that I DID REPORT THIS TO THE NIH AND THEY DELIBERATELY IGNORED MY INFORMATION is my personal testimony, and some handwritten notes that I took at the time (this was in the Spring of 1990). I may be able to locate at least one witness who could corroborate my story (the NIH site monitor for Syracuse).

But the way that I look at this is that it's never too late to report this to the NIH, AGAIN. And the important thing is that I still have ALL of my original documents (an entire box full of material) which I tried to share with them in 1990. I have precise names, patient numbers, dates, lab values, memos, etc. I KNOW that my information is accurate, because I was so thorough and meticulous (not to mention HONEST) in my record-keeping. That's why they hired me – I'm an extremely detail-oriented, "numbers" person. Thus, all of my information could, in theory, be verified by referring to the original research forms and NIH documents from that time period, which must still exist and (theoretically) could be obtained through the Freedom of Information Act. Ideally, my second attempts to report this could lead to a Congressional Investigation. That is certainly what I will be calling for. The seriousness of my allegations certainly warrants such an investigation. For the NIH to knowingly ignore serious and credible DOCUMENTED reports of gross scientific misconduct coming from someone working on the INSIDE of these trials – if that doesn't constitute scientific "fraud," I don't know what does. Especially when we look at the real-life gruesome outcome of this deliberate refusal to even INVESTIGATE my allegations to see if there was any merit to them (along with all of the other glaringly obvious, telltale signs and warnings coming from around the globe, which were also ignored at that time) – all of this intentional "blindness" on the part of the NIH, the FDA, Burroughs Wellcome, etc., led to the unnecessary and unimaginable suffering of countless individuals (of both "HIV+" people and their loved ones), and the unnecessary deaths of (in my view) tens of thousands of people. This dreadful holocaust continues to this day. Parks Mankahlana, couldn't have summed it up better when he said "...the profit takers who are benefiting from the scourge of HIV/AIDS will disappear to the affluent beaches of the world to enjoy wealth accumulated from humankind ravaged by a dreaded disease."

Knowing what I know "first hand" about AZT, and knowing how it should NEVER have received FDA approval under ANY circumstances, this is one of many reasons why I am especially grateful to the members of the Perth group, Peter Duesberg, John Lauritsen, Celia Farber, Anthony Brink and many others for the outstanding work that they have done in documenting the case against AZT.

***

I was an eyewitness (and later a whistle-blower) to gross negligence and fraud in the Phase III clinical trials of AZT (1987 to 1990). I've been saying to people for years that AZT was NEVER proven to be safe or effective. From the particular studies in which I was involved, it would have been impossible to prove anything. The data was such a mess! I now realize that AZT is a deadly poison. All "AIDS drug" trials since that time have been based on the same flawed model. The big difference is that now there is even LESS meaningful oversight, and even MORE of an economic incentive for physicians to enroll patients. And recent drug trials have also been characterized by an absurdly brief follow-up period (24 or 36 weeks, for example), and effectiveness is often said to be determined by "surrogate markers" which have never been proven to relate to actual clinical health and/or increased survival. But, the early AZT studies were like the big "granddaddy" of all of this ensuing insanity!

I did not know John Lauritsen at the time that he wrote his book, AZT: Poison by Prescription (1990), but I later told him that, if I had known him at that time, I could have given him several additional chapters for his book! In this book he meticulously documents serious fraud which took place at other participating hospitals (I was in Syracuse, NY), particularly at a hospital in Boston. When I first read John's book, it was like reading my own autobiography! Talk about deja vu!

In spite of what I witnessed, I was not aware, however, of the deeper problems within "AIDS science" until many years later. It was in 1997 that I first heard about the views of the "AIDS dissidents." After educating myself regarding the many unexplained and nonscientific paradoxes and absurdities of the orthodox "HIV/AIDS" model, and after studying the alternative views proposed by the various "AIDS dissidents," I started doing public speaking on this topic. I especially want to share my story with as many people as possible about the fraud which I witnessed firsthand in the early AZT trials. I always tell people that if the general public knew what I knew about AZT, this so-called "drug" would be banned immediately.

***

My name is Lynn Gannett. As the Data Manager for the first two years and seven months of the NIH-sponsored AIDS clinical trials conducted at the Syracuse, New York, clinic (September 1987 to March 1990), my belief is that the data which came from the Syracuse site is ABSOLUTELY WORTHLESS! I would NEVER trust my health or my life to the results of this so-called "research" or in the hands of these so-called "medical professionals." I can only speculate that if these things occurred at this site, that similar things may have and in all likelihood did occur at the other participating sites. The things that I witnessed at this clinic would HORRIFY any reasonable observer. The level of medical incompetence, unprofessionalism, unethical, dishonest, corrupt, illegal and immoral behavior was shocking and inexcusable. The data was so inaccurate and so full of holes that I often compare it to Swiss cheese. I felt like I was trapped in the middle of an awful movie about "mad scientists." If there was a "rule" that could be broken - they broke it! The following examples outline some of the most egregious examples of what I witnessed:

* The Principal Investigator, an MD, and the Study Coordinator, an RN, showed a huge interest in enrolling as many patients as possible on studies (which would entitle them to more money and perceived prestige) and showed little interest in the research itself - specifically in the integrity, accuracy and completeness of the data.

* The Study Coordinator (and other medical staff responsible for study patients) often displayed a significant lack of understanding and unfamiliarity with the study protocols and important memos concerning their implementation - as though she had not even read them, or had totally misunderstood and misinterpreted them, even in instances pertaining to terminology and procedures FUNDAMENTAL to the protocol itself, often months after the study had been underway.

e.g. In what I consider to have been the most serious, disturbing and grossly incompetent situation that I witnessed, which came dangerously close to resulting in death, and unquestionably resulted in extreme unnecessary suffering, PID #110434, a black, obese, diabetic, HIV+ female with a history of serious heart problems, experienced severe hematologic toxicity from the 081 study drug (AZT), which had progressed to a GRADE IV toxicity by week 24 and resulted in her coming into the emergency room with "severe shortness of breath, fatigue and weakness," and required her to be hospitalized for a total of five days. BECAUSE NO ONE, DOCTOR OR NURSE, SHOWED ANY RESPONSIBILITY FOR, KNOWLEDGE OF, INTEREST IN OR RECOGNITION OF THE IMPORTANCE OF THE EXPLICITLY-DEFINED TOXICITY (ADVERSE REACTION) AND DOSE MANAGEMENT STEPS AND PROCEDURES OUTLINED IN THE PROTOCOL, instead of being taken OFF the AZT due to the Grade IV toxicity, her dose was reduced from 1000 mg/day to 500 mg/day, in complete violation of protocol requirements which explicitly require DISCONTINUATION of study drug. Additionally, early Grade I and Grade II toxicities should have indicated the need for interim lab monitoring of Hemoglobin, especially with this patient's complicated medical history, but instead this patient had NO lab work performed between week 20 (13DEC89) and week 24 (10JAN90), even though she was in for a pentamidine treatment on 20DEC89 and could have easily had a blood sample drawn. At some point during this time interval, her original medical chart was "lost," never to be found again, requiring a new chart to be made up, which subsequently obviously lacked significant information concerning her medical history. I was shocked, outraged and horrified when this whole situation occurred, and documented this gross medical incompetence and blatant violation of protocol requirements as carefully as I could because I wanted everything to be ON RECORD so that no one could later deny it or cover it up. (See attached memo dated 01FEB90 and lab flow chart showing toxicity progression.)

* Patients were ROUTINELY enrolled who failed to meet eligibility requirements, especially when it came to specific required lab values and test ranges (i.e., within the required number of days prior to enrollment). There are many, many examples. Below are a few (also see attached 05OCT89 list of 081 screening lab eligibility failures):

e.g. In the most blatant example, PID #110264C, a female partner of an HIV+ male, was enrolled on study 019 and took study drug for THREE weeks before it was discovered that she was actually HIV NEGATIVE! (The Elisa came back as a false positive but the Western Blot came back negative.) The test results date predated her enrollment on study date. She was also on oral contraceptives at the time, another eligibility violation.

E.g. You might think that this would be the last time a patient would be enrolled without an HIV+ test result "in hand" - not so. PID #110316's HIV+ test results are dated 06JAN89, ONE MONTH AFTER his enrollment date (05DEC88)!

e.g. Other patients had been routinely enrolled without HIV+ test results documentation available, often based simply on referrals from other physicians. An example is PID #110153H, a referral patient from Binghamton who, to my knowledge, has no HIV+ test results in his chart TO THIS DAY! After a year or two of my repeated requests to the Study Coordinator for this information, she finally obtained a LETTER ONLY from the referring physician "verifying" his HIV+ status, who also apparently had no supporting documentation.

* There were COUNTLESS unreported (meaning unreported on the research forms) diagnoses, opportunistic infections, symptoms, concomitant medications, and adverse reactions. Except for "symptoms" (which were asked for at every visit), these significant things (which each REQUIRE reporting) should have been reported on one of several "as needed" or optional case report forms used to track this information - an extra step which was rarely taken. I often observed, as did the RTI (Research Triangle Institute) site monitors, this unreported information recorded or mentioned in the patient's regular medical chart.

E.g. From the 22JUN89 site monitor's report: "Of the six protocol 002 charts which were reviewed for the first critical event verification, four reported death as the first event even though at least one OI [opportunistic infection] has preceded the death. These OI's were not reported. In another instance, it was impossible to determine what had happened to the patient between the time of randomization and death because the records were missing."

* Incorrect lab tests were ROUTINELY ordered (either required labs omitted or unrequired labs ordered by mistake), and the wrong prescriptions were ROUTINELY written (for example, 1200 mg/day instead of 1000 mg/day). When I questioned these and other similar mistakes, I would be chastised by the Principal Investigator and/or Study Coordinator for being too "nit picky" or for inappropriately questioning someone's medical "expertise" since I did not have (nor did my position require) a medical degree.

* Medical lab results were ROUTINELY transcribed incorrectly onto the research forms by the Study Coordinator (who I suspect may have dyslexia - at the very least, she does not have the "detail-oriented" type of mind necessary for this type of research position).

* Syracuse had an unusually high and excessive rate of "no shows" (often meaning "not even scheduled to begin with") and "not dones" compared to the other clinics.

* On a regular basis, I would have to REPEATEDLY request data from the Study Coordinator, and we routinely missed deadlines.

E.g. There was one group of approximately 90 (!) forms which were "missing" for over a year and a half. When these forms were eventually "found," mostly blank, the Study Coordinator filled in much of the information with, in most cases, no supporting documentation or progress notes in the charts. I have always believed that this data was just "fudged" or made up, because there would have been no other written record of these things (such as vital signs).

* Informed consent forms were ROUTINELY backdated, sometimes weeks or even months after enrollment.

E.g. In at least one instance, a patient was asked to sign (and did sign, along with the Principal Investigator and Study Coordinator) an informed consent form for the WRONG study (PID #110076A signed an informed consent for study 116 but was being enrolled on study 117).

* The Principal Investigator and Study Coordinator displayed such open hostility and contempt toward the site monitors that there was a high turnover (4 different site monitors in a 3-year period). These site monitors could have easily uncovered this corruption if they had done their jobs carefully (which the first 3, at least, did NOT do) and over an extended period of time.

* On March 21, 1990, after attempting unsuccessfully for over one year to address and resolve these SERIOUS issues with the Principal Investigator and Study Coordinator, and after watching in horror as the situation worsened severely with the implementation of the DDI studies (see attached memo dated 19MAR90), and after being retaliated against in many vicious and mean-spirited ways by both the Principal Investigator and Study Coordinator merely for repeatedly raising these issues and insisting on some type of corrective action, I felt compelled, in good conscience, to resign my position as Data Manager and immediately report this critical situation to the RTI site monitor.

E.g. After reporting this to the site monitor, she checked with her boss, who in turn checked with her boss, and the decision was made to launch a "special audit and investigation" of the Syracuse site by the program office. I was asked to mail copies of all of my documentation supporting my claims to the site monitor. In a 27MAR90, 1:40 PM, phone call, the site monitor told me that her boss "never heard of anything of this magnitude," and referred to the situation as "uncharted waters."

E.g. In a 27MAR90, 4:00 PM (later that same afternoon), phone call with Carolyn Fassi, who called me from NIH on behalf of Dr. Kantz, she thanked me for bringing these issues to their attention and said it would be unnecessary for me to forward copies of my documentation to the site monitor or to NIH. She also stated that they "can't act directly" based on my claims or supporting documentation, that they would "keep a close eye" on the Syracuse site, that they "won't use my information against the site or me," and ended by saying that he (Dr. Kantz) "may not even need to call me, except to clarify something." In other words, "don't call us, we'll call you." I never received a call from their office or anyone else associated with these studies again.

