The Gary Null Show
The Gary Null Show - 09.16.21

The Gary Null Show - 09.16.21

September 16, 2021

Virologists reveal how poor man’s amino acid cure for COVID-19 would abolish need for vaccines

Bio-Virus Research Inc (Nevada), September 15, 2021

A natural cure for COVID-19 that is widely available and affordable for even the poorest of people on the planet has been confirmed by a team of virologists who have spent a lifetime studying the underlying causes of viral infections.

Backed by decades of research and safety data for herpes-family viruses, U.S.-based researchers at Bio-Virus Research Inc, Reno, Nevada, report on the successful treatment of the first 30 frontline doctors and nurses and a thousand-plus patients given the amino acid lysine to prevent and even abolish COVID-19 coronavirus infections at a clinic in the Dominican Republic.  Astonishingly, symptoms of COVID-19 are reported to have dissipated within hours of this natural treatment.

The medical staff at a clinic in the Dominican Republic was coming down with two cases of coronavirus per month before lysine therapy was instituted.

The virologists, Drs. Christopher Kagan, Bo Karlicki and Alexander Chaihorsky, strongly suggested the front-line healthcare workers embark on a daily regimen of lysine therapy due to daily exposure to the virus.  Their ground-breaking report is published online at ResearchGate.net.

Arginine/lysine balance

Lysine therapy interrupts the replication of viruses, including COVID-19 coronavirus, by countering arginine, an amino acid that fosters the eruption of dormant viruses.  Lysine has been safely used for decades to quell herpes virus outbreaks that cause cold sores on the lips (herpes labialis), a treatment pioneered by one of the Bio-Virus Research team members in 1974.

Lysine is available in foods and in concentrated form in inexpensive dietary supplements (250 500-milligram lysine tablets can be purchased for under $5 US or 2-cents per tablet), making affordable lysine therapy possible.

Lysine/arginine imbalance would explain why patients who have been infected with COVID-19 have recurrent infections, even after vaccination.

Lysine Rx in Dominican Republic

The daily therapeutic supplement regimen for the medical staff in the Dominican Republic consisted of 2000 milligrams of lysine capsules along with restricted dietary consumption of arginine-rich foods such as nuts, chocolate, orange juice, pumpkin, sesame seeds, wheat germ.

The Bio-Virus Research team found doses of supplemental lysine up to 4000 milligrams to be safe and effective.

Foods that have a high ratio of lysine over arginine such as eggs, tofu, fish (not raw), sardines, cheese, meats such as pork, poultry and red meat, and yogurt) provide a high ratio of lysine over arginine, thus blocking replication of all coronaviruses including COVID-19.

According to the virologists who were interviewed by this reporter, over 1000 patients have now been successfully treated with surprisingly rapid dissolution of symptoms and return to health.  Even severely infected COVID-19 patients have been able to come off the ventilator with lysine therapy, say doctors.

Third-party validation for lysine therapy

Writing in the International Journal of Infectious Diseases another research team based in New York and Texas reports that arginine depletion is a strategy to quell both coronaviruses and other herpes family viruses.

In 2016 researchers documented that lysine impairs the growth of coronaviruses in a lab dish.

The Bio-Virus Research team are not loners nor out on a scientific limb.  A report, published in the Journal of Antivirals & Antiretrovirals, is what prompted to the current discovery that was put into clinical practice in the Dominican Republic.  The science was in place prior to the announcement a mutated coronavirus was sweeping the globe which no one had immunity towards.

Dietary intake

The Recommended Daily dietary intake of lysine is 2660 milligrams for a 154-lb (70 kilogram) adult; 3640 milligrams during pregnancy.

Dietary intake of lysine in western populations ranges from 40-180 milligrams per day per kilogram (2.2 lbs.) of body weight, or 2800-12,600 milligrams for a 154 lb. (70 kilogram) adult.

It is the balance of arginine to lysine that controls the eruption of dormant viruses in the body.  The average intake of arginine is estimated to be 4000-6000 milligrams per day.

Other health benefits

Supplemental lysine also has other health benefits.  Lysine increases absorption of calcium, relieves bouts of anxiety, promotes wound healing, and is helpful for other conditions.  Cholesterol is deposited in binding sites within coronary arteries.  When lysine (and vitamin C) occupy those binding sites, cholesterol is not deposited in arteries.

Prevalence of herpes viral infections

Worldwide many billions of people harbor dormant herpes viruses that erupt into disease from time to time.  In 2016 an estimated 3.7 billion people had herpes simplex virus infection– around 66.6% of the world’s population aged 0 to 49.

Availability of lysine

Lysine is largely produced by the tons for animal feedstuffs.  Roughly 2,200,000 tons of lysine are produced annually.  There is no shortage.

Billions may benefit

The most frequent medical application of lysine therapy has been the quelling of active herpes infections (on skin, lips, etc.), and eradication of Epstein-Barr infection, Bell’s palsy, etc.

Researchers bemoan the fact that lysine therapy hasn’t become a mainstay in the treatment of herpes infections that affect ~80% of the world’s population over expensive and problematic anti-viral drugs because it doesn’t generate sufficient profit to attract funding for human clinical trials.  Lysine is superior to various anti-viral drugs.

If lysine lives up to its promise as a universal COVID-19 antidote for therapeutic and preventive use, unless billionaire Bill Gates buys up and mothballs all the lysine production plants in the world like he has bought off agricultural land, and bought off news media, vaccine makers and politicians, the need for vaccines will become a moot and meaningless practice for COVID-19.

Because of the long-term safety record of this dietary amino acid, the public can take lysine as a non-prescription preventive “medicine.”

Epidemiologists baffled by low rate of coronavirus infections in India

Despite its large population and poor sanitation, disease trackers are baffled by India’s low rate of coronavirus infections.  Maybe it is India’s lysine-rich diet of yogurt, lamb, chicken, fish curry that protects its population from viral disease.  The striking difference in the country-to-country prevalence of Herpes Simplex-2 infections (only 9.6% in South East Asian countries and 10.7% in Europe vs. 24.0% in the Americas and 43.9% in Africa) could be explained by the lysine/arginine ratio in native diets.

Treat the severely ill; skip the problematic vaccines

Vaccination is not fool proof.  Vaccinated patients are testing positive for COVID-19.  Doctors can choose to treat the 3 in 10,000 COVID-19 severely infected patients who are at risk for a mortal outcome with lysine rather than needlessly vaccinate billions of people.  Mass vaccination would not be needed, nor would lockdowns, quarantines and questionable mass face mask use be required.  The pandemic would be rapidly extinguished by a public information campaign regarding lysine-rich foods and dietary supplements.  The public can take action on its own today without adverse consequences.  Literally, trillions of dollars would be saved worldwide.  If not for COVID-19, at least for herpes infections.

The shame is on the World Health Organization with a budget of $8.482 billion or the Centers For Disease Control with a budget of $7.875 billion that overlook safe and economical cures like lysine.  This report serves as evidence the world is being gamed to plunder the masses of their health and wealth.  The people of the world need to stop heeding advice from public health officials and practice preventive medicine on their own volition.

There is additional evidence that lysine also halts the growth of influenza and coxsackie viruses.

Further research

Researchers at Bio-Virus Research Inc. are searching for research funds to further document the benefits of lysine therapy. 

 

 

Omega-3 and Omega-6 supplement improves reading for children

 

University of Gothenburg, Sweden - September 14, 2021 

 

Supplement of omega-3 and omega-6 fatty acids may improve reading skills of mainstream schoolchildren, according to a new study from Sahlgrenska Academy, at the University of Gothenburg, Sweden. Children with attention problems, in particular, may be helped in their reading with the addition of these fatty acids.

 

The study included 154 schoolchildren from western Sweden in grade 3, between nine and ten years old. The children took a computer-based test (known as the Logos test) that measured their reading skills in a variety of ways, including reading speed, ability to read nonsense words and vocabulary.

 

The children were randomly assigned to receive either capsules with omega-3 and omega-6, or identical capsules that contained a placebo (palm oil) for 3 months. The children, parents and researchers did not learn until the study was completed which children had received fatty acids and which had received the placebo. After three months, all children received real omega-3/6 capsules for the final three months of the study.

 

"Even after three months, we could see that the children's reading skills improved with the addition of fatty acids, compared with those who received the placebo. This was particularly evident in the ability to read a nonsense word aloud and pronounce it correctly (phonologic decoding), and the ability to read a series of letters quickly (visual analysis time)," says Mats Johnson, who is chief physician and researcher at the Gillberg Neuropsychiatry Centre at Sahlgrenska Academy, University of Gothenburg.

 

No children diagnosed with ADHD were included in the study, but with the help of the children's parents, the researchers could identify children who had milder attention problems. These children attained even greater improvements in several tests, including faster reading already after three months of receiving fatty acid supplements.

 

Polyunsaturated fats and their role in children's learning and behavior is a growing research area.

 

"Our modern diet contains relatively little omega-3, which it is believed to have a negative effect on our children when it comes to learning, literacy and attention," says Mats Johnson. "The cell membranes in the brain are largely made up of polyunsaturated fats, and there are studies that indicate that fatty acids are important for signal transmission between nerve cells and the regulation of signaling systems in the brain."

 

Previous studies in which researchers examined the effect of omega-3 as a supplement for mainstream schoolchildren have not shown positive results, something Mats Johnson believes may depend on how these studies were organized and what combination and doses of fatty acids were used. This is the first double-blind, placebo-controlled study showing that omega-3/6 improves reading among mainstream schoolchildren.

 

"Our study suggests that children could benefit from a dietary supplement with a special formula. To be more certain about the results, they should also be replicated in other studies," says Mats Johnson.

The article Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden was published by The Journal of Child Psychology and Psychiatry. 

 

  

Elevated stress hormones linked to higher risk of high blood pressure and heart events

Kyoto University (Japan) & University of California at Los Angeles, Sept. 13, 2021 

Adults with normal blood pressure and high levels of stress hormones were more likely to develop high blood pressure and experience cardiovascular events compared to those who had lower stress hormone levels, according to new research published today in Hypertension, an American Heart Association journal.

Studies have shown that cumulative exposure to daily stressors and exposure to traumatic stress can increase cardiovascular disease risk. A growing body of research refers to the mind-heart-body connection, which suggests a person’s mind can positively or negatively affect cardiovascular health, cardiovascular risk factors and risk for cardiovascular disease events, as well as cardiovascular prognosis over time.

“The stress hormones norepinephrine, epinephrine, dopamine and cortisol can increase with stress from life events, work, relationships, finances and more. And we confirmed that stress is a key factor contributing to the risk of hypertension and cardiovascular events,” said study author Kosuke Inoue, M.D., Ph.D., assistant professor of social epidemiology at Kyoto University in Kyoto, Japan. Inoue also is affiliated with the department of epidemiology at the Fielding School of Public Health at the University of California, Los Angeles.

“Previous research focused on the relationship between stress hormone levels and hypertension or cardiovascular events in patients with existing hypertension. However, studies looking at adults without hypertension were lacking,” Inoue said. “It is important to examine the impact of stress on adults in the general population because it provides new information about whether routine measurement of stress hormones needs to be considered to prevent hypertension and CVD events.”

Study subjects were part of the MESA Stress 1 study, a substudy of the Multi-Ethnic Study of Atherosclerosis (MESA), a large study of atherosclerosis risk factors among more than 6,000 men and women from six U.S. communities. As part of MESA exams 3 and 4 (conducted between July 2004 and October 2006), white, Black and Hispanic participants with normal blood pressure from the New York and Los Angeles sites were invited to participate in the substudy MESA Stress 1. In this substudy, researchers analyzed levels of norepinephrine, epinephrine, dopamine and cortisol – hormones that respond to stress levels. Hormone levels were measured in a 12-hour overnight urine test. The substudy included 412 adults ages 48 to 87 years. About half were female, 54% were Hispanic, 22% were Black and 24% were white.

Participants were followed for three more visits (between September 2005 and June 2018) for development of hypertension and cardiovascular events such as chest pain, the need for an artery-opening procedure, or having a heart attack or stroke.

Norepinephrine, epinephrine and dopamine are molecules known as catecholamines that maintain stability throughout the autonomic nervous system—the system that regulates involuntary body functions such as heart rate, blood pressure and breathing. Cortisol is a steroid hormone released when one experiences stress and is regulated by the hypothalamic-pituitary-adrenal axis, which modulates stress response. 

“Although all of these hormones are produced in the adrenal gland, they have different roles and mechanisms to influence the cardiovascular system, so it is important to study their relationship with hypertension and cardiovascular events, individually,” Inoue said. 

Their analysis of the relationship between stress hormones and development of atherosclerosis found:

  • Over a median of 6.5-year follow-up period, every time the levels of the four stress hormones doubled was associated with a 21-31% increase in the risk of developing hypertension.
  • During a median of 11.2-years of follow-up, there was a 90% increased risk of cardiovascular events with each doubling of cortisol levels. There was no association between cardiovascular events and catecholamines.

“It is challenging to study psychosocial stress since it is personal, and its impact varies for each individual. In this research, we used a noninvasive measure — a single urine test — to determine whether such stress might help identify people in need of additional screening to prevent hypertension and possibly cardiovascular events,” Inoue said.

"The next key research question is whether and in which populations increased testing of stress hormones could be helpful. Currently, these hormones are measured only when hypertension with an underlying cause or other related diseases are suspected. However, if additional screening could help prevent hypertension and cardiovascular events, we may want to measure these hormone levels more frequently.”

A limitation of the study is that it did not include people who had hypertension at the study’s start, which would have resulted in a larger study population. Another limitation is that researchers measured stress hormones via a urine test only, and no other tests for stress hormone measurement were used.

 

Spirulina alleviates high fat diet-induced cognitive impairment via the gut-brain axis

Weifang People’s Hospital (China), September 9, 2021

Increasing evidence suggested that the gut microbiome-brain axis plays a critical role in regulating cognitive functions. In this study, we aimed to investigate the dietary treatment effect of Spirulina platensis on learning deficits in high fat diet (HFD) fed mice and clarify the potential mechanisms via investigating the gut microbiome-brain axis. Dietary administration of 1% and 2% Spirulina platensis for 16 weeks significantly improved the spatial learning and memory performance of the HFD-fed mice in both Barnes Maze test and Morris water maze test. The Aβ accumulation, tau-hyperphosphorylation, and neuroinflammation in the hippocampus were significantly inhibited by Spirulina platensisSpirulina platensis also abrogated HFD induced gut microbial dysbiosis and unbalance of gut microbial metabolites indicating its modulating effect on the gut-brain axis. This study provides further evidence for the application of Spirulina platensis as functional supplement for treatment of Alzheimer’s disease.

Spirulina platensis was frequently used as both a food ingredient and a medical supplement to counteract various metabolic disorders worldwide. In the present study, we found that Spirulina platensis dietary supplementation significantly prevented the cognitive deficits induced by HFD- feeding in mice. For the first time, we identified the inhibition effect of Spirulina platensis on β-amyloid generation, tau-hyperphosphorylation, neuroinflammation, and the gut microbiota dysbiosis.

In conclusion, the present study proved the beneficial effect of Spirulina platensis on cognitive impairment in HDF-fed AD mice and cleared Aβ, inhibited tau-hyperphosphorylation, and ameliorated neuroinflammation in the brain. Spirulina platensis also abrogated HFD induced gut microbial dysbiosis and unbalance of gut microbial metabolites indicating that Spirulina platensis might ameliorated cognitive deficits through regulating the gut-brain axis (Fig. 6). This study provides potent evidence for the application of Spirulina platensis as functional supplement for treatment of AD.

 

Regular exercise may lower risk of developing anxiety by almost 60%

University of Lund (Sweden), September 13, 2021

A quick online search for ways to improve our mental health will often come up with a myriad of different results. However, one of the most common suggestions put forward as a step to achieving wellness—and preventing future issues—is doing some physical exercise, whether it be a walk or playing a team sport.

Anxiety disorders—which typically develop early in a person's life—are estimated to affect approximately 10% of the world's population and has been found to be twice as common in women compared to men. And while exercise is put forward as a promising strategy for the treatment of anxiety, little is known about the impact of exercise dose, intensity or physical fitness level on the risk of developing anxiety disorders.

To help answer this question, researchers in Sweden have published a study in Frontiers in Psychiatry to show that those who took part in the world's largest long-distance cross-country ski race (Vasaloppet) between 1989 and 2010 had a "significantly lower risk" of developing anxiety compared to non-skiers during the same period.

The study is based on data from almost 400,000 people in one of the largest ever population-wide epidemiology studies across both sexes.

Surprising finding among female skiers

"We found that the group with a more physically active lifestyle had an almost 60% lower risk of developing anxiety disorders over a follow-up period of up to 21 years," said first author of the paper, Martine Svensson, and her colleague and principal investigator, Tomas Deierborg, of the Department of Experimental Medical Science at Lund University, Sweden.

"This association between a physically active lifestyle and a lower risk of anxiety was seen in both men and women."

However, the authors found a noticeable difference in exercise performance level and the risk of developing anxiety between male and female skiers.

While a male skier's physical performance did not appear to affect the risk of developing anxiety, the highest performing group of female skiers had almost the double risk of developing anxiety disorders compared to the group which was physically active at a lower performance level.

"Importantly," they said, "the total risk of getting anxiety among high-performing women was still lower compared to the more physically inactive women in the general population".

These findings cover relatively uncharted territory for scientific research, according to the researchers, as most previous studies focused on depression or mental illness as opposed to specifically diagnosed anxiety disorders. Furthermore, some of the largest studies looking at this topic only included men, were much smaller in sample size, and had either limited or no follow-up data to track the long-term effects of physical activity on mental health.

Next steps for research

The surprising discovery of an association between physical performance and the risk for anxiety disorders in women also emphasized the scientific importance of these findings for follow-up research.

"Our results suggest that the relation between symptoms of anxiety and exercise behavior may not be linear," Svensson said.

"Exercise behaviors and anxiety symptoms are likely to be affected by genetics, psychological factors, and personality traits, confounders that were not possible to investigate in our cohort. Studies investigating the driving factors behind these differences between men and women when it comes to extreme exercise behaviors and how it affects the development of anxiety are needed."

They added that randomized intervention trials, as well as long-term objective measurements of physical activity in prospective studies, are also needed to assess the validity and causality of the association they reported. But does this mean that skiing in particular can play an important role in keeping anxiety at bay, as opposed to any other form of exercise? Not so, Svensson and Deierborg said, given that previous studies have also shown the benefits of keeping fit on our mental health.

"We think this cohort of cross-country skiers is a good proxy for an active lifestyle, but there could also be a component of being more outdoors among skiers," they said.

"Studies focusing on specific sports may find slightly different results and magnitudes of the associations, but this is most likely due to other important factors that affect mental health and which you cannot easily control in research analysis.

 

Gut microbes are key to health benefit delivered by hops compound

Oregon State University, September 13, 2021

The health-enhancing performance of a compound found in hops is dependent upon its interactions with intestinal microorganisms, new research by Oregon State University shows.

Understanding how xanthohumol, often abbreviated as XN, works is important for unlocking its potential to counter diet-induced obesity and the health risksassociated with a global obesity epidemic, including type 2 diabetes and liver and heart disease, researcher Adrian Gombart says.

"We showed that the gut microbiota are necessary for the beneficial effects of XN on glucose metabolism," said Gombart, professor of biochemistry and biophysics in the OSU College of Science and a principal investigator at the university's Linus Pauling Institute. "There is an important interaction between the compound and the microbes in the gut that provides the benefits we see in our studies with mice."

Gombart led a team of 20 scientists from three Oregon State colleges in research that compared the glucose metabolism effects of xanthohumol on two sets of mice: "conventional" ones with gut microbiota, and those engineered to be "germ free," i.e. have no gut microbes.

Glucose metabolism, the body's ability to convert the sugar into fuel, generally suffers impairment as someone becomes obese, which in turn can lead to the person becoming more overweight. Faulty glucose metabolism also negatively affects brain physiology and is at the root of multiple medical conditions including diabetes and heart disease.

In previous studies involving mice, Gombart and colleagues found that XN improved the animals' health and changed the composition of their microbiome, the latter leading them to suspect that the mix of microbes played a role in XN's healthful effects.

"In this study, we fed mice either a diet low in calories, high in calories, or high in calories but supplemented with XN for 10 weeks," he said. "We found that only the conventional mice with XN supplementation showed improved glucose metabolism and that XN increased the relative abundance of three bacteria, Akkermansia muciniphila, Parabacteroides goldsteinii and Alistipes finegoldii."

Gombart added that the study yielded some evidence that those three microbes are at least partially responsible for the health benefits associated with XN, but the entire microbial community may be playing a role as well.

"We can't rule that out," he said. "We know that XN needs the intestinal microbiota to deliver its benefits, and there are complex diet-host-microbiota interactions that bring changes in both microbial composition and functional capacity. Diet is recognized as a major force in shaping gut microbe composition, and future studies will look for insights into the various interactions at play."

Earlier mouse model studies by co-author Fred Stevens, professor of pharmaceutical sciences in the OSU College of Pharmacy and also a principal investigator at the Linus Pauling Institute , have shown that XN, a polyphenol found in hops' cones, has a number of anti-obesity properties. It improves cognitive function and it suppresses weight gain associated with a high-fat diet, fat accumulation in adipose tissue and insulin resistance.

Insulin resistance is when cells don't respond well to the hormone that allows for the uptake of glucose from the bloodstream. It causes the pancreas to make more and more insulin to keep blood glucose levels within a non-harmful range and is a risk factor for non-alcoholic fatty liver disease.

 

Antioxidant protects neurons

 

University of Edinburgh   September 12 2021 

 

Research involving a potent antioxidant, described in Scientific Reports, suggests that the compound could help protect cells in several conditions, including Parkinson’s disease, multiple sclerosisand cell transplants.

In their report, a team from the University of Edinburgh observe that the flavonoids quercetin and myricetin are among the most potent dietary antioxidants. Structural modification of myricetin has resulted in the development a new compound known as Proxison. In the current research, Proxison demonstrated 10 times the ability to protect against oxidative stress induced by the compound tert-Butyl hydroperoxide (tBHP) in neuroblastoma cells compared to quercetin, while several other antioxidants showed no effects. Proxison, as well as a high concentration of quercetin, also provided significant protection against cell death in tBHP-treated cells. Similar results were obtained in another neural cell line.

An investigation of the antioxidants’ ability to be taken up by the cells showed significant intracellular levels of quercetin and Proxison, and evidence for some localization of Proxison in the cells’ mitochondria.

In zebrafish embryos, Proxison helped protect against neuronal cell loss induced by a neurotoxic compound. Quercetin was also protective, but was less potent than Proxison. Neither therapy affected normal embryonic development.

“This novel antioxidant can be applied to investigate oxidative stress in disease models, like alpha-synucleinopathies and other neurodegeneration models,” Nicola J. Drummond and colleagues conclude. “In addition, Proxison could have applications for regenerative medicine where oxidative stress has been implicated in poor cell survival of transplanted cells, with the advantage that the molecule can be pre-loaded into cells prior to transplantation. Proxison could also have applications for conditions, such as stroke or cardiac infarction, in which a temporary, but acute, exposure to oxidative stress is experienced, as well as diseases in which oxidative stress and mitochondrial dysfunction are core features.”

The Gary Null Show - 09.15.21

The Gary Null Show - 09.15.21

September 15, 2021

Dietary propolis supplementation reduced proinflammatory cytokines associated with air pollution exposure, without impacting on immune cell infiltration or lung function

New Zealand Institute for Plant and Food Research, September 10, 2021

Air pollution is estimated to cause 7 million annual deaths globally. Our aim was to determine if dietary propolis consumption could prevent the immune and functional damage in a mouse model of acute urban dust exposure. Female C57BL/6J mice were challenged three times with intranasal urban dust over seven days which significantly increased proinflammatory cytokines and immune cells in the lung 24 h post final challenge. Dietary New Zealand propolis (2%) with gamma cyclodextrin supplementation reduced urban dust-induced lung TNFα, IL-4, and IL-6 cytokine production; but did not alter immune cell infiltration into the lung, or lung function outcomes. This suggests that daily consumption of 8% propolis with gamma cyclodextrin supplemented food was sufficient to reduce urban dust pollution-induced proinflammatory cytokine production but was not sufficient to prevent immune cell recruitment into the lung or lung function decline in a murine model of lung inflammation.

In this study we found that daily consumption of a New Zealand propolis reduced proinflammatory cytokines within the lung in response to acute urban dust exposure but this inhibition was not sufficient to reduce immune cell infiltration or prevent increased airways tissue constriction. These results suggest that dietary supplementation of 8% propolis with gamma cyclodextrin (equivalent to 2% propolis resin) does not result in sufficient bioavailable concentrations of the bioactive polyphenolics to fully overcome urban dust pollution-induced acute immune cell infiltration into the lung. Other studies have shown that acute gavage consumption or intraperitoneal injection of specific propolis bioactive components can protect against a number of different immune challenges within the lung. These effects appear to be both concentration and administration route dependent, and may not be achievable using unenriched propolis as a dietary intervention.
 

20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment

Comprehensive Pain Management Institute (Ohio), August 6, 2021

New research published in the Journal of Evidence-Based Integrative Medicine shows that early intervention against a Wuhan coronavirus (Covid-19) infection using natural, over-the-counter remedies is a safe and effective way to avoid complications.