The Gary Null Show - 06.24.21

Public Service -- If you are a New York resident and 18 years and older -- Religious vaccine exemptions still apply

Michael (Mike) Kane has worked as a New York City public school teacher for over 13 years and is a steering committee member of NY TEACHERS FOR CHOICE, a grassroots union caucus of educators and parents that is 100% opposed to all medical mandates to maintain employment. Recently TEACHERS FOR CHOICE sued the NYC Department of Education with their attorney Michael Sussman and won a court-ordered stipulation pertaining to in-school COVID testing and privacy rights. Kane has been a proud union member and active supporter of the United Federation of Teachers (UFT) for his entire career. He is a former union delegate, served on union consultation committees, lobbied in Albany on behalf of the union on multiple occasions, and protested with rank-&-file union members against the Bloomberg administration. His website is www.nyteachersforchoice.org

The Gary Null Show - 06.23.21

Propolis for Upper Respiratory Tract Infections

The Gary Null Show - 06.22.21

Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS

 University Hospital Wuerzburg (Germany), June 12, 2021

Abstract

The interplay between inflammation and oxidative stress is a vicious circle, potentially resulting in organ damage. Essential micronutrients such as selenium (Se) and zinc (Zn) support anti-oxidative defense systems and are commonly depleted in severe disease. This single-center retrospective study investigated micronutrient levels under Se and Zn supplementation in critically ill patients with COVID-19 induced acute respiratory distress syndrome (ARDS) and explored potential relationships with immunological and clinical parameters. According to intensive care unit (ICU) standard operating procedures, patients received 1.0 mg of intravenous Se daily on top of artificial nutrition, which contained various amounts of Se and Zn. Micronutrients, inflammatory cytokines, lymphocyte subsets and clinical data were extracted from the patient data management system on admission and after 10 to 14 days of treatment. Forty-six patients were screened for eligibility and 22 patients were included in the study. Twenty-one patients (95%) suffered from severe ARDS and 14 patients (64%) survived to ICU discharge. On admission, the majority of patients had low Se status biomarkers and Zn levels, along with elevated inflammatory parameters. Se supplementation significantly elevated Se (p = 0.027) and selenoprotein P levels (SELENOP; p = 0.016) to normal range. Accordingly, glutathione peroxidase 3 (GPx3) activity increased over time (p = 0.021). Se biomarkers, most notably SELENOP, were inversely correlated with CRP (r_s = −0.495), PCT (r_s = −0.413), IL-6 (r_s = −0.429), IL-1β (r_s = −0.440) and IL-10 (r_s = −0.461). Positive associations were found for CD8⁺ T cells (r_s = 0.636), NK cells (r_s = 0.772), total IgG (r_s = 0.493) and PaO₂/FiO₂ratios (r_s = 0.504). In addition, survivors tended to have higher Se levels after 10 to 14 days compared to non-survivors (p = 0.075). Sufficient Se and Zn levels may potentially be of clinical significance for an adequate immune response in critically ill patients with severe COVID-19 ARDS.

Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms

Louisiana State University, June 20, 2021

Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire.

Study Question: 

Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia?

Study Design: 

A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout.

Measures and Outcomes: 

Sleep was evaluated by polysomnography and 5 validated questionnaires. Serum indoleamine 2,3-dioxygenase (IDO), the kynurenine-to-tryptophan ratio, and prostaglandin E2 were measured. In vitro, Caco-2 cells were stimulated with interferon-gamma, and the ability of cherry juice procyanidin to inhibit IDO which degrades tryptophan and stimulates inflammation was measured. The content of procyanidin B-2 and other major anthocyanins in cherry juice were determined.

Results: 

Eleven subjects were randomized; 3 with sleep apnea were excluded and referred. The 8 completers with insomnia increased sleep time by 84 minutes on polysomnography (P = 0.0182) and sleep efficiency increased on the Pittsburgh Sleep Quality Index (P = 0.03). Other questionnaires showed no significant differences. The serum kynurenine-to-tryptophan ratio decreased, as did the level of prostaglandin E2 (both P < 0.05). In vitro, cherry juice procyanidin B-2 dose-dependently inhibited IDO.

Conclusions: 

Cherry juice increased sleep time and sleep efficiency. Cherry juice procyanidin B-2 inhibited IDO, increased tryptophan availability, reduced inflammation, and may be partially responsible for improvement in insomnia.

Many with migraines have vitamin deficiencies, says study

Cincinnati Children’s Hospital, June 10, 2021 

A high percentage of children, teens and young adults with migraines appear to have mild deficiencies in vitamin D, riboflavin and coenzyme Q10—a vitamin-like substance found in every cell of the body that is used to produce energy for cell growth and maintenance.

These deficiencies may be involved in patients who experience migraines, but that is unclear based on existing studies.

"Further studies are needed to elucidate whether vitamin supplementation is effective in migraine patients in general, and whether patients with mild deficiency are more likely to benefit from supplementation," says Suzanne Hagler, MD, a Headache Medicine fellow in the division of Neurology at Cincinnati Children's Hospital Medical Center and lead author of the study.

Dr. Hagler and colleagues at Cincinnati Children's conducted the study among patients at the Cincinnati Children's Headache Center. She will present her findings at 9:55 am Pacific time Friday, June 10, 2016 at the 58th Annual Scientific Meeting of the American Headache Society in San Diego.

Dr. Hagler's study drew from a database that included patients with migraines who, according to Headache Center practice, had baseline blood levels checked for vitamin D, riboflavin, coenzyme Q10 and folate, all of which were implicated in migraines, to some degree, by previous and sometimes conflicting studies. Many were put on preventive migraine medications and received vitamin supplementation, if levels were low. Because few received vitamins alone, the researchers were unable to determine vitamin effectiveness in preventing migraines.

She found that girls and young woman were more likely than boys and young men to have coenzyme Q10 deficiencies at baseline. Boys and young men were more likely to have vitamin D deficiency. It was unclear whether there were folate deficiencies. Patients with chronic migraines were more likely to have coenzyme Q10 and riboflavin deficiencies than those with episodic migraines.

Previous studies have indicated that certain vitamins and vitamin deficiencies may be important in the migraine process. Studies using vitamins to prevent migraines, however, have had conflicting success.

Research suggests mask-wearing can increase struggles with social anxiety

University of Waterloo (Canada), June 21, 2021

People who struggle with social anxiety might experience increased distress related to mask-wearing during and even after the COVID-19 pandemic.

A paper authored by researchers from the University of Waterloo's Department of Psychology and Centre for Mental Health Research and Treatment also has implications for those who haven't necessarily suffered from social anxiety in the past.

"The adverse effects of the COVID-19 pandemic on mental health outcomes, including anxiety and depression, have been well-documented," said David Moscovitch, professor of clinical psychology and co-author of the paper. "However, little is known about effects of increased mask-wearing on social interactions, social anxiety, or overall mental health.

"It is also possible that many people who didn't struggle with social anxiety before the pandemic may find themselves feeling more anxious than usual as we emerge out of the pandemic and into a more uncertain future -- especially within social situations where our social skills are rusty and the new rules for social engagement are yet to be written."

Social anxiety is characterized by negative self-perception and fear that one's appearance or behaviour will fail to conform with social expectations and norms. Social anxiety disorder is an extreme manifestation that affects up to 13 per cent of the population. 

The researchers reviewed existing literature addressing three factors that they hypothesized might contribute to social anxiety associated with mask-wearing: hypersensitivity to social norms, bias in the detection of social and emotional facial cues, and propensity for self-concealment as a form of safety behaviour.

"We found that mask-wearing by people with social anxiety is likely to be influenced by their perception of social norms and expectations, which may or may not be consistent with public-health guidelines and can vary widely by region and context," said Sidney Saint, an undergraduate psychology student at Waterloo and lead author of the paper.

The paper also highlights that people with social anxiety have difficulty detecting ambiguous social cues and are likely to interpret them negatively. These individuals also tend to worry about sounding incomprehensible or awkward. "We believe that both issues are likely to be magnified during interactions with masks," Saint said.

Another highlighted impact is that masks can function as a type of self-concealment strategy that enables people with social anxiety to hide their self-perceived flaws. Therefore, the desire for self-concealment may motivate their use of masks over and above their desire to protect themselves from contagion. "Due to their self-concealing function, masks may be difficult for some people to discard even when mask-wearing is no longer required by public health mandates," Saint said. 

In addition to contributing insights to guide clinicians toward effective assessment and treatment, the paper shows that people with social anxiety may be particularly vulnerable to periods of norm transitions where expectations for mask-wearing are in flux or become a matter of personal choice.

Going with your gut can result in better decision-making than using detailed data methods, study shows

City University London, June 21, 2021

Managers who use their gut instinct together with simple decision-making strategies may make equally good, but faster, decisions as those who use data to reach an outcome, a new study has found.

The report, co-authored by academics at the Business School (formerly Cass), King's Business School, and the University of Malta, finds that the reliance on data analysis in decision-making might be counterproductive as this reduces decision-making speed without ensuring more accuracy.

The research, based on information from 122 advertising, digital, publishing, and software companies, finds that using data to inform decision making under high uncertainty is often not optimal. This may explain why 12 different publishers initially rejected the opportunity to publish "Harry Potter and the Philosopher's Stone' – because it had no data to inform its potential.

A recent survey revealed that 92 percent of Fortune 1000 companies were reporting increased investment in data initiatives, although it appears this may not always be necessary.

The authors asked managers how they made decisions on their most recent innovation project, including the extent to which they used data, instinct, and other simple heuristics (mental strategies). The findings outlined that among those decision-making methods were:

1. Majority—choosing what the most people wanted
2. Tallying—picking the choice with the greatest quantity of positive points
3. Experience—selecting the option that the most experienced individual on the team wanted.

Managers were asked whether they think they made the right decision and how fast they were in reaching that decision. Results showed that managers relied on their own instinct as much as data, using 'tallying' more than any other metric.

Dr. Oguz A. Acar, Reader in Marketing at the Business School and co-author of the report, said: "This research shows that data-driven decision-making is not the panacea in all situations and may not result in increased accuracy when facing uncertainty.

"Under extreme uncertainty, managers, particularly those with more experience, should trust the expertise and instincts that have propelled them to such a position. The nous developed over years as a leader can be a more effective than an analytical tool which, in situations of extreme uncertainty, could act as a hindrance rather than a driver of success."

"Choosing among alternative new product development projects: The role of heuristics" is published in Psychology and Marketing.

Pretreatment by rosemary extract or cell transplantation improves memory deficits of Parkinson disease

Damghan University (Iran) June 21 2021

According to news originating from Damghan, Iran, research stated, “The therapeutic effect of adipose tissue-derived stem cells (ADSCs) or RE on hippocampal neurogenesis and memory in Parkinsonian rats were investigated. Male rats were lesioned by bilateral intra-nigral injections of 6-OHDA and divided into six groups: 1. Lesion 2 and 3: RE and water groups were lesioned rats pretreated with RE or water, from 2weeks before neurotoxin injection and treated once a day for 8weeks post lesion. 4&5: Cell and alpha-MEM (alpha-minimal essential medium) received intravenous injection of BrdU-labeled ADSCs or medium, respectively from 10days post lesion until 8weeks later. 6: Sham was injected by saline instead of neurotoxin.”

Our news journalists obtained a quote from the research from Damghan University, “Memory was assessed using Morris water Maze (MWM), one week before and at 1, 4 and 8weeks post 6-OHDA lesion. After the last probe, the animals were sacrificed and brain tissue obtained. Paraffin sections were stained using cresyl violet, anti-BrdU (Bromodeoxyuridine / 5-bromo-2’-deoxyuridine), anti-GFAP (Glial fibrillary acidic protein) and anti-TH antibodies. There was a significant difference of time spent in the target quadrant between groups during probe trial at 4 and 8 weeks’ post-lesion. Cell and RE groups spent a significantly longer period in the target quadrant and had lower latency as compared with lesion. Treated groups have a significantly higher neuronal density in hippocampus compared to water, alpha-MEM and lesion groups. BrdU positive cells were presented in lesioned sites. The GFAP (Glial fibrillary acidic protein) positive cells were reduced in treated and sham groups compared to the water, alpha-MEM and lesion groups.”

According to the news editors, the research concluded: “Oral administration of RE (Rosemary extract) or ADSCs injection could improve memory deficit in the Parkinsonian rat by neuroprotection.”

Inadequate vitamin D levels associated with interstitial lung disease

Johns Hopkins University, June 20 2021. 

An article appearing in the Journal of Nutrition documents a link between decreased vitamin D levels and a greater risk of early signs of interstitial lung disease (ILD), a group of disorders characterized by inflammation and scarring that can lead to lung damage. Although ILD can be caused by environmental and other factors, some cases have unknown causes.

The investigation included 6,302 participants in the Multi-Ethnic Study of Atherosclerosis who had information available concerning their initial serum 25-hydroxyvitamin D concentrations and computed tomography (CT) imaging that included partial views of the lungs. Ten years after enrollment, 2,668 participants had full lung CT scans that were evaluated for presence of scar tissue and other abnormalities.

Subjects who had deficient vitamin D levels of less than 20 ng/mL had more spots on their lungs that were suggestive of damage in comparison with subjects whose vitamin D was adequate. Among those who had full lung CT scans, deficient or intermediate (between 20-30 ng/mL) vitamin D levels were associated with a 50-60% greater risk of abnormalities suggestive of ILD.

"We knew that the activated vitamin D hormone has anti-inflammatory properties and helps regulate the immune system, which goes awry in ILD," commented senior author Erin Michos, MD, MHS. “There was also evidence in the literature that vitamin D plays a role in obstructive lung diseases such as asthma and COPD, and we now found that the association exists with this scarring form of lung disease too."

"Our study suggests that adequate levels of vitamin D may be important for lung health,” she concluded. “We might now consider adding vitamin D deficiency to the list of factors involved in disease processes, along with the known ILD risk factors such as environmental toxins and smoking.”

The Gary Null Show - 06.21.21

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The Gary Null Show - 06.18.20

Are the Covid-19 vaccines “safe and effective”?

The Gary Null Show - 06.17.21

Dr. Elizabeth Mumper is pediatrician, and the president and CEO of Rimland Center in Virginia that mentors medical practitioners and clinicians working with children with neurodevelopmental problems. She also runs a general pediatric practice -- Advocates for Children, and her Advocates for Families practice is devoted to caring for autistic children and those with learning disabilities.  Liz has received many awards for her work with children including a public service award from the National Press Club and being named Woman of the Year by the YWCA.  Earlier she was the medical director of the Autism research Center. Dr Mumper received her medical degree from the Medical College of Virginia and did her residency at the University of Massachusetts and the University of Virginia. Later she served as chief resident of pediatrics at the University of Virginia. She has traveled worldwide lecturing on children with autism and mentoring physicians internationally. Her website is RimlandCenter.com

The Gary Null Show - 06.16.21

The Gary Null Show Notes – 06.16.21

The Gary Null Show - 06.15.21

After receiving a bachelor’s degree from Baylor University, Dr. McCullough completed his medical degree as an Alpha Omega Alpha graduate from the University of Texas Southwestern Medical School in Dallas. He went on to complete his internal medicine residency at the University of Washington in Seattle, cardiology fellowship including service as Chief Fellow at William Beaumont Hospital, and master’s degree in public health at the University of Michigan. Dr. McCullough is a consultant cardiologist and Vice Chief of Medicine at Baylor University Medical Center in Dallas, TX. He is a Principal Faculty in internal medicine for the Texas A & M University Health Sciences Center. Dr. McCullough is an internationally recognized authority on the role of chronic kidney disease as a cardiovascular risk state with > 1000 publications and > 500 citations in the National Library of Medicine. His works include the “Interface between Renal Disease and Cardiovascular Illness” in Braunwald’s Heart Disease Textbook. Dr. McCullough is a recipient of the Simon Dack Award from the American College of Cardiology and the International Vicenza Award in Critical Care Nephrology for his scholarship and research. Dr. McCullough is a founder and current president of the Cardiorenal Society of America, an organization dedicated to bringing cardiologists and nephrologists together to work on the emerging problem of cardiorenal syndromes. His works have appeared in the New England Journal of Medicine, Journal of the American Medical Association, Lancet and other top-tier journals worldwide. He is the co-editor of Reviews in Cardiovascular Medicine, and associate editor of the American Journal of Cardiology and Cardiorenal Medicine. He serves on the editorial boards of multiple specialty journals. Dr. McCullough has made presentations on the advancement of medicine across the world and has been an invited lecturer at the New York Academy of Sciences, the National Institutes of Health, U.S. Food and Drug Administration (FDA), European Medicines Agency, and the U.S. Congressional Oversight Panel.

The Gary Null Show - 06.14.21

The Covid-19 Pandemic and the Corruption of Genuine Science

Richard Gale & Gary Null PhD
Progressive Radio Network, June 10, 2021
Medical science has made such tremendous progress that there is hardly a healthy human left. — Aldous Huxley

For half a century, the pharmaceutical industry has shown near zero tolerance towards criticism against its unequivocal failures and medical catastrophes. Permanent disabilities and deaths due to unsafe drugs, such as Merck’s anti-inflammatory drug Vioxx, Pizer’s Bextra, synthetic hormone replacement therapy, thalidomide, and the earlier cellular pertussis and the 1976 influenza vaccines, are regarded as the collateral damage of getting unsafe medical products on the market. During the past two decades a tightly-knit and collaborative relationship has evolved between the pharmaceutical industry, federal health agencies, Congress, Silicon Valley, and the new culture of billionaire philanthropists such as Bill Gates. Due to the large web of funders favoring corporate financial interests and CDC-sponsored educational programs, the mainstream media is now the successful advertiser for pharmaceutical ambitions. As a consequence, modern medicine’s dire risks to public health are undermined. The broader picture and the darker players operating behind the tragic legacy of medical iatrogenic failures remain largely hidden from the public. In recent years those physicians, researchers and health advocates who dissent from the pharmaceutical narrative often face a formidable blowback resulting in censorship and destroyed reputations.

Over forty years ago, sociologist and philosopher Ivan Illich prophetically observed a conspicuous unfolding of modern medicine becoming divorced from itself and the ethical basis for treating illnesses. He wrote, “the medical establishment has become a major threat to health.” Illich was among the first poignant critics of the corporatization of medicine to address the problems of “medicalization,” the process by which very human non-medical conditions are redefined as medical diseases and then diagnosed and pharmaceutically treated as such. This has been a result of hardened scientific materialism’s ascendency as the final judge over national healthcare. Increasingly researchers, more often than not funded by private drug companies and backed by an army of lobbyists, are discovering ways to reevaluate health conditions with only flimsy clinical evidence into the actual etiology of disease — even infectious pandemics. Psychiatric practice, which today relies almost exclusively on a drug-based model, is the greatest serial offender. Yet systemic corruption throughout our national healthcare has been a boon for drug makers who can then develop novel medications for illnesses that could otherwise be treated by less expensive and safer drugless therapies “Modern medicine is a negation of health,” Illich wrote in his acclaimed book Medical Nemesis: The Expropriation of Health. “It isn’t organized to serve human health, but only itself, as an institution. It makes more people sick than it heals.” It is a system that today depends upon volumes of flawed medical clinical trials, financial incentives, institutional bureaucracy, revolving doors between government and private industry, rampant conflicts of interests, and an aggressive propaganda machine that has had enormous success in marginalizing and ridiculing critics both within and outside the medical complex. Our medical edifice has violated every defining principle of scientific inquiry that should place uncompromising value on objective, unbiased inquiry and open conversation and debate over conflicting views. To invoke the precautionary principle is a personal confession of heresy. Over the years, the steady rise in the number of class action and criminal lawsuits against pharmaceutical firms, Freedom of Information Act submissions, and false testimonies by federal health officials before Congressional subcommittees have confirmed Illich’s warnings.

For Illich the dangerous consequence is that conventional medicine has become depersonalized. Whereas in the past malpractice was treated as a serious ethical issue – and iatrogenic death, or fatalities due to medical error, is now the US’s third leading cause of mortality – it is simply perceived as a technical glitch that can be corrected by further technical solutions. As a result of persistent self-denial over conventional medicine’s inherent failures, the dominant medical paradigm that now governs the nation’s health has succeeded in barricading itself behind a monolithic propaganda machine and a compliant media with the ability to marginalize criticism and to hermetically seal itself from being called to legal account. Even worse, it has usurped the sovereignty we have over our bodies and transferred this power to a technocracy that deeply believes it is upholding the integrity of science. However it is a science solely molded in the image of medical bureaucrats and their powerful allies who have been christened as experts.

And all of these past medical failures, the estimated 90 percent of junk pharmaceutical clinical trials published in junk medical journals, institutionalized hubris, and the drug makers’ capture of our health agencies is being openly staged in the handling of the Covid-19 pandemic on the global theater.

When we are being lectured to recite the pandemic mantra in unison by Joe Biden, Governor Andrew Cuomo, the UK’s Boris Johnson, and one of the church of Scientism’s head priests Neil DeGrasse Tyson — “Follow the Science” – whose science is being referred to? Is it the 19th century mechanistic science, which continues to be the foundation for modern evolutionary biology, neuroscience, psychiatry and vaccinology? Is it the pseudo-science promulgated by the cult of Skepticism that pollutes hundreds of Wikipedia’s health entries? Is it corporate, pharmaceutical-based science; medical research and discovery motivated by astronomical commercial incentives to appease the hedonic financial appetites of shareholders? For Anthony Fauci, he has imagined himself as the incarnation of science. Replying to MSNBC’s Chuck Todd, Fauci made his self-proclamation, “what you’re seeing as attacks on me quite frankly are attacks on science.”

Or is it science that is meticulously vetted by a range of independent professionals who aspire to arrive at the truth of a medical problem or to find a medical solution? It is this latter group who are most inclined to impartially review the pros and cons of scientific papers, the clinical trials of a drug, vaccine, medical device and diagnostic tool; then, based upon the empirical evidence, a medical intervention’s value, efficacy and safety is properly determined. Sadly this latter group is rarely if ever invited to sit at the regulatory table or to advise national health policy. Rather, the pursuit of medical facts about disease and pandemics has ceased to be a evidence-based methodology of objective inquiry and has become a means to institute authority and control over a population. “You can’t really follow the science,” states the philosopher of science Matthew Crawford, “because science doesn’t lead anywhere. It can illuminate various courses of action; for example by quantifying the risks that attend each. It can help to specify the trade offs… but it can’t make the choices for us.” Modern medicine’s failure to recognize this has, in Crawford’s opinion, led to a “victimology joining hands with scientism.” That is, medicine as an ideology and not a science. The consequence is that those who question or challenge the dominant medical ideology are censored, cancelled and have their reputations destroyed

We must come to the conclusion that modern conventional medicine has lacked the enthusiasm to uncover scientific truths for many decades. The pandemic’s mantra, “follow the science,” has been waxed into a meaningless banality. It is an empty amoral platitude for bureaucrats and media pundits with MD and PHD decorating their names. Unlike the “hard sciences,” such as mathematics and physics, medical practice is “soft.” Medical certainty, as in the serious hard sciences, should have as its objective “value-neutral truth.” Medicine and medical discovery is equally an art form. It is supposed to be grounded upon scientific evidence in order to make reasonable decisions. The debate over whether the practice of medicine is an art or an empirically based science has raged for decades. Over two decades ago, the British Medical Journal published an article, “The Practice of Clinical Medicine as an Art and as a Science.” The authors spread out on the table the prime principle to govern medical research as a determining factor for publication.

“… scientific thinking should, must, be insulated from all kinds of psychological, sociological, economic, political, moral and ideological factors which tend to influence thought in life and society. Without those proscriptions, objective knowledge of truth will degenerate into prejudice and ideology.”

Unfortunately, none of the self-anointed captains now steering our global and governmental health agencies to confront the SARS-CoV-2 pandemic and the deeply worrisome escalation of Covid-19 vaccine injuries and deaths, has ever bothered to give this fundamental scientific axiom a moment’s worth of reflection. Reported Covid-19 vaccine injuries and deaths in the CDC’s Vaccine Adverse Events Reporting System now dwarf those from all other vaccines during the past two decades combined. The “experts,” such as Anthony Fauci and the FDA’s new Commissioner Janet Woodcock – a 35-year careerist at one of our most discredited regulatory agencies, hold their high rank within the medical hierarchy because they were seduced to sacrifice “objective knowledge of truth” in return for prestige, power and wealth. They serve as the prejudiced and ideological protectors of authentic science’s antithesis: the pharmaceutical industrial complex

We do not need to stretch too deep into Western medicine’s history — back to the era of leeches, blood-letting and exorcizing neurological disorders — to find examples of medical consensus and treatments displaying humanity’s sheer stupidity. We have continued to inherit this madness up into the 21st century, and during the pandemic it blazes before our eyes.

Unfortunately, too many Americans and citizens in other nations are blindly willing to surrender their faith and trust to medical experts, the latest drug or vaccine on the market, and the federal regulators who are mandated to assure that these medications and vaccines have been scrupulously reviewed to evaluate their safety and efficacy profiles. We assume that medical interventions are evidence-based. We believe they are founded upon scientifically sound and reliable observation, data collection and analysis. Yet we only need to look at modern history to find many examples of Western medicine being categorically wrong.

In the 1940s and throughout the 1970s, millions of Americans smoked. In some households every adult smoked. Even physicians, who were viewed as the exemplars of health and knowledge, smoked regularly. Doctors would be featured on advisements endorsing different cigarette brands. After a smoker reached 40, being diabetic, overweight, or having a cardiovascular illness and emphysema was considered as normal aging. Medical leaders assured us that this could not possibly be associated with smoking. They were believed because they were of course the “experts.” To speak out against cigarettes as the culprit behind these preventable conditions was taboo. Consequently several generations of Americans suffered and died prematurely and needlessly because the science accepted by the nation’s health officials was unconditionally false.

California State University bioethicist and author of The Illusion of Evidence Based Medicine, Prof. Leemon McHenry views the epidemic of bad medical research as similar to dirty money laundering. After reviewing thousands of clinical trial documents, he observed the means by which pharmaceutical companies intentionally design flawed clinical trials favoring their drugs and vaccines, generate dubious data and then wash it through a corrupt methodology to make the product look clean at the other end. During an interview, Prof McHenry said it was like throwing darts at a door and then later drawing a target on the door so the darts appear to have hit a bull’s-eye. Drug makers have mastered these tricks and our regulatory officials are consistently fooled and left none the wiser.

For those who grew up in the Great and Baby Boom generations, stress reduction was virtually unknown. Exercise was perceived as unnecessary after high school and college. A plant-based or vegetarian diet was viewed as extreme. The different iterations of the American food pyramid, starting with the Food for Young Children guide in 1916 and leading up to the 1979 Daily Food Guide, suffered from a serious lack of knowledge and a misunderstanding about nutrition. There was little bimolecular understanding about the dangers of sugar and excessive salt. Processed foods, preservatives and chemical dyes were being completely ignored. The only dietary supplement that was widely recommended was iron and to a lesser degree Vitamin C. Today we can look back upon these national dietary standards as medieval; yet the horrendous lack of science that supported our unhealthy American lifestyle was part of a scheme to indoctrinate people. And private corporations profited exorbitantly by sustaining these illusions. In the 20th century alone, leading medical journals and government agencies would promote electroshock therapy, bariatric surgery, mercury amalgams and dental fluoride, diethylstilbestrol, synthetic hormone replacement, artificial sweeteners such as saccharine and Monsanto’s aspartame and vaccine ethylmercury. However, today researchers frequently publish research papers identifying the very serious health risks for these products, which earlier were supported by reams of fraudulent corporate-sponsored research to court regulators.

But despite all of the reliable scientific data, it has failed to rein in national health policies and the conduct of the CDC, NIAID and FDA to lessen the health risks Americans are exposed to daily.