Researchers from Ohio looked at modalities that are readily available for the Chinese Virus, including zinc, zinc ionophores, vitamins C, D3, and E, and l-lysine. These items were categorized in the study as “preventive measures” and “early-stage treatments” that can help to avoid the need for more “advanced” anti-covid measures such as pharmaceutical drugs and vaccines.

Each of these tested remedies is natural, by the way, and the results of what they can do are impressive. Once again, nature wins out as our most abundant medicine cabinet, far exceeding anything cooked up in a lab.

The clinical study found that this “multi-component OTC (over-the-counter) ‘core formulation’ regimen” successfully protected test subjects against getting sick from the Chinese Virus, even as others got sick.

“While both groups were moderate in size, the difference between them in outcomes over the 20-week study period was large and stark: Just under 4% of the compliant test group presented flu-like symptoms, but none of the test group was COVID-positive,” the paper reveals.

“[W]hereas 20% of the non-compliant control group presented flu-like symptoms, three-quarters of whom (15% overall of the control group) were COVID-positive.”

For 20 weeks, test subjects took these natural supplements. Adjustments were made for those with pre-existing health conditions and other health factors that may have influenced the outcome.

Since all of the remedies utilized fall into the “low cost” category, anyone can access them. They are all dubbed as “anti-viral” as well, meaning they are safe and effective for use against viruses.

By taking advantage of these remedies early, the paper explains, people can help to protect themselves against the types of adverse events that are causing some people to have to be hospitalized and put on a ventilator.

“From early March through the end of July 2020, one of us (LM) monitored approximately 600 patients in Columbus and Cleveland, Ohio cities heavily affected by the COVID-19 pandemic, and did consultations with several colleagues (including JL) in the New York City metropolitan area, also heavily hit,” the paper explains.

“Over that 5-month period, we dealt with dozens of clinical and/or test-confirmed cases of COVID-19. Much of the monitoring was performed via telemedicine; approximately 20% was performed in-office. It is from in-office monitored patients and staff that the study groups emerged.”

We have been covering some of these same remedies along with others that have been scientifically shown to help protect against spike protein-induced illness.

Hydroxychloroquine (HCQ), as one example, is a zinc ionophore that helps to deliver more zinc into cells for improved immune function. Epigallocatechin gallate (EGCG), a polyphenol component of green tea, is a natural zinc ionophore that improves zinc absorption.

For this latest study, the research team used quina (cinchona) plant bark extract and quercetin as zinc ionophores, as these, too, help to deliver more healing nutrients like zinc to the cells.

“The core supplementation formulation components have been demonstrated … to have beneficial effects both outside of and within clinical settings in the prevention of viral infections and also in the treatment of early stages of such diseases,” the study reveals.

“Zinc ionophores can … be utilized to gain the anti-viral benefit of enhanced intracellular Zn+2 concentrations while limiting tolerance / side-effect / toxicity issues associated with elevated serum levels of zinc supplementation.”

You can review the full paper at this link.

 
 

Neuroprotective effect of L-carnitine against glyceraldehyde-induced metabolic impairment

University Politecnica delle Marche (Italy), September 7, 2021

According to news reporting originating from Ancona, Italy, research stated, “Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive regression and memory loss. Dysfunctions of both glucose metabolism and mitochondrial dynamics have been recognized as the main upstream events of the degenerative processes leading to AD.”

Our news editors obtained a quote from the research from the School of Medicine, “It has been recently found that correcting cell metabolism by providing alternative substrates can prevent neuronal injury by retaining mitochondrial function and reducing AD marker levels. Here, we induced an AD-like phenotype by using the glycolysis inhibitor glyceraldehyde (GA) and explored whether L-carnitine (4-N-trimethylamino-3-hydroxybutyric acid, LC) could mitigate neuronal damage, both in SH-SY5Y neuroblastoma cells and in rat primary cortical neurons. We have already reported that GA significantly modified AD marker levels; here we demonstrated that GA dramatically compromised cellular bioenergetic status, as revealed by glycolysis and oxygen consumption rate (OCR) evaluation. We found that LC ameliorated cell survival, improved OCR and ATP synthesis, prevented the loss of the mitochondrial membrane potential (Dps) and reduced the formation of reactive oxygen species (ROS). Of note, the beneficial effect of LC did not rely on the glycolytic pathway rescue. Finally, we noticed that LC significantly reduced the increase in pTau levels induced by GA. Overall, these findings suggest that the use of LC can promote cell survival in the setting of the metabolic impairments commonly observed in AD.”

According to the news editors, the research concluded: “Our data suggest that LC may act by maintaining mitochondrial function and by reducing the pTau level.”

 

 

Hyperbaric oxygen study shows reversal of biologic hallmarks responsible for development of Alzheimer disease

Tel Aviv University  & Shamir Medical Center (Israel), September 10, 2021

A new study, published today in peer-review medical journal Aging, marks the first time non-pharmaceutical clinical exploration proves efficacy in reversing the main activators of Alzheimer's disease.   

Using a specific protocol of hyperbaric oxygen therapy (HBOT), cerebral blood flow (CBF) improved/increased in elderly patients by 16-23%, alleviating vascular dysfunction and amyloid burden. The study, part of a comprehensive research program directed toward aging and accompanying ailments as a reversible disease, holds promise for a new strategic approach to the prevention of Alzheimer's by addressing not only the symptoms or targeting biomarkers, but rather the core pathology and biology responsible for the advancement of the disease. 

Vascular dysfunction is a crucial element in the development of Alzheimer's and cognitive decline:

  • Amyloid beta deposits in the brain blood vessel walls are the most common vascular pathology in Alzheimer's. 
  • Reduced blood flow to the brain and its related decrease in oxygen supply (hypoxia) can precede the clinical onset of dementia and correlates with the degree of cognitive impairment in Alzheimer's.

The comprehensive research, conducted at the Sagol School of Neuroscience at Tel Aviv University and the Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center, was led by study co-authors, Professor Shai Efrati, M.D.; Professor Uri Ashery, Ph.D.; Ronit Shapira, Ph.D.; Pablo Blinder, Ph.D.; Amir Hadanny, M.D. Using combined data from an animal model of Alzheimer's, where effects were evaluated directly on brain tissue (Sagol School of Neuroscience at Tel Aviv University); humans, assessed with the use of high-resolution MRI and computerized cognitive test (Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center); correlating results displayed beneficial effects of HBOT on patients suffering from mild cognitive impairment (MCI), the stage before dementia. Each patient received 60 HBOT sessions over a 90-day period, showcasing substantial improvement in cognitive functions – with memory, attention and information processing speed exhibiting the strongest results. 

"After dedicating our HBOT research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have discovered for the first time HBOT induces degradation and clearance of pre-existing amyloid plaques – treatment, and the appearance of newly formed plaques- prevention," explains Professor Uri Ashery. "Elderly patients suffering from significant memory loss at baseline revealed an increase in brain blood flow and improvement in cognitive performance, demonstrating HBOT potency to reverse core elements responsible for the development of Alzheimer's disease."

"By treating vascular dysfunction, we're mapping out the path toward Alzheimer's prevention. More research is underway to further demonstrate how HBOT can improve cognitive function and become an influential tool in the imperative fight against the disease," affirms Professor Efrati, research group leader and medical advisor to Aviv Scientific. 

Aviv has developed a unique medical treatment protocol that includes HBOT, cognitive and physical training, and nutritional coaching, to enhance brain and body performance of aging adults at Aviv Clinics, currently available in Central Florida and Dubai. 

HBOT is already used in patients with other pathologies and is known to be a relatively safe treatment modality, illustrating its potential to be easily implanted in clinical practice. In recent years, there is growing scientific evidence that certain protocols of HBOT can improve brain oxygen supply, induce proliferation of neuronal stem cells and induce generation of new blood vessels and neurons in the brain.

 

 

 

Increased flatulence from eating plant-based diet found to indicate healthier gut microbiome

Center for Biomedical Research Network for Liver and Digestive Diseases (Spain), September 10, 2021

A team of researchers affiliated with a host of institutions across Spain has found that the increase in flatulence experienced by people switching to a plant-based diet is an indication of a healthier gut microbiome. In their paper published in the journal Nutrients, the group describes experiments they conducted with healthy, male volunteers regarding diet, fecal sample size and flatulence.

It is widely known that switching from a fat or carbohydrate-based diet to one that features more vegetables results in more flatulence—particularly if the switch is to cruciferous vegetables. But as the researchers with this new effort have noted, little research has been done to learn more about the association between diet and flatulence.

To learn more about the impact of switching to a plant-based diet on digestion and the gut biome, the researchers enlisted the assistance of 18 healthy, adult male volunteers. Each was asked to eat a western-style diet and then to switch to the plant-based Mediterranean diet for two weeks.

Over the study period, the volunteers were asked to count the number of times they defecated each day and to capture and weigh each stool sample. Each of the volunteers was also asked to count the number of times they passed gas. The volunteers were also asked to submit to randomized testing that involved measuring the amount of gas that was emitted during episodes of flatulence, using balloons.

The researchers found that the change in diet did not change the number of times the volunteers defecated each day—but it did change the amount of material discharged. The researchers found the plant-based diet doubled the stool size on average. The researchers note this was due to a huge increase in the mass of bacterial growth and excretion. The data also showed that the number of flatulence episodes increased by seven times per day on the plant-based diet—and each discharge had approximately 50% more gas. The researchers note this was due to fermenting of plant material in the gut.

The researchers suggest their experiments show that a plant-based diet promotes more healthy types of gut bacteria which leads to better overall gut health.

 

Physical exercise can relieve tumor-associated anemia

University of Basel (Switzerland), September 10, 2021

Many cancer patients suffer from anemia leaving them fatigued, weak, and an impaired ability to perform physical activity. Drugs only rarely alleviate this type of anemia. Researchers at the University of Basel have now been able to show what causes the anemia, and that physical exercise can improve this condition.

The two major symptoms of cancer are loss of muscle mass and a reduced hemoglobin level, leading to weight loss, fatigue, lethargy and reduced physical performance. Moreover, both symptoms—atrophy and anemia—prompt many patients to schedule a doctor's appointment, then resulting in the diagnosis of a tumor. Why cancer causes muscle atrophy and anemia is not yet understood, and treatment is currently difficult.

The fact that anemia leads to a decline of the overall state of health and can negatively affect the course of cancer therapy highlights the urgency to obtain insights into causes and potential remedies. In collaboration with the Department of Biomedicine at the University of Basel, the research group of Professor Christoph Handschin at the Biozentrum has now been able to show in a mouse model that cancer not only triggers a systemic inflammatory reaction, but also massively changes the handling of lipids and other metabolites in the body.

The body's fight is unsuccessful

These changes result in a tumor-related enhanced destruction of red blood cells. The study published in Science Advances shows that exercise normalizes these metabolic abnormalities and thereby reduces the anemia caused by cancer.

The body tries to counteract the degradation by increasing red blood cell productionin the bone marrow and the spleen—without success. However, the increased production of blood cells is insufficient to prevent tumor-associated anemia. "We have now been able to clarify how cancer causes the degradation of red blood cells," says Christoph Handschin. "Cancer massively alters the metabolism of lipids and other compounds. This alters not only the red blood cells but also the macrophages, causing a sharp increase in red blood cells destruction by the macrophages." Macrophages are a type of white blood cells and part of the immune system.

Exercise normalizes metabolism and alleviates anemia

The research group attempted to normalize the metabolism by pharmacological means. However, none of the drugs could significantly improve the anemia. In contrast, however, the metabolism was regulated to such an extent by exercise that the anemia also decreased. Even the abnormal increase in red blood cell production could be reduced to a lower level. "Training was able to restore tumor-induced metabolic remodeling and inflammation sufficiently to blunt the excessive blood cell formation and destruction," explained Handschin.

This study provides novel insights into the development of tumor-associated anemia. The findings suggest that exercise is a useful therapy for cancer patients, in order to counteract anemia and associated fatigue and lethargy and in turn to improve their general well-being and quality of life. This also leads to improved tolerance of radio- and chemotherapy, as has previously been established.

 

Mango could help maintain gut bacteria at risk from high-fat diets

Oklahoma State University, September 13, 2021

Mango consumption could help prevent the loss of beneficial gut bacteria caused by a high fat diet, according to research on mice.

The findings, published in the Journal of Nutrition , appears to reveal for the first time the positive impact of mango on gut microbiota.

In the study, 60 male mice were assigned to one of four dietary treatment groups for 12 weeks - control (with 10% of calories from fat), high fat (with 60% calories from fat), or high fat with 1% or 10% mango. All high-fat diets had similar macronutrient, calcium, phosphorus, and fiber content.

“We investigated the effects of freeze-dried mango pulp combined with an high-fat diet on the cecal microbial population and its relation to body composition, lipids, glucose parameters, short-chain fatty acid (SCFA) production, and gut inflammatory markers in a mouse model of diet-induced obesity,” the study reports.

The high-fat dietary treatment with 10% mango (equivalent to 1½ cups of fresh mango pieces) was found to be the most effective in preventing the loss of beneficial bacteria from a high-fat diet without decreasing body weight or fat accumulation.

Specifically, mango supplementation regulated gut bacteria in favor of Bifidobacteria and Akkermansia and enhanced short-chain fatty acid (SFCA) production. SCFAs have been shown to possess a wide range of beneficial effects, such as anti-inflammatory properties.

Fibre benefits

In previous studies, Bifidobacteria, for example, has been found to be lower in both obese individuals and those with type-2 diabetes. Similar results have been observed withAkkermansia in animal studies. High-fat diets, meanwhile, have been linked to gut dysbiosis, or bacterial imbalances within the intestinal tract.

"Fibre and other bioactive compounds in plant-based foods are suggested to prevent gut dysbiosis caused by a high-fat diet," said Edralin A. Lucas, professor of nutritional sciences at Oklahoma State University and lead researcher of the study.

"Mango is a good source of fibre and has been reported in previous studies to have anti-obesogenic, hypoglycemic and immunomodulatory properties. The results of this animal study showed that adding mango to the diet may help maintain and regulate gut health and levels of beneficial bacteria levels.”

India, China, Indonesia and Thailand are the top four Mango growing countries, accounting for well over half the total global production.

Although more research is needed on the effects of mango on human health, this study suggests that mango consumption may be important in improving gut health particularly for those consuming a high-fat diet, the researchers concluded.

The Gary Null Show - 09.14.21

The Gary Null Show - 09.14.21

September 14, 2021

Kim Iversen analyzes Dr. Fauci's past support of AZT to treat HIV/AIDS and his current support of mRNA vaccines for COVID-19.

The Gary Null Show - 09.13.21
The Gary Null Show - 09.10.21
The Gary Null Show - 09.09.21

The Gary Null Show - 09.09.21

September 9, 2021

Eating a plant rich diet reduces risk of developing COVID-19

King's College London, September 8, 2021

A recent study, published in Gut, by researchers from King's and Harvard Medical School, examines data from nearly 600,000 ZOE COVID Study app contributors. Participants completed a survey about the food they ate during Feb 2020 (pre-pandemic), making it the largest study in this space. 19% of these contributors contracted COVID-19.

People with the highest quality diet were around 10% less likely to develop COVID-19 than those with the lowest quality diet, and 40% less likely to fall severely ill.

This is the first longitudinal study of diet and COVID-19 and the first to show that a healthy diet cuts the chances of developing the disease in the first place.

Rather than looking at specific foods or nutrients, the survey was designed to look at broader dietary patterns which are reflective of how people actually eat. The survey produced a 'diet quality score' that reflected the overall merit of each person's diet. Diets with high quality scores were found to contain plant-based foods such as fruits, vegetables and whole grains, as well as oily fish, less processed foods and refined carbohydrates. A low diet quality score is associated with diets high in ultra processed foods and low amounts of plant based foods.

The researchers found that people who ate the highest quality diet were around 10% less likely to develop COVID-19 than those with the least nutritious diet and 40% less likely to become severely ill if they developed COVID-19.

The relationship between diet quality and COVID-19 risk still remained after accounting for all potential confounding factors. Factors included age, body mass index (BMI), ethnicity, smoking, physical activity and underlying health conditions. Mask-wearing habits and population density were also considered.

The impact of diet was amplified by individual life situations, with people living in low-income neighborhoods and having the lowest quality diet being around 25% more at risk from COVID-19 than people in more affluent communities who were eating in the same way.

Based on these results, the researchers estimate that nearly a quarter of COVID-19 cases could have been prevented if these differences in diet quality and socioeconomic status had not existed.

This further highlights that improved access to nutritious, healthier food could be substantive for bettering public health, especially among the underprivileged members of the community.

Professor Tim Spector, professor of genetic epidemiology at the School of Life Course Sciences, says that "these findings chime with recent results from our landmark PREDICT study, showing that people who eat higher quality diets (with low levels of ultra-processed foods) have a healthier collection of microbes in their guts, which is linked to better health. You don't have to go vegan, but getting more diverse plants on your plate is a great way to boost the health of your gut microbiome, improve your immunity and overall health, and potentially reduce your risk from COVID-19."

 

Targeting the gut to relieve rheumatoid arthritis

University College London, September 6, 2021

UCL researchers have shown that damage to the lining of the gut plays an important role in the development of rheumatoid arthritis, paving the way for a new approach to treating the disease.

In the pre-clinical study, which used mouse models and patient samples, the research team propose that restoration of the gut-barrier could offer a new therapeutic approach to reducing the severity of Rheumatoid arthritis (RA) symptoms.

Rheumatoid arthritis is a chronic disease that causes joint pain, swelling, and inflammation. Despite understanding of some of the genetic and environmental factors that might be involved in the development of arthritis, scientists still do not completely understand what initiates disease and how it accelerates. Recent research in this area is exploring how the bacteria in the gut might be involved in the development of arthritis, with researchers suggesting that growth of 'bad' bacteria in the gut might play a part in initiating the disease.

Co-lead author, Professor Claudia Mauri (UCL Division of Infection & Immunity), said: "We wanted to know what was happening in the gut and whether changes to the intestinal lining—which usually acts as a barrier to protect the body from bacteria—are a feature of the disease and contribute to its development."

Using pre-clinical mouse models and patient samples, the team found that blood markers of gut damage were raised compared to healthy people even at the earliest stages of arthritis, and that these markers of damage got higher the more the disease progressed; and, unexpectedly, there were distinct signs of inflammation, as might be seen in inflammatory bowel disease. The team also showed that the lining of the gut became 'leaky,' potentially allowing the passage of bacteria to cross the gut lining into the body, enhancing inflammation both in the gut and potentially in the joints.

"Our findings suggest that the intestinal lining is a therapeutic target. Importantly, we found that using existing drugs that restore the gut-barrier integrity i.e., prevent the gut from becoming leaky or inhibit inflammatory cells from moving to and from to the gut, could reduce the severity of arthritis in pre-clinical models," says Professor Mauri.

"Current treatments for rheumatoid arthritis don't appear to correct the problems in the gut and so may leave the patient susceptible to reactivation of disease from the continuing inflammation in that area. Going forward, we need to evaluate the therapeutic impact of treating the intestinal lining of rheumatoid arthritis patients in addition to their joints. Maintaining gut health both through diet and pharmacological intervention may be a valuable new strategy."

 

Body fat mass percentage reduced among trial participants who received melatonin supplements

Shahid Beheshti University of Medical Sciences (Iran), September 3, 2021

According to news reporting originating from the Department of Clinical Nutrition and Dieteticsby research stated, “Obesity, as the most common metabolic disorder in the world, is characterized by excess body fat. This study is aimed at determining the effects of melatonin supplementation on body weight, nody mass index (BMI), waist circumference (WC), and body fat mass percentage (BFMP) in people with overweight or obesity.”

The news correspondents obtained a quote from the research from Department of Clinical Nutrition and Dietetics: “Thirty eight overweight or class-I obese adult individuals were recruited in the study (8 men and 30 women). Participants prescribed a weight-loss diet and then randomly were allocated to melatonin or placebo groups. Participants received either a 3-milligram melatonin or placebo tablet per day for 12 weeks. In order to assess differences at the significance level of 0.05, repeated measure ANOVA and paired t-test were used. According to the results, a significant reduction was found in participants’ body weight, WC, and BMI in both groups (p=0.001). However, for the last six weeks, significant reductions of these parameters were observed only in the melatonin group (p=0.01).”

According to the news reporters, the research concluded: “The BFMP of participants in the melatonin group showed a significant reduction at the end of the study compared to the initial measurements (p=0.008). Nevertheless, the results of the present study alone are not sufficient to conclude on the effects of melatonin consumption on anthropometric indices, and it seems that further studies are required in this regard.”

 

Boom in social stress may contribute to population decline

UMass Amherst scientist has new hypothesis for changes in reproductive behavior and physiology

University of Massachusetts, September 7, 2021

A University of Massachusetts Amherst environmental health scientist has developed an “overlooked hypothesis” to help explain the projected global population decline beginning in 2064: social stress.

Stress from social media and other largely empty or overwhelming social interactions may be leading or contributing to changes in reproductive behavior and reproductive physiology, suggests Alexander Suvorov, associate professor in the UMass Amherst School of Public Health and Health Sciences

In a review article, published in the journal Endocrinology, he examines various theories surrounding previous human population decline as models predict a “remarkable” decrease from 9.7 billion people in 2064 to 8.8 billion by 2100. Some countries’ populations already have peaked and are projected to decline by 50% by the end of the century.

“A unique feature of the upcoming population drop is that it is almost exclusively caused by decreased reproduction, rather than factors that increase rates of mortality (wars, epidemics, starvation, severe weather conditions, predators, and catastrophic events),” he writes.

Suvorov outlines a hypothesis that connects reproductive trends with population densities, proposing that density reflects the quality and frequency of social interactions. 

“Rising population numbers contribute to less meaningful social interactions, social withdrawal and chronic stress, which subsequently suppresses reproduction,” the manuscript states.

Over the past 50 years, a 50% decrease in sperm counts has occurred. Stress is known to suppress sperm count, ovulation and sexual activity, Suvorov notes. While changes in reproductive physiology are usually attributed to the effects of endocrine-disrupting pollutants, Suvorov believes it is not the only factor.

“Numerous wildlife and laboratory studies demonstrated that population peaks are always followed by increased stress and suppressed reproduction,” Suvorov says. “When a high population density is reached, something is happening in the neuroendocrine system that is suppressing reproduction. The same mechanisms happening in wildlife species may be at work in humans as well.”

Suvorov points to several changes in reproductive behavior that contribute to the population drop, including people having fewer children and waiting longer to start families or choosing to be child-free. But he says biological changes are likely happening as well. More research is needed, he says, such as studies to determine cortisol levels in human blood, an important measure of stress. 

“A better understanding of the causal chain involved in reproduction suppression by population density-related factors may help develop interventions to treat infertility and other reproductive conditions,” Suvorov writes. 

He hopes his hypothesis offers up an enticing area of research that scientists from different fields will be interested in exploring.

“The goal of this paper is to attract attention to a completely overlooked hypothesis – and this hypothesis is raising more questions than it is giving answers,” Suvorov says. “I hope it will trigger interest of people from very different domains and that after additional studies we will have a much better picture of to what extent population density is connected with social stress and how social stress is connected to reproduction, and what we can do about it.”

A common-sense place to start, he suggests: “Back off social media.”

 

 

Vitamin D cuts asthma exacerbation by 74% in children: Review

Anhui Medical University (China), August 30 2021

Vitamin D supplementation may cut the risk of asthma exacerbation in children but it does not impact respiratory infections in healthy children, a review has found.

The review of seven randomised controlled clinical trials weighed up "inconsistent" findings on the effect of vitamin D supplementation on the prevention of childhood acute respiratory infections (ARI). 

Published in the British Journal of Nutrition, it found overall there was not a statistically significant reduction in the risk of ARI, all-cause mortality or the rate of hospital admission due to respiratory infection in healthy children.

However, in children previously diagnosed with asthma, vitamin D supplementation resulted in a 74% reduction in the risk of asthma exacerbation.

"Our findings indicate a lack of evidence supporting the routine use of vitamin D supplementation for the prevention of ARI in healthy children; however, they suggest that such supplementation may benefit children previously diagnosed with asthma."

Potential impact 

According to the World Health Organisation (WHO) about 235 million people suffer from asthma, which is particularly common in children. It cited asthma as one of the major non-communicable diseases facing the world today.

The condition means air passages of the lungs become inflamed and narrowed.  

The causes of asthma are not completely understood but it is thought to be a combination of genetic predisposition and environmental exposure to irritants like allergens, tobacco smoke and air pollution.

ARI refers to the infection of the sinuses, throat, airways or lungs usually caused by viruses or bacteria. They can be particularly dangerous for people with asthma. According to a 2013 paper , an estimated 11.9 million episodes of severe ARI and three million episodes of very severe ARI in young children resulted in hospital admissions in 2010 globally.

Meanwhile a separate paper from the Child Health Epidemiology Reference Group of WHO and UNICEF  found almost two-thirds of the 7.6 million children worldwide who died within the first five years of life died of infectious diseases. Within these two-thirds, pneumonia was the leading cause for a total of 1.396 million deaths. 

WHO has said in the past that further research on vitamin D supplementation and the possible decrease in frequency and severity of respiratory infections in children was needed before specific recommendations could be made.

The Chinese researchers wrote in their review: "Although vitamin D is widely recognised for its importance in calcium metabolism and bone health, researchers have spent several years focusing on its growing number of possible non-calcaemic health effects.

"One of the more promising areas of study is the relationship between vitamin D status and respiratory infection. Recent research has indicated that vitamin D may play a role in protecting against ARI by increasing the body’s production of naturally acting antibiotics."