It is now 15 months since the World Health Organization declared a pandemic on March 11th of last year. The mainstream media has followed in lockstep with the government’s public relations narrative. It has lied about the reliability of PCR testing as a gold standard; injuries and deaths from the J&J, Moderna and Pfizer vaccines are either rejected or reframed as unfortunate anomalies. We may hear about the rare non-promising study against the use of inexpensive Covid-19 treatments such as hydroxychloroquine and ivermectin; but the many dozens of studies recommending these drugs are flatly ignored. Nor are our health officials telling us the truth about the adverse effects of prolonged mask-wearing, social isolation and quarantines, the vaccines’ safety profiles, the inflated numbers of Covid-19 cases and mortalities, and approving expensive novel drugs shown to be questionably effective.

While many criticize Big Pharma’s abuse of public relations firms to whitewash their noxious public image, in 2015, The Hill reported that the federal government spent over $4 billion on public relations services and over half of that went to the world’s largest firms. Last September, Trump’s Department of Health and Human Services (HHS) awarded the PR firm Fors Marsh Group $250 million to twist the handling of the pandemic in his favor. In 2012, Obama’s HHS gave $20 million to the Porter Novelli PR firm and $26 million to Ogilvy Public Relations for publicity damage control over controversies in his Affordable Care Act. Surely large PR firms have an enormous role within the cartel of governments’ health ministries, the World Health organization, the drug and vaccine industry, and billionaire donors who are now directing the pandemic.

Fortunately the faux scientific artifice upon which the authoritarians in power have defined the pandemic is crumbling. For the first time in medical history, tens of thousands of physicians and medical professionals are calling out our officials and the drug companies for vagrant acts of corruption and deception. Anthony Fauci’s control over the pandemic narrative is in jeopardy. The theory behind a natural origin of the virus is likely a sham; laboratory “gain of function” research to engineer pathogenic coronaviruses has been covered up with lies. We are discovering that health officials intentionally exaggerated SARS-CoV-2’s severity and sabotaged viable medical alternatives to curtail the progression of infection in a way that is scientifically sound, compassionate, and not jeopardized by pharmaceutical interests. ‘The deepest sin against the human mind,” Huxley warned, “is to believe things without evidence.” In the face of millions of unnecessary and preventable Covid-19 deaths due to the irresponsible authority handed to the Fauci-s, Gates-s, Tedros-s, and Matt Handcock-s of the world, a grave moral sin has been committed by allowing technocratic scientism to override medical evidence.

The Gary Null Show - 06.11.21

What does the FDA's recent meeting of the Vaccine and Related Biological Advisory Committee tell us about the government's handling of stopping the pandemic only by vaccination

Dr. Meryl Nass is an internal medicine physician in Maine and activist who specializes in treating patients with Gulf War syndrome, adverse reactions from the anthrax vaccine and vaccine safety and efficacy in general.  In the past she has testified on six separate occasions before Congress on behalf of veterans suffering from the causes of Gulf War syndrome. Meryl is also active in opposing vaccine mandates and critiquing the false claims and fear mongering about infectious disease epidemics and corruption within the medical industrial military complex.  She serves on the Board of the Alliance for Human Research Protection, a non profit organization run by Vera Sharav that advances medical ethics that uphold human rights and protect humans from wrongful medical interventions. Her work is cited in many professional articles and publications. She holds degrees from MIT and her medical degree from the Mississippi School of Medicine.  Dr Nass' website where she blogs is AnthraxVaccine.blogspot.com

The Gary Null Show - 06.10.21

 The Gary Null Show is here to inform you on the best news in health, healing, the environment. 

The Gary Null Show - 06.09.21

The Gary Null Show - 06.08.21

Growing evidence fruit may lower type 2 diabetes risk

Research has found eating at least two serves of fruit daily has been linked with 36% lower odds of developing type 2 diabetes

Edith Cowan University (Australia), June 2, 2021

Eating at least two serves of fruit daily has been linked with 36 percent lower odds of developing type 2 diabetes, a new Edith Cowan University (ECU) study has found. 

The study, published today in the Journal of Clinical Endocrinology and Metabolism, revealed that people who ate at least two serves of fruit per day had higher measures of insulin sensitivity than those who ate less than half a serve. 

Type 2 diabetes is a growing public health concern with an estimated 451 million people worldwide living with the condition. A further 374 million people are at increased risk of developing type 2 diabetes.

The study's lead author, Dr Nicola Bondonno from ECU's Institute for Nutrition Research, said the findings offer fresh evidence for the health benefits of fruit. 

"We found an association between fruit intake and markers of insulin sensitivity, suggesting that people who consumed more fruit had to produce less insulin to lower their blood glucose levels," said Dr Bondonno. 

"This is important because high levels of circulating insulin (hyperinsulinemia) can damage blood vessels and are related not only to diabetes, but also to high blood pressure, obesity, and heart disease.

"A healthy diet and lifestyle, which includes the consumption of whole fruits, is a great strategy to lower your risk of developing type 2 diabetes."

Fresh is best

The study examined data from 7,675 Australians participating in the Baker Heart and Diabetes Institute's AusDiab Study and assessed fruit and fruit juice intake and the prevalence of diabetes after five years.

Dr Bondonno said they did not observe the same beneficial relationship for fruit juice. 

"Higher insulin sensitivity and a lower risk of diabetes was only observed for people who consumed whole fruit, not fruit juice," she said. 

"This is likely because juice tends to be much higher in sugar and lower in fibre." 

Dr Bondonno said that it's still unclear exactly how fruit contributes to insulin sensitivity, but it is likely to be multifaceted. 

"As well as being high in vitamins and minerals, fruits are a great source of phytochemicals which may increase insulin sensitivity, and fibre which helps regulate the release of sugar into the blood and also helps people feel fuller for longer," she said.

"Furthermore, most fruits typically have a low glycaemic index, which means the fruit's sugar is digested and absorbed into the body more slowly." 

The study builds on Dr Bondonno's research into the health benefits of fruit and vegetables, particularly those that contain a key nutrient known as flavonoids. The research is part of ECU's Institute of Nutrition Research.

Ginkgo biloba leaves have multicomponent and multitarget synergistic effects on treatment of neurodegenerative diseases

Jiangsu Kanion Pharmaceutical Co (China), June 1, 2021

According to news reporting out of Jiangsu, People’s Republic of China, research stated, “Ginkgo biloba L. leaves (GBLs), as widely used plant extract sources, significantly improve cognitive, learning and memory function in patients with dementia. However, few studies have been conducted on the specific mechanism of Neurodegenerative diseases (NDs).”

Our news journalists obtained a quote from the research from Jiangsu Kanion Pharmaceutical Co. Ltd., “In this study, network pharmacology was employed to elucidate potential mechanism of GBLs in the treatment of NDs. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to obtain the chemical components in accordance with the screening principles of oral availability and drug-like property. Potential targets of GBLs were integrated with disease targets, and intersection targets were exactly the potential action targets of GBLs for treating NDs; these key targets were enriched and analyzed by the protein protein interaction (PPI) analysis and molecular docking verification. Key genes were ultimately used to find the biological pathway and explain the therapeutic mechanism by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Twenty-seven active components of GBLs may affect biological processes such as oxidative reactions and activate transcription factor activities. These components may also affect 120 metabolic pathways, such as the PI3K/AKT pathway, by regulating 147 targets, including AKT1, ALB, HSP90AA1, PTGS2, MMP9, EGFR and APP. By using the software iGEMDOCK, the main target proteins were found to bind well to the main active components of GBLs.”

According to the news editors, the research concluded: “GBLs have the characteristics of multi-component and multi-target synergistic effect on the treatment of NDs, which preliminarily predicted its possible molecular mechanism of action, and provided the basis for the follow-up study.”

This research has been peer-reviewed.

Diets that promote inflammation could increase breast cancer risk

Analysis of dietary patterns for over 350,000 women suggests eating more anti-inflammatory foods helps lower risk

Catalan Institute of Oncology and Biomedical Research Institute (Spain) June 7, 2021

 A new study of more than 350,000 women found that women with diets incorporating more foods that increase inflammation in the body had a 12% increase in their risk of breast cancer compared to women who consume more anti-inflammatory diets. The new findings are being presented at NUTRITION 2021 LIVE ONLINE. 

The study authors found that moving from a more anti-inflammatory diet toward one that increases inflammation upped breast cancer risk in an almost linear manner. Foods that increase inflammation include red and processed meat; high-fat foods such as butter, margarines and frying fats; and sweets including sugar, honey and foods high in sugar. Fruits, vegetables, legumes, tea and coffee all have potentially anti-inflammatory properties.

"Most studies examining diet and breast cancer risk have focused on single nutrients or foods rather than the whole diet," said the study's first author Carlota Castro-Espin, a predoctoral fellow at the Catalan Institute of Oncology and Bellvitge Biomedical Research Institute in Barcelona, Spain. "People consume food not nutrients, thus examining overall dietary patterns, rather than single components of diets can lead to more accurate conclusions when analysing associations with a health outcome such as breast cancer." 

The new results are based on data from the European Investigation into Cancer and Nutrition (EPIC) study, a prospective study that recruited more than 500,000 participants across 10 European countries starting in the mid-1990s. The study included more than 13,000 breast cancer diagnoses during approximately 15 years of follow-up. 

The typical diet for EPIC participants was measured for a year using food frequency or diet history questionnaires. The researchers used this information to calculate an inflammatory score for each study participant based on their intake of 27 foods. 

The researchers examined dietary patterns linked with inflammation because long-term, low grade inflammation has been linked with the development of breast cancer. The large number of women in the study allowed the researchers to take a more nuanced look at the relationship between dietary patterns and breast cancer risk. 

Their analysis showed that the increase in breast cancer risk due to pro-inflammatory diets appears to be more pronounced among premenopausal women. They also found that the association did not vary by breast cancer hormone receptor subtypes. 

"Our results add more evidence of the role that dietary patterns play in the prevention of breast cancer," said Castro-Espin. "With further confirmation, these findings could help inform dietary recommendations aimed at lowering cancer risk." 

As a next step, the researchers plan to evaluate the association of the inflammatory potential of diet and other dietary patterns with breast cancer survival using participants in the EPIC study. 

Emerging impact of quercetin in the treatment of prostate cancer

Shahid Beheshti University of Medical Sciences (Iran), June 3, 2021

According to news originating from Tehran, Iran, research stated, “Quercetin is a flavonoid agent detected in fruits and vegetables with anti-inflammatory, antioxidant, and anticancer effects. This flavonoid can suppress cell cycle transition and induce apoptosis in neoplastic cells.”

Our news reporters obtained a quote from the research from Shahid Beheshti University of Medical Sciences: “Therapeutic effects of quercetin have been assessed in diverse cancers including prostate cancer through the establishment of in vitro and in vivo experiments. Moreover, this agent might prevent the initiation of this type of cancer as it indirectly blocks the activity of promoters of two important genes in the pathogenesis of prostate cancer i.e. androgen receptor (AR) and prostate specific antigen (PSA). Several in vitro investigations have identified the differential influence of quercetin on normal prostate cells versus neoplastic cells, emphasizing its specific cytotoxic effects on cancerous cells. The most appreciated route of quercetin effect on prostate cancer cells is the detachment of Bax from Bcl-xL and the stimulation of caspase families. Besides, quercetin might enhance the effects of other therapeutic options against prostate cancer. For instance, a combination of TNF-related apoptosis-inducing ligand (TRAIL) and quercetin has been recommended as a novel modality for the treatment of prostate cancer.”

According to the news editors, the research concluded: “These kinds of strategies might overcome resistance to apoptosis in cancer cells. In the current paper, we summarize the recent data about the preventive and therapeutic influences of quercetin in prostate cancer.”

Breast microbiome modified by diet, fish oil

Wake Forest School of Medicine, June 4 2021. 

Findings reported on June 3, 2021 in Cancer Research add evidence to the effects of diet on the breast’s microbiome, the community of microorganisms that exists in breast tissue. 

“We have recently demonstrated that dietary patterns modulate mammary microbiota populations,” wrote David R. Soto-Pantoja and colleagues. “An important and largely open question is whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer.”

To help answer this question, the researchers fed a high fat or a control diet to mice that are susceptible to developing breast cancer. Animals that received the high fat diet had a greater number of tumors, more rapid tumor growth and larger tumor size than those that received the control diet. 

Next, mice that were given high fat diets received fecal transplants from mice that received control diets, and control diet-fed animals received transplants from high fat diet-fed animals. The team found that animals that received the control diet developed as many tumors as mice that received the high fat diet.  

In a double-blind trial, breast cancer patients were given fish oil supplements or a placebo for two to four weeks prior to surgical removal of their tumors. The researchers observed a change in the microbiota of tumor and normal breast tissue in participants who received fish oil, including an increase in Lactobacilli (which has been associated with reduce breast cancer tumor growth in animals) in normal tumor-adjacent breast tissue of participants who received fish oil for four weeks. 

"Obesity, typically associated with a high-fat diet consumption, is a well-known risk factor in postmenopausal breast cancer," commented coauthor Katherine L. Cook, PhD, of Wake Forest University. "This study provides additional evidence that diet plays a critical role in shaping the gut and breast microbiome."

Self-administered aroma foot massage may reduce symptoms of anxiety

Okayama University (Japan), June 8, 2021 

Researchers at Okayama University conduct the first community-based study on the effects of self-administered aromatherapy foot massage on stress and anxiety symptoms. The results suggest aromatherapy massages might provide an inexpensive, simple way of managing anxiety.

The continuing popularity of complementary therapies, such as aromatherapy and massage, has prompted scientists to investigate the effects of such therapies on the body in more detail. Complementary therapies are said to reduce the symptoms associated with stress and anxiety, and therefore may reduce the chances of severe illness, such as hypertension and heart disease. The precise effects on the body following such therapies is unclear, however.

Previous studies have focused on the effects of massage and aromatherapy treatments on blood pressure and mental state in hospitalized patients in Japan, but none have been conducted on individuals living in the community. Now, Eri Eguchi and co-workers at Okayama University, together with researchers across Japan, have conducted the first study into the effect of aromatherapy-based foot massage on blood pressure, anxiety and health-related quality of life in people living in the community.

57 participants took part in the study; 52 women and 5 men. Baseline blood pressure and heart rate values were taken at the start and end of the four-week trial period, as well as at a follow-up session 8 weeks later. Participants also completed questionnaires on anxiety status and health-related quality of life at each stage of the trial. The participants were divided into two groups, and one group were taught to perform a 45-minute aromatherapy-based foot massage on themselves three times a week for four weeks.

The results suggest that aroma foot massage decreased the participants' average blood pressure readings, and state of anxiety, and tended to increased mental health-related quality of life score. However the effect of massages was not significant with changes in other factors such as physical health-related quality of life scores and heart rate.

In their paper published in March 2016 in PLOS One, Eguchi's team are cautiously optimistic about the potential for self-administered massage to reduce anxiety in the population: "[although] it was difficult to differentiate the effects of the aromatherapy from the effects of the massage therapy... [the combination] may be an effective way to increase mental health and improve blood pressure."

Aromatherapy and massage

Aromatherapy has long been used to relieve stress and anxiety in populations across the globe. Different aroma essential oils are said to have different properties, and are used to induce relaxation and promote well-being. Trials have indicated that certain essential oils, when inhaled, can reduce blood pressure levels and alleviate depression by stimulating the olfactory system.

Massage (in its many forms) also has a long history in therapeutic medicine, and the practice of manipulating key pressure points in the body to induce relaxation has been shown to improve mental and physical health. However, detailed scientific studies of the effects of aromatherapy foot massage – an increasingly popular treatment in Japan – on blood pressure and perceived quality of life are limited.

Significance and further work

While the trial carried out by Eguchi and her team is limited in some respects, their results provide an initial starting point from which to extend studies into the benefits of aroma foot massage for the general population. Their findings that massage, or the aromatherapy, or a combination of both, reduce blood pressurereadings (at least in the short term) warrants further investigation.

Eguchi and her team acknowledge that their decision to advertise for participants may have encouraged more health-conscious and pro-active people to apply. They also received far more applications from women than men, although their age-range (from 27 to 72) was diverse. Further work is needed to determine the effect of aroma foot massage on specific age and sex categories, for example, before such interventions are encouraged in the wider population.

Proteomics reveals how exercise increases the efficiency of muscle energy production

University of Copenhagen (Denmark), May 27, 2021

Mitochondria are the cell's power plants and produce the majority of a cell's energy needs through an electrochemical process called electron transport chain coupled to another process known as oxidative phosphorylation. A number of different proteins in mitochondria facilitate these processes, but it's not fully understood how these proteins are arranged inside mitochondria and the factors that can influence their arrangement.

Now, scientists at the University of Copenhagen have used state-of-the-art proteomics technology to shine new light on how mitochondrial proteins gather into electron transport chain complexes, and further into so-called supercomplexes. The research, which is published in Cell Reports, also examined how this process is influenced by exercise training. 

"This study has allowed for a comprehensive quantification of electron transport chain proteins within supercomplexes and how they respond to exercise training. These data have implications for how exercise improves the efficiency of energy production in muscle," says Associate Professor Atul S. Deshmukh from the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen. 

Traditional methods provide too little detail

It is already well established that exercise training stimulates mitochondrial mass and affects the formation of supercomplexes, which allows mitochondria in skeletal muscle to produce energy more efficiently. But questions remain about which complexes cluster into supercomplexes and how.

To better understand supercomplex formation, particularly in response to exercise, the team of scientists studied two groups of mice. One group was active, and given an exercise wheel for 25 days, and the second group was sedentary, and was not provided the exercise wheel. After 25 days, they measured the mitochondrial proteins in skeletal muscle from both groups to see how the supercomplexes had changed over time. 

When scientists typically analyze how supercomplexes form, they use antibodies to measure one or two proteins per electron transport chain complex. But as there can be up to 44 proteins in a complex, this method is both time consuming and provides limited information about what happens to the remainder of the proteins in each complex. 

As a result, there is a lack of detailed knowledge in the field.

Proteomics helps supercomplexes give up their secrets

To generate much more detailed data, the team applied a proteomic technology called mass spectrometry to measure the mitochondrial proteins. By applying proteomics instead of antibodies, the scientists were able to measure nearly all of the proteins in each complex. This provided unprecedented detail of mitochondrial supercomplexes in skeletal muscle and how exercise training influences their formation. Their approach demonstrated that not all of the proteins in each complex or a supercomplex respond to exercise in the same manner. 

"Mitochondrial protein content is known to increase with exercise, thus understanding how these proteins assemble into supercomplexes is crucial to decipher how they work. Our research represents a valuable and precious resource for the scientific community, especially for those studying how the mitochondrial proteins organize to be better at what they do best: produce energy under demand,", explains Postdoc Alba Gonzalez-Franquesa.

The interdisciplinary project was a collaboration between the Deshmukh, Treebak and Zierath Groups at CBMR, and the Mann Group at the Novo Nordisk Foundation Center for Protein Research.

The Gary Null Show - 06.07.21

W.H.O WHISTLE BLOWER ASTRID STUCKELBERGER 

New study into green tea's potential to help tackle COVID-19

Swansea University, June 4, 2021

As India continues to be ravaged by the pandemic, a Swansea University academic is investigating how green tea could give rise to a drug capable of tackling Covid-19.

Dr Suresh Mohankumar carried out the research with colleagues in India during his time at JSS College of Pharmacy, JSS Academy of Higher Education and Research in Ooty prior to taking up his current role at Swansea University Medical School.

He said: "Nature's oldest pharmacy has always been a treasure of potential novel drugs and we questioned if any of these compounds could assist us in battling the Covid-19 pandemic? 

"We screened and sorted a library of natural compounds already know to be active against other coronaviruses using an artificial intelligence-aided computer programme. 

"Our findings suggested that one of the compounds in green tea could combat the coronavirus behind Covid-19."

The researchers' work has now been highlighted by online journal RSC Advances and has been included in its prestigious hot articles collection chosen by editors and reviewers.

Associate Professor Dr Mohankumar emphasised that the research was still in its early days and a long way from any kind of clinical application.

"The compound that our model predicts to be most active is gallocatechin, which is present in green tea and could be readily available, accessible, and affordable. There now needs to be further investigation to show if it can be proven clinically effective and safe for preventing or treating Covid-19. 

"This is still a preliminary step, but it could be a potential lead to tackling the devastating Covid-19 pandemic.

Dr Mohankumar has worked in pharmacy education, research and administration around the world for more than 18 years and recently moved to Swansea to join its new MPharm programme.

Head of Pharmacy Professor Andrew Morris said: "This is fascinating research and demonstrates that natural products remain an important source of lead compounds in the fight against infectious diseases. I'm also really pleased to see this international research collaboration continuing now that Dr Mohankumar has joined the Pharmacy team."

Dr Mohankumar added he is now looking forward to seeing how the work can be developed: "There now needs to be appropriate pre-clinical and clinical studies and we would welcome potential collaborators and partners to help carry this work forward."

Turkish study finds high prevalence of vitamin D deficiency in breast cancer patients

Ankara Numune Research Hospital (Turkey), June 1, 2021

According to news reporting from Ankara, Turkey, research stated, “We aimed to reveal vitamin D levels in women with breast cancer. 561 women with primary breast cancer were included in the study.”

The news correspondents obtained a quote from the research from Ankara Numune Training and Research Hospital, “The median age was 55.86 years (between 20 - 78 years). All of the patients were treated with curative intend. None of the patients had metastatic disease. The median 25(OH)D level was 11.92ng/ml and the mean 25(OH)D level was 13.91ng/ml. Deficiency was detected in 456 patients (81.28%) and insufficiency was detected in 61 patients (10.87 %).”

According to the news reporters, the research concluded: “This study points out that vitamin D levels in breast cancer patients should be measured and be corrected whenever diagnosed.”

This research has been peer-reviewed.

Low levels of omega-3 associated with higher risk of psychosis, says study

RCSI University of Medicine and Health Sciences (Ireland), June 1, 2021

New research has found that adolescents with higher levels of an omega-3 fatty acid in their blood were less likely to develop psychotic disorder in early adulthood, suggesting that it may have a potential preventative effect of reducing the risk of psychosis.

The study, led by researchers from RCSI University of Medicine and Health Sciences, is published in Translational Psychiatry.

Over 3,800 individuals in Bristol's Children of the 90s health study were assessed for psychotic disorder, depressive disorder and generalized anxiety disorder at age 17 and at age 24.

During these assessments, blood samples were collected, and the researchers measured the levels of omega-6 fatty acids, which generally increase inflammation in the body, and omega-3 fatty acids, which generally reduce inflammation.

While there was little evidence that fatty acids were associated with mental disorders at age 17, the researchers found that 24-year-olds with psychotic disorder, depressive disorder and generalized anxiety disorder had higher levels of omega-6 than omega-3 fatty acids compared to those without these disorders.

The researchers also found that 24-year-olds with psychotic disorder had lower levels of DHA, an omega-3 fatty acid typically found in oily fish or dietary supplements, than 24-year-olds without psychotic disorder. In a group of over 2,700 individuals who were tracked over time, adolescents with higher levels of DHA at age 17 were 56% less likely to develop psychotic disorder seven years later at age 24. This suggests that DHA in adolescence may have a potential preventative effect of reducing the risk of psychosis in early adulthood.

These results remained consistent when accounting for other factors such as sex, body mass index, tobacco smoking and socio-economic status.

"The study needs to be replicated, but if the findings are consistent, these results would suggest that enhanced dietary intake of omega-3 fatty acids among adolescents, such as through oily fish like mackerel, could prevent some people from developing psychosis in their early twenties," said Professor David Cotter, senior author of the study and professor molecular psychiatry at RCSI.

"The results could also raise questions about the relationship between the development of mental health disorders and omega-6 fatty acids, which are typically found in vegetable oils."

David Mongan, RCSI Ph.D. student and Irish Clinical Academic Training (ICAT) Fellow, analyzed the data with the supervision of Professor David Cotter and Professor Mary Cannon from the RCSI Department of Psychiatry. The ICAT program is supported by the Wellcome Trust and the Health Research Board, the Health Service Executive National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland.

"We need to do more research to learn about the mechanisms behind this effect, but it could possibly be related to reducing inflammation or decreasing inappropriate pruning of brain connections during adolescence," said Dr. David Mongan, the study's first author, who is a psychiatry trainee and Ph.D. student at RCSI.

Foods that can help protect against sun damage

Blount Memorial Weight Management Center, May 31, 2021

As the summer season approaches and we all hopefully get a chance to spend more time outside, we mustn’t forget how critical it is that we take steps to protect our skin.

Whether you’re going on a beach trip or just doing outdoor chores, it’s important to remember to wear sunscreen and reapply it often. Just because you didn’t get sunburned last year or last week, that doesn’t mean you are immune to the sun’s harmful rays.

In fact, most experts recommend sunscreen use year-round, not just in the summer. The American Academy of Dermatologyrecommends using a waterproof sunscreen with a sun protection factor, or SPF, of at least 30, and that protects against UVA and UVB rays. But, did you know there also are certain foods that can help protect your skin from the sun’s rays, as well?

“A diet rich in certain foods actually can help protect your skin from harmful UV rays,” said Heather Pierce from the Blount Memorial Weight Management Center. “They, in no way, should serve as a replacement for traditional sunscreen, but they can act as additional ways to protect your skin this spring and summer. A few foods, in particular, are high in certain minerals and nutrients that support healthy skin and can give us a little extra protection from the sun,” she said.

First up, Pierce says, are tomatoes, which you may already be consuming on your burgers or salads at those backyard cookouts.

“Tomatoes contain lycopene, which is a phytochemical that has been shown in research to help protect the skin against sunburns, particularly with concentrated sources such as tomato paste and carrot juice. And the good news is that they just happen to be in season. Watermelons also are good sources of lycopene, and, fortunately, they’re pretty popular this time of year, too.”

Pierce says you also should look to avocados and pomegranates for a little extra sun protection.

“When the sun is damaging our skin, it’s typically the result of oxidative stress and inflammation, so a lot of the foods we would eat for anti-inflammatory diet for a condition, such as heart disease, actually are protecting our skin, too.

“Avocados contain healthy oils that work to keep your skin protected, so throw a little avocado on your sandwiches this summer, and you can easily get that added bit of protection. Pomegranates, too, contain ellagic acid, which supports glutathione production that can fight skin damage caused by free radicals. Citrus fruits, of course, contain vitamin C, but the skins of citrus fruits also contain an essential oil called limonene that offers skin protection, too. You can easily add this to your diet by putting a little lemon or orange zest in your drinks or foods.”

Two more sun-protecting foods, Pierce says, are green tea and those all-important Omega 3 fats.