The review was conducted by researchers at the Anhui Medical University, Shaoxing Center for Disease Control and Prevention, Huzhou Center for Disease Control and Prevention, Anhui Institute of Schistosomiasis Control and the Anhui Provincial Family Planning Institute of Science and Technology in China.

It included trials in Japan, Afghanistan, India, Poland and Mongolia that compared vitamin D supplementation with either placebo or no intervention in children younger than 18 years of age. 

Source: British Journal of Nutrition

 

 

CoQ10 may improve facial wrinkles: RCT

Institute of Cosmetics ( Slovenia), September 9, 2021

High dose co-enzyme Q10 supplementation may improve wrinkles around the eyes and other parts of the face, says a new study.

Scientists from the Institute of Cosmetics in Ljubljana, Slovenia report that 150 mg per day of CoQ10 (Q10Vital) for 12 weeks were associated with reduced wrinkles around the eyes, and around the mouth and lips, compared with placebo.

On the other hand, no photoprotection or effects on skin hydration or thickness were observed, according to findings published in Biofactors .

“In the present study, the administration of a dietary supplement containing CoQ10 over a 12-week period showed several anti-ageing effects as it reduced wrinkles, improved skin smoothness and microrelief as well as skin firmness. It also helped the skin combat seasonal changes since it prevented negative viscoelasticity seasonal changes during winter,” they wrote.

CoQ10, a substance similar to a vitamin, is found in every cell in the body and is a key part of cells’ energy production machinery.  Levels of CoQ10 have been shown to decline with age and in particular with statin use, which can account for some of the muscular pain and weakness that some users experience as a side effect of the drugs.  CoQ10 also functions as an antioxidant, and while it is used in many dietary supplement, functional food ans cosmetic products, evidence to support its benefits for the skin is “scarce”, said the Slovenian researchers.

To test this, they recruited 32 healthy people with an average age of 53 to participate in their randomized, placebo-controlled intervention study. The participants were randomly assigned to one of three groups: Placebo, low dose CoQ10 (50 mg per day), or high dose CoQ10 (150 mg per day), for 12 weeks.

Results showed that, while the anti-wrinkle benefits around the eyes were observed for both CoQ10 groups, the high dose produced additional reductions in wrinkles around the mouth, nose and lips (nasolabial folds, corner of the mouth lines and upper radial lip lines).

“It should be noted that some baseline skin parameters are quite variable and it would therefore be beneficial to perform a study on a higher number of subjects to allow clearer conclusions regarding some parameters,” wrote the researchers. “For example, the study was under-powered for dermis parameters (intensity, thickness). Supplementation over a longer period and several seasons would also be worth testing as this study was conducted during winter, and also, 12 weeks is quite a short time to detect nutritional effects on skin, considering the length of the skin regeneration cycle.

“Considering this, a longer study period would also provide valuable insights into dose-response relationships. While we were unable to show such a relationship in our study, such an effect might (or might not) be observed if supplementation were to be done over more skin cycles.”

The Gary Null Show - 09.08.21

The Gary Null Show - 09.08.21

September 8, 2021
VIDEOS 
 
 
 
 

 

20 Years of Government-Sponsored Tyranny: The Rise of the Security-Industrial Complex from 9/11 to COVID-19

 

By John W. Whitehead & Nisha Whitehead
September 7, 2021

“I tell you, freedom and human rights in America are doomed. The U.S. government will lead the American people in — and the West in general — into an unbearable hell and a choking life.”—Osama bin Laden (October 2001), as reported by CNN

What a strange and harrowing road we’ve walked since September 11, 2001, littered with the debris of our once-vaunted liberties. We have gone from a nation that took great pride in being a model of a representative democracy to being a model of how to persuade a freedom-loving people to march in lockstep with a police state.
 
Our losses are mounting with every passing day.
 
What began with the post-9/11 passage of the USA Patriot Act  has snowballed into the eradication of every vital safeguard against government overreach, corruption and abuse.
 
The citizenry’s unquestioning acquiescence to anything the government wants to do in exchange for the phantom promise of safety and security has resulted in a society where the nation has been locked down into a militarized, mechanized, hypersensitive, legalistic, self-righteous, goose-stepping antithesis of every principle upon which this nation was founded.
 
Set against a backdrop of government surveillance, militarized police, SWAT team raids, asset forfeiture, eminent domain, overcriminalization, armed surveillance drones, whole body scanners, stop and frisk searches, police violence and the like—all of which have been sanctioned by Congress, the White House and the courts—our constitutional freedoms have been steadily chipped away at, undermined, eroded, whittled down, and generally discarded.
 
The rights embodied in the Constitution, if not already eviscerated, are on life support.
 
Free speech, the right to protest, the right to challenge government wrongdoing, due process, a presumption of innocence, the right to self-defense, accountability and transparency in government, privacy, press, sovereignty, assembly, bodily integrity, representative government: all of these and more have become casualties in the government’s war on the American people, a war that has grown more pronounced since 9/11.
 
Indeed, since the towers fell on 9/11, the U.S. government has posed a greater threat to our freedoms than any terrorist, extremist or foreign entity ever could.

 

 

While nearly 3,000 people died in the 9/11 attacks, the U.S. government and its agents have easily killed at least ten times that number of civilians in the U.S. and abroad since 9/11 through its police shootings, SWAT team raids, drone strikes and profit-driven efforts to police the globe, sell weapons to foreign nations (which too often fall into the hands of terrorists), and foment civil unrest in order to keep the security industrial complex gainfully employed.
 
The American people have been treated like enemy combatants, to be spied on, tracked, scanned, frisked, searched, subjected to all manner of intrusions, intimidated, invaded, raided, manhandled, censored, silenced, shot at, locked up, denied due process, and killed.
 
In allowing ourselves to be distracted by terror drills, foreign wars, color-coded warnings, pandemic lockdowns and other carefully constructed exercises in propaganda, sleight of hand, and obfuscation, we failed to recognize that the U.S. government—the government that was supposed to be a “government of the people, by the people, for the people”—has become the enemy of the people.
 
Consider that the government’s answer to every problem has been moregovernment—at taxpayer expense—and less individual liberty.
 
Every crisis—manufactured or otherwise—since the nation’s early beginnings has become a make-work opportunity for the government to expand its reach and its power at taxpayer expense while limiting our freedoms at every turn: The Great Depression. The World Wars. The 9/11 terror attacks. The COVID-19 pandemic.
 
Viewed in this light, the history of the United States is a testament to the old adage that liberty decreases as government (and government bureaucracy) grows. Or, to put it another way, as government expands, liberty contracts.
 
This is how the emergency state operates, after all, and we should know: after all, we have spent the past 20 years in a state of emergency.
 
From 9/11 to COVID-19, “we the people” have acted the part of the helpless, gullible victims desperately in need of the government to save us from whatever danger threatens. In turn, the government has been all too accommodating and eager while also expanding its power and authority in the so-called name of national security.
 
This is a government that has grown so corrupt, greedy, power-hungry and tyrannical over the course of the past 240-plus years that our constitutional republic has since given way to idiocracy, and representative government has given way to a kleptocracy (a government ruled by thieves) and a kakistocracy (a government run by unprincipled career politicians, corporations and thieves that panders to the worst vices in our nature and has little regard for the rights of American citizens).
 
What this really amounts to is a war on the American people, fought on American soil, funded with taxpayer dollars, and waged with a single-minded determination to use national crises, manufactured or otherwise, in order to transform the American homeland into a battlefield.
 
Indeed, the government’s (mis)management of various states of emergency in the past 20 years has spawned a massive security-industrial complex the likes of which have never been seen before. According to the National Priorities Project at the progressive Institute for Policy Studies, since 9/11, the United States has spent $21 trillion on “militarization, surveillance, and repression.”
 
Clearly, this is not a government that is a friend to freedom.
 
Rather, this is a government that, in conjunction with its corporate partners, views the citizenry as consumers and bits of data to be bought, sold and traded.
 
This is a government that spies on and treats its people as if they have no right to privacy, especially in their own homes while the freedom to be human is being erased.
 
This is a government that is laying the groundwork to weaponize the public’s biomedical data as a convenient means by which to penalize certain “unacceptable” social behaviors. Incredibly, a new government agency HARPA (a healthcare counterpart to the Pentagon’s research and development arm DARPA) will take the lead in identifying and targeting “signs” of mental illness or violent inclinations among the populace by using artificial intelligence to collect data from Apple Watches, Fitbits, Amazon Echo and Google Home.
 
This is a government that routinely engages in taxation without representation, whose elected officials lobby for our votes only to ignore us once elected.
 
This is a government comprised of petty bureaucrats, vigilantes masquerading as cops, and faceless technicians.
 
This is a government that railroads taxpayers into financing government programs whose only purpose is to increase the power and wealth of the corporate elite.
 
This is a government—a warring empire—that forces its taxpayers to pay for wars abroad that serve no other purpose except to expand the reach of the military industrial complex.
 
This is a government that subjects its people to scans, searches, pat downs and other indignities by the TSA and VIPR raids on so-called “soft” targets like shopping malls and bus depots by black-clad, Darth Vader look-alikes.
 
This is a government that uses fusion centers, which represent the combined surveillance efforts of federal, state and local law enforcement, to track the citizenry’s movements, record their conversations, and catalogue their transactions.
 
This is a government whose wall-to-wall surveillance has given rise to a suspect society in which the burden of proof has been reversed such that Americans are now assumed guilty until or unless they can prove their innocence.
 
This is a government that treats its people like second-class citizens who have no rights, and is working overtime to stigmatize and dehumanize any and all who do not fit with the government’s plans for this country.
 
This is a government that uses free speech zones, roving bubble zones and trespass laws to silence, censor and marginalize Americans and restrict their First Amendment right to speak truth to power.
 
This is a government that persists in renewing the National Defense Authorization Act (NDAA), which allows the president and the military to arrest and detain American citizens indefinitely based on the say-so of the government.
 
This is a government that saddled us with the Patriot Act, which opened the door to all manner of government abuses and intrusions on our privacy.
 
This is a government that, in direct opposition to the dire warnings of those who founded our country, has allowed the Department of Homeland Security (DHS) to establish a standing army by way of programs that transfer surplus military hardware to local and state police.
 
This is a government that has militarized American’s domestic police, equipping them with military weapons such as “tens of thousands of machine guns; nearly 200,000 ammunition magazines; a million hollow-point bullets; thousands of pieces of camouflage and night-vision equipment; and hundreds of silencers, armored cars and aircraft,” in addition to armored vehicles, sound cannons and the like.
 
This is a government that has provided cover to police when they shoot and kill unarmed individuals just for standing a certain way, or moving a certain way, or holding something—anything—that police could misinterpret to be a gun, or igniting some trigger-centric fear in a police officer’s mind that has nothing to do with an actual threat to their safety.
 
This is a government that has created a Constitution-free zone within 100 miles inland of the border around the United States, paving the way for Border Patrol agents to search people’s homes, intimately probe their bodies, and rifle through their belongings, all without a warrant. Nearly 66% of Americans (2/3 of the U.S. population, 197.4 million people) now live within that 100-mile-deep, Constitution-free zone.
 
This is a government that treats public school students as if they were prison inmates, enforcing zero tolerance policies that criminalize childish behavior, and indoctrinating them with teaching that emphasizes rote memorization and test-taking over learning, synthesizing and critical thinking.
 
This is a government that is operating in the negative on every front: it’s spending far more than what it makes (and takes from the American taxpayers) and it is borrowing heavily (from foreign governments and Social Security) to keep the government operating and keep funding its endless wars abroad. Meanwhile, the nation’s sorely neglected infrastructure—railroads, water pipelines, ports, dams, bridges, airports and roads—is rapidly deteriorating.
 
This is a government that has empowered police departments to make a profit at the expense of those they have sworn to protect through the use of asset forfeiture laws, speed traps, and red light cameras.
 
This is a government whose gun violence—inflicted on unarmed individuals by battlefield-trained SWAT teams, militarized police, and bureaucratic government agents trained to shoot first and ask questions later—poses a greater threat to the safety and security of the nation than any mass shooter. There are now reportedly more bureaucratic (non-military) government agents armed with high-tech, deadly weapons than U.S. Marines.
 
This is a government that has allowed the presidency to become a dictatorship operating above and beyond the law, regardless of which party is in power.

 

This is a government that treats dissidents, whistleblowers and freedom fighters as enemies of the state.
 
This is a government that has in recent decades unleashed untold horrors upon the world—including its own citizenry—in the name of global conquest, the acquisition of greater wealth, scientific experimentation, and technological advances, all packaged in the guise of the greater good.
 
This is a government that allows its agents to break laws with immunity while average Americans get the book thrown at them.
 
This is a government that speaks in a language of force. What is this language of force? Militarized police. Riot squads. Camouflage gear. Black uniforms. Armored vehicles. Mass arrests. Pepper spray. Tear gas. Batons. Strip searches. Surveillance cameras. Kevlar vests. Drones. Lethal weapons. Less-than-lethal weapons unleashed with deadly force. Rubber bullets. Water cannons. Stun grenades. Arrests of journalists. Crowd control tactics. Intimidation tactics. Brutality. Contempt of cop charges.
 
This is a government that justifies all manner of government tyranny and power grabs in the so-called name of national security, national crises and national emergencies.
 
This is a government that exports violence worldwide, with one of this country’s most profitable exports being weapons. Indeed, the United States, the world’s largest exporter of arms, has been selling violence to the world in order to prop up the military industrial complex and maintain its endless wars abroad.
 
This is a government that is consumed with squeezing every last penny out of the population and seemingly unconcerned if essential freedoms are trampled in the process.
 
This is a government that routinely undermines the Constitution and rides roughshod over the rights of the citizenry, eviscerating individual freedoms so that its own powers can be expanded.
 
This is a government that believes it has the authority to search, seize, strip, scan, spy on, probe, pat down, taser, and arrest any individual at any time and for the slightest provocation, the Constitution be damned.

The Gary Null Show  - 09.07.21

The Gary Null Show - 09.07.21

September 7, 2021

Pomegranate peel has protective effects against enteropathogenic bacteria

US Department of Agriculture, August 31, 2021

A recent study by the U.S. Department of Agriculture revealed that pomegranate peel extract contains bioactive compounds that have potential antibacterial activity. The study’s findings were published in the journal Nutrition Research.

  • Pomegranate fruit peel is considered an agricultural waste product. However, it is a rich source of polyphenols like punicalins, punicalagins and ellagic acids.
  • Earlier studies have shown that products derived from pomegranates have health benefits, including antibacterial activity, in vitro.
  • There is limited evidence, however, of their antibacterial activity in vivo.
  • For this study, researchers sought to determine the antibacterial properties of pomegranate peel extract in vivo. In particular, they focused on the punicalin, punicalagin and ellagic acid present in the peel extract.
  • The researchers infected C3H/He mice with the bacterial pathogen Citrobacter rodentium, a bacterium that mimics the enteropathogenic bacterium, Escherichia coli. Prior to infection, the mice were orally treated with water or pomegranate peel extract.
  • Twelve days after infection, the researchers examined C. rodentium colonization of the colon and spleen, as well as changes in tissue and gene expression. Fecal excretions were also analyzed for C. rodentium.
  • The results revealed that the pomegranate peel extract reduced weight loss and mortality induced by C. rodentium infection.
  • The extract also reduced C. rodentium colonization of the spleen.
  • Additionally, pomegranate peel extract decreased the extent of damage in the colon caused by C. rodentium infection.

In sum, pomegranate fruit peel extract contains bioactive compounds that can help reduce the severity of C. rodentium infection in vivo.

 

Vitamin D may protect against young-onset colorectal cancer

Dana-Farber Cancer Institute and Harvard  School of Public Health, September 1, 2021

Consuming higher amounts of Vitamin D - mainly from dietary sources - may help protect against developing young-onset colorectal cancer or precancerous colon polyps, according to the first study to show such an association.

The study, recently published online in the journal Gastroenterology, by scientists from Dana-Farber Cancer Institute, the Harvard T.H. Chan School of Public Health, and other institutions, could potentially lead to recommendations for higher vitamin D intake as an inexpensive complement to screening tests as a colorectal cancer prevention strategy for adults younger than age 50.

While the overall incidence of colorectal cancer has been declining, cases have been increasing in younger adults - a worrisome trend that has yet to be explained. The authors of the study, including senior co-authors Kimmie Ng, MD, MPH, of Dana-Farber, and Edward Giovannucci, MD, DSc., of the T.H. Chan School, noted that vitamin D intake from food sources such as fish, mushrooms, eggs, and milk has decreased in the past several decades. There is growing evidence of an association between vitamin D and risk of colorectal cancer mortality. However, prior to the current study, no research has examined whether total vitamin D intake is associated with the risk of young-onset colorectal cancer.

“Vitamin D has known activity against colorectal cancer in laboratory studies. Because vitamin D deficiency has been steadily increasing over the past few years, we wondered whether this could be contributing to the rising rates of colorectal cancer in young individuals,” said Ng, director of the Young-Onset Colorectal Cancer Center at Dana-Farber. “We found that total vitamin D intake of 300 IU per day or more - roughly equivalent to three 8-oz. glasses of milk - was associated with an approximately 50% lower risk of developing young-onset colorectal cancer.”

The results of the study were obtained by calculating the total vitamin D intake - both from dietary sources and supplements - of 94,205 women participating in the Nurses’ Health Study II (NHS II). This study is a prospective cohort study of nurses aged 25 to 42 years that began in 1989. The women are followed every two years by questionnaires on demographics, diet and lifestyle factors, and medical and other health-related information. The researchers focused on a primary endpoint - young-onset colorectal cancer, diagnosed before 50 years of age. They also asked on a follow-up questionnaire whether they had had a colonoscopy or sigmoidoscopy where colorectal polyps (which may be precursors to colorectal cancer) were found.

During the period from 1991 to 2015 the researchers documented 111 cases of young-onset colorectal cancer and 3,317 colorectal polyps. Analysis showed that higher total vitamin D intake was associated with a significantly reduced risk of early-onset colorectal cancer. The same link was found between higher vitamin D intake and risk of colon polyps detected before age 50.

The association was stronger for dietary vitamin D - principally from dairy products - than from vitamin D supplements. The study authors said that finding could be due to chance or to unknown factors that are not yet understood.

Interestingly, the researchers didn’t find a significant association between total vitamin D intake and risk of colorectal cancer diagnosed after age 50. The findings were not able to explain this inconsistency, and the scientists said further research in a larger sample is necessary to determine if the protective effect of vitamin D is actually stronger in young-onset colorectal cancer.

In any case, the investigators concluded that higher total vitamin D intake is associated with decreased risks of young-onset colorectal cancer and precursors (polyps). “Our results further support that vitamin D may be important in younger adults for health and possibly colorectal cancer prevention,” said Ng. “It is critical to understand the risk factors that are associated with young-onset colorectal cancer so that we can make informed recommendations about diet and lifestyle, as well as identify high risk individuals to target for earlier screening.”

 

 

Choosing personal exercise goals, then tackling them immediately is key to sustaining change

University of Pennsylvania, September 1, 2021

When people set their own exercise goals – and then pursue them immediately – it’s more likely to result in lasting positive changes, according to a new study at the Perelman School of Medicine at the University of Pennsylvania. The results of this research are especially important because they were found among an underserved population that is at particularly high risk of having or developing heart conditions. The study was published in JAMA Cardiology.

“Most behavior change programs involve goal-setting, but the best way to design that process is unknown,” said lead author Mitesh Patel, MD, MBA, an associate professor of Medicine at Penn and vice president for Clinical Transformation at Ascension. “Our clinical trial demonstrated that physical activity increased the most when patients chose their goals rather than being assigned them, and when the goals started immediately rather than starting lower and gradually increasing over time. These findings are particularly important because the patients were from lower-income neighborhoods and may face a number of challenges in achieving health goals.”

This study consisted of 500 patients from low-income neighborhoods, mainly in West Philadelphia but also elsewhere in and outside of the city. Participants either had a cardiovascular disease or were assessed to have a near-10 percent risk of developing one within a decade. These high-risk patients stood to greatly gain from increased physical activity.

Patel’s previous work at the Penn Medicine Nudge Unit often focused on the use of gamification, a concept used to create behavioral change by turning it into a game. The work usually tested whether playing a game attached to physical activity goals could make significant increases against not playing a game, or between different versions of a game.

As with past studies, every participant was given a wearable step tracker that recorded their daily step counts through Penn’s Way to Health platform. But what set this study apart from many of its predecessors was that the main outcomes of the research were less about participation in the games themselves and more about how goals were established, as well as when participants were encouraged to pursue them.

Once every participant got their wearable step counter, they were given a week or two to get used to it. This time period also functioned as a baseline-setting period for everyone’s pre-intervention daily step count. After that, participants were randomly assigned to the control group, which didn’t have step goals or games attached, or one of the gaming groups with goals.

Those in the gamified group also went through two other sets of random assignments. One determined whether they’d have input on their step goal, or whether they’d just be assigned a standard one. The second decided whether each participant would immediately start working toward their goals (for the entire 16-week intervention), or whether they’d ramp up to it, with minor increases in goals, until the full goals kicked in at week nine.

After analyzing the results, the researchers saw that the only group of participants who achieved significant increases in activity were those who chose their own goals and started immediately. They had the highest average increase in their steps compared to the group with no goals, roughly 1,384 steps per day. And, in addition to raw step counts, the study also measured periods of sustained, high activity, amounting to an average increase of 4.1 minutes daily.

Comparatively, those who were assigned their goals or had full goals delayed for half the intervention only increased their daily steps above the control group’s average by between 500 and 600 steps.

“Individuals who select their own goals are more likely to be intrinsically motivated to follow through on them,” said Kevin Volpp, MD, PhD, director of the Center for Health Incentives and Behavioral Economics. “They feel like the goal is theirs and this likely enables greater engagement.”

The study didn’t end when the researchers turned the games off. Participants kept their activity trackers, and in the eight weeks following the intervention, the group that chose their goals and started immediately kept up their progress. In fact, they achieved almost the exact same average in steps – just three less than during the active games.

“It is exciting to see that the group that increased their activity levels by the most steps maintained those levels during follow-up,” Patel said. “This indicates that gamification with self-chosen and immediate goals helped these patients form a new habit.”

Many programs, whether offered through work or by health insurance companies, offer incentives for boosts in physical activity. But these goals are often fairly static and assigned based on round numbers. Patel, Volpp, and colleagues believe this research suggests that adjusting goal setting in these programs can have a significant impact. And if these adjustments lead to gains among people with lower incomes, whom cardiovascular disease kill at 76 percent higher rates, that could be particularly important.          

“Goal-setting is a fundamental element of almost every physical activity program, whether through a smartphone app or in a workplace wellness program,” Volpp said. “Our findings reveal a simple approach that could be used to improve the impact of these programs and the health of their patients.”

 

Comparing seniors who relocate long-distance shows that where you live affects your longevity

Massachusetts Institute of Technology, September 1, 2021

Would you like to live longer? It turns out that where you live, not just how you live, can make a big difference.

That's the finding of an innovative study co-authored by an MIT economist, which examines senior citizens across the U.S. and concludes that some locations enhance longevity more than others, potentially for multiple reasons.

The results show that when a 65-year-old moves from a metro area in the 10th percentile, in terms of how much those areas enhance longevity, to a metro area the 90th percentile, it increases that person's life expectancy by 1.1 years. That is a notable boost, given that mean life expectancy for 65-year-olds in the U.S. is 83.3 years.

"There's a substantively important causal effect of where you live as an elderly adult on mortality and life expectancy across the United States," says Amy Finkelstein, a professor in MIT's Department of Economics and co-author of a newly published paper detailing the findings.

Researchers have long observed significant regional variation in life expectancy in the U.S., and often attributed it to "health capital"—tendencies toward obesity, smoking, and related behavioral factors in the regional populations. But by analyzing the impact of moving, the current study can isolate and quantify the effect that the location itself has on residents.

As such, the research delivers important new information about large-scale drivers of U.S. health outcomes—and raises the question of what it is about different places that affects the elderly's life expectancy. One clear possibility is the nature of available medical care. Other possible drivers of longevity include climate, pollution, crime, traffic safety, and more.

"We wanted to separate out the role of people's prior experiences and behaviors—or health capital—from the role of place or environment," Finkelstein says.

The paper, "Place-Based Drivers of Mortality: Evidence of Migration," is published in the August issue of the American Economic Review. The co-authors are Finkelstein, the John and Jennie S. MacDonald Professor of Economics at MIT, and Matthew Gentzkow and Heidi Williams, who are both professors of economics at Stanford University.

To conduct the study, Finkelstein, Gentzkow, and Williams analyzed Medicare records from 1999 to 2014, focusing on U.S. residents between the ages of 65 and 99. Ultimately the research team studied 6.3 million Medicare beneficiaries. About 2 million of those moved from one U.S. "commuting zone" to another, and the rest were a random 10 percent sample of people who had not moved over the 15-year study period. (The U.S. Census Bureau defines about 700 commuting zones nationally.)

A central element of the study involves seeing how different people who were originally from the same locations fared when moving to different destinations. In effect, says Finkelstein, "The idea is to take two elderly people from a given origin, say, Boston. One moves to low-mortality Minneapolis, one moves to high-mortality Houston. We then compare thow long each lives after they move."

Different people have different health profiles before they move, of course. But Medicare records include detailed claims data, so the researchers applied records of 27 different illnesses and conditions—ranging from lung cancer and diabetes to depression—to a standard mortality risk model, to categorize the overall health of seniors when they move. Using these "very, very rich pre-move measures of their health," Finkelstein notes, the researchers tried to account for pre-existing health levels of seniors from the same location who moved to different places.