“Green tea is, of course, high in antioxidants, which can help guard against UV radiation,” Pierce said. “It also promotes DNA repair and has anti-inflammatory compounds that are helpful for repair, as well. Omega 3 fats always are important, particularly if you’re eating a heart healthy diet, but Omega 3 also has been shown to reduce the risk of a particular type of skin cancer by nearly 20%. With that in mind, look for ways to add Omega 3 sources such as salmon, chia seeds or flaxseed to your meals. If you can, try getting fish in your diet at least once per week,” she explained. “It’ll taste great and your skin will get a little sun protection boost, as well.”

Seaweed could potentially help fight food allergies

Mount Sinai Hospital, June 2, 2021

Seaweed has long been a staple food in many Asian countries and has recently caught on as a snack food in America as a healthful alternative to chips. The edible algae that fall in the category of seaweed are low-calorie and packed with nutrients. In addition, now scientists have found that a type of commercial red algae could help counteract food allergies. They report their findings in mice in ACS' Journal of Agricultural and Food Chemistry.

Food allergies are a major global health issue that can be life threatening in some cases. One study by researchers at Mount Sinai Hospital estimates that the condition affects about 8 percent of children and 5 percent of adults worldwide. In people who are allergic, certain compounds in food trigger a cascade of immune system reactions that lead to symptoms such as hives, wheezing and dizziness -- and in the worst cases, anaphylactic shock. Previous research has suggested that certain seaweed varieties contain polysaccharides with anti-asthmatic and anti-allergy effects. But no one had investigated whether similar molecules in Gracilaria lemaneiformis, a commercial variety of red algae, might have similar properties. Guang-Ming Liu and colleagues wanted to find out.

The researchers isolated polysaccharides from G. lemaneiformis and fed them to a group of mice sensitive to tropomyosin, a protein that is a major shellfish allergen. Another group of mice, also sensitive to tropomyosin, did not get the polysaccharides. After both groups were given the allergen, allergy symptoms in the treated mice were reduced compared to the untreated animals. Further studying polysaccharides from G. lemaneiformis could help lead to a better understanding of food allergies and their prevention, the researchers say.

 Barley lowers not one but two types of 'bad cholesterol', review suggests

St Michael’s Hospital (Toronto), June 8, 2021 

Eating barley or foods containing barley significantly reduced levels of two types of "bad cholesterol" associated with cardiovascular risk, a St. Michael's Hospital research paper has found. Barley reduced both low-density lipoprotein, or LDL, and non-high-density lipoprotein, or non-HDL, by seven per cent.

The review also indicated that barley had similar cholesterol-lowering effects as oats, which is often the go-to grain for health benefits.

The research review, published in The European Journal of Clinical Nutrition, included 14 studies on clinical trials conducted in seven countries, including Canada.

It is the first study to look at the effects of barley and barley products on both LDL and non-HDL cholesterol in addition to apolipoprotein B, or apoB, a lipoprotein that carries bad cholesterol through the blood. Measuring non-HDL and apoB provides a more accurate assessment for cardiovascular risk, as they account for the total 'bad cholesterol' found in the blood.

"The findings are most important for populations at high risk for cardiovascular disease, such as Type 2 diabetics, who have normal levels of LDL cholesterol, but elevated levels of non-HDL or apo B," said Dr. Vladimir Vuksan, research scientist and associate director of the Risk Factor Modification Centre of St. Michael's. "Barley has a lowering effect on the total bad cholesterol in these high-risk individuals, but can also benefit people without high cholesterol."

High cholesterol and diabetes are major risk factors for cardiovascular disease and stroke, historically treated with medications. However, Dr. Vuksan's research and work focuses on how dietary and lifestyle changes can reduce these risk factors.

"Barley's positive effect on lowering cholesterol is well-documented and has been included in the Canadian strategy for reducing cardiovascular risk," said Dr. Vuksan. "Health Canada, the FDA and several health authorities worldwide have already approved health claims that barley lowers LDL cholesterol, but this is the first review showing the effects on other harmful lipids."

Despite its benefits Dr. Vuksan said barley is not as well-established as some other health-recommended foods—such as oats. Barley consumption by humans has fallen by 35 per cent in the last 10 years. Canada is one of the top five world producers of barley—almost 10 megatonnes per year—but human consumption accounts for only two per cent of the crop yield, with livestock making up the other 98 per cent.

"After looking at the evidence, we can also say that barley is comparably effective as oats in reducing overall risk of cardiovascular disease" said Dr. Vuksan.

Barley is higher in fibre, has twice the protein and almost half the calories of oats, which are important considerations for those with weight or dietary concerns. Dr. Vuksan said barley can be enjoyed in a variety of ways. He recommends trying to incorporate barley into existing recipes, using it as a substitute for rice or even on its own—just like oatmeal.

The Gary Null Show - 06.04.21

Vitamin B6 deficiency enhances the noradrenergic system, leading to behavioral deficits

Tokyo Metropolitan Institute of Medical Science, May 27, 2021

Schizophrenia is a heterogeneous psychiatric disorder characterized by positive symptoms such as hallucinations and delusions, negative symptoms such as apathy and lack of emotion, and cognitive impairment. We have reported that VB6 (pyridoxal) levels in peripheral blood of a subpopulation of patients with schizophrenia is significantly lower than that of healthy controls. More than 35% of patients with schizophrenia have low levels of VB6 (clinically defined as male: < 6 ng/ml, female: < 4 ng/ml). VB6 level is inversely proportional to severity score on the positive and negative symptom scale (PANSS), suggesting that VB6 deficiency might contribute to the development of schizophrenia symptoms. In fact, a recent review has shown the decreased VB6 in patients with schizophrenia as the most convincing evidence in peripheral biomarkers for major mental disorders. Additionally, we recently reported that high-dose VB6 (pyridoxamine) was effective in alleviating psychotic symptoms, particularly the PANSS negative and general subscales, in a subset of patients with schizophrenia. Although a link between lower VB6 level and schizophrenia is widely hypothesized, the mechanism behind this remains poorly understood.

VB6 is not synthesized de novo in humans, but is primarily obtained from foods. In the present study, to clarify the relationship between VB6 deficiency and schizophrenia, we generated VB6-deficient (VB6(-)) mice through feeding with a VB6-lacking diet as a mouse model for the subpopulation of schizophrenia patients with VB6 deficiency. After feeding for 4 weeks, plasma VB6 level in VB6(-) mice decreased to 3% of that in control mice. The VB6(-) mice showed social deficits and cognitive impairment. Furthermore, the VB6(-) mice showed a marked increase in 3-methoxy-4-hydroxyphenylglycol (MHPG) in the brain, suggesting enhanced NA metabolism in VB6(-) mice. We confirmed the increased NA release in the prefrontal cortex and the striatum of VB6(-) mice through in vivo microdialysis. These findings suggest that the activities of NAergic neuronal systems are enhanced in VB6(-) mice.

Furthermore, VB6 supplementation directly into the brain using an osmotic pump ameliorated the hyperactivation of the NAergic system and behavioral abnormalities. indicating that the enhanced NA turnover and the behavioral deficits shown in the VB6(-) mice are attributed to VB6 deficiency in the central nervous system. In addition, the ?2A adrenergic receptor agonist guanfacine also improved the hyperactivated NAergic system in the frontal cortex and behavioral disorders. These results show that the behavioral deficits in VB6(-) mice may be caused by an enhancement of NAergic signaling.

Schizophrenic patients with VB6 deficiency, who account for more than 35% of all patients, present with relatively severe clinical symptoms and treatment resistance. Our findings suggest that a new therapeutic strategy targeting the NAergic system might be effective for these patients. They will also provide evidence based on pathophysiology for a new therapeutic strategy called "VB6 treatment for schizophrenia," which we are currently conducting clinical research on.

Families with a child with ADHD can benefit from mindfulness training

Radboud University Medical Center (Netherlands), May 27, 2021

Children with ADHD are generally treated with medication and/or behavioral treatments. However, medication-alone is insufficient in a quarter to a third of the children. For that reason, the scientists investigated whether a mindfulness-based intervention (MBI) would have a positive effect on children who did not respond sufficiently to other ADHD treatments. MBIs can elicit positive effects on psychological symptoms and behavior of children and parents. 

In the study, two groups of children between the ages of eight and sixteen were compared. One group received only regular care (CAU, care-as-usual), and the other group also received MYmind, the mindfulness-based intervention (MBI) with at least one parent. They did this training for a period of eight weeks.

A striking result was that parents especially benefited from this training. There was an increase in mindful parenting, self-compassion and an improvement in mental health among the parents. These effects were still visible six months after the end of the training. In the children, there were some effects on ADHD symptoms, anxiety, and autistic traits, but effects were small. Yet, a subgroup appeared to benefit: One in three children reliably improved on self-control following MYmind, whereas only one in ten improved when following only regular care.

Professor of Environmental Sensitivity in Health and psychologist Corina Greven of Radboudumc, the Donders Institute and Karakter says that usual interventions for children with ADHD typically do not target mental health of parents, although they often struggle with parenting stress, anxiety or own ADHD symptoms. "While effects in children were small, we still found effects in the parents. Interviewing families , our team also discovered that many families reported important improvements in family relationships and insight in and acceptance of ADHD. We need to go broader than just looking at whether an intervention reduces symptoms, and include additional outcomes that families find important." The study was conducted in collaboration with the Radboud Center for Mindfulness.

Sweet cherry anthocyanins support liver health

Zhei-Jang University (China), June 1, 2021

Anthocyanins from sweet cherries may protect against diet-induced liver steatosis, or excessive amounts of fat in the liver’s tissue, says a new study with rats. 

The study , published in the journal Nutrition, built upon the abundant existing literature on the beneficial role anthocyanins have as an antioxidative, anti-inflammatory, and anti-hyperlipidemic component.

Specifically, the cyanidin-3-glucoside variant “[has] been reported to ameliorate hepatic steatosis and adipose inflammation,” the researchers wrote. The condition known as liver steatosis is a common non-alcoholic fatty liver disease usually treated with drugs, but according to the researchers, some drug used for treatment “are usually accompanied by some adverse effect.”

For 15 weeks, the researchers investigated the effects of sweet cherry anthocyanin supplementation have on alleviating high-fat diet-induced liver steatosis in rodents to explore the possibility of a none-drug treatment for the liver condition.

Preparing the mice and the sweet cherry anthocyanins

The sweet cherry anthocyanin was extracted and pulverized, with one mg of the anthocyanin measured to contain amounts of cyanidine-3-rutinoside and pelargonidin-3-rutinoside, among other things.

Thirty male rodents were used for the study. The animals were housed five per cage and randomly divided into three groups: 10 rodents fed a low-fat diet, 10 rodents fed a high-fat diet, and 10 rodents fed a high-fat diet supplemented with sweet cherry anthocyanins.

The supplementation was given in liquid form at 200 mg/kg orally at the same time daily for 15 weeks, and the body weights and food intakes were monitored weekly.

Observations

The mice were sacrificed at week 15 after a half-day fast. Blood samples were collected and livers collected, rinsed with cold saline, and then weighed.

An automatic biochemistry analyser was used to measure total cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

They found that at week 15, mice fed a high-fat diet supplemented with sweet cherry anthocyanins “displayed a significant reduction in body weight, liver weight, and liver index” compared to the mice that were only given a high-fat diet without supplementation.

They also found the serum levels for tricylglycerol, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in high-fat diet mice to be substantially higher than those fed a low-fat diet, but the group supplemented with the anthocyanin resulted in a significant reduction in these serum parameters.”

According to the researchers, the results demonstrated how sweet cherry anthocyanins may be developed into a supplement to “protect from high-fat diet-induced hepatic steatosis in mice,”leading to a suggested potential for the anthocyanin’s application in the “treatment of hepatic steatosis and other obesity related metabolic disorders.”

Healthy lifestyle linked to better cognition for oldest adults -- regardless of genetic risk

New study suggests importance of maintaining healthy lifestyle even after age 80

Duke University & Kunshan University (China), June 1, 2021

A new analysis of adults aged 80 years and older shows that a healthier lifestyle is associated with a lower risk of cognitive impairment, and that this link does not depend on whether a person carries a particular form of the gene APOE. Xurui Jin of Duke Kunshan University in Jiangsu, China, and colleagues present these findings in the open-access journal PLOS Medicine.

The APOE gene comes in several different forms, and people with a form known as APOE ε4 have an increased risk of cognitive impairment and Alzheimer's disease. Previous research has also linked cognitive function to lifestyle factors, such as smoking, exercise, and diet. However, it has been unclear whether the benefits of a healthy lifestyle are affected by APOE ε4, particularly for adults over 80 years of age.

To clarify the relationship between APOE ε4 and lifestyle, Jin and colleagues examined data from 6,160 adults aged 80 or older who had participated in a larger, ongoing study known as the Chinese Longitudinal Healthy Longevity Survey. The researchers statistically analyzed the data to investigate links between APOE ε4, lifestyle, and cognition. They also accounted for sociodemographics and other factors that could impact cognition.

The analysis confirmed that participants with healthy lifestyles or intermediately healthy lifestyles were significantly less likely to have cognitive impairment than those with an unhealthy lifestyle, by 55 and 28 percent, respectively. In addition, participants with APOE ε4 were 17 percent more likely to have cognitive impairment than those with other forms of APOE.

A previous study suggested that in individuals at low and intermediate genetic risk, favorable lifestyle profiles are related to a lower risk of dementia compared to unfavorable profiles. But these protective associations were not found in those at high genetic risk. However, the investigation showed the link between lifestyle and cognitive impairment did not vary significantly based on APOE ε4 status which represented the genetic dementia risk. This suggests that maintaining a healthier lifestyle could be important for maintaining cognitive function in adults over 80 years of age, regardless of genetic risk. 

This cross-sectional study emphasized the importance of a healthy lifestyle on cognitive health. While further research will be needed to validate these findings among different population, this study could help inform efforts to boost cognitive function for the oldest of adults.

In the next step, the team will explore this association using the AD polygenetic risk score (AD-PRS) and explore the interactive relationship between AD-PRS and lifestyle on cognition with the longitudinal data.

Study shows BPA exposure below regulatory levels can impact brain development

University of Calgary (Canada) June 1, 2021

BPA disrupts development of the mouse brain sleep centre (outlined), image on right. The change can impact behaviour. The control image on the left ("CON") shows sleep centre without BPA. Credit: Kurrasch lab, published in Science Advances

Humans are exposed to a bath of chemicals every day. They are in the beds where we sleep, the cars that we drive and the kitchens we use to feed our families. With thousands of chemicals floating around in our environment, exposure to any number is practically unavoidable. Through the work of researchers like Dr. Deborah Kurrasch, Ph.D., the implications of many of these chemicals are being thoroughly explored.

"Manufacturers follow standards set by regulatory bodies, it's not up to the manufacturers to prove the chemicals in consumer products are safe," says Kurrasch, a researcher in the University of Calgary's Hotchkiss Brain Institute (HBI) and Alberta Children's Research Institute at the Cumming School of Medicine. "Scientists play a critical role and do the meticulous work of determining where the risks lie."

Kurrasch's research over the past decade has focused on a chemical that is broadly recognizable: Bisphenol A, also known as BPA. This chemical is commonly found in plastics, canned food linings, and even thermal receipts. Studies from Kurrasch's lab contribute to the collective research that shows the harms of exposure to this industrial compound.

The latest study out of Kurrasch's lab, published in Science Advances, suggests that continued vigilance is needed. A postdoctoral researcher in her lab, Dr. Dinu Nesan, Ph.D., examined the impact of low levels of BPA exposure to pregnant mice and the brain development of their offspring.

"Our goal was to model BPA levels equivalent to what pregnant women and developing babies are typically exposed to," says Kurrasch. "We purposefully did not use a high dose. In fact, our doses were 11-times and nearly 25-times lower than those deemed safe by Health Canada and the FDA (U.S. Food and Drug Administration), respectively. Even at these low levels, we saw effects on prenatal brain development in the mice."

Using this BPA exposure model, Nesan found striking changes to the brain region responsible for driving circadian rhythms, the suprachiasmatic nucleus, located in the hypothalamus. When prenatally exposed to these low levels of BPA, the suprachiasmatic nucleus failed to develop properly. This change can have implications for sleep, activity levels, and other behaviors.

"Previously we showed embryonic exposure to low-dose BPA can affect the timing of when neurons develop in zebrafish, but it was unclear whether a similar effect would be observed in a mammalian model with more similarities to humans," says Nesan, first author on the study. When neurons develop, they rely on proper signals to guide them. If neurons develop too early, the cues they experience are different, which can lead to developmental errors such as migrating to the wrong location, becoming the wrong type of neuron, or forming inappropriate connections. These errors can lead to altered behaviors later in life.

"Our study shows that in pregnant mice, prenatal exposure to BPA affects the timing of neuron development in the fetal brain, which has lasting effects on behaviors. Offspring that are exposed to BPA during gestation are awake longer and exhibit hyperactivity. The prenatal BPA exposure seems to change the brain's circadian cues, causing the animals to have elevated energy levels and spend less time resting," says Nesan.

The researchers are hopeful their findings will add continued pressure on regulatory bodies to keep revisiting their determinations around safe levels of BPA.

"We think there's an incredible abundance of data showing BPA exposure guidelines are not yet at the appropriate level, which includes even the EU (European Union) who is leading on this front, but their 'safe' levels are still twice the dose we used in our study" says Kurrasch, "We hope our research serves as a reminder that low dose BPA is still capable of causing changes that are measurable and significant."

Her message of how to interpret this research is simple:

• Limit your exposure to BPA the best you can. 
• Maintain smart practices with plastics in your kitchen, for example not heating them, and using glass or stainless steel when possible.

This research was conducted in collaboration with Dr. Michael Antle, Ph.D., professor of psychology and member of the HBI.

Selenium plus CoQ10 intake associated with reductions in D-dimer and cardiovascular mortality

Linköping University (Sweden), June 2, 2021

Findings from a randomized, double-blind, placebo-controlled trial, published on April 17, 2021 in the journal Nutrients,revealed a reduction in D-dimer levels among older Swedish men and women who received selenium and coenzyme Q10 (CoQ10), as well as a lower risk of mortality from cardiovascular disease in individuals having higher D-dimer levels at baseline. 

Coenzyme Q10 is an antioxidant involved in the mitochondria’s production of energy. It has been estimated that the body’s production of CoQ10 at the age of 80 years is approximately half that of someone who is 20 years old. 

Selenium is a trace element necessary for normal function of human cells. Dietary intake of this mineral may be insufficient in areas of the world that have low soil selenium levels. Selenium also is necessary for the function of many antioxidant enzymes, including one which recycles CoQ10, and has anti-inflammatory activity.

D-dimer is a fragment of degraded fibrin and is commonly used to assess for the presence or degradation of potentially dangerous blood clots (venous thromboembolism or pulmonary embolism). It also reflects the activity of peripheral artery disease and has been shown to be associated with endothelial dysfunction and inflammation even in the absence of thromboembolism.

The current investigation included 213 men and women aged 70 to 88 years who did not have conditions known to influence D-dimer concentrations (e.g., atrial fibrillation, malignancies). Participants received a placebo or 200 micrograms selenium plus 200 milligrams CoQ10 daily for four years. 

Blood samples collected from the subjects upon enrollment in the trial and at 48 months were analyzed for levels of D-dimer. Although D-dimer levels were not significantly different between groups at the beginning of the trial, it was noted to be significantly associated with age. At 48 months, a significantly lower level of D-dimer was found among those who received selenium and CoQ10 in comparison with the placebo, which was maintained after adjustment for co-variates that might influence D-dimer (such as C-reactive protein). 

When participants with D-dimer levels that were above the median of all participants at baseline were analyzed, an association was found between intake of selenium and CoQ10 and a lower risk of cardiovascular mortality. Among those whose D-dimer levels were higher than 0.21 mg/L at the beginning of the study, one person among 53 who received selenium and CoQ10 died during a median 4.9-year follow-up period compared to 8 of the 52 who received a placebo. Mortality from all causes was also lower in the selenium and CoQ10 group; however, the reduction failed to reach statistical significance.

This group also reported a larger study, which didn’t exclude individuals having conditions known to increase D-dimer, finding that in the older Swedish citizens the combination of selenium and CoQ10 significantly increased heart systolic function, lowered NT-proBNP (which is elevated during heart failure) and decreased risk of cardiovascular mortality, defined as death from myocardial infarctions, cerebrovascular lesions, cardiac arrythmias, heart failure or aortic aneurysms.1

“[Intake of] selenium and coenzyme Q10 in a group of elderly low in selenium and coenzyme Q10 prevented an increase in D-dimer and reduced the risk of cardiovascular mortality in comparison with the placebo group,” concluded first author Urban Alehagen and his colleagues. “The obtained results also illustrate important associations between inflammation, endothelial function and cardiovascular risk.”

Effect of Korean Red Ginseng on Cognitive Function and Quantitative EEG in Alzheimer Patients

Seoul Medical Center  (Korea) June 1, 2021

Researchers detail new data in Neurodegenerative Diseases. According to news reporting originating in Seoul, South Korea  research stated, "Korean red ginseng (KRG) has a nootropic effect. This study assessed the efficacy of KRG on cognitive function and quantitative electroencephalography (EEG) in patients with Alzheimer's disease (AD)."

The news reporters obtained a quote from the research from Seoul Medical Center, "Fourteen patients with AD (mean age, 74.93 years; 11 women and 3 men) were recruited and treated with KRG (4.5 g per day) for 12 weeks. Cognitive function was assessed by the Korean Mini-Mental State Examination (K-MMSE) and the Frontal Assessment Battery (FAB). EEG performed before and after treatment were analyzed with quantitative spectral analysis. The FAB score improved significantly after 12 weeks of treatment. In the relative power spectrum analysis performed according to responsiveness, alpha power increased significantly in the right temporal area of the responders. The increments of relative alpha power in the right temporal, parietal, and occipital areas were significantly higher in the responders than the nonresponders."

According to the news reporters, the research concluded: "This study indicates the efficacy of KRG on frontal lobe function in AD, related to increasing relative alpha power."

The Gary Null Show - 06.03.21

The Gary Null Show - 06.02.21

Dr. Byram Bridle, Viral Immunologist, U of Guelph - Viral immunologist from the University of Guelph discussing latest discoveries about Covid vaccines and spike protein. An exclusive investigation separating rumor from fact in the origin of Covid-19.
***Numerous scientific insiders are signing onto the “lab origin” theory for Covid-19 and a link to controversial research funded by your tax dollars.
***High profile health figures who have attempted to “debunk” the lab origin theory are linked to funding and vaccine research partnerships with China’s Wuhan Institute of Virology.
***The U.S.- Chinese research genetically engineered bat coronavirus so that it infected human airway cells in mice, in order to invent vaccines and other therapeutics.
***U.S. taxpayer money supported the controversial vaccine research with Chinese scientists through the National Institutes of Health (NIH) and the U.S. Agency for International Development (USAID). Some support came from the National Institute of Allergy and Infectious Diseases (NIAID), led by Dr. Anthony Fauci.
Go to SharylAttkisson.com for more.

The Gary Null Show - 06.01.21

Researchers study preventing cancer and diabetes with the maqui berry

NOVA Southeastern University of Florida, May 27, 2021

Aristotelia chilensis, also known as maqui berry, is a fruit-bearing shrub native to South America. 

According to a study published in the journal Phytochemical Analysis, maqui berries are rich in anthocyanins, which give the fruits their dark purple color. Anthocyanins are plant pigments that possess many remarkable biological properties, such as antioxidant, anti-inflammatory, anti-viral and anti-cancer activities.

In a recent study, researchers at NOVA Southeastern University in Florida discussed the potential of Chilean maqui berry for use as a nutritional supplement that can help treat hyperinsulinemia and related diseases. Hyperinsulinemia, or higher-than-normal insulin levels, is often caused by insulin resistance, which is said to be the precursor to diabetes. Chronic hyperinsulinemia also promotes cancer growth by allowing insulin to exert its oncogenic effects, which include enhancing growth factor-dependent cell proliferation, among others.

The researchers discussed how Chilean maqui berry can help with insulin resistance and reduce cancer risk in an article published in the journal Food Science and Human Wellness.

The medicinal benefits of Chilean maqui berry

Researchers have long considered nutritional supplementation to be a possible alternative or adjunct treatment to conventional therapies for common ailments and diseases. According to recent studies, maqui berries can reduce postprandial insulin levels by as much as 50 percent and are just as effective as metformin at increasing insulin sensitivity and stabilizing blood glucose levels.

Maqui berries’ mechanism of action involves inhibiting sodium-dependent glucosetransporters in the small intestine and slowing the rate of entry of glucose in the bloodstream. Thanks to these actions, maqui berries can effectively reduce the likelihood of blood sugar spikes and prevent the corresponding rise in insulin levels that follows. 

At the same time, maqui berries contribute to cancer prevention since chronically high blood glucose levels — besides chronic hyperinsulinemia — are also linked to the development of cancer. In fact, numerous studies have shown that diabetics and prediabetics have an elevated risk of developing cancerous growths.

Based on the findings of previous studies, the researchers believe that consistent supplementation with Chilean maqui berries could indirectly reduce the risk of cancer and other diseases that are promoted by hyperglycemia (high blood sugar) and hyperinsulinemia.

Studies reveal that social isolation and quarantine throughout the COVID-19 pandemic may have a detrimental impact on physical and mental health of people living with pre-existing conditions

University of Naples (Italy) and Teva Pharmaceuticals, May 30, 2021

Abstract 803: Impact of social isolation and quarantine on the course of diabetes mellitus and its complications during Covid 19 pandemic in Adjara Region Country of Georgia

Abstract 1337: Psychological distress in patients with hypocortisolism during mass quarantine for Covid-19 epidemic in Italy

Studies reveal that social isolation and quarantine throughout the COVID-19 pandemic may have a detrimental impact on people living with pre-existing conditions. 

Social isolation and quarantine can have a detrimental impact on physical and mental health of people living with pre-existing conditions, according to two studies being presented at the 23rd European Congress of Endocrinology (e-ECE 2021) 

The studies bring together research on the impact of social isolation and quarantine for people living with diabetes in the Adjara Region of Georgia, and on patients with hypocortisolism in Italy. Both studies reported that social isolation during the pandemic caused significant psychological and/or physical distress on the observed individuals. 

Data from the first study revealed that the impact of quarantine on people living with diabetes in the Adjara Region caused blood pressure (BP) levels to increase in 88.2% of patients with 50% of these cases resulting in high BP hospitalisation. In addition to these physical factors, increased feelings of anxiety and fear were observed on 82% of patients. In the second study, patients with hypocortisolism experienced increased anxiety and depression, associated with a dissatisfaction feeling of self and a reduced resiliency, when compared with Italian healthy controls. As these are all contributing factors to overall health deterioration, these findings suggest further research is required to allow patients with pre-existing conditions to remain fit and healthy during the current pandemic.

In the Adjara Region study, Dr Liana Jashi and the research team disseminated an online questionnaire and collected answers from 16 endocrinologists and 22 family and general practice doctors. The study confirmed the negative, indirect effects social isolation and quarantine had on people living with diabetes. It reported a list of negative effects such as the reduced access to medical care, weight gain and increased cigarette and alcohol consumption. Physical activity decreased by 29.8%, a vital preventative to further physical and psychological problems. 