Still, even assessing people by 27 measures does not completely describe their health, so Finkelstein, Gentzkow, and Williams also estimated what fraction of people's health conditions they had not observed—essentially by calibrating the observed health of seniors against health capital levels in places they were moving from. They then consider how observed health varies across individuals from the same location moving to different destinations and, assuming that differences in unobserved health—such as physical mobility—vary in the same way as observed differences in health, they adjust their estimates accordingly.

All told, the study found that many urban areas on the East and West Coasts—including New York City, San Francisco, and Miami—have positive effects on longevity for seniors moving there. Some Midwestern metro areas, including Chicago, also score well.

By contrast, a large swath of the deep South has negative effects on longevity for seniors moving there, including much of Alabama, Arkansas, Louisiana, and northern Florida. Much of the Southwest, including parts of Texas, Oklahoma, New Mexico, and Arizona, fares similarly poorly.

The scholars also estimate that health capital accounts for about 70 percent of the difference in longevity across areas of the U.S., and that location effects account for about 15 percent of the variation.

"Yes, health capital is important, but yes, place effects also matter," Finkelstein says.

Other leading experts in health economics say they are impressed by the study. Jonathan Skinner, the James O. Freeman Presidential Professor of Economics, Emeritus, at Dartmouth College, says the scholars "have provided a critical insight" into the question of place effects "by considering older people who move from one place to another, thus allowing the researchers to cleanly identify the pure effect of the new location on individual health—an effect that is often different from the health of long-term residents. This is an important study that will surely be cited and will influence health policy in coming years."

The Charlotte Effect: What makes a difference?

Indeed, the significance of place effects on life expectancy is also evident in another pattern the study found. Some locations—such as Charlotte, North Carolina—have a positive effect on longevity but still have low overall life expectancy, while other places—such as Santa Fe New Mexico—have high overall life expectancy, but a below-average effect on the longevity of seniors who move there.

Again, the life expectancy of an area's population is not the same thing as that location's effect on longevity. In places where, say, smoking is highly prevalent, population-wide longevity might be subpar, but other factors might make it a place where people of average health will live longer. The question is why.

"Our [hard] evidence is about the role of place," Finkelstein says, while noting that the next logical step in this vein of research is to look for the specific factors at work. "We know something about Charlotte, North Carolina, makes a difference, but we don't yet know what."

With that in mind, Finkelstein, Gentzkow, and Williams, along with other colleagues, are working on a pair of new studies about health care practices to see what impact place-based differences may have; one study focuses on doctors, and the other looks at the prescription opioid epidemic.

In the background of this research is a high-profile academic and policy discussion about the impact of health care utilization. One perspective, associated with the Dartmouth Atlas of Health Care project, suggests that the large regional differences in health care use it has documented have little impact on mortality. But the current study, by quantifying the variable impact of place, suggest there may be, in turn, a bigger differential impact in health care utilization yet to be identified.

For her part, Finkelstein says she would welcome further studies digging into health care use or any other factor that might explain why different places have different effects on life expectancy; the key is uncovering more hard evidence, wherever it leads.

"Differences in health care across places are large and potentially important," Finkelstein says. "But there are also differences in pollution, weather, [and] other aspects. … What we need to do now is get inside the black box of 'the place' and figure out what it is about them that matters for longevity."

 

Gut bacteria influence brain development

Researchers discover biomarkers that indicate early brain injury in extreme premature infants

University of Vienna (Austria), September 3, 2021

The early development of the gut, the brain and the immune system are closely interrelated. Researchers refer to this as the gut-immune-brain axis. Bacteria in the gut cooperate with the immune system, which in turn monitors gut microbes and develops appropriate responses to them. In addition, the gut is in contact with the brain via the vagus nerve as well as via the immune system. "We investigated the role this axis plays in the brain development of extreme preterm infants," says the first author of the study, David Seki. "The microorganisms of the gut microbiome - which is a vital collection of hundreds of species of bacteria, fungi, viruses and other microbes - are in equilibrium in healthy people. However, especially in premature babies, whose immune system and microbiome have not been able to develop fully, shifts are quite likely to occur. These shifts may result in negative effects on the brain," explains the microbiologist and immunologist.

Patterns in the microbiome provide clues to brain damage
"In fact, we have been able to identify certain patterns in the microbiome and immune response that are clearly linked to the progression and severity of brain injury," adds David Berry, microbiologist and head of the research group at the Centre for Microbiology and Environmental Systems Science (CMESS) at the University of Vienna as well as Operational Director of the Joint Microbiome Facility of the Medical University of Vienna and University of Vienna. "Crucially, such patterns often show up prior to changes in the brain. This suggests a critical time window during which brain damage of extremely premature infants may be prevented from worsening or even avoided."

Comprehensive study of the development of extremely premature infants
Starting points for the development of appropriate therapies are provided by the biomarkers that the interdisciplinary team was able to identify. "Our data show that excessive growth of the bacterium Klebsiella and the associated elevated γδ-T-cell levels can apparently exacerbate brain damage," explains Lukas Wisgrill, Neonatologist from the Division of Neonatology, Pediatric Intensive Care Medicine and Neuropediatrics at the Department of Pediatric and Adolescent Medicine at the Medical University of Vienna. "We were able to track down these patterns because, for a very specific group of newborns, for the first time we explored in detail how the gut microbiome, the immune system and the brain develop and how they interact in this process," he adds. The study monitored a total of 60 premature infants, born before 28 weeks gestation and weighing less than 1 kilogram, for several weeks or even months. Using state-of-the-art methods - the team examined the microbiome using 16S rRNA gene sequencing, among other methods - the researchers analysed blood and stool samples, brain wave recordings (e.g. aEEG) and MRI images of the infants' brains.

Research continues with two studies
The study, which is an inter-university clusterproject under the joint leadership by Angelika Berger (Medical University of Vienna) and David Berry (University of Vienna), is the starting point for a research project that will investigate the microbiome and its significance for the neurological development of prematurely born children even more thoroughly. In addition, the researchers will continue to follow the children of the initial study. "How the children's motoric and cognitive skills develop only becomes apparent over several years," explains Angelika Berger. "We aim to understand how this very early development of the gut-immune-brain axis plays out in the long term. " The most important cooperation partners for the project are already on board: "The children's parents have supported us in the study with great interest and openness," says David Seki. "Ultimately, this is the only reason we were able to gain these important insights. We are very grateful for that."

 

 

Amino acid supplements may boost vascular endothelial function in older adults: Study

University of Alabama, August 28, 2021

A combination of HMB (a metabolite of leucine), glutamine and arginine may improve vascular function and blood flow in older people, says a new study.

Scientists from the University of Alabama report that a supplement containing HMB (beta-hydroxy-beta-methylbutyrate), glutamine and arginine (Juven by Abbott Nutrition) increased flow-mediated dilation (FMD - a measure of blood flow and vascular health) by 27%, whereas no changes were observed in the placebo group.

However, the researchers did not observe any changes to markers of inflammation, including high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-alpha (TNF-alpha)

“Our results indicate that 6 months of dietary supplementation with HMB, glutamine and arginine had a positive impact on vascular endothelial function in older adults,” wrote the researchers, led by Dr Amy Ellis in the European Journal of Clinical Nutrition . “These results are clinically relevant because reduced endothelial-dependent vasodilation is a known risk factor for cardiovascular diseases.

“Further investigation is warranted to elucidate mechanisms and confirm benefits of foods rich in these amino acids on cardiovascular outcomes.”

The study supported financially by the National Center for Complementary and Alternative Medicine.

Study details

Dr Ellis and her co-workers recrtuited 31 community-dwelling men and women aged between 65 and 87 to participate in their randomized, placebo-controlled trial. The participants were randomly assigned to one of two groups: The first group received the active supplements providing 3 g HMB, 14 g glutamine and 14 g arginine per day; while the second group received a placebo.

After six months of intervention, the researchers found that FMD increased in the HMB + glutamine + arginine group, but no such increases were observed in the placebo group.

While no changes in CRP or TNF-alpha levels were observed in the active supplement group, a trend towards an increase in CRP levels was observed in the placebo group, but this did not reach statistical significance, they noted.

“Although no previous studies have examined this combination of amino acids on vascular function, we hypothesized that the active ingredients of the supplement would act synergistically to improve endothelial function by reducing oxidative stress and inflammation,” wrote the researchers. “However, although we observed a trend for increasing hsCRP among the placebo group (P=0.059), no significant changes in hsCRP or TNF-alpha were observed for either group.

“Possibly, the effects of the supplement on reducing oxidative stress and inflammation were subclinical, or the high variability in these biomarkers, particularly hsCRP, among our small sample could have precluded visible differences.”

The researchers also noted that an alternate mechanism may also be responsible, adding that arginine is a precursor of the potent vasodilator nitric oxide

“Although investigation of this mechanism was beyond the scope of this study, it is feasible that the arginine in the supplement improved endothelial-dependent vasodilation by providing additional substrate for nitric oxide synthesis,” they added.

 

 

Moderate coffee drinking associated with lower risk of mortality during 11-year median follow-up

Semmelweis University (Bulgaria), September 1 2021. 

Research presented at ESC (European Society of Cardiology) Congress 2021 revealed a lower risk of dying from any cause during an 11-year median period among light to moderate coffee drinkers in comparison with men and women who had no intake.

The study included 468,629 UK Biobank participants of an average age of 56.2 years who had no indications of heart disease upon enrollment. Coffee intake was classified as none, light to moderate at 0.5 to 3 cups per day or high at over 3 cups per day. A subgroup of participants underwent magnetic resonance imaging (MRI) of the heart to assess cardiac structure and function. 

Light to moderate coffee intake during the follow-up period was associated with a 12% decrease in the risk of dying from any cause, a 17% lower risk of cardiovascular mortality and a 21% reduction in the incidence of stroke in comparison with the risks associated with not drinking coffee. 

“The imaging analysis indicated that, compared with participants who did not drink coffee regularly, daily consumers had healthier sized and better functioning hearts,” reported study author Judit Simon, of Semmelweis University in Budapest. “This was consistent with reversing the detrimental effects of aging on the heart.”

“To our knowledge, this is the largest study to systematically assess the cardiovascular effects of regular coffee consumption in a population without diagnosed heart disease,” she announced. “Our results suggest that regular coffee consumption is safe, as even high daily intake was not associated with adverse cardiovascular outcomes and all-cause mortality after a follow-up of 10 to 15 years. Moreover, 0.5 to 3 cups of coffee per day was independently associated with lower risks of stroke, death from cardiovascular disease, and death from any cause.”

The Gary Null Show - 09.06.21

The Gary Null Show - 09.06.21

September 7, 2021

The Covid Vaccines and Pathological Evidence of Harm

 

Dr Ryan Cole is a trained medical physician who has worked as a board certified dermatopatholoist since 2004. He is the founding CEO and Medical director of Cole Diagnostics in Garden City, Idaho -- the state's largest independent medical laboratory using cutting edge technology to specialize in pathology and clinical services. He has become one of the more outspoken opponents to the current national pandemic policies within the medical community, and has testified before a New Hampshire legislative session. Earlier Dr. Cole gained expertise in immunology while working as a chief fellow of pathology at the Mayo CLinic, a chief fellow of surgical pathology at the Medical College of Virginia and received his medical degree from Virginia Commonwealth University.  Ryan's website is ColeDiagnostics.com
The Gary Null Show - 09.03.21

The Gary Null Show - 09.03.21

September 3, 2021

Both sucrose and high fructose corn syrup linked to increased health risks

University of California at Davis, August 31, 2021

Consuming sucrose, the more "natural form of sugar," may be as bad for your health as consuming high fructose corn syrup, according to a University of California, Davis, study published in the Journal of Clinical Endocrinology and Metabolism.

"This is the first dietary intervention study to show that consumption of both sucrose- and high fructose corn-sweetened beverages increase liver fat and decrease insulin sensitivity," said Kimber Stanhope, a research nutrition biologist with the UC Davis School of Veterinary Medicine. "People often have a skewed perspective of aspartame and give sucrose a pass, but this study suggests that consumers should be equally concerned about both major added sugars in our food supply."

Participants (18 to 40 years old) were assigned to beverage groups matched for sex, body mass index, fasting triglyceride, lipoprotein and insulin concentrations. They drank three servings a day of either a sucrose-sweetened beverage, a high fructose corn-sweetened beverage, or an aspartame-sweetened beverage for 16 days.

The double-blind study was unique in that the 187 subjects lived in a clinical unit for 3.5 days before beverage consumption and during the final days of beverage consumption. Thus, their diet and activity levels were controlled prior to the assessments of risk factors that occurred before and after beverage consumption. This control helped the researchers document how quickly the study subjects, even those who were very lean or normal weight, showed changes in liver fat, insulin sensitivity, and circulating lipids, lipoproteins and uric acid when they drank the added sugars. There were no significant differences between the effects of sucrose and those of high fructose corn syrup, and both the sugar-sweetened beverages increased risk factors compared with aspartame-sweetened beverages.

"Within the span of two weeks, we observed a significant change in liver fat and insulin sensitivity in the two groups consuming sucrose- or high fructose corn syrup-sweetened beverages," Stanhope said. "That's concerning because the prevalence of fatty liver [nonalcoholic fatty liver disease] and Type 2 diabetes continues to increase globally."

Decreased insulin sensitivity is an important risk factor for Type 2 diabetes, and seeing a clinically significant change within two weeks highlights the need for consumers to read labels carefully and be aware of the source of added sugars, she said. Sucrose may be labeled as sugar, cane sugar or evaporated cane juice among other names, but they're all sugar.

Consumer misconception

Stanhope said the study is important because many consumers consider high fructose corn syrup to be more detrimental to health than sucrose. Many consumers also believe consuming sucrose is safer than consuming aspartame.

Previous human and animal studies have shown that sugar-sweetened beverages are associated with increased fat in the liver. This study further substantiates that those beverages can promote fat accumulation in the liver and lead to metabolic syndrome.

"It's all physiologically connected, although we're not sure [in what] direction it goes," Stanhope said. "It's very likely that the mechanism by which we develop metabolic syndrome goes through liver fat and insulin resistance. An increase in liver fat can be benign for a certain amount of time and for certain people. But it can also progress to associated inflammation in liver cells that causes fibrosis and negatively impacts liver function, which can make an individual more prone to liver cancer."

 

Consuming a Mediterranean diet associated with lower risk of sudden cardiac death during 9.8-year period

University of Alabama, August 31, 2021

The July issue of the Journal of the American Heart Association reported the finding of a trend toward a lower risk of sudden cardiac death in association with greater adherence to a Mediterranean diet during an average of 9.8 years of follow-up.* The study also uncovered a trend toward a higher risk of sudden cardiac death associated with greater intake of a Southern dietary pattern.

Sudden cardiac death, as defined by the National Heart, Lung, and Blood Institute-sponsored expert panel is “an unexpected death without obvious extracardiac cause, occurring with a rapid witnessed collapse, or if unwitnessed, occurring within one hour after the onset of symptoms.”

The current investigation included 21,069 participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which included men and women aged 45 years and older, among whom 42% were black. A high proportion of study participants resided in a region of the U.S. often referred to as the “stroke belt”. In previous research, five dietary patterns were derived from responses to dietary questionnaires administered upon enrollment in REGARDS. These included a pattern observed in the Southeastern United States that is characterized by added fats, fried food, eggs, organ meat, processed meat and sugar‐sweetened beverages. All subjects’ diets were subsequently scored for adherence to a Mediterranean diet, which included a high intake of vegetables, fruit, legumes, cereals and fish; a lower intake of meat and dairy products; a high ratio of monounsaturated fat to saturated fat consumption, and moderate alcohol intake. In-home examinations obtained physical measurements, information concerning medication use, a physical health summary, electrocardiographic evaluation, and blood and urine sample collection. Cardiovascular events and deaths were tracked via twice-yearly calls to participants or next of kin, and other methods. 

During follow-up, 401 sudden cardiac deaths occurred. After adjustment for a number of factors, subjects whose Mediterranean diet scores placed them among the top one-third of participants had a risk of sudden cardiac death that was 26% lower than subjects whose scores were among the lowest third. The protective effect of the diet was limited to participants with no history of coronary heart disease at the beginning of the study.

Among men and women whose adherence to the Southern dietary pattern was among the top quarter of participants, the risk of sudden cardiac death was 46% higher than those among the lowest quarter.

“We know of no published studies investigating the possible associations of dietary patterns with risk of sudden cardiac death,” wrote authors James M. Shikany, DrPH, of the University of Alabama at Birmingham, and colleagues. However, they remarked that protective effects against the condition have been revealed in association with nuts and fish, which are Mediterranean diet components. They added that the omega 3 fatty acids in fatty fish have been proposed as responsible for the benefit observed in association with greater fish intake and may help protect against sudden cardiac death via their effects on resting heart rate, blood pressure, vascular endothelial function, triglyceride concentrations, inflammatory pathways and other factors. Furthermore, laboratory studies have revealed antiarrhythmic effects for omega 3s. 

“Although observational in nature, these data suggest that diet may be a modifiable risk factor for sudden cardiac death and should be discussed with patients,” they wrote.  

 

 

 

Aging-US: Dietary supplementation with green tea catechins and cocoa flavanols

Cocoa, but not GTE, reduced aging-associated microgliosis and increased the proportion of neuroprotective microglial phenotypes

Universitat de Lleida and Institut de Recerca Biomèdica de Lleida (Spain), September 1, 2021

Aging-US published "Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system" which reported that green tea extract (GTE) and cocoa-supplemented diets significantly improved survival rate of mice. GTE increased density of VAChT and VGluT2 afferent synapses on neuromuscular junctions.

Cocoa, but not GTE, reduced aging-associated microgliosis and increased the proportion of neuroprotective microglial phenotypes.

Dr. Jordi Calderó from IRBLleida said, "Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is considered the main causative factor of the physical performance decline in the elderly."

Sarcopenia, the progressive loss of skeletal muscle mass and function with age, is considered the main causative factor of the physical performance decline in the elderly. The compromised muscular function associated to sarcopenia has a negative impact on the life quality of older adults and increases the risk for disability, fall-associated injuries, morbidity, and mortality. The authors have recently reported a marked increase in the microglial and astroglial pro-inflammatory phenotypes (M1 and A1, respectively) in the spinal cord of aged mice. This may be due to the presence of anti-inflammatory and neuroprotective (M2 and A2) glial subpopulations. Caloric restriction, based on a diet low in calories, has been shown to attenuate aging sarcopenia in various species by acting at different levels of the skeletal muscle.

Caloric restriction has also been reported to ameliorate age-related changes in rodent NMJs and to prevent MN and motor axon degeneration found to occur with aging [11, 21]. In a similar way, some dietary supplements have been shown to counteract age related changes that contribute to neuromuscular dysfunction (reviewed by [12) Plant flavonoids have gained particular attention as dietary compounds for keeping good health and preventing a number of diseases, particularly cardiac disorders and cancer.

The Calderó Research Team concluded in their Aging-US Research Output that, green tea and cocoa flavonoids from GTE and cocoa significantly increased survival rate of aged mice. Both diets preserved NMJ innervation and maturity, delayed the senescence process of the skeletal muscle, and enhanced its regenerative capacity. Future research is needed to investigate whether higher doses of flavonoid are needed and/or longer-term interventions can help restore proper motor function.

 

How the mind sharpens the senses

Ruhr University Bochum (Germany), August 27, 2021

A study conducted with experienced scholars of Zen-Meditation shows that mental focussing can induce learning mechanisms, similar to physical training. Researchers at the Ruhr-University Bochum and the Ludwig-Maximilians-University München discovered this phenomenon during a scientifically monitored meditation retreat. The journal Scientific Reports, from the makers of Nature, has now published their new findings on the plasticity of the brain.

Participants of the study use a special meditation technique

The participants were all Zen-scholars with many years of meditation practice. They were scientifically escorted during a four-day Zen-retreat in the spiritual center "Benediktushof", Germany. The retreat was held in complete silence, with at least eight hours of meditation per day. All participants practiced their familiar meditation, which is characterized by a non-specific monitoring of thoughts and surroundings. Additionally, some participants applied a special finger-meditation for two hours per day, during which they were asked to specifically focus on their right index finger and become aware of spontaneously arising sensory percepts in this finger. Subsequent assessment of the group that practiced finger-meditation showed a significant improvement in the tactile acuity of the right index and middle finger. A control group that had maintained their familiar meditation practice for the whole time, showed no changes in tactile acuity.

Data show significant improvement of the sense of touch

In order to assess the sense of touch quantitatively, researchers measured the so-called "two-point discrimination threshold". This marker indicates how far apart two stimuli need to be, in order to be discriminated as two separate sensations. After the finger meditation, the performance improved on average by 17 percent. By comparison, tactile acuity of the visually impaired is 15 to 25 percent above that of typical sighted individuals, because their sense of touch is used so intensively to make up for the reduced visual information. Hence, the changes induced by meditation are comparable to those achieved by intense long-term training.

Meditation induces plasticity and learning processes as active training or physical stimulation

It is known for long that extensive training induces neuroplasticity, which denotes the ability of the brain to adapt and restructure itself, thereby improving perception and behavior. Recently, the group of neuroscientists of the Neural Plasticity Lab headed by Hubert Dinse has shown that these processes can be initiated even without training by mere exposure to passive stimulation, which was translated only recently into a stimulating glove, which is used as therapeutical intervention in stroke patients. The fact that merely mental states without any physical stimulation can improve perception has now been shown for the first time. "The results of our study challenge what we know about learning mechanisms in the brain. Our concept of neuroplasticity must be extended, because mental activity seems to induce learning effects similar to active stimulation and physical training," Dinse suggests.

  

 

Antibiotics increase the risk of colon cancer

Umea University (Sweden), September 1, 2021

There is a clear link between taking antibiotics and an increased risk of developing colon cancer within the next five to ten years. This has been confirmed by researchers at Umeå University, Sweden, after a study of 40,000 cancer cases. The impact of antibiotics on the intestinal microbiome is thought to lie behind the increased risk of cancer.

“The results underline the fact that there are many reasons to be restrictive with antibiotics. While in many cases antibiotic therapy is necessary and saves lives, in the event of less serious ailments that can be expected to heal anyway, caution should be exercised. Above all to prevent bacteria from developing resistance but, as this study shows, also because antibiotics may increase the risk of future colon cancer,” explains Sophia Harlid, cancer researcher at Umeå University.

Researchers found that both women and men who took antibiotics for over six months ran a 17 per cent greater risk of developing cancer in the ascending colon, the first part of the colon to be reached by food after the small intestine, than those who were not prescribed any antibiotics. However, no increased risk was found for cancer in the descending colon. Nor was there an increased risk of rectal cancer in men taking antibiotics, while women taking antibiotics had a slightly reduced incidence of rectal cancer.

The increased risk of colon cancer was visible already five to ten years after taking antibiotics. Although the increase in risk was greatest for those taking most antibiotics, it was also possible to observe an admittedly small, but statistically significant, increase in the risk of cancer after a single course of antibiotics.

The present study uses data on 40,000 patients from the Swedish Colorectal Cancer Registry from the period 2010–2016. These have been compared to a matched control group of 200,000 cancer-free individuals drawn from the Swedish population at large. Data on the individuals’ antibiotic use was collected from the Swedish Prescribed Drug Register for the period 2005–2016. The Swedish study broadly confirms the results of an earlier, somewhat smaller British study.

In order to understand how antibiotics increase the risk, the researchers also studied a non-antibiotic bactericidal drug used against urinary infections that does not affect the microbiome. There was no difference in the frequency of colon cancer in those who used this drug, suggesting that it is the impact of antibiotics on the microbiome that increases the risk of cancer. While the study only covers orally administered antibiotics, even intravenous antibiotics may affect the gut microbiota in the intestinal system.

“There is absolutely no cause for alarm simply because you have taken antibiotics. The increase in risk is moderate and the affect on the absolute risk to the individual is fairly small. Sweden is also in the process of introducing routine screening for colorectal cancer. Like any other screening programme, it is important to take part so that any cancer can be detected early or even prevented, as cancer precursors can sometimes be removed,” says Sophia Harlid. 

 

 

High dose vitamin C may stop the progression of leukemia, study reveals

Perlmutter Cancer Center at New York University August 28, 2021

Exciting new research shows that a six-month regimen of high-dose intravenous vitamin C slowed the progression of leukemia by stopping leukemic cells from multiplying.

The study builds upon other research that demonstrates vitamin C’s potential to inhibit and even kill cancer cells – without harming healthy tissue. Let’s take a closer look at how vitamin C is demonstrating its amazing potential to fight cancer.

Vitamin C stimulates a vital cancer-fighting enzyme

In leukemia, white blood cells fail to mature, so they regenerate themselves and multiply uncontrollably – a process that stops the body from producing the mature white blood cells needed by the immune system to fight infections. Researchers have discovered that a gene mutation plays a major role in the development of many cases of leukemia.

50 percent of patients with chronic myelomonocytic leukemia, 30 percent of patients with pre-leukemia and 10 percent of acute myeloid leukemia patients have a genetic disorder that decreases amounts of TET2 – a vital enzyme that helps undifferentiated cells mature into normal blood cells. This TET2 gene mutation accounts for 42,500 cancers yearly in the United States.

The new study, conducted at Perlmutter Cancer Center at New York University Langone Health and published in the peer-reviewed scientific journal Cell, examined vitamin C’s potential to stimulate TET2 – and the results were encouraging.