"This study highlights that people living with diabetes require greater support during pandemics to maintain exercise and protect their physical and mental health. National health services should use these data and future studies to implement better social care around supporting people with pre-existing conditions," commented Dr Jashi.

In the second study, Dr Chiara Simeoli at the University of Naples reported data collected during the last three weeks of the mass quarantine lasted 2 months in Italy, in a web-survey-based, multicenter, case- control research involving 12 different Italian centres. The study confirmed that a large cohort of 478 patients with hypocortisolism, and particularly, 363 with adrenal insufficiency and 115 with congenital adrenal hyperplasia, adequately treated with glucocorticoids, showed higher anxiety and depression, associated with a dissatisfaction feeling of self and a reduced resiliency, when compared with Italian healthy controls, suggesting the detrimental impact of social isolation on mental health of these patients, particularly frail and vulnerable to infections and stress. Moreover, patients with adrenal insufficiency reported a worse quality of life than patients with congenital adrenal hyperplasia. 

"These findings confirmed that beyond the huge impact on physical health, COVID-19 epidemic, social isolation and mass quarantine represent significant psychological stressors, causing severe effects on mental health, even more on people with pre-existing conditions. An empowerment of psychological counselling for these vulnerable patients during COVID-19 should be considered by national health-care services," adds Dr Simeoli. 

Both studies indicate that additional larger studies over a longer period of time are needed for further investigation.

Researchers discover link between local oxygen depletion in the brain and Alzheimer's disease

University of Seville (Spain), May 24, 2021

The study, published in the journal Nature Aging and led by the laboratories of Dr. Alberto Pascual (CSIC), from the Neuronal Maintenance Mechanisms Group, and Prof. Javier Vitorica (University of Seville/CIBERNED) of the Physiopathology of Alzheimer's Disease Group at IBiS, demonstrates for the first time that low oxygen levels in the so-called senile plaques in the brain reduces the immune system's defensive capacity against the disease.

The study also suggests that this lack of oxygen in the brain enhances the action of disorders associated with Alzheimer's disease that are characterized by low systemic oxygen levels, such as atherosclerosis and other cardiovascular diseases.

What happens in the brain?

A characteristic feature of Alzheimer's patients is the accumulation of highly toxic substances in their brains, known as senile plaques. The brain has an immune system whose main component are the microglial cells, which were first described and named 100 years ago by Pío del Río Hortega, a disciple of Ramón y Cajal. In the absence of damage, these cells facilitate the neurons' function. In response to Alzheimer's disease, microglia defend neurons by surrounding senile plaques, preventing their spread in the brain and decreasing damage.

Alzheimer's disease is aggravated by other pathologies, such as cardiovascular diseases, which cause a decrease in oxygen levels in the body. This study has revealed reduced oxygen levels around senile plaques, compromising microglial activity (Image, center). When this is compounded by reduced oxygen supply to the brain due to other systemic pathologies, the microglia are unable to provide protection and there is an increase in the pathology associated with the disease.

Relevance

Alzheimer's disease is the leading cause of dementia in Spain and around the world. In Spain, its incidence is increasing dramatically as the population ages. Unfortunately, the origin of the disease remains unknown.

The mechanism proposed in this study is mediated by the expression of the HIF1 molecule, whose discoverers received the Nobel Prize in Physiology or Medicine in 2019. Increased HIF1 levels compromise the mitochondrial activity of microglial cells and limit their protective capacity against disease.

This study opens new lines of research to improve the metabolic capacity of microglia, which would enable a sustained response over time against the disease. Indirectly, the study supports previous work highlighting the importance of maintaining good cardiovascular health for healthy aging.

Effect of different doses of melatonin on learning and memory deficit in Alzheimer model

Guilan University of Medical Sciences (Iran), May 21, 2021

According to news reporting out of Rasht, Iran, research stated, “Alzheimer Disease (AD) is an age-related neurodegenerative disorder with a progressive impairment of cognitive function. The pineal gland hormone melatonin (MEL) has been known as a protection agent against AD.”

Our news reporters obtained a quote from the research from Guilan University of Medical Sciences: “However, the effect of melatonin in various doses is inconsistent. In this study, we aimed to investigate two doses of MEL on learning and memory in the amyloid-beta (Ab)-induced AD in the rats. Forty-eight male Wistar rats were used in the experiment and randomly divided control, sham, vehicle, AD, AD+MEL10 mg/kg, and AD+MEL 20 mg/kg groups. Intracerebroventricular injection of Ab1-42 was used to develop the animal model of AD. Also, MEL-treated groups received an intraperitoneal injection of MEL for 4 next weeks. The Morris Water Maze (MWM) and Passive Avoidance Learning (PAL) tests were used to examine animals’ learning and memory. The brain of animals was removed for immunohistochemistry for anti- Amyloid Precursor Protein (APP). Intra-peritoneal injection of MEL significantly improve learning and memory in MWM (P=0.000) and PAL test (P=0.000), but there were no significant changes in the two groups that received the melatonin (P>0.05). Histopathological analysis revealed that the clearance of APP deposition in the AD+MEL20 group was considerable compared with the AD+MEL10 group (P=0.000).”

According to the news editors, the research concluded: “Our findings indicate that 10 and 20 mg/kg doses of melatonin have similar results on learning and memory in the AD model. But 20 mg/kg of melatonin has significantly more effect on the clearance of APP deposition.”

Effects of flaxseed on blood pressure, body mass index, and total cholesterol in hypertensive patients: A randomized clinical trial

Lorestan University of Medical Sciences (Iran), May 25, 2021

Objectives

Given the antioxidant properties of flaxseed and its biologically active ingredients, this study was conducted to determine the effects of flaxseed supplementation on body mass index (BMI), blood pressure, and total cholesterol levels in patients with hypertension.

Methods

In this triple-blind clinical trial, 112 patients, with an age range of 35 to 70 years, were randomized to 2 groups receiving 10 g (n=45) and 30 g (n=45) of flaxseed supplementation and 1 group receiving placebo (n=45) for 12 weeks by stratified block randomization. They were evaluated in terms of systolic (SBP) and diastolic blood pressure (DBP), BMI, and total serum cholesterol. Physical activity was measured using the International Physical Activity Questionnaire–Short Form (IPAQ–SF) and food intake was assessed using the Food Frequency Questionnaire (FFQ). The data were analyzed with SPSS, version 22, using the chi-square, Kruskal–Wallis, repeated measures analysis, ANOVA, and ANCOVA tests.

Results

The interaction effects among the study groups and time on the mean SBP (p = 0.001), DBP (p = 0.001), total cholesterol level (p = 0.032), and BMI (p < 0.001) were significant. During the study, the 30-g group achieved the best results, so that a 13.38-unit decrease in SBP was observed compared to a 1.72 unit increase in the placebo group and a 5.6-unit decrease in DBP was measured compared to a 2.39 unit increase in the placebo group. BMI decreased by 0.86 units compared to 0.06 units in the placebo group. Total cholesterol also decreased by 20.4 units compared to 11.86 units in the placebo group.

Conclusion

The results of this study showed that flaxseed can be effective in reducing blood pressure, total cholesterol, and body mass index in hypertensive patients in a twelve-week period.

Study: Don't count on caffeine to fight sleep deprivation

Michigan State University, May 27, 2021

Rough night of sleep? Relying on caffeine to get you through the day isn't always the answer, says a new study from Michigan State University.

Researchers from MSU's Sleep and Learning Lab, led by psychology associate professor Kimberly Fenn, assessed how effective caffeine was in counteracting the negative effects of sleep deprivation on cognition. As it turns out, caffeine can only get you so far.

The study -- published in the most recent edition of Journal of Experimental Psychology: Learning, Memory, & Cognition -- assessed the impact of caffeine after a night of sleep deprivation. More than 275 participants were asked to complete a simple attention task as well as a more challenging "placekeeping" task that required completion of tasks in a specific order without skipping or repeating steps.

Fenn's study is the first to investigate the effect of caffeine on placekeeping after a period of sleep deprivation.

"We found that sleep deprivation impaired performance on both types of tasks and that having caffeine helped people successfully achieve the easier task. However, it had little effect on performance on the placekeeping task for most participants," Fenn said.

She added: "Caffeine may improve the ability to stay awake and attend to a task, but it doesn't do much to prevent the sort of procedural errors that can cause things like medical mistakes and car accidents." 

Insufficient sleep is pervasive in the United States, a problem that has intensified during the pandemic, Fenn said. Consistently lacking adequate sleep not only affects cognition and alters mood, but can eventually take a toll on immunity. 

"Caffeine increases energy, reduces sleepiness and can even improve mood, but it absolutely does not replace a full night of sleep, Fenn said. "Although people may feel as if they can combat sleep deprivation with caffeine, their performance on higher-level tasks will likely still be impaired. This is one of the reasons why sleep deprivation can be so dangerous."

Fenn said that the study has the potential to inform both theory and practice. 

"If we had found that caffeine significantly reduced procedural errors under conditions of sleep deprivation, this would have broad implications for individuals who must perform high stakes procedures with insufficient sleep, like surgeons, pilots and police officers," Fenn said. "Instead, our findings underscore the importance of prioritizing sleep."

Parkinson's disease more likely in people with depression, study suggests

Umea University (Sweden), May 21 2021

People with depression may be more likely to develop the movement disorder Parkinson's disease, according to new research published in Neurology.

According to the authors of the study, depression is more common in people with Parkinson's disease than those without the movement disorder.

"We saw this link between depression and Parkinson's disease over a timespan of more than 2 decades, so depression may be a very early symptom of Parkinson's disease or a risk factor for the disease," says study co-author Prof. Peter Nordström, at Umeå University in Sweden.

Parkinson's disease is a progressive disorder of the nervous system that affects how a person moves, including how they speak and write. As well as problems with movement, Parkinson's disease can also cause cognitive problems, neurobehavioral problems and sensory difficulties.

The authors of the study state that depression is more common in patients with Parkinson's disease than in members of the general population. The mood disorder has a major influence on health-related quality of life and could also be involved in more rapid deterioration of cognitive and motor functions.

However, few studies have investigated this association for periods of longer than 10 years, with any long-term findings so far inconclusive.

For the study, the researchers used a cohort consisting of all Swedish citizens aged 50 years and above as of December 31st, 2005. From this group, they then took the 140,688 people diagnosed with depression .

These individuals were each matched with three control participants (a total of 421,718 controls) of the same age and sex who had not been diagnosed with depression.

The participants were then followed for up to 26 years. A total of 1,485 people with depression (1.1%) developed Parkinson's disease during this time, compared with 1,775 of those who did not have depression (0.4%).

On average, Parkinson's disease was diagnosed 4.5 years after the beginning of the study, with the likelihood of the disorder developing decreasing over time.

The researchers calculated that participants with depression were 3.2 times more likely than those without depression to develop Parkinson's disease within a year of the study beginning. After 15-25 years, the researchers found participants with depression were almost 50% more likely to develop the condition.

If a participant's depression was severe, their likelihood of developing Parkinson's disease was also higher. For example, those who had been hospitalized for depression five or more times were 40% more likely to develop Parkinson's disease than participants who had been hospitalized for depression just once.

In addition to these observations, the researchers examined siblings. No link was found between one sibling having Parkinson's disease and the other having depression.

"This finding gives us more evidence that these two diseases are linked," says Prof. Nordström. "If the diseases were independent of each other but caused by the same genetic or early environmental factors, then we would expect to see the two diseases group together in siblings, but that didn't happen."

The authors suggest there are a number of mechanisms that could explain their findings. Depression or antidepressive treatment could increase the risk of Parkinson's disease, depression could be an early symptom of Parkinson's disease, or that the two conditions could share environmental causative factors.

In the paper, the authors acknowledge that they are unable to evaluate the potential role of substances used in antidepressive treatment as risk factors for Parkinson's disease. The study is an observational one and cannot determine causation.

"Our findings suggest a direct association between depression and subsequent [Parkinson's disease], supported by a time-dependent hazard ratio, a dose-response pattern for recurrent depression, and a lack of evidence for coaggregation among siblings," the authors conclude.

"Given that the association was significant over more than two decades of follow-up, depression may be a very early prodromal symptom of or a causal risk factor for [Parkinson's disease]."

Elsewhere, a study published in December previously suggested that users of methamphetamine are at three times more risk of getting Parkinson's disease than people who do not use illegal drugs.

The Gary Null Show - Ronnie Cummings - 05.31.21

Exposing the lies behind the Covid-19 pandemic and the motivations behind it

Ronnie Cummins is the co-founder and International Director of the Organic Consumers Association and its Mexican affiliate Via Organica, the largest non-profit organization serving over 2 million consumers to safeguard organic standards and promote healthy sustainable agriculture and commerce.  In the 1990s, he was a director of the Foundation for Economic Trends in Washington DC. With almost  a million members, the Association is a non profit public interest organization campaigning for sustainable health and justice on critical issues of food safety, industrial agriculture, genetic engineering, Fair Trade and environmental sustainability. Ronnie has been a life-long activist in the human rights, anti-nuclear, labor and agricultural movements. His writings appear on numerous alternative, independent news including Commondreams, Truthout, and Huffington Post.  He is the author of “Genetically Engineered Foods: A Self Defense Guide for Consumers” and has just released a new book co-authored with Dr. Joseph Mercola, "The Truth About Covid-19: Exposing the Great Reset, Lockdowns, Vaccine Passports and the New Normal" which exquisitely goes into each of these topics.   His organization’s website is www.OrganicConsumers.org