Genetically restoring TET2 blocks replication of cancer cells and safely kills them

The researchers found that intravenous high-dose vitamin C helps restore TET2 function, causing “faulty” stem cells in bone marrow to die off.

Vitamin C produced results when it was used on human leukemia cells carrying the TET2 mutation – and it also stopped the growth of transplanted leukemia cancer stem cells in mice that had been genetically engineered to lack TET2.

The vitamin achieved this effect by promoting DNA demethylation in the cancerous cells. Researchers also found that combining vitamin C with PARP inhibitors – drugs which cause cancer cell death – improved its effectiveness even more. In fact, vitamin C seemed to have a potentiating effect, making the leukemic cells more vulnerable to the PARP inhibitors.

Study author Benjamin Neel, Ph.D., noted that the team was excited by the prospect that high-dose vitamin C might become a “safe treatment for blood diseases caused by TET2-deficient leukemia stem cells, most likely in combination with other targeted therapies.” Neel called for preclinical and clinical trials to test high-dose intravenous vitamin C in human patients – and for further research to identify other substances that might help to potentiate the vitamin C treatment.

Researchers are particularly hopeful that using vitamin C with cancer drugs could provide an alternative to toxic chemotherapy – which can be dangerous and even fatal to patients with acute myeloid leukemia.

Note: The researchers used extremely high dosages of intravenous vitamin C in the study – amounts that would be impossible to obtain by oral ingestion alone.

Amazing NEWS: Vitamin C has outperformed approved clinical and experimental drugs

Other recent, peer-reviewed research is blazing exciting new inroads into the area of potential uses of this powerful vitamin to stop cancer.

In a study newly published in Oncotarget, researcher found that high-dose vitamin C stopped tumors cold by impairing cancer stem cell metabolism and interfering with their ability to grow and spread.

Researchers noted that the nutrient worked as a pro-oxidant in cancer cells – stripping them of the antioxidant glutathione and producing oxidative stress and apoptosis, or cell death. In addition, vitamin C interfered with glycolysis, the process that creates energy in cell mitochondria.

And, while lethal to cancer cells, it left healthy cells unaffected.

The researchers concluded that vitamin C was a “promising new agent,” and called for more study to explore its use in preventing and slowing tumors.

The team also reported that vitamin C outperformed seven different substances, including stiripinol – an FDA-approved clinical drug – and various experimental medications. Researchers noted that vitamin C was 1,000 times – that’s right, 1,000 times – more effective in combating cancer stem cells than 2-DG, an experimental pharmaceutical drug.

(It is hard to understand why these eye-opening results have received so little attention from mainstream medicine. Especially in light of the fact that – unlike toxic chemotherapy drugs – this essential vitamin has caused few side effects in clinical studies.)

But, I think we can quickly see how this news might be threatening to the profits of the pharmaceutical industry.

The fact is: conventional medicine has long downplayed or ignored promising vitamin C research. But, as forward-thinking, innovative researchers continue to examine vitamin C’s many benefits, its potential to combat cancer may yet be recognized.

The Gary Null Show - 09.02.21

The Gary Null Show - 09.02.21

September 2, 2021

Remarkable Mind

What has the Democratic Party really become in renewing the nation

 

Dr. Michael Hudson is one of our nation’s finest and most important economists and Wall Street financial analysts. Dr. Paul Craig Roberts has called Michael “the world’s best economist.” He is the President of The Institution for the Study of Long-Term Economic Trends, and a distinguished research professor of economics at the University of Missouri. He was the Chief Economic Policy Advisor for the Rep. Dennis Kucinich’s 2008 presidential campaign and has served as an adviser to the White House, State and Defense departments and served as an economic advisor to other governments including Iceland, Latvia and China.  Michael has written many books and important papers and articles, including "Lending, Foreclosure and Redemption from Bronze Age Finance to the Jubilee Year" which is about debt forgiveness, and “Killing the Host: How Financial Parasites and Debt Bondage Destroy the Global Economy” that addresses the cause and effect behind the polarization of the 1% versus 99% emerged. His website is Michael-Hudson.com

The Gary Null Show -  09.01.21

The Gary Null Show - 09.01.21

September 1, 2021

The Government Assault Against Ivermectin and other Effective SARS-2 Treatments 

 

Richard Gale and Gary Null PhD

Progressive Radio Network, September 1, 2021

 

 

Had the FDA and Anthony Fauci’s National Institute for Allergies and Infectious Disease (NIAID) started approving existing clinically-proven and inexpensive drugs for treating malaria, parasites and other pathogens at the start of the pandemic, millions of people would have been saved from experiencing serious infections or dying from the SARS-CoV-2 virus. Why federal health officials never followed this strategy is a question the mainstream media refuses to ask. 

 

Another question that the medical establishment, let alone our compliant media, is why have they failed to ask whether there are reliable studies in the peer-reviewed literature and testimonies from thousands of day-to-day clinical physicians worldwide who treat Covid-19 patients with these drugs, in particular hydroxychloroquine (HCQ) and Ivermectin. We may also point out the many different natural remedies, such as nigella sativa, curcumin, vitamin D, melatonin, etc, which have been shown to be effective against SARS-2 infections. In most nations, there has been enormous success in treating Covid patients at the early and moderate stages of infection. However, in the US, Anthony Fauci, Bill Gates, the FDA and our federal medical officials have categorically denied their use.  In fact during the past couple weeks, there has been an aggressive and concerted effort to erect obstacles to prevent the employment of these more effective drugs. More recently a widespread campaign is underway to denigrate them altogether.

 

For example, the TOGETHER trial is now touted by the mainstream media as a flagship study showing that ivermectin is ineffective and even dangerous to prescribe. The study was conducted by professor Edward Mills at McMaster University in Ontario. If we are to believe the New York Times, the trial, which enrolled 1,300 patients, was discontinued because Mills claimed the drug was no better than a placebo. However, there is strong reason to believe this entire trial was nothing less than a staged theatrical performance. When asked, Mills denied having any conflict of interests.  However, Mills happens to be employed as a clinical trial advisor for the Bill and Melinda Gates Foundation.  The Gates Foundation was also the trial’s principal funder.  It may be noted that various organizations and agencies in other nations, such as the Health Products Regulatory Authority in South Africa, which have banned ivermectin, are often funded by Gates. It is naïve to believe that Gates has any philanthropic intentions whatsoever to see a highly effective treatment for SARS-2 infections reach worldwide approval. These drugs are in direct competition to his enormous investments and unwavering commitment to the Covid-19 vaccines.

 

In the meantime, Americans only have monoclonal antibody therapy and the controversial and ineffective drug Remdesivir at their disposal. Remdesivir’s average effectiveness for late stage treatment is only 22 percent.  A Chinese study published in The Lancet found no statistically significant benefit in the drug and 12 percent of participants taking the drug had to discontinue treatment due to serious adverse effects, especially liver and kidney damage. 

 

When questions are posited as a general argument for advocating expedient measures to protect public health during this pandemic, would it not have been wise to have prioritized for emergency use HCQ, Ivermectin, and other remedies with a record of curtailing Covid, such as the antibiotic azithromycin, zinc, selenium, Vitamins C and D, and melatonin as a first line of defense?  There was absolutely no need to have waited for experimental vaccines or experimental drugs such as Remdesivir before the pandemic became uncontrollable.  But this is what Fauci and Trump, and now Biden, permitted to happen.

 

If this strategy of medical intervention had been followed, would it have been successful?  The answer is likely an unequivocal “yes”.  Both HCQ and, even better, Ivermectin have been prophylactically prescribed by physicians working on pandemic’s front lines with enormous success.  Yet those American physicians struggling to get this urgent message out to federal health officials are being marginalized and ridiculed en masse. Only in the US, the UK, France, South Africa and several other developed nations has there been a stubborn hubris to deny their effectiveness. The World Health Organization recommends Ivermectin for Covid-19 so why not the US and these other nations? Under oath, multiple physicians and professors at American medical schools have testified before Congress to present the scientific evidence supporting HCQ and Ivermectin.  These are otherwise medical professionals at the very heart of treating Covid-19 patients. 

 

Today, American journalism is in shambles. In fact, it is a disgrace.  The American public is losing trust in the media. Whether it is CNN, the New York Times, the Washington Post, the liberal tabloid Daily Beast, NPR or PBS, each has unlimited resources to properly investigate the federal and institutional machinery behind the government health policies being thrust upon us.  Yet no mainstream journalist has found the moral compass to bring this truth to the public. 

 

In the meantime, we are allowing millions to die, and countless others to be seriously affected from a severe infection because of professional medical neglect and a healthcare system favoring the pharmaceutical industry’s frantic rush to develop expensive novel drugs and experimental vaccines. The incentive by the drug makers is to take every advantage available within the FDA’s emergency use loopholes to get their products approved as quickly as possible.  The primary advantage is that these novel drugs and vaccines can then leap over regulatory hurdles, which otherwise would require them to conduct lengthy and thorough clinical trials to prove their efficacy and safety. The consequence is that none of the new pharmaceutical Covid-19 interventions have been adequately reviewed.

 

On the other hand, HCQ and Ivermectin have an established legacy of prior research and have been on the market for decades. Worldwide, it is not unreasonable to claim that billions of people have been treated with these drugs.  

 

Below is a breakdown of the studies conducted so far for HCQ, Ivermectin and Vitamin D specifically for combatting the SARS-CoV-2 virus

 

Hydroxychloroquine

 

344 studies, 250 peer-reviewed have been conducted specifically for Covid-19

281 have been clinical trials that involved 4,583 scientists and over 407,627 patients

64% improvement in 31 early treatment trials

75% improvement in 13 early stage infection treatment mortality results

21% improvement in 190 late stage infection treatment trials (patients in serious condition)

23% improvement in 44 randomized controlled trials

Full list of HCQ studies and details:  https://c19hcq.com

 

Ivermectin 

 

131 studies, 52 peer-reviewed have been conducted specifically for Covid-19

63 have been clinical trials that involved 613 scientists and over 26,398 patients

58% improvement in 31 randomized controlled trials 

86% improvement in 14 prophylaxis trials

72% improvement in 27 early stage infection treatment trials

40% improvement in 22 late stage infection treatment trials

58% improvement in 25 mortality results

Full list of Ivermectin studies and details:  https://c19ivermectin.com

 

Other inexpensive repurposed drugs for treating SARS-2

 

Fluvoxamine

 

88% improvement in early treatment

29% improvement in late stage treatment

63% improvement in all 7 peer-reviewed studies

 

Vitamin D

 

101 studies conducted by over 875 scientists

63 sufficiency studies with 34,863 patients

33 treatment trials with 46,860 patients

42% improvement in 33 treatment trials

56% improvement in 68 sufficiency studies

55% improvement in 19 treatment mortality results

Full list of Vitamin D studies and details:  https://c19vitamind.com

 

In contrast there have been 21 studies enrolling 35,744 patients in Remdesivir trials showing only a 22% improvement in all studies combined. This rate is below that of simply taking probiotics (5 studies at 24% improvement), melatonin (7 studies at 62% improvement), curcumin (4 studies at 71% improvement), nigella sativa (3 studies at 84% improvement), quercetin (4 studies at 76% improvement), and aspirin (7 studies at 37% improvement).  Despite the small number of trials and low numbers of enrolled participants, early results indicate that greater attention and funding needs to be allocated for more rigorous research if there is to be any success in curbing SARS-2 infections’ severity.

 

Please share this information. The inept policies and measures being taken by our federal health officials and by both the former Trump and present Biden administrations are unparalleled in American healthcare history. And never before has the media been so willing to self-censor and been so grossly irresponsible to hide the published science and the truth. 

The Gary Null Show -  08.31.21

The Gary Null Show - 08.31.21

August 31, 2021

 Peter McCullough, MD testifies to Texas Senate HHS Committee 

Interview With Dr. Hector Carvallo: Pioneer In Ivermectin, Iota Carrageenan, Bromhexine And COVID-19

LISTEN LIVE NUMBER: 1-717-734-6955

 
NEW Archive: 1-631-359-9463
 
Voicemail: ‪(862) 800-6805  
 
Order Number: 877-627-5065

 

The Gary Null Show - 08.30.21

The Gary Null Show - 08.30.21

August 30, 2021

VACCINE SYNDROME: HOW THE EXPERIMENTAL ANTHRAX VACCINE KILLED 35,000 MILITARY MEN AND WOMEN

Vaccine Syndrome is a film produced by Oscar nominated filmmaker Scott Miller, and provides exclusive interviews with military personnel who have had experience with the controversial anthrax vaccine.

The film claims that over 35,000 soldiers have died from the anthrax vaccine, according to a “RAC-GWVI Government Report” published in 2008.

Compare that to how many soldiers have died in combat in both Iraq and Afghanistan, which is 6753 at the time of the filming.

The film starts out with a dramatized recreating of Lance Corporal Jared Schwartz, who refused to receive the anthrax vaccine.

He had to face a military tribunal without legal counsel, and read a prepared statement.

That statement can be found online, such as at the GulfWarVets.com website.

The film also mentions how pharmaceutical companies have legal immunity from any injuries or deaths resulting from vaccines, and that the civilian population only has recourse to sue the federal government in a special Vaccine Court.

However, military personnel are prohibited from suing in this court, which is part of the National Vaccine Compensation Program.

https://vaccineimpact.com/2020/35000-soldiers-died-from-the-experimental-anthrax-vaccine-more-than-those-who-died-in-combat-in-afghanistan-and-iraq-combined/

The Gary Null Show - 08.27.21
The Gary Null Show -  08.26.21
The Gary Null Show - 08.25.21

The Gary Null Show - 08.25.21

August 25, 2021

The Gary Null Show Notes – 08.25.21

  1. American Medical Association Calls for Covid-19 Vaccine Mandates

  2. China, 2049

  3. The Leak That ‘Exposed the True Afghan War’

  4. Fauci Dismisses “Freedom” In Call For Vaccine Mandates: “The Time Has Come. Enough Is Enough.”

  5. A New Low for the FDA

  6. Eight Key Points on America’s Defeat in Afghanistan

  7. 2 Things Mainstream Media Didn’t Tell You About FDA’s Approval of Pfizer Vaccine

  8. America in an Age of Faucism

    Today’s Videos

1.  Dave Cullen Video on Mandating Vaccines: ” Vaccination: They’re Becoming Desperate”

2. The Dunning-Kruger Effect – Cognitive Bias – Why Incompetent People Think They Are Competent

3. Dr. Malone Sounds Alarm On Liability Coverage Of Pfizer Vax Start this clip at 5.00 in when Dr. Malone begins to speak.

4. Dr. Ryan Cole #StoptheMandate (start at 1:25)

Study suggests vitamin D supplementation may serve as part of strategy for autoimmune and infectious diseases associated with leaky gut

MacKay Children’s Hospital (Taiwan), August 15, 2021

According to news reporting from Taipei, Taiwan, research stated, “Vitamin D (VD) plays an important role not only in mineral balance and skeletal maintenance but also in immune modulation. VD status was found correlated with the pathophysiology and severity of inflammatory bowel diseases and other autoimmune disorders. Epithelial barrier function is primarily regulated by the tight-junction (TJ) proteins.”

The news reporters obtained a quote from the research from MacKay Children’s Hospital: “In this study, we try to establish an animal model by raising mice fed VD-deficient diet and to investigate the effects of VD-deficient diet on gut integrity and zonulin expression. Male C57BL/6 mice were administered either VD-deficient [VDD group, 25(OH)2D3 0 IU/per mouse] or VD-sufficient [VDS group, 25(OH)2D3 37.8 IU/per mouse] special diets for 7 weeks. Body weight and diet intake were recorded weekly. Serum VD levels were detected. After sacrifice, jejunum and colon specimens were collected. The villus length and crypt depth of the jejunum as well as mucosa thickness of the colon were measured. Various serum pro-inflammatory cytokines and intestinal TJ proteins were assessed. The serum level of zonulin and the mRNA expression of jejunum zonulin were also investigated. We found that mice fed a VDD diet had a lower serum level of VD after 7 weeks (p < 0.001). VDD mice gained significant less weight (p = 0.022) and took a similar amount of diet (p = 0.398) when compared to mice raised on a VDS diet. Significantly decreased colon mucosa thickness was found in VDD mice compared with the VDS group (p = 0.022). A marked increase in serum pro-inflammatory cytokine levels was demonstrated in VDD mice. All relative levels of claudin (CLD)-1 (p = 0.007), CLD-3 (p < 0.001), CLD-7 (p < 0.001), and zonulin-1 (ZO-1, p = 0.038) protein expressions were significantly decreased in the VDD group when compared to the VDS group. A significant upregulation of mRNA expression of jejunum zonulin (p = 0.043) and elevated serum zonulin (p = 0.001) were found in the VDD group.”

According to the news editors, the research concluded: “We successfully demonstrated that VDD could lead to impaired barrier properties. We assume that sufficient VD could maintain intestinal epithelial integrity and prevent mucosal barrier dysfunction. VD supplementation may serve as part of a therapeutic strategy for human autoimmune and infectious diseases with intestinal barrier dysfunction (leaky gut) in the future. To our knowledge, this is the first study to demonstrate that VDD could lead to a significant upregulation in mRNA expression of the jejunum zonulin level and also a marked elevation of serum zonulin in a mouse model.”

Investigating the anti-hypertensive effects of pumpkin seed oil

Marymount University (US) and University of Guilan (China), August 24, 2021

In a study, researchers from Iran and the U.S. found that pumpkin seed oil can potentially treat hypertension in postmenopausal women. Their report was published in Complementary Therapies in Clinical Practice.

  • Postmenopausal women are more likely to develop hypertension than men of the same age.
  • In vivo studies reveal that pumpkin seed oil has anti-hypertensive activity.
  • The team investigated the effects of pumpkin seed oil supplementation on vascular function and heart rate variability in postmenopausal women with elevated blood pressure.
  • Participants were assigned to take either a pumpkin seed oil supplement or a placebo for the six-week study. Those in the experimental group took 3 grams of pumpkin seed oil every day.
  • Brachial and central blood pressure, wave reflection (augmentation index, AIx), arterial stiffness (SI) and various HRV parameters were measured at baseline and at the end of the study.
  • Those who took pumpkin seed oil had significantly lower AIx, brachial and systolic blood pressure after treatment. SI and HRV parameters remained unchanged for the treatment group and the placebo group at the end of the study.

In sum, taking pumpkin seed oil may improve arterial hemodynamics in postmenopausal women.\

 

Lack of exercise and poor nutrition could increase the risk of diseases like dementia

Kings College London, August 23, 2021

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that both diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the brain produces new brain cells) long before their onset.

The study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, suggests that altered neurogenesis in the brain could potentially represent an early biomarker for both CD and dementia.

The investigation studied how the blood of participants with and without CD and dementia could influence hippocampal neurogenesis in laboratory settings and whether diet and exercise were important factors. Specifically, blood samples of 418 French adults over the age of 65 were collected 12-years prior to CD and dementia diagnosis and tested on human hippocampal stems cells. Additionally, information on each participant’s sociodemographic, lifestyle, and clinical data were collected and incidence cognition status and dementia were measured every two to three years over a 12-year period.

Over the course of the study, the researchers established that 12 years prior to diagnosis, both CD and Alzheimer’s were associated with levels of neural stem cell death. The team also found that exercise, nutrition, vitamin D levels, carotenoid and lipid levels are all associated with the rate at which cells die off. Furthermore, physical activity and nutrition were key factors that then also determined CD status. Specifically, researchers found that reduced physical activity and increased malnutrition both increased cell death which in turn increased the risk for future CD.

While previous studies have established that diet and exercise have some protective effects against CD and dementia, these roles have been poorly understood at the neurobiological level. To date, studies on animals have shown how diet and exercise can directly influence hippocampal neurogenesis, potentially explaining how exercise and diet may biologically exert their effects, but this study sheds further light on this in the context of a human model.

Dr. Sandrine Thuret, the study’s lead investigator said, “Our study has demonstrated not only that there are individual markers of hippocampal neurogenesis associated with CD and dementia 12 years later, but also that there is some degree of specificity with respect to diagnoses of dementia subtypes. If an individual displays an increase in their levels of cell death during differentiation (when neural stem cells are becoming neurons), we can look at this as a potential warning sign of CD. Conversely, a decrease in levels of cell death during proliferation (the process by which a single cell divides into a pair) and reduced hippocampal progenitor cell integrity could be viewed as a predictor for Alzheimer’s Disease and Vascular dementia, respectively.”

According to Alzheimer’s Research UK, there were a total of 525,315 people living with a dementia diagnosis in the UK in 2020. Rates of cognitive decline and dementia are expected to triple in prevalence by 2040.

Dr. Andrea du Preez, the study’s first author from King’s IoPPN said, “While more work is undoubtedly needed to fully understand how diet and exercise might modulate hippocampal neurogenesis, our findings may represent an effective early preventative strategy against CD and dementia.”

Mindfulness may improve cognition in older adults

University College London, August 23, 2021

Mindfulness may provide modest benefits to cognition, particularly among older adults, finds a new review of evidence led by UCL researchers.

The systematic review and meta-analysis, published in Neuropsychology Review, found that, while mindfulness is typically geared towards improving mental health and well-being, it may also provide additional benefits to brain health.

The study’s lead author, PhD student Tim Whitfield (UCL Psychiatry) said that “the positive effects of mindfulness-based programs on mental health are already relatively well-established. Here, our findings suggest that a small benefit is also conferred to cognition, at least among older adults.”

The researchers reviewed previously published studies of mindfulness, and identified 45 studies that fit their criteria, which incorporated a total of 2,238 study participants. Each study tested the effects of a mindfulness-based intervention delivered by a facilitator in a group setting, over at least four sessions, while excluding mindfulness retreats in order to have a more homogenous set of studies.

The majority of studies involved a certified instructor teaching participants techniques such as sitting meditation, mindful movement and body scan, generally on a weekly basis across six to 12 weeks, while also asking participants to continue the practices in their own time.

The researchers found that overall, mindfulness conferred a small but significant benefit to cognition.

Subgroup analysis revealed that the effect was slightly stronger for people over 60, while there was not a significant effect for people under 60.

Tim Whitfield commented that “executive function is known to decline with age among older adults; the improvement in people over 60 suggests that mindfulness may help guard against cognitive decline, by helping to maintain or restore executive function in late adulthood. It might be easier to restore cognitive functions to previous levels, rather than to improve them beyond the developmental peak.”

When they investigated which aspects of cognition were affected, the researchers found that mindfulness was beneficial only to executive function, and more specifically, there was strong evidence of a small positive effect on working memory (which is one facet of executive function).

The researchers also analyzed whether mindfulness outperformed other ‘active interventions’ (such as brain training, relaxation, or other health or educational programs) or only when compared to people who were not offered any alternative treatment. They found that cognitive benefits of mindfulness were only significant compared with an ‘inactive’ comparison, which means they cannot rule out that the benefits may have been at least partly derived from an expectation of treatment benefits, or social interactions.

The researchers say that more research is needed into which characteristics of mindfulness training may be more likely to confer cognitive benefits, or whether delivering interventions over longer periods, or in intensive retreat settings, might yield greater cognitive benefits.

Senior author Dr Natalie Marchant (UCL Psychiatry) said that they “know mindfulness-based programs benefit mental health, and our paper now suggests that mindfulness may also help to maintain cognitive faculties as people age. Mindfulness practices do not share much in common with cognitive test measures, so it is notable that mindfulness training’s impact appears to transfer to other domains. While our review only identified a small benefit to executive function, it remains possible that some types of mindfulness training might deliver larger gains.”

Major Depression Symptoms Improved with Chlorella

University of Western Australia, August 23rd 2021 

 

The symptoms of depression are often treated with drugs that can have long-term adverse side effects. A new study finds chlorella significantly reduces symptoms of major depression.

Research from the University of Western Australia in Perth has found that chlorella can significantly improve symptoms of depression.

The researchers tested 92 patients with major depressive disorder – a disorder that affects millions of people around the world.

The researchers split the patients into two groups. They gave 42 of the patients 1,800 milligrams of Chlorella vulgaris extract per day. The other 50 patients continued their standard care.

The researchers used a scale called the Hospital Anxiety and Depression Scale (HADS) to test the patients’ symptoms of depression, along with the Beck Depression Inventory II (BDI-II) scale. Both of these have been used in clinical settings to establish the range of depressive symptoms and the severity of the diagnosis.

After six weeks of treatment with either the standard pharmaceutical treatment or chlorella extract, the researchers found that those patients who had taken the chlorella had significantly reduced scores in both depression tests. The BDI-II scores went down by over four points and the HADS scores went down by 3.71 points.

To give some reference, the HADS scale consists of 21 points, and anything over an 8 is considered symptomatic of anxiety or depression.

In addition to reduced total scores, the researchers also saw significant reductions in some of the subset scores. For example, physical and cognitive symptoms were significantly improved in the chlorella group, and subscales for depression and anxiety were significantly lower among the chlorella group.

The researchers concluded:

“This pilot exploratory trial provides the first clinical evidence on the efficacy and safety of adjunctive therapy with CVE in improving physical and cognitive symptoms of depression as well as anxiety symptoms in patients who are receiving standard antidepressant therapy.”

Chlorella is a microalga. It is a single-celled algae that is typically grown in controlled growth medium tanks. It is significantly high in protein, with over 40 percent protein, with all of the essential amino acids. It also contains proteins that stimulate growth hormone and brain neurotransmitters.

Concentrated extract was used in this study due to the fact that whole chlorella can be difficult for the body to break down the cell wall. An extract provides the contents of the cell after the cell wall has been broken.

Greater adherence to Mediterranean diet associated with decreased cardiometabolic risk during pregnancy

University of Granada, August 20, 2021

According to news reporting out of Granada, Spain,research stated, “Studies regarding dietary patterns and cardiometabolic risk markers during pregnancy are scarce. The aim of the present study was to analyse whether different degrees of adherence to the Mediterranean diet (MD) and the MD components were associated with cardiometabolic markers and a clustered cardiometabolic risk during pregnancy.”

Our news journalists obtained a quote from the research from the University of Granada, “This study comprised 119 pregnant women from the GEStation and FITness (GESTAFIT) project. Dietary habits were assessed with a food frequency questionnaire at the 16th and 34th gestational weeks (g.w.). The Mediterranean Diet Score was employed to assess MD adherence. The following cardiometabolic markers were assessed: pre-pregnancy body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). A greater MD adherence was associated with a better cardiometabolic status in cross-sectional (16th g.w. and 34th g.w.) and prospective analyses (MD adherence at the 16th g.w. and cardiometabolic markers at the 34th g.w.; SBP, DBP and HDL-C; all, p< 0.05). Participants with the highest MD adherence (Tertile 3) had a lower clustered cardiometabolic risk than those with the lowest MD adherence (Tertile 1) at the 16th and 34th g.w. (both, p< 0.05). A higher intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts were associated with a lower cardiometabolic risk during pregnancy (all, p< 0.05).”

According to the news editors, the research concluded: “A higher MD adherence, a greater intake of fruits, vegetables and fish and a lower intake of refined cereals and red meat and subproducts showed a cardioprotective effect throughout gestation.”

Unhealthy diet during pregnancy could be linked to ADHD

King’s College London and the University of Bristol , August 20, 2021

 

New research led by scientists from King’s College London and the University of Bristol has found that a high-fat, high-sugar diet during pregnancy may be linked to symptoms of ADHD in children who show conduct problems early in life. Published in the Journal of Child Psychology and Psychiatry, this study is the first to indicate that epigenetic changes evident at birth may explain the link between unhealthy diet, conduct problems and ADHD.

Early onset conduct problems (e.g. lying, fighting) and attention-deficit/hyperactivity disorder (ADHD) are the leading causes of child mental health referral in the UK. These two disorders tend to occur in tandem (more than 40 per cent of children with a diagnosis of conduct disorder also have a diagnosis of ADHD) and can also be traced back to very similar prenatal experiences such as maternal distress or poor nutrition.

In this new study of participants from the Bristol-based ‘Children of the 90s’ cohort, 83 children with early-onset conduct problems were compared with 81 children who had low levels of conduct problems. The researchers assessed how the mothers’ nutrition affected epigenetic changes (or DNA methylation) of IGF2, a gene involved in fetal development and the brain development of areas implicated in ADHD – the cerebellum and hippocampus. Notably, DNA methylation of IGF2 had previously been found in children of mothers who were exposed to famine in the Netherlands during World War II.

The researchers from King’s and Bristol found that poor prenatal nutrition, comprising high fat and sugar diets of processed food and confectionary, was associated with higher IGF2 methylation in children with early onset conduct problems and those with low conduct problems.

Higher IGF2 methylation was also associated with higher ADHD symptoms between the ages of 7 and 13, but only for children who showed an early onset of conduct problems.

Dr Edward Barker from King’s College London said: ‘Our finding that poor prenatal nutrition was associated with higher IGF2 methylation highlights the critical importance of a healthy diet during pregnancy. These results suggest that promoting a healthy prenatal diet may ultimately lower ADHD symptoms and conduct problems in children. This is encouraging given that nutritional and epigenetic risk factors can be altered.’

Dr Barker added: ‘We now need to examine more specific types of nutrition. For example, the types of fats such as omega 3 fatty acids, from fish, walnuts and chicken are extremely important for neural development.

‘We already know that nutritional supplements for children can lead to lower ADHD and conduct problems, so it will be important for future research to examine the role of epigenetic changes in this process.’

Green tea may help protect against sunburn

Taiyo Kagaku Co (Japan), August 24, 2021

A systematic review and meta-analysis published in a recent issue of Molecules found an association between oral intake or topical application of green tea catechins and a reduction in ultraviolet (UV) radiation-induced sunburn, which is an inflammatory reaction of the skin to UV exposure, clinically known as erythema.*

Catechins are a type of flavonoid that occur in plants such as Camellia sinensis (tea). Green tea catechins include (-)-epigallocatechin-3-gallate (EGCG), well known for its anti-cancer and health-promoting effects, (-)-epicatechin, and many other similar molecules. These compounds have been recognized as having anti-inflammatory, antioxidant and photo-protective properties.

“To our knowledge, this is the first meta-analysis to assess the effectiveness of green tea catechins specifically on measures of ultraviolet radiation-induced erythema and related pro-inflammatory mediators,” authors Mahendra P. Kapoor and colleagues wrote. “Regular intake of as low as 540 mg of green tea catechins per day could be beneficial for the protection against ultraviolet radiation-induced erythema, wherein green tea catechin metabolites are bioavailable at the dermis and epidermis levels of the skin, and thus increase the minimal dose of radiation (MED) required to induce erythema.”

Dr Kapoor added that the study “suggests that green tea catechins can strengthen the skin’s tolerance to ultraviolet radiation-induced skin damage from radiation through the prevention of the ultraviolet radiation-induced perturbation of epidermal barrier functions.”

Study details: 12 weeks of green tea intake yields benefits

The meta-analysis included three randomized, double-blind, placebo-controlled trials and one non-double-blind, non-placebo-controlled study that examined potential protective effects of orally administered capsules containing green tea catechins against sunburn (clinically known as erythema) induced by solar-simulated UV radiation. Two additional studies that involved a single dose of topically administered catechins were separately analyzed.

Pooled analysis of data from three studies that evaluated erythema in skin exposed to UV radiation before and after 12 or more weeks of green tea catechin intake revealed a favorable effect in association with catechin intake. Both low and high doses of the green tea capsules were effective at decreasing low-dose UV radiation-induced erythema. It was also noted that a significant favorable effect was seen in the one study which assessed UV radiation-induced erythema after green tea intake for only six weeks, but as none of the other studies assessed this shorter duration of intake, further analysis was not performed.

When green tea catechins’ effects compared to a placebo were analyzed, pooling the data of two placebo-controlled trials confirmed their effectiveness against low-intensity UV radiation-induced erythema.

Pooling data from participants in the studies involving topical green tea catechins revealed significant benefit for green tea at higher UV radiation doses.

The Gary Null Show - 08.24.21

The Gary Null Show - 08.24.21

August 24, 2021

Two Top Virologists’ Frightening Warnings About COVID Injections: Ignored by Government and Big Media

By Joel S. Hirschhorn
NOQ Report, August 21 2021
 

 

When two great minds come to similar conclusions about the current global push to vaccinate everyone with the COVID experimental vaccines, we should pay close attention.  Both highly experienced scientists have a totally negative view of the vaccination effort.  Worse than being ineffective, they point to negative health outcomes for the global population.  These two truth-telling acclaimed medical researchers make Fauci look as inept, deceitful and dangerous as he is.

The point made in this article is not only has Fauci pushed the wrong potentially disastrous pandemic solution, he has blocked the right one.

Much of what the two virologists say is very technical in nature.  This article simplifies their controversial messages without losing their essential meanings.  The public needs to understand their warnings that refute all the propaganda pushing vaccines from government and public health agencies as well as big media.

Warning: Keep reading and you may become depressed.

*

Dr. Luc Montagnier

First considered is the thinking of Dr. Luc Montagnier, a French virologist and recipient of the 2008 Nobel Prize in Medicine for his discovery of the human immunodeficiency virus (HIV).  He has a doctorate in medicine.  But there is a lot more to conclude he is a great expert: He has received more than 20 major awards, including the French National Order of Merit and the Légion d’honneur.  He is a recipient of the Lasker Award, the Scheele Award, the Louis-Jeantet Prize for medicine , the Gairdner Award  the Golden Plate Award of the American Academy of Achievement, King Faisal International Prize (known as the Arab Nobel Prize), and the Prince of Asturias Award.

He has worked hard to expose the dangers of the COVID-19 vaccines, still experimental but sadly may soon be fully approved.  The vaccines don’t stop the virus, argues the prominent virologist, they do the opposite — they “feed the virus,” and facilitate its development into stronger and more transmittable variants.  These new virus variants will be more resistant to vaccination and may cause more health implications than their “original” versions.

Montagnier refers to the mass vaccine program as an “unacceptable mistake” and are a “scientific error as well as a medical error.”  His assertion is that “The history books will show that…it is the vaccination that is creating the variants.”  In other words: “There are antibodies, created by the vaccine,” forcing the virus to “find another solution” or die.  “This is where the variants are created.  It is the variants that “are a production and result from the vaccination.”  Stop and think about these thoughts.  Have you heard a better explanation of variant creation?  I doubt it.

He is talking about the mutation and strengthening of the virus from a phenomenon known as Antibody Dependent Enhancement (ADE).  ADE is a mechanism that increases the ability of a virus to enter cells and cause a worsening of the disease.

Data from around the world confirms ADE occurs in SARS-CoV-2, which causes COVID-19, says Montagnier. “You see it in each country, it’s the same: the curve of vaccination is followed by the curve of deaths.”  Sounds like what we are now hearing more about, namely escalating breakthrough infections that kill some people.  And this spiral into disaster may have no end.

In a November 2020 documentary he emphasized harmful and irrational mask mandates as well as lockdowns, quarantines, abuses of government overreach, and supported use of effective COVID treatments such as hydroxychloroquine.  The film was banned by YouTube and most other mainstream outlets.  At that time Fauci had succeeded in blocking wide use of the cheap generic based treatments for COVID and pursued the wait for the vaccine strategy.

Montagnier has been a vocal critic of the mass vaccination campaign.  In a letter to the President and Judges of the Supreme Court of the State of Israel, which unrolled the world’s speediest and the most massive vaccination campaign, Montagnier argued for its suspension.  He said: “I would like to summarize the potential dangers of these vaccines in a mass vaccination policy.”  Here they are:

1. Short-term side effects: these are not the normal local reactions found for any vaccination, but serious reactions involve the life of the recipient such as anaphylactic shock linked to a component of the vaccine mixture, or severe allergies or an autoimmune reaction up to cell aplasia.  In this group we should include a number of lethal blood problems involving clots and loss of platelets that cause strokes, brain bleeds and other impacts.

Lack of vaccine protection:

2.1 In induced antibodies do not neutralize a viral infection, but on the contrary facilitate it depending on the recipient.  The latter may have already been exposed to the virus asymptomatically.  Naturally induced antibodies may compete with the antibodies induced by the vaccine.

2.2 The production of antibodies induced by vaccination in a population highly exposed to the virus will lead to the selection of variants resistant to these antibodies.  These variants can be more virulent or more transmissible.  This is what we are seeing now.  An endless virus-vaccine race that will always turn to the advantage for the virus.

Long-term effects: Contrary to the claims of the manufacturers of messenger RNA vaccines, there is a risk of integration of viral RNA into the human genome. Our cells have the ability to reverse transcriptase from RNA into DNA. Although this is a rare event, its passage through the DNA of germ cells and its transmission to future generations cannot be excluded.

His bottom line: “Faced with an unpredictable future, it is better to abstain.”  But most people will find it extremely difficult to resist all the coercion and vaccine mandates.

Back in April 2020, before all the talk of variants and before the rollout of the experimental vaccines, Montagnier urged people to refuse vaccines against COVID-19 when they become available.  His main point should always be remembered: “instead of preventing the infection, they [would] accelerate infection.”  Today, the newly occurring variants of SARS-CoV-2 that affect vaccinated people prove his thesis.  With his scientific thinking, mass vaccination may cause a new, more deadly wave of pandemic infection.

As to the much talked about and hope for herd immunity, he has said: “the vaccines Pfizer, Moderna, Astra Zeneca do not prevent the transmission of the virus person-to-person and the vaccinated are just as transmissive as the unvaccinated.  Therefore the hope of a ‘collective immunity’ by an increase in the number of vaccinated is totally futile.”

On the positive side, he advocated this: “The early treatment of infection with ivermectin and bacterial antibiotic because there is a bacterial cofactor that amplifies the effects of the virus. “

Dr. Vanden Bossche

The stark views of Montagnier have been shared by the esteemed Belgium virologist Dr. Vanden Bossche.  He too has considerable credentials that make his views worth consideration.  He has PhD degree in Virology from the University of Hohenheim, Germany.  He held faculty appointments at universities in Belgium and Germany.  He was at the German Center for Infection Research in Cologne as Head of the Vaccine Development Office.  He has been in the private sector at several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) where he worked on vaccine R&D as well as vaccine development.  He also worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager.

His views have been analyzed in a recent article.  He too has loudly called for a halt to mass-vaccination programs.  He believes that if the jabs are not halted, they could lead to the evolution of stronger and stronger variants of the virus until a “supervirus” takes hold and wipes out huge numbers of people.

This is his bold view:

“Given the huge amount of immune escape that will be provoked by mass vaccination campaigns and flanking containment measures, it is difficult to imagine how human interventions would not cause the COVID-19 pandemic to turn into an incredible disaster for global and individual health.”

Here is an essential element of his thinking.  Pretty much everything being done in the pandemic doesn’t guarantee elimination of the virus.  What is happening is selective viral ‘immune escape’ where viruses continue to be shed from those who are infected [both vaccinated and nonvaccinated] because neutralizing antibodies fail to prevent replication and elimination of the virus.

The evolutionary selection pressure on the virus through ‘immune escape,’ creates ever more virulent strains of the virus that have a competitive advantage over other variants and will increasingly have the potential to break through the antibody defenses.  Defenses provided by the vaccine induced immune system.  This is ‘vaccine resistance.’  What happens is that vaccine makers keep trying to outsmart variants, but fail.  So, they keep pushing boosters and yearly vaccine shots.  This is the more is better approach.  This is aided by suppression of many negative facts about the vaccines by big media.

A frightening forecast by Bossche is that the worst of the pandemic is still to come.  Hard to believe considering all the bad news propaganda about cases, hospitalizations and deaths.  But he thinks we are now experiencing the calm before the ultimate storm.  Imagine a new wave of infection far worse than anything we’ve seen so far is how Bossche thinks.

How does this happen?  There will be more mutants or variants to which the adaptive immune system from vaccine shots provides little resistance.  At the same time there will be decreased innate or natural immune effectiveness.  Unless people take a number of steps to boost their natural immunity.

Bossche consistently points to a lack of evidence that the existing global, mass vaccination program that has been mounted while there is still significant infection around, is unprecedented and there is no scientific evidence that this will work.  This is why he is largely ignored.

He stresses that historic vaccination programs have always emphasized the importance of vaccinating populations prophylactically in the absence of infection pressure.

He also argues that if different types of vaccine were used that provided sterilizing immunity i.e., that prevented immune escape and killed all viruses in those vaccinated, the situation would be entirely different.  Most people do not understand that the current experimental vaccines do not actually kill the virus; and that both the vaccinated and nonvaccinated shed the virus.  These vaccines do not stop viral transmission.  And all the contagion control measures simply to not work effectively enough to stop wide spread of the virus in its various forms.

Here is his big picture view: “There is only one single thing at stake right now and that is the survival of our human race, frankly speaking.”

But there are more strong words recently said by Bossche to pay attention to:

“every person out there who is ‘partially’ or ‘fully’ vaccinated is a walking disease incubation system that puts everyone else at risk of contracting a deadly, vaccine-caused ‘variant’ that could kill them.  The ‘vaccinated’ are walking murderers spreading disease to others.  Getting injected for the Fauci Flu is not only foolish; it is also a form of murder in that unvaccinated people are now at risk of contracting the deadly diseases being manufactured inside the bodies of the vaccinated.  If Trump had never introduced the vaccine in the first place, the pandemic would have long ago fizzled out.  Since his vaccines continue to be pushed … however, the ‘Delta’ variant is spreading like wildfire, soon to be followed by other ‘variants’ as we enter the fall season.”

This too is a very strong view.  The “mass vaccination program is…unable to generate herd immunity.”  If true, there is little hope of seeing the COVID pandemic ending.

What is the solution?  Bossche has identified the needed alternative to the current massive vaccine effort.  It is this; “This first critical step can only be achieved by calling an immediate halt to the mass vaccination program and replacing it by widespread use of antiviral chemoprophylactics while dedicating massive public health resources to scaling early multidrug treatments of Covid-19 disease.”  This is referring to the early home/outpatient treatment protocols based on cheap, safe and fully approved generics like ivermectin and hydroxychloroquine; these also work as preventatives.  Pandemic Blunder provides much data and advice on using this treatment approach.  So, both virologists support use of what Fauci has blocked.

These action recommendations were also made by Bossche “Provide – at no cost – early multidrug treatment to all patients in need.  Roll out campaigns to promote healthy diets and lifestyle.”  In other words, people need to take actions to boost their natural immunity, this should include vitamins and supplements, including this cocktail: vitamin C, vitamin D, zine and quercetin.

Conclusions

Take a moment to consider that Patrick Wood on the Bannon show on August 21 concluded that all the available data from the US and Europe shows some 100,000 people have died from the COVID experimental vaccines.  I agree with that assessment.  And by the time you read this FDA may have given full approval to the Pfizer vaccine.

After considering what these two experts have said it is appropriate to criticize what current government officials say, namely blame the unvaccinated for the surges in COVID cases, hospitalizations and deaths.  The major alternative to this thinking is that it is the vaccinated people who are creating pandemic problems, including the variants.  The strong conclusion is that the current vaccines are ineffective, nonprotective and dangerous.

What is needed is an entirely new approach to COVID vaccines. Perhaps there are companies working on this.  This would threaten the trillion-dollar business of the current vaccine makers.

If the people, agencies and institutions with all the power listening to these two very smart people they would devote all their energies to using alternatives to the current vaccines.  We have them.  Notably, the treatment protocols that so many great doctors have created and used to help their patients.

Many other physicians and medical researchers have called for a halt to the current vaccine bonanza for big drug companies.  In the meantime, on a daily basis for all those willing to look at the facts, it is clearer and clearer that the experimental vaccines are not effective.  It is insanity to keep doing or expanding what is not working.  That is the insane world we are now experiencing even as more and people die from breakthrough infections, blood problems and other bad vaccine health impacts.

Perhaps the ugly truth about the vaccines will be widely revealed only when there are massive, widespread deaths despite all the shots and jabs.  That will be too late to change pandemic management from money-driven stupidity to life-saving, medically moral actions.

*

Dr. Joel S. Hirschhorn, author of Pandemic Blunder and many articles on the pandemic, worked on health issues for decades.  As a full professor at the University of Wisconsin, Madison, he directed a medical research program between the colleges of engineering and medicine.  As a senior official at the Congressional Office of Technology Assessment and the National Governors Association, he directed major studies on health-related subjects; he testified at over 50 U.S. Senate and House hearings and authored hundreds of articles and op-ed articles in major newspapers.  He has served as an executive volunteer at a major hospital for more than 10 years.  He is a member of the Association of American Physicians and Surgeons and America’s Frontline Doctors and has been a long-time contributor to the sites of Kettle Moraine.

The Gary Null Show - 08.23.21
The Gary Null Show - 08.20.21

The Gary Null Show - 08.20.21

August 20, 2021

The Gary Null Show Notes – 08.20.21

  1. Over 32,000 People DEAD in Brazil Following COVID-19 Vaccines According to Official Media Report

  2. The BBC Are A Disgrace

  3. A fourth globalisation: A new form of trade is reshaping our world, and it’s driven by the movement of bits and bytes, not goods, around the globe

  4. Moderna’s stock price is ‘ridiculous,’ says BofA analyst

  5. Baby Teeth Collected Six Decades Ago Will Reveal the Damage to Americans’ Health Caused by US Nuclear Weapons Tests

  6. Celebrate the Heroes Who Warned Us That Afghanistan Would Be a Disaster

  7. Chinese social media users mocked the US troop withdrawal in Afghanistan, saying the Taliban takeover was ‘more smooth than the presidential transition in the US’

  8. Immunocompromised people make up nearly half of COVID-19 breakthrough hospitalizations – an extra vaccine dose may help

  9. Pfizer Covid jab declines faster than AstraZeneca: study

  10. 21,766 DEAD Over 2 Million Injured (50% SERIOUS) Reported in European Union’s Database of Adverse Drug Reactions for COVID-19 Shots

  11. Existing drugs kill SARS-CoV2 in cells

  12. Welcome to the Pyrocene

  13. Vaccine Deaths Pile Up Without Media Coverage

  14.  FDA Expands Supplement Attack, Targets Hemp Oil

  15. The Taliban are sitting on $1 trillion worth of minerals the world desperately needs

     
     
     

    Today’s Videos:

    1. Covid Roundtable

    2. Jordan Peterson Leaves the Audience SPEECHLESS | One of the Best Motivational Speeches Ever

    3. What Happens When You Only Pursue Pleasure – Alan Watts

    4. The Dunning-Kruger Effect – Cognitive Bias – Why Incompetent People Think They Are Competent

    Study shows millets can reduce risk of developing cardiovascular disease

    International Crops Research Institute for the Semi-Arid Tropics, August 18, 2021

    The consumption of millets can reduce total cholesterol, triacylglycerols (commonly known as triglycerides) and BMI according to a new study that analyzed the data of 19 studies with nearly 900 people. The latest study was undertaken by five organizations and led by International Crops Research Institute for the Semi-Arid Tropics (ICRISAT).

    The results published in Frontiers in Nutrition bring critically needed scientific backing to the efforts to popularize and return millets to diets, especially as staples, to combat the growing prevalence of obesity and being overweight in children, adolescents and adults.

    The study showed that consuming millets reduced total cholesterol by 8%, lowering it from high to normal levels in the people studied. There was nearly a 10% decrease in low- and very low-density lipoprotein cholesterol (commonly viewed as ‘bad cholesterol’) and triacylglycerol levels in blood. Through these reductions, the levels went from above-normal to normal range. In addition, consuming millets decreased blood pressure with the diastolic blood pressure decreasing by 5%.

    Dr S Anitha, the study’s lead author and Senior Nutritionist at ICRISAT, explained, “We were very surprised by the number of studies that had already been undertaken on the impact of millets on elements that impact cardiovascular diseases. This is the very first time anyone has collated all these studies and analyzed their data to test the significance of the impact. We used a meta-analysis, and results came out very strongly to show significant positive impact on risk factors for cardiovascular disease.”

    The study also showed that consuming millets reduced BMI by 7% in people who were overweight and obese (from 28.5 ± 2.4 to 26.7 ± 1.8 kg/m2), showing the possibility of returning to a normal BMI (<25 kg/m2). All results are based on consumption of 50 to 200 g of millets per day for a duration ranging from 21 days to four months.

    These findings are influenced by comparisons that show that millets are much higher in unsaturated fatty acids, with 2 to 10 times higher levels than refined wheat and milled rice as well as being much higher than whole grain wheat.

    “This latest review further emphasizes the potential of millets as a staple crop that has many health benefits. It also strengthens the evidence that eating millet can contribute to better cardiovascular health by reducing unhealthy cholesterol levels and increasing the levels of whole grains and unsaturated fats in the diet,” said Professor Ian Givens, a co-author of the study and Director at University of Reading’s Institute of Food, Nutrition and Health (IFNH) in the UK.

    “Obesity and being overweight are increasing globally in both wealthy and poorer countries, so the need for solutions based on healthier diets is critical.  This new information on the health benefits of millets further supports the need to invest more in the grain, including in its whole value chain from better varieties for farmers through to agribusiness developments,” said Dr Jacqueline Hughes, Director General, ICRISAT.

    The study identified a number of priority future research areas including the need to study all different types of millets, understand any differences by variety alongside the different types of cooking and processing of millets and their impact on cardiovascular health. Given the positive indicators to date, more detailed analysis on the impact of millets on weight management is also recommended. All relevant parameters are also recommended to be assessed to gain a deeper understanding of the impacts millets consumption on hyperlipidemia and cardiovascular disease.

    “A key recommendation from the study is for government and industry to support efforts to diversify staples with millets, especially across Asia and Africa. Given that millets are hardy and climate smart, returning to this traditional staple makes a lot of sense and is a critical solution that could be the turning point of some major health issues,” highlighted Ms Joanna Kane-Potaka, a co-author and Executive Director of the Smart Food initiative, ICRISAT.

    How people manipulate their own memories

    Ruhr University Bochum (Germany), August 18, 2021

    People remember past experiences through the so-called episodic memory system. In the process, they can manipulate their memories on three levels, describe Dr. Roy Dings and Professor Albert Newen from the Institute of Philosophy II at Ruhr-Universität Bochum in a theoretical paper. It has been published online in the journal Review of Philosophy and Psychology on 13. August 2021. The researchers explain how people recall past experiences and modify them in the process. “We often construct memories of important events in a way that suits us,” outlines Albert Newen.

    Memories are not photographic representations

    Adults mainly remember significant experiences that were linked to very positive or very negative feelings, such as a unique experience on holidays, a driving test or a wedding. The memory is not a photographic excerpt of the past, but a construct that is fed by the perception of a past event; however, when the perceived situation is stored and, above all, recalled, a variety of construction processes take place. “To paraphrase Pippi Longstocking, you might say: I make the past world the way I like it,” as Roy Dings illustrates.

    People can influence the construction of a past scenario on three processing levels – something that usually happens automatically and unconsciously. The source of influence is the narrative self-image: “When we talk to friends, we tell about ourselves the things that are important to us,” says Roy Dings. “We refer to these aspects as the narrative self-image.”

    The constructive model of memory recall

    The authors, as well as all members of the Bochum-based research group “Constructing Scenarios of the Past”, work on the assumption that a memory is formed when a memory trace is activated by a stimulus: the wedding invitation card on the pinboard, for example, activates a memory trace of the wedding table. However, according to the Bochum model of episodic memory, the situation is then augmented by general background knowledge that is available in semantic memory. When the memory trace and background knowledge merge, a vivid memory picture emerges, for example of the bride’s greeting, and, eventually, the person talks about the event the way they experienced it.

    Three levels of influence

    The process of scenario construction includes the stimulus that triggers the memory, the actual processing, and the result, i.e. the memory image and the associated description. People can be influenced by all three components. Firstly, they tend to specifically look for the triggering stimulus for positive memories and avoid it for negative memories. For example, they put a wedding photo on the office desk, but avoid encounters with people with whom unpleasant memories are associated.

    Secondly, the self-image can also influence what background information is drawn upon to augment the sparse memory trace into a vivid memory; this is what determines the rich memory image in the first place.

    Thirdly, the description associated with a memory image can be either very concrete or rather abstract. The memory image can be described in concrete terms either as the beginning of the bride’s address or in more abstract terms as the beginning of the growing together of two families. The more abstract the associated description, the more likely a person is to remember the experience from an observer’s perspective, i.e. as an object in the scene; in this case, the feelings associated with the experience are less intense. The level of description chosen by the self-image influences the memory image and how it is experienced – and in particular, in what form it is then recorded.

    “Essentially, this means we shape our memories in such a way that we protect our positive self and tend to mitigate the challenges posed by negative memories that do not fit our self-image,” concludes Albert Newen.

    Study findings suggest adherence to healthy lifestyle may slow biological aging in middle-aged and older adults

    Peking University (China), August 16, 2021

    According to news reporting originating from Beijing, People’s Republic of China, research stated, “Little is known about the effects of lifestyle modification on biological aging in population-based studies of middle-aged and older adults. We examined the individual and joint associations of multiple lifestyle factors with accelerated biological aging measured by change in frailty index (FI) over 8 years in a prospective study of Chinese adults.”

    Our news editors obtained a quote from the research from Peking University, “Data were obtained on 24,813 participants in the China Kadoorie Biobank (CKB) on lifestyle factors and frailty status at baseline and at 8 years after baseline. Adherence to healthy lifestyle factors included non-smoking or quitting smoking for reasons other than illness, avoidance of heavy alcohol consumption, daily intake of fruit and vegetables, being physically active, body mass index (BMI) of 18.5-23.9 kg/m 2, and waist-to-hip ratio (WHR) <0.90 (men)/0.85 (women). FI was constructed separately at baseline and resurvey using 25 age- and health-related items. Overall, 8,760 (35.3%) individuals had a worsening frailty status. In multivariable-adjusted logistic regression analyses, adherence to healthy lifestyle was associated with a lower risk of worsening frailty status. Compared with robust participants maintaining 0-1 healthy lifestyle factors, the corresponding OR (95% CI) was 0.93 (0.83-1.03), 0.75 (0.67-0.84), 0.68 (0.60-0.77), and 0.55 (0.46-0.65) for robust participants with 2, 3, 4, and 5-6 healthy lifestyle factors. The decreased risk of frailty status worsening by adherence to healthy lifestyle factors was similar in both middle-aged and older adults, and in both robust and prefrail participants at baseline.”

    According to the news editors, the research concluded: “Adherence to a healthy lifestyle may attenuate the rate of change in biological aging in middle-aged and older Chinese adults.”

    This research has been peer-reviewed.

    Uterine fibroid treatment with vitamin D combined with ECGC and vitamin B6: a controlled pilot study

    Hospital Santa Maria (Portugal), August 16, 2021

    According to news reporting originating from the Hospital Santa Maria research stated, “Uterine fibroids are the most common benign tumor in women and a specific treatment is not available. The combination of epigallocatechin gallate (EGCG), vitamin D and B6 in treating uterine fibroids (UFs) recently showed a promising efficacy.”

    The news journalists obtained a quote from the research from Hospital Santa Maria: “Here we tried to evaluate the efficiency of the combination to improve gynaecologycal and cardiological parameters. 43 women with a diagnosis of UF were enrolled and divided into two groups: a) study group, treated twice a day with 150 mg EGCG, 25 g vitamin D and 5 mg vitamin B6, for 4 months; b) control group, with no intervention. Volume, number of UFs, menstrual bleeding, pelvic discomfort, anemia and hypertension were monitored and analyzed. One UF developed in the control group, but none in the treated group. UF size significantly decreased from 10.73 ± 5.52 cm3 at baseline to 7.98 ± 4.00 cm3 after 4 months of treatment (p < 0.0001), while it remained unchanged in the control group (10.21 ± 5.83 cm3 at T0 to 10.62 ± 6.28 cm3 at T1). Menstrual bleeding and anemia ameliorated only in the treated women.”

    According to the news reporters, the research concluded: “Supplementation with EGCG, vitamin D and B6 is a safe and novel approach for the management of UFs, reducing volume and improving menstrual bleeding and anemia of women presenting such symptoms.”

    One Acupuncture Treatment Drops Blood Pressure For Over a Month Without Medication 

    Susan Samueli Center for Integrative Medicine, August 20, 2021

    Emerging evidence from a research study shows acupuncture may be an effective treatment for hypertension. Acupuncture regulates blood pressure, blood flow and body temperature. Patients with hypertension treated with acupuncture experienced drops in their blood pressure that lasted up to a month and a half, researchers with the Susan Samueli Center for Integrative Medicine have found.

    Their work is the first to scientifically confirm that this ancient Chinese practice is beneficial in treating mild to moderate hypertension, and it indicates that regular use could help people control their blood pressure and lessen their risk of stroke and heart disease.

    The reports of side effects show that acupuncture works, says Dr. Marc Micozzi, editor of the textbook Fundamentals of Complementary Alternative Medicine and executive director of the College of Physicians of Philadelphia. He says, “People need to understand that part of taking alternative medicine seriously is to take a look at and understand the side effects.”

    “This clinical study is the culmination of more than a decade of bench research in this area,” said Dr. John Longhurst, a University of California, Irvine cardiologist and former director of the Samueli Center. “By using Western scientific rigor to validate an ancient Eastern therapy, we feel we have integrated Chinese and Western medicine and provided a beneficial guideline for treating a disease that affects millions in the U.S.”

    Participants were treated at UCI’s Institute for Clinical & Translational Science. Study results appear in Medical Acupuncture.

    Longhurst and his UCI colleagues Dr. Peng Li and Stephanie Tjen-A-Looi conducted tests on 65 hypertensive patients who were not receiving any hypertension medication. Separated randomly into two groups, the subjects were treated with electroacupuncture – a form of the practice that employs low-intensity electrical stimulation – at different acupoints on the body.

    “In the hands of a trained professional, acupuncture is very safe and effective. Like everything else, acupuncture is not effective for everything. Certainly, it has demonstrated itself as effective for pain that does not respond well to even high doses of medication or chronic pain,”says Bruce Dubin, dean of Ohio University’s College of Osteopathic Medicine.

    In one group of 33 receiving electroacupuncture on both sides of the inner wrists and slightly below each knee, the researchers found a noticeable drop in blood pressure rates in 70 percent of participants – an average of 6 to 8 mmHg for systolic blood pressure (the high number) and 4 mmHg for diastolic blood pressure (the low number). These improvements persisted for a month and a half.

    Also in this group, the team identified significant declines in blood concentration levels of norepinephrine (41 percent), which constricts blood vessels and increases blood pressure and glucose levels; and renin (67 percent), an enzyme produced in the kidneys that helps control blood pressure. In addition, the electroacupuncture decreased aldosterone (22 percent), a hormone that regulates electrolytes.

    No consequential blood pressure changes were found in the group of 32 who received electroacupuncture at other acupoints along the forearm and lower leg.

    Although the blood pressure reductions in the first cohort were relatively small – mostly in the 4-to-13-mmHg range – the researchers noted that they were clinically meaningful and that the technique could be especially useful in treating systolic hypertension in patients over 60.

    “Because electroacupuncture decreases both peak and average systolic blood pressure over 24 hours, this therapy may decrease the risk for stroke, peripheral artery disease, heart failure and myocardial infarction in hypertensive patients,” Longhurst said.

    Research uncovers how fructose in the diet contributes to obesity

    Weill Cornell Medical College, August 19, 2021

    Eating fructose appears to alter cells in the digestive tract in a way that enables it to take in more nutrients, according to a preclinical study from investigators at Weill Cornell Medicine and NewYork-Presbyterian. These changes could help to explain the well-known link between rising fructose consumption around the world and increased rates of obesity and certain cancers.

    The research, published August 18 in Nature, focused on the effect of a high-fructose diet on villi, the thin, hairlike structures that line the inside of the small intestine. Villi expand the surface area of the gut and help the body to absorb nutrients, including dietary fats, from food as it passes through the digestive tract. The study found that mice that were fed diets that included fructose had villi that were 25 percent to 40 percent longer than those of mice that were not fed fructose. Additionally, the increase in villus length was associated with increased nutrient absorption, weight gain and fat accumulation in the animals.

    “Fructose is structurally different from other sugars like glucose, and it gets metabolized differently,” said senior author Dr. Marcus DaSilva Goncalves, the Ralph L. Nachman Research Scholar, an assistant professor of medicine in the Division of Endocrinology, Diabetes and Metabolism and an endocrinologist at NewYork-Presbyterian/Weill Cornell Medical Center. “Our research has found that fructose’s primary metabolite promotes the elongation of villi and supports intestinal tumor growth.”

    The investigators didn’t plan to study villi. Previous research from the team, published in 2019, found that dietary fructose could increase tumor size in mouse models of colorectal cancer, and that blocking fructose metabolism could prevent that from happening. Reasoning that fructose might also promote hyperplasia, or accelerated growth, of the small intestine, the researchers examined tissues from mice treated with fructose or a control diet under the microscope.

    The observation that the mice on the high-fructose diet had increased villi length, which was made by first author Samuel Taylor, a Tri-Institutional M.D.-Ph.D. Program student in Dr. Goncalves’ lab, was a complete surprise. And once he made the discovery, he and Dr. Goncalves set out to learn more.

    After observing that the villi were longer, the team wanted to determine whether those villi were functioning differently. So they put mice into three groups: a normal low-fat diet, a high-fat diet, and a high-fat diet with added fructose. Not only did the mice in the third group develop longer villi, but they became more obese than the mice receiving the high-fat diet without fructose.

    The researchers took a closer look at the changes in metabolism and found that a specific metabolite of fructose, called fructose-1-phosphate, was accumulating at high levels. This metabolite interacted with a glucose-metabolizing enzyme called pyruvate kinase, to alter cell metabolism and promote villus survival and elongation. When pyruvate kinase or the enzyme that makes fructose-1-phospate were removed, fructose had no effect on villus length. Previous animal studies have suggested that this metabolite of fructose also aids in tumor growth.

    According to Taylor, the observations in mice make sense from an evolutionary perspective. “In mammals, especially hibernating mammals in temperate climates, you have fructose being very available in the fall months when the fruit is ripe,” he said. “Eating a lot of fructose may help these animals to absorb and convert more nutrients to fat, which they need to get through the winter.”

    Dr. Goncalves added that humans did not evolve to eat what they eat now. “Fructose is nearly ubiquitous in modern diets, whether it comes from high-fructose corn syrup, table sugar, or from natural foods like fruit,” he said. “Fructose itself is not harmful. It’s a problem of overconsumption. Our bodies were not designed to eat as much of it as we do.”

    Future research will aim to confirm that the findings in mice translate to humans. “There are already drugs in clinical trials for other purposes that target the enzyme responsible for producing fructose-1-phosphate,” said Dr. Goncalves, who is also a member of the Sandra and Edward Meyer Cancer Center. “We’re hoping to find a way to repurpose them to shrink the villi, reduce fat absorption, and possibly slow tumor growth.”

     

    1. reuteri supplements may modulate gut insulin metabolism: RCT

    Heinrich-Heine University (Germany), August 20, 2021

    Consumption of Lactobacillus reuteri probiotics may boost insulin release in healthy people, says a new study.

    Tablets containing Nutraceutix’s L. reuteri strain (ATCC strain SD-5865) and its patented BIO-tract delivery technology were found to increase insulin secretion by 49%, according to findings published in Diabetes Care.

    Daily administration of L. reuteri tablets for four weeks was also associated with 76% and 43% increases in glucose-stimulated glucagon-like peptides (GLP)-1 and -2 release, wrote researchers from Germany, Denmark and the US. GLP-1(incretin) is known to play a key role in insulin secretion and beta-cell function in the pancreas, while GLP-2 is reported to enhance intestinal function.

    “[A]dministration of probiotic L. reuteri increased insulin secretion and incretin release in humans,” wrote the researchers, led by Prof Michael Roden from Heinrich-Heine University in Dusseldorf. “This effect was not caused by a modulation of the fecal microbiota, suggesting a direct effect of the Lactobacilli on host physiology.

    “The increase of the intestinotrophic gut peptide, GLP-2, which may contribute to intestinal integrity, was accompanied by stable concentrations of endotoxin and immune mediators.

    “Therefore, administration of a specific bacterial strain might have clinical implications by improving incretin-mediated beta-cell function in individuals with impaired glucose homeostasis and therefore warrants further studies on specific bacterial strains in type 2 diabetes.”

    Prof Roden and his co-workers recruited 11 lean and 10 obese glucose tolerant people with an average age of 50 to participate in their prospective, double-blind, randomized trial. Participants received a daily L. reuteri dose of 20 billion colony forming units (CFUs) per day or placebo for four weeks. The probiotic was encapsulated by Nutraceutix using its BIO-tract technology, which is protected by US Patents 8,540,980 and 8,007,777 , and other international patents

    Results showed that, in addition to the increases in insulin sectretion, GLP-1, and GLP-2 levels, the probiotic supplements were also associated with a 55% increase in C-peptide secretion. C-peptide is a protein that joins the A- and B-chains of insulin. It is secreted in equal measure to insulin and is seen as an important measure of insulin secretion.

    “An increase of GLP-2 secretion most probably enhances the expression of tight junctions in the intestinal wall, with the consequence of decreased gut permeability and leakage of endotoxin,” they explained. “It has been suggested that low-grade metabolic inflammation driven by endotoxin translocation is the proposed mechanism by which the microbiota may contribute to systemic inflammation in obesity due to increased intestinal permeability.

    “Lactobacilli may have the capability to improve intestinal integrity in rodents, which may diminish the LPS [lipopolysaccharide, an endotoxin] overflow from the gut to the circulation and thereby reduce the systemic concentrations of inflammatory markers.”

    However, the researchers did not find any significant effects for systemic inflammation or oxidative stress in the study participants over four weeks, nor were there any impacts on insulin sensitivity, body mass, or levels of circulating cytokines.

    The study was co-funded by the Heinrich-Heine University, the German Center for Diabetes Research, and the Danone Institute for Nutrition and Health.

The Gary Null Show - 08.19.21

The Gary Null Show - 08.19.21

August 19, 2021

A berry vine found in Asia proves useful in combating lung cancer

Okayama University (Japan), August 17, 2021

Lung cancer is known to be the most fatal form of cancer. Chemicals like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) found in tobacco are usually the main culprits behind smoking-related lung cancer causing cancer biologists to actively explore targeted treatments. Now, a research group led by Associate Professor ARIMOTO-KOBAYASHI Sakae at Okayama University has reported the potential of a berry-producing vine, Vitis coignetiae Pulliat (colloquially known as Yamabudo in Japan), against lung cancer in mice.

The team has previously shown that juice extracted from the Yamabudo fruit and 2,6-dimethoxy-1,4-benzoquinone (DBQ), a chemical found within it, have protective effects against skin cancer. Thus, in this study the potential of both these chemicals was investigated. Mice were first treated with NNK to establish lung cancer models and tumors that subsequently developed within their lungs were assessed. After 30 weeks, mice given Yamabudo juice or DBQ showed greatly reduced tumor size. To understand the mechanism of Yamabudo further, human lung cancer cells were employed. NNK induces cancer by facilitating a chemical change in the DNA structure, known as DNA methylation. To mimic this process, cells were exposed to MNNG (a chemical that artificially induces DNA methylation) and the effects of Yamabudo were studied. Indeed, cells that were treated with Yamabudo juice or DBQ showed lower levels of DNA methylation. 

The DNA methylation induced by NNK also plays a role in mutating the DNA, making all exposed cells susceptible to cancer. The methylated forms of DNA tend to form large complexes which can undergo damage more easily. Therefore, NNK-induced mutations were analyzed next to see if Yamabudo also plays a protective role in this regard. The number of NNK-induced mutations was, in fact, found to be considerably reduced by Yamabudo juice or DBQ. Yamabudo thus mitigated lung cancer by repairing the DNA damage caused by toxins. Lastly, the team also assessed biological pathways which typically help cancer cells proliferate. While all such pathways were active in the lung cancer cells, treatment with Yamabudo showed a dampening of these cancer-facilitating signals.

“Stimulation of repair of alkyl DNA adducts and suppressed growth signaling pathways are potential anti-tumorigenic targets of Yamabudo juice and DBQ in NNK-induced lung tumorigenesis,” conclude the researchers. Given the broad range of tumor-suppressing properties Yamabudo displays, it is one herbal medicine that should be explored further in lung cancer research.

Background
Yamabudo: Vitis coignetiae Pulliat, also known as crimson glory vine or “Yamabudo” in Japan, is a berry-producing vine that grows primarily in East Asia. The juice extracted from Yamabudo berries comprises several chemical compounds that have medicinal properties. While its protective properties against skin cancer have briefly been shown before, this is the first study that explores the potential of Yamabudo in lung cancer.

DNA methylation: DNA methylation is a natural chemical process intended to regulate proper functioning of our genes. A chemical group known as the “methyl” group is usually bound onto specific regions of the DNA as a mechanism to prevent genes from being turned on when not in use. However, certain toxins and other external factors can also induce DNA methylation which sometimes prevents important genes (such as those that suppress cancer) from being active. Unfortunately, the methylated forms of DNA are passed on when cells replicate. DNA methylation thereby also abets the spread of cancer. Controlling DNA methylation is an important strategy in keeping certain cancers in check.

Vitamin D may protect against young-onset colorectal cancer

Dana Farber Cancer Institute, August 17, 2021

Consuming higher amounts of Vitamin D – mainly from dietary sources – may help protect against developing young-onset colorectal cancer or precancerous colon polyps, according to the first study to show such an association.

The study, recently published online in the journal Gastroenterology, by scientists from Dana-Farber Cancer Institute, the Harvard T.H. Chan School of Public Health, and other institutions, could potentially lead to recommendations for higher vitamin D intake as an inexpensive complement to screening tests as a colorectal cancer prevention strategy for adults younger than age 50.

While the overall incidence of colorectal cancer has been declining, cases have been increasing in younger adults – a worrisome trend that has yet to be explained. The authors of the study, including senior co-authors Kimmie Ng, MD, MPH, of Dana-Farber, and Edward Giovannucci, MD, DSc., of the T.H. Chan School, noted that vitamin D intake from food sources such as fish, mushrooms, eggs, and milk has decreased in the past several decades. There is growing evidence of an association between vitamin D and risk of colorectal cancer mortality. However, prior to the current study, no research has examined whether total vitamin D intake is associated with the risk of young-onset colorectal cancer.

“Vitamin D has known activity against colorectal cancer in laboratory studies. Because vitamin D deficiency has been steadily increasing over the past few years, we wondered whether this could be contributing to the rising rates of colorectal cancer in young individuals,” said Ng, director of the Young-Onset Colorectal Cancer Center at Dana-Farber. “We found that total vitamin D intake of 300 IU per day or more – roughly equivalent to three 8-oz. glasses of milk – was associated with an approximately 50% lower risk of developing young-onset colorectal cancer.”

The results of the study were obtained by calculating the total vitamin D intake – both from dietary sources and supplements – of 94,205 women participating in the Nurses’ Health Study II (NHS II). This study is a prospective cohort study of nurses aged 25 to 42 years that began in 1989. The women are followed every two years by questionnaires on demographics, diet and lifestyle factors, and medical and other health-related information. The researchers focused on a primary endpoint – young-onset colorectal cancer, diagnosed before 50 years of age. They also asked on a follow-up questionnaire whether they had had a colonoscopy or sigmoidoscopy where colorectal polyps (which may be precursors to colorectal cancer) were found.

During the period from 1991 to 2015 the researchers documented 111 cases of young-onset colorectal cancer and 3,317 colorectal polyps. Analysis showed that higher total vitamin D intake was associated with a significantly reduced risk of early-onset colorectal cancer. The same link was found between higher vitamin D intake and risk of colon polyps detected before age 50. 

The association was stronger for dietary vitamin D – principally from dairy products – than from vitamin D supplements. The study authors said that finding could be due to chance or to unknown factors that are not yet understood.

Interestingly, the researchers didn’t find a significant association between total vitamin D intake and risk of colorectal cancer diagnosed after age 50. The findings were not able to explain this inconsistency, and the scientists said further research in a larger sample is necessary to determine if the protective effect of vitamin D is actually stronger in young-onset colorectal cancer.

In any case, the investigators concluded that higher total vitamin D intake is associated with decreased risks of young-onset colorectal cancer and precursors (polyps). “Our results further support that vitamin D may be important in younger adults for health and possibly colorectal cancer prevention,” said Ng. “It is critical to understand the risk factors that are associated with young-onset colorectal cancer so that we can make informed recommendations about diet and lifestyle, as well as identify high risk individuals to target for earlier screening.”

The study was funded by grants from the U.S. National Institutes of Health and the Department of Defense; by the American Cancer Society Mentored Research Scholar Grant; and by the Project P Fund.

Ng’s disclosures include research funding from Pharmavite, Revolution Medicines, Janssen, and Evergrande Group; Advisory boards for Array Biopharma, Seattle Genetics, and BiomX; and consulting for X-Biotix Therapeutics.

Lack of exercise and poor nutrition could increase the risk of diseases like dementia

Kings College London, August 17, 2021

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has found that both diet and exercise can influence the risk of cognitive decline (CD) and dementia by potentially influencing hippocampal neurogenesis (the process by which the brain produces new brain cells) long before their onset.

The study, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, suggests that altered neurogenesis in the brain could potentially represent an early biomarker for both CD and dementia.

The investigation studied how the blood of participants with and without CD and dementia could influence hippocampal neurogenesis in laboratory settings and whether diet and exercise were important factors. Specifically, blood samples of 418 French adults over the age of 65 were collected 12-years prior to CD and dementia diagnosis and tested on human hippocampal stems cells. Additionally, information on each participant’s sociodemographic, lifestyle, and clinical data were collected and incidence cognition status and dementia were measured every 2 to 3 years over a 12-year period.

Over the course of the study, the researchers established that 12 years prior to diagnosis, both CD and Alzheimer’s were associated with levels of neural stem cell death. The team also found that exercise, nutrition, vitamin D levels, carotenoid and lipid levels are all associated with the rate at which cells die off. Furthermore, physical activity and nutrition were key factors that then also determined CD status.  Specifically, researchers found that reduced physical activity and increased malnutrition both increased cell death which in turn increased the risk for future CD.

While previous studies have established that diet and exercise have some protective effects against CD and dementia, these roles have been poorly understood at the neurobiological level. To date, studies on animals have shown how diet and exercise can directly influence hippocampal neurogenesis, potentially explaining how exercise and diet may biologically exert their effects, but this study sheds further light on this in the context of a human model.

Doctor Sandrine Thuret, the study’s lead investigator from King’s IoPPN said “Our study has demonstrated not only that there are individual markers of hippocampal neurogenesis associated with CD and dementia 12 years later, but also that there is some degree of specificity with respect to diagnoses of dementia subtypes.

“Specifically, if an individual displays an increase in their levels of cell death during differentiation (when neural stem cells are becoming neurons), we can look at this as a potential warning sign of CD. Conversely, a decrease in levels of cell death during proliferation (the process by which a single cell divides into a pair) and reduced hippocampal progenitor cell integrity could be viewed as a predictor for Alzheimer’s Disease and Vascular dementia, respectively.”

According to Alzheimer’s Research UK, there were a total of 525,315 people living with a dementia diagnosis in the UK in 2020[1]. Rates of cognitive decline and dementia are expected to triple in prevalence by 2040.

Dr Andrea du Preez, the study’s first author from King’s IoPPN said, “While more work is undoubtedly needed to fully understand how diet and exercise might modulate hippocampal neurogenesis, our findings may represent an effective early preventative strategy against CD and dementia.”

Acupuncture improves symptoms of chronic prostatitis/chronic pelvic pain syndrome compared to sham treatment

China Academy of Chinese Medical Sciences, August 17, 2021 

A multicenter randomized trial showed that 20 sessions of acupuncture over 8 weeks resulted in greater improvement in symptoms of moderate to severe chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) compared with sham therapy. Treatment effects endured over 24 weeks follow up. The findings are published in Annals of Internal Medicine.

CP/CPPS manifests discomfort or pain in the pelvic region for at least 3 of the previous 6 months without evidence of infection. Lower urinary tract symptoms, psychological issues, and sexual dysfunction may also be involved. Men with CP/CPPS may have a poor quality of life due to the many neuropsychophysiologic pathophysiology factors associated with the disorder, such as inflammation in the prostate, anxiety and stress, and dyssynergic voiding. Antibiotics, a-blockers, and anti-inflammatories are the mainstays of treatment in clinical practice, but they have limited effectiveness and are associated with adverse events with long-term use. Acupuncture has shown promise as an alternative treatment, but high-quality evidence is scarce.

Researchers from the China Academy of Chinese Medical Sciences randomly assigned 440 male participants (220 in each group) to either 8 weeks of acupuncture or sham therapy to assess the long-term efficacy of acupuncture for improving symptoms of CP/CPPS. The treatment was considered effective if participants achieved a clinically important reduction of at least 6 points from baseline on the National Institutes of Health Chronic Prostatitis Symptom Index at weeks 8 and 32. Ascertainment of sustained efficacy required the between-group difference to be statistically significant at both time points. The researchers found that compared with the sham acupuncture group, larger proportions of participants in the acupuncture group reported marked or moderate improvements in symptoms at all assessment points. No significant difference was found in changes in International Index of Erectile Function 5 score at all assessment time points or in peak and average urinary flow rates at week 8. No serious adverse events were reported in either group.

According to the researchers, these findings show long-term efficacy of acupuncture and provide high-quality evidence for clinical practice and guideline recommendations.

Eicosapentaenoic acid (EPA) decreases amyloid beta-induced neurotoxicity by decreasing neuroinflammation through regulation of microglial polarization

Yunnan University (CHina), August 16, 2021

According to news reporting originating in Yunnan, People’s Republic of China, research stated, “Although the cause of Alzheimer’s disease (AD) is still controversial, it is generally accepted that neuroinflammation plays a key role in AD pathogenesis. Thus, regulating the polarization of microglia will help in recovering from AD since microglia can be polarized into classical M1 and alternative M2 phenotypes, M1 microglia leading to neuroinflammation and M2 microglia acting as anti-inflammatory effectors.”

Financial support for this research came from National Natural Science Foundation of China (NSFC).

The news reporters obtained a quote from the research from Yunnan University, “Our previous study demonstrated that eicosapentaenoic acid (EPA), an essential n-3 polyunsaturated fatty acid, may modulate glial cell activity and functions, but it is not clear whether EPA plays a role in microglial polarization. Here, we aimed to test the hypothesis that EPA may regulate the polarization of microglia and subsequently alleviate neuroinflammation and neuronal damage. Male C57BL/6 mice were fed an EPA -supplemented diet or a palm oil -supplemented diet for 42 days. On day 28 of diet feeding, the mice received a single intracerebroventricular injection of beta-peptide fragment 1-42(A beta(1-42)) or saline. The polarization of M1 and M2 microglia was evaluated by western blot using the respective markers. Changes in inflammatory cytokine mRNA levels were examined using real-time PCR. Neurological deficits were analysed using the Morris water maze and TdT-mediated dUTP Nick-End Labeling (TUNEL) assays. EPA supplementation effectively reversed the increasing trend of M1 microglial markers and the decreased expression of M2 microglial markers in the hippocampus mediated by A beta(1-42) and normalized the A beta-induced upregulation of proinflammatory cytokines and the downregulation of anti-inflammatory factors. Consistent with these findings, EPA significantly improved cognitive function and inhibited apoptotic neuronal death in the hippocampus.”

According to the news reporters, the research concluded: “These results demonstrated that EPA appears to have potential effects on regulating microglial polarization, which contributes to alleviating neuroinflammation and may have beneficial effects for preventing and treating AD.”

This research has been peer-reviewed.

Yoga and meditation improve mind-body health and stress resilience

University of Southern California  August 19, 2021 

Many people report positive health effects from practicing yoga and meditation, and experience both mental and physical benefits from these practices. However, we still have much to learn about how exactly these practices affect mind-body health. A new research article published in Frontiers in Human Neuroscience investigates the effects of yoga and meditation on brain derived neurotrophic factor (BDNF), the activity on the hypothalamic pituitary adrenal (HPA) effects and inflammatory markers. By studying the participants of an intensive 3-month yoga and meditation retreat, the researchers found that the practices positively impacted BDNF signaling, the cortisol awakening response (CAR) and immunological markers, and in addition improved subjective wellbeing.

In this study, the retreat participants were assessed before and after participating in a 3-month yoga and meditation retreat that involved daily meditation and Isha yoga, accompanied by a vegetarian diet. The yogic practices consisted of physical postures, controlled breathing practices, and seated meditations during which the participants focused on mantra repetition, breath, emptying the mind and bodily sensation. The researchers measured psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, as well as pro- and anti-inflammatory cytokines. They also collected data on psychometric variables including mindfulness, absorption, depression and anxiety, and investigated the relationship between psychological improvements and biological changes.

The data showed that participation in the retreat was associated with decreases in both self-reported anxiety and depression as well as increases in mindfulness. The research team observed increases in the plasma levels of BDNF, a neuromodulator that plays an important role in learning, memory and the regulation of complex processes such as inflammation, immunity, mood regulation, stress response and metabolism. They also observed increases in the magnitude of the cortisol awakening response (CAR) which is part of the hypothalamic pituitary adrenal axis (HPA), suggesting improved stress resilience. Moreover, there was a decrease in inflammatory processes caused by an increase of the anti-inflammatory cytokine Interleukin-10 and a reduction of the pro-inflammatory cytokine Interleukin-12 after the retreat. "It is likely that at least some of the significant improvements in both HPA axis functioning as exemplified by the CAR as well as neuroimmunologic functioning as exemplified by increases in BDNF levels and alterations in cytokines were due to the intensive meditation practice involved in this retreat," says corresponding author Dr Baruch Rael Cahn (University of Southern California, USA).

The research team hypothesize that the pattern of biological findings observed in their study is linked to enhanced resilience and wellbeing. "The observed increased BDNF signaling possibly related to enhanced neurogenesis and/or neuroplasticity, increased CAR likely related to enhanced alertness and readiness for mind-body engagement, and increased anti- and pro-inflammatory cytokines possibly indicating enhanced immunological readiness," explains Dr Cahn. "An intriguing possible link between the effects on BDNF and the CAR is hippocampal functional integrity, since increased BDNF levels due to physical exercise has previously been shown to relate with hippocampal neurogenesis and likely relate to its positive effects on well-being and depression."

In the light of previous studies of the positive effects of meditation on mental fitness, autonomic homeostasis and inflammatory status, the researchers think that their findings are related to the meditative practices that the retreat participants engaged in. However, they suggest that some of the observed changes may also be related to the physical aspects of the retreat - yoga practice and diet - and that the observed change patterns are a reflection of wellbeing and mind-body integration. The next step will be to conduct further research in order to clarify the extent to which the positive changes on mind-body wellness and stress resilience are related to the yoga and meditation practices respectively, and to account for other possible contextual factors such as social dynamics, diet and the impact of the teacher. "To our knowledge, our study is the first to examine a broad range of pro- and anti-inflammatory markers in a healthy population before and after a yoga-meditation intervention. Our findings justify further studies of yoga and meditation retreats assessing for the replicability, specificity and long-term implications of these findings," concludes Dr Cahn.

 
The Gary Null Show - 08.18.21
The Gary Null Show - 08.17.21

The Gary Null Show - 08.17.21

August 17, 2021
 
 

Dr Piers Robinson is an expert on communication, media and world politics, focusing on conflict and war and especially the role of propaganda. He is presently Co-Director of the Organisation for Propaganda Studies, Convenor of the Working Group on Syria, Propaganda and Media and Associated Researcher with the Working Group on Propaganda and the 9/11 ‘War on Terror’. From 2016 – 2019, he was Professor and Chair in Politics, Society and Political Journalism at the University of Sheffield. He has also served on the boards of several academic journals. He has lectured at the NATO Defense College in Rome and briefed senior UK military commanders and diplomats, and his research interests focus on Organised Persuasive Communication and Contemporary Propaganda and his current projects include Propaganda and the Syrian conflict; Propaganda and the 9/11 Global War on Terror and Covid19.

The Gary Null Show -  08.16.21
The Gary Null Show - 08.13.21

The Gary Null Show - 08.13.21

August 13, 2021

Curcumin: modulator of key molecular signaling pathways in hormone-independent breast cancer

Monash University Malaysia, August 10, 2021

According to news reporting originating from Selangor, Malaysia,  research stated, “Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among women worldwide.”

Our news correspondents obtained a quote from the research from Monash University Malaysia: “Despite the overall successes in breast cancer therapy, hormone-independent HER2 negative breast cancer, also known as triple negative breast cancer (TNBC), lacking estrogens and progesterone receptors and with an excessive expression of human epidermal growth factor receptor 2 (HER2), along with the hormone-independent HER2 positive subtype, still remain major challenges in breast cancer treatment. Due to their poor prognoses, aggressive phenotype, and highly metastasis features, new alternative therapies have become an urgent clinical need. One of the most noteworthy phytochemicals, curcumin, has attracted enormous attention as a promising drug candidate in breast cancer prevention and treatment due to its multi-targeting effect. Curcumin interrupts major stages of tumorigenesis including cell proliferation, survival, angiogenesis, and metastasis in hormone-independent breast cancer through the modulation of multiple signaling pathways. The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-qB pathway, p53 pathway, and Wnt/b-catenin, as well as apoptotic and cell cycle pathways.”

According to the news reporters, the research concluded: “Besides, its therapeutic implications in clinical trials are here presented.”

 
 

Ultrasound remotely triggers immune cells to attack tumors in mice without toxic side effects

University of California San Diego, August 11, 2021
 

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

The new experimental therapy significantly slowed down the growth of solid cancerous tumors in mice.

The team, led by the labs of UC San Diego bioengineering professor Peter Yingxiao Wang and bioengineering professor emeritus Shu Chien, detailed their work in a paper published Aug. 12 in Nature Biomedical Engineering.

The work addresses a longstanding problem in the field of cancer immunotherapy: how to make chimeric antigen receptor (CAR) T-cell therapy safe and effective at treating solid tumors.  

CAR T-cell therapy is a promising new approach to treat cancer. It involves collecting a patient’s T cells and genetically engineering them to express special receptors, called CAR, on their surface that recognize specific antigens on cancer cells. The resulting CAR T cells are then infused back into the patient to find and attack cells that have the cancer antigens on their surface.

This therapy has worked well for the treatment of some blood cancers and lymphoma, but not against solid tumors. That’s because many of the target antigens on these tumors are also expressed on normal tissues and organs. This can cause toxic side effects that can kills cells—these effects are known as on-target, off-tumor toxicity.

“CAR T cells are so potent that they may also attack normal tissues that are expressing the target antigens at low levels,” said first author Yiqian (Shirley) Wu, a project scientist in Wang’s lab.

“The problem with standard CAR T cells is that they are always on—they are always expressing the CAR protein, so you cannot control their activation,” explained Wu.

To combat this issue, the team took standard CAR T cells and re-engineered them so that they only express the CAR protein when ultrasound energy is applied. This allowed the researchers to choose where and when the genes of CAR T cells get switched on.

“We use ultrasound to successfully control CAR T cells directly in vivo for cancer immunotherapy,” said Wang, who is a faculty member of the Institute of Engineering in Medicine and the Center for Nano-ImmunoEngineering, both at UC San Diego. What’s exciting about the use of ultrasound, noted Wang, is that it can penetrate tens of centimeters beneath the skin, so this type of therapy has the potential to non-invasively treat tumors that are buried deep inside the body.

The team’s approach involves injecting the re-engineered CAR T cells into tumors in mice and then placing a small ultrasound transducer on an area of the skin that’s on top of the tumor to activate the CAR T cells. The transducer uses what’s called focused ultrasound beams to focus or concentrate short pulses of ultrasound energy at the tumor. This causes the tumor to heat up moderately—in this case, to a temperature of 43 degrees Celsius (109 degrees Fahrenheit)—without affecting the surrounding tissue. The CAR T cells in this study are equipped with a gene that produces the CAR protein only when exposed to heat. As a result, the CAR T cells only switch on where ultrasound is applied.

The researchers put their CAR T cells to the test against standard CAR T cells. In mice that were treated with the new CAR T cells, only the tumors that were exposed to ultrasound were attacked, while other tissues in the body were left alone. But in mice that were treated with the standard CAR T cells, all tumors and tissue expressing the target antigen were attacked.

“This shows our CAR T-cell therapy is not only effective, but also safer,” said Wu. “It has minimal on-target, off-tumor side effects.”

The work is still in the early stages. The team will be performing more preclinical tests and toxicity studies before it can reach clinical trials.

 

 

Lycopene ameliorates diabetic osteoporosis via anti-inflammatory, antioxidation 

Shaanxi University of Technology (China), August 10, 2021

According to news originating from Shaanxi University of Technology research stated, “Diabetic osteoporosis (DOP) is one of the complications of diabetes, with high morbidity, and high disability rate. Here, we established a diabetic rat model and administered lycopene to observe its effect on DOP.”

Our news editors obtained a quote from the research from Shaanxi University of Technology: “Our results showed that ten weeks lycopene treatment lowered blood glucose, improved diabetic induced polydipsia, overeating and body weight loss. Lycopene treatment also enhanced bone mineral density, restored bone mechanical and bone Micro-CT parameters of diabetic rats. Subsequently, lycopene decreased serum inflammatory cytokines levels and increased serum anti-oxidant indicators levels. Moreover, lycopene reduced the number of bone marrow adipocytes, and osteoclasts numbers of diabetic rats. The serum bone turnover markers levels were down-regulated after lycopene treatment. Meanwhile, the bone and serum OPG, RUNX 2 expression levels were up-regulated by lycopene in diabetic rats, and the OPG/RANKL ratio was also up-regulated.”

According to the news editors, the research concluded: “This study showed that lycopene could ameliorate diabetic induced bone loss via anti-inflammatory, anti-oxidation, and increasing OPG/RANKL ratio in diabetic rats. Lycopene could be used for nutritional intervention in patients with diabetic osteoporosis.”

 

 

Research shows just 8 weeks of meditation studies can make your brain quicker

Birmingham University (UK), August 12, 2021
Researchers at Binghamton University scanned students' brains before and after eight weeks of meditation training. Credit: Binghamton University

Millions of people around the world seek mental clarity through meditation, most of them following or inspired by the centuries-old practices of Buddhism.

Anecdotally, those who meditate say it helps to calm their minds, recenter their thoughts and cut through the "noise" to show what really matters. Scientifically, though, showing the effects of meditation on the human brainhave proved to be tricky.

A new study from Binghamton University's Thomas J. Watson College of Engineering and Applied Science tracked how practicing meditation for just a couple of months changed the brain patterns of 10 students in the University's Scholars Program.

The seed for the research came from a casual chat between Assistant Professor Weiying Dai and lecturer George Weinschenk, MA '01, Ph.D. '07, both from the Department of Computer Science.

Weinschenk is a longtime meditation practitioner whose wife worked as an administrator at the Namgyal Monastery in Ithaca, which is the North American seat of the Dalai Lama's personal monastery.

"I developed very close friendships with several of the monks," he said. "We would hang out together, and I even received instruction from some of the Dalai Lama's teachers. I took classes there, I read a lot and I earned a three-year certificate in Buddhist studies."

Dai has studied brain mapping and biomedical image processing, and while earning her Ph.D. at the University of Pittsburgh, she tracked Alzheimer's disease patients using magnetic resonance imaging (MRI) scans.

"I'm interested in brain research to see how our brains are really functioning and how all different kinds of disease affect our brain," she said. "I really have zero medical training, but I pick up all this knowledge or background from reading the literature and talking with the experts."

The two faculty members had neighboring offices and shared a conversation one day about their backgrounds. Weinschenk mentioned that he had been asked to teach a semester-long class for the Scholars Program on meditation.

"I told Weiying, 'Yeah, meditation really can have a transformative effect on the brain,'" Weinschenk said. "She was a little skeptical, especially about whether such a short amount of time spent learning how to meditate, whether that would make any difference. She suggested we might be able to quantify such a thing with modern technology."

For the fall 2017 semester, Dai secured grant funding, and their collaboration began. Near the beginning of the semester, she took the participants to Cornell University for MRI scans of their brains. Weinschenk taught students how to meditate, told them to practice five times a week for 10 or 15 minutes, and asked them to keep a journal record of their practice. (The syllabus also included other lessons about the cultural transmissions of meditation and its applications for wellness.)

"Binghamton University Scholars are high achievers who want to do the things they are assigned and do well on them, so they didn't require much prompting to maintain a regular meditation routine," he said. "To guarantee objective reporting, they would relate their experiences directly to Weiying about how frequently they practiced."

The results, recently published in the journal Scientific Reports, show that meditation training led to faster switching between the brain's two general states of consciousness.

One is called the default mode network, which is active when the brain is at wakeful rest and not focused on the outside world, such as during daydreaming and mind-wandering. The other is the dorsal attention network, which engages for attention-demanding tasks.

The findings of the study demonstrate that meditation can enhance the brain connection among and within these two brain networks, indicating the effect of meditation on fast switching between the mind wandering and focusing its attention as well as maintaining attention once in the attentive state.

"Tibetans have a term for that ease of switching between states—they call it mental pliancy, an ability that allows you to shape and mold your mind," Weinschenk said. "They also consider the goal of concentration one of the fundamental principles of self-growth."

Dai and Weinschenk are still parsing through the data taken from the 2017 MRI scans, so they have yet to test other Scholars Program students. Because Alzheimer's disease and autism could be caused by problems with the dorsal attention network, Dai is making plans for future research that could use meditation to mitigate those problems.

"I'm thinking about an elderly study, because this population was young students," she said. "I want to get a healthy elderly group, and then another group with early Alzheimer's disease or mild cognitive impairment. I want to see whether the changes in the brain from meditation can enhance cognitive performance. I'm writing the proposal and trying to attract the funds in that direction."

Though once skeptical about the subject, "I'm pretty convinced about the scientific basis of meditation after doing this study," she added. "Maybe I'll just go to George's class when he teaches it so that I can benefit, too!"

 

Study shows how food preservatives may disrupt human hormones and promote obesity

Cedars-Sinai Medicine Institute, August 9, 2021 

Can chemicals that are added to breakfast cereals and other everyday products make you obese? Growing evidence from animal experiments suggests the answer may be "yes." But confirming these findings in humans has faced formidable obstacles - until now.

A study published in Nature Communications details how Cedars-Sinai investigators developed a novel platform and protocol for testing the effects of chemicals known as endocrine disruptors on humans.

The three chemicals tested in this study are abundant in modern life. Butylhydroxytoluene (BHT) is an antioxidant commonly added to breakfast cereals and other foods to protect nutrients and keep fats from turning rancid; perfluorooctanoic acid (PFOA) is a polymer found in some cookware, carpeting and other products; and tributyltin (TBT) is a compound in paints that can make its way into water and accumulate in seafood.

The investigators used hormone-producing tissues grown from human stem cells to demonstrate how chronic exposure to these chemicals can interfere with signals sent from the digestive system to the brain that let people know when they are "full" during meals. When this signaling system breaks down, people often may continue eating, causing them to gain weight.

"We discovered that each of these chemicals damaged hormones that communicate between the gut and the brain," said Dhruv Sareen, PhD, assistant professor of Biomedical Sciences and director of the Induced Pluripotent Stem Cell Core Facility at the Cedars-Sinai Board of Governors Regenerative Medicine Institute. "When we tested the three together, the combined stress was more robust."

Of the three chemicals tested, BHT produced some of the strongest detrimental effects, Sareen said.

While other scientists have shown these compounds can disrupt hormone systems in laboratory animals, the new study is the first to use human pluripotent stem cells and tissues to document how the compounds may disrupt hormones that are critical to gut-to-brain signaling and preventing obesity in people, Sareen said.

"This is a landmark study that substantially improves our understanding of how endocrine disruptors may damage human hormonal systems and contribute to the obesity epidemic in the U.S.," said Clive Svendsen, PhD, director of the institute and the Kerry and Simone Vickar Family Foundation Distinguished Chair in Regenerative Medicine. More than one-third of U.S. adults are considered to be obese, according to federal statistics.

The new testing system developed for the study has the potential to provide a much-needed, safe and cost-effective method that can be used to evaluate the health effects of thousands of existing and new chemicals in the environment, the investigators say.

For their experiments, Sareen and his team first obtained blood samples from adults, and then, by introducing reprogramming genes, converted the cells into induced pluripotent stem cells. Then, using these stem cells, the investigators grew human epithelium tissue, which lines the gut, and neuronal tissues of the brain's hypothalamus region, which regulates appetite and metabolism.

The investigators then exposed the tissues to BHT, PFOA and TBT, one by one and also in combination, and observed what happened inside the cells. They found that the chemicals disrupted networks that prepare signaling hormones to maintain their structure and be transported out of the cells, thus making them ineffective. The chemicals also damaged mitochondria - cellular structures that convert food and oxygen into energy and drive the body's metabolism.

Because the chemical damage occurred in early-stage "young" cells, the findings suggest that a defective hormone system potentially could impact a pregnant mother as well as her fetus in the womb, Sareen said. While other scientists have found, in animal studies, that effects of endocrine disruptors can be passed down to future generations, this process has not been proved to occur in humans, he explained.

More than 80,000 chemicals are registered for use in the U.S. in everyday items such as foods, personal care products, household cleaners and lawn-care products, according to the National Toxicology Program of the U.S. Department of Health and Human Services. While the program states on its website that relatively few chemicals are thought to pose a significant risk to human health, it also states: "We do not know the effects of many of these chemicals on our health."

Cost and ethical issues, including the health risk of exposing human subjects to possibly harmful substances, are among the barriers to testing the safety of many chemicals. As a result, numerous widely used compounds remain unevaluated in humans for their health effects, especially to the hormone system.

"By testing these chemicals on actual human tissues in the lab, we potentially could make these evaluations easier to conduct and more cost-effective," Sareen said.

 

Social activities help dementia patients stay sharp, avoid depression

University of Sheffield (UK), August 12, 2021

Approximately 6 million people in the U.S. are suffering from dementia, as well 50 million people worldwide. There is currently no cure for the degenerative condition and medical treatments often have side effects such as vomiting, loss of appetite, and muscle pains. Now, researchers say patients can greatly benefit from a type of treatment that doesn’t come with such downsides and helps their brain avoid additional decline.

A new study suggests that mixing with other people helps dementia patients stay sharp and fend off depression. Scientists say the type of treatment known as “cognitive stimulation” could make living with dementia easier for hundreds of thousands of people.

“Dementia is one of the biggest global challenges that we face,” says senior author Dr. Claudia von Bastian, of the University of Sheffield, in a statement. “Our research highlights that cognitive stimulation can be a safe, relatively cheap, and accessible treatment to help reduce some of the core symptoms of dementia and may even alleviate symptoms of depression.”

The researchers analyzed the use of cognitive stimulation as an effective treatment for people with dementia. They found that getting patients involved in social and group activities helped combat depression and boost global cognition.

Global cognition refers to five types of brain function: attention, memory, verbal fluency, language, and awareness. “It’s great that governments now recognize the importance for people to live well with dementia. We’ve seen far more energy and resources put into developing initiatives to support this, such as cognitive stimulation, which is now used widely across the world,” notes co-author Dr. Ben Hicks, of Brighton and Sussex Medical School.

“We still need to learn more about the key ingredients of cognitive stimulation which lead to these benefits and how they influence the progression of dementia. However, the absence of negative side-effects and the low costs of this treatment means the benefits are clear,” adds Dr. von Bastian.

More research is needed to determine whether cognitive stimulation and other non-pharmaceutical treatments could help the growing number of people who suffer fromdementia.

 

 “Our research is the first to comprehensively interrogate the evidence base for its effectiveness, using the most up-to-date statistical techniques. While early signs are positive, there’s an urgent need to improve the rigor of evaluative research and better assess the long-term benefits of cognitive stimulation. People with dementia need effective treatments, and, as a research community, this is what we must deliver,” added Dr. Hicks.

 

 

Resveratrol supplementation improves arterial stiffness in type 2 diabetics

Toho University (Japan), August 18 2021

A randomized, double-blind study reported on in the International Heart journal found improvements in arterial stiffness and oxidative stress among type 2 diabetics who were supplemented with resveratrol.

The trial included 50 diabetic men and women who received 100 milligrams resveratrol or a placebo daily for 12 weeks. Cardio-ankle vascular index (CAVI, a novel diagnostic measure of arterial stiffness that is a marker of atherosclerosis) and blood pressure were assessed at the beginning and end of the study, in addition to blood assessments of oxidative stress and other factors.

At the end of the study, subjects who received resveratrol had significantly lower blood pressure, less oxidative stress and decreased arterial stiffness in comparison with values obtained at the beginning of the study.  Participants who received a placebo experienced no significant changes in these areas.

“The primary finding in the present study was that oral supplementation of resveratrol for 12 weeks decreased CAVI in patients with type 2 diabetes mellitus,” authors Haruki Imamura, MD, and colleagues at Toho University Sakura Medical Center in Japan write. “Many previous studies have demonstrated increased CAVI in atherosclerotic diseases such as acute coronary syndrome and stroke, and these reports indicate that CAVI reflects organic atherosclerosis.”

They suggest that a reduction in oxidative stress may be one mechanism involved in the improvement in arterial stiffness observed in this study among participants who received resveratrol. Improved endothelial function via increased nitric oxide production may be another mechanism.

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