The Gary Null Show

The Gary Null Show - 11.29.22

VIDEOS:
Video Emerges Where Fauci and Others Planned for a “Universal mRNA Flu Vaccine” Which Became the “COVID-19 mRNA Vaccine” Because People were not Afraid Enough of the Flu Virus (1:51)
You’re Not Going To Believe This! | Mark Steyn & Eva Vlaardingerbroek (3:03)
Neil Oliver – ‘…it’s a toxic hell…’ (START @ 9:00)
Gravitas: Who helped Taliban repair the abandoned American aircraft? (7:25)
 
Healthy plant-based diets associated with lower colorectal cancer risk in menKyung Hee University, South Korea, November 28, 2022
Eating a plant-based diet rich in healthy plant foods—such as whole grains, vegetables, and legumes—and low in unhealthy plant foods—including refined grains, fruit juices, and added sugars—is associated with a lower risk of colorectal cancer in men. The findings are published in the open access journal BMC Medicine.Jihye Kim, the corresponding author, said, “Colorectal cancer is the third-most common cancer worldwide, and the risk of developing colorectal cancer over a lifetime is one in 23 for men and one in 25 for women. Although previous research has suggested that plant-based diets may play a role in preventing colorectal cancer, the impact of plant foods’ nutritional quality on this association has been unclear. Our findings suggest that eating a healthy plant-based diet is associated with a reduced risk of colorectal cancer.” Researchers from Kyung Hee University, South Korea found that among a population of 79,952 American men, those who ate the highest average daily amounts of healthy plant-based foods had a 22% lower risk of colorectal cancer, compared to those who ate the lowest amounts of healthy plant foods. However, the authors did not identify any significant associations between the nutritional quality of plant-based diets and colorectal cancer risk among a population of 93,475 American women. Jihye Kim said, “We speculate that the antioxidants found in foods such as fruits, vegetables, and whole grains could contribute to lowering colorectal cancer risk by suppressing chronic inflammation, which can lead to cancer. As men tend to have a higher risk of colorectal cancer than women, we propose that this could help explain why eating greater amounts of healthy plant-based foods was associated with reduced colorectal cancer risk in men but not women.” The authors found that the association between the nutritional quality of plant-based diets and colorectal cancer risk among men varied by race and ethnicity. Among Japanese American men, colorectal cancer risk was 20% lower for those who ate the highest amount of healthy plant foods per day than for those who ate the lowest amount. Among white men, those who ate the highest amount of highest amount of healthy plant foods had a 24% lower colorectal cancer risk than those who ate the lowest amount. The authors did not identify any significant associations between plant-based diets and colorectal cancer risk among African American, Latino or Native Hawaiian men.
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Green Mediterranean diet reduces twice as much visceral fat as traditional Mediterranean dietBen-Gurion University of the Negev (Israel), November 28, 2022
Following the green Mediterranean diet significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra “tire” around your waist. Recently, researchers compared the green Mediterranean diet to the traditional Mediterranean diet and a non-Mediterranean healthy diet in a large-scale clinical interventional trial—the DIRECT PLUS. Subsequent analysis found that the green Mediterranean diet reduced visceral fat by 14%, the Mediterranean diet by 7% and the non-Mediterranean healthy diet by 4.5%. The study was published in BMC Medicine. Reducing visceral fat is considered the true goal of weight loss, as it is a more important indicator than a person’s weight or the circumference of their waist. Visceral fat aggregates over time between organs, and produces hormones and poisons linked to heart disease, diabetes, dementia and premature death. The DIRECT-PLUS trial research team was the first to introduce the concept of the green Mediterranean diet. This modified Mediterranean diet is further enriched with dietary polyphenols and is lower in red/processed meat than the traditional Mediterranean diet. On top of a daily intake of walnuts (28 grams), the participants consumed 3-4 cups of green tea/day and 100 grams (frozen cubes) of duckweed green shake/day. The aquatic green plant duckweed is high in bioavailable protein, iron, B12, vitamins, minerals, and polyphenols and substituted meat intake. The team has shown in previous studies that the green Mediterranean diet has a variety of salutary effects ranging from the microbiome to age-related degenerative diseases. A group of 294 participants took part in the 18-month long trial. “A 14% reduction in visceral fat is a dramatic achievement for making simple changes to your diet and lifestyle. Weight loss is an important goal only if it is accompanied by impressive results in reducing adipose tissue,” notes Dr. Hila Zelicha.
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Are older women being over-screened for cervical cancer?University of Illinois at Chicago, November 28, 2022
A new study published in JAMA Internal Medicine suggests that women over the age of 65 may be undergoing unnecessary cervical cancer screenings and that more public health data is needed on the utilization of cervical cancer screening-associated services among older women to prevent potential harm and unnecessary costs.
The study, which is authored by experts from the University of Illinois Chicago, the University of California San Francisco and the U.S. Centers for Disease Control and Prevention, looked at Medicare claims data from 1999 to 2019 for fee-for-service care for women over the age of 65.
The analysis showed that in 2019 more than 1.3 million women received cervical cancer screening-associated services, such as a Pap test, colposcopy, and other cervical procedures after age 65. While these services cost more than $83 million, the researchers concluded they were of “unclear clinical appropriateness.”
“Cervical cancer screening and other preventive services are among our most important tools for keeping people healthy throughout life, but screenings should also follow evidence-based guidelines to prevent overspending, potential complications and patient discomfort,” said study co-author Dr. Hunter Holt, assistant professor of family and community medicine at the University of Illinois Chicago.
According to recommendations and guidelines from the U.S. Preventive Services Task Force, the American Cancer Society and the American College of Obstetrics and Gynecology, women considered to be of average risk can stop undergoing routine cervical cancer screening once they reach the age of 65 if they have had adequate prior screening. “The decision to end cervical cancer screening for women after age 65 requires review of past screening results and related medical history. This process can promote cervical cancer prevention and prevent harms and costs from unnecessary tests and procedures,” said Jin Qin, study co-author and epidemiologist in CDC’s Division of Cancer Prevention and Control.
The researchers say that the high rates of screening among older women is potentially concerning.
“It could be that women are getting screened when they do not need to, or that these women are considered to be at higher-than-average risk, for example, because they have not been adequately screened prior to 65. We do not want to see either of these things and unfortunately, there is not enough public health data to shed light on the causes,” said Holt, who is also affiliated with the University of Illinois Cancer Center at UIC.
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Chemotherapy could increase disease susceptibility in future generationsWashington State University, November 28, 2022
A common chemotherapy drug could carry a toxic inheritance for children and grandchildren of adolescent cancer survivors, Washington State University-led research indicates.
The study, published online in iScience, found that male rats who received the drug ifosfamide during adolescence had offspring and grand-offspring with increased incidence of disease. While other research has shown that cancer treatments can increase patients’ chance of developing disease later in life, this is one of the first-known studies showing that susceptibility can be passed down to a third generation of unexposed offspring.
“The findings suggest that if a patient receives chemotherapy, and then later has children, that their grandchildren, and even great-grandchildren, may have an increased disease susceptibility due to their ancestors’ chemotherapy exposure,” said Michael Skinner, a WSU biologist and corresponding author on the study.
Given this study’s implications, the researchers recommend that cancer patients who plan to have children later take precautions, such as using cryopreservation to freeze sperm or ova before having chemotherapy.
In the study, researchers exposed a set of young male rats to ifosfamide over three days, mimicking a course of treatment an adolescent human cancer patient might receive. Those rats were later bred with female rats who had not been exposed to the drug. The resulting offspring were bred again with another set of unexposed rats.
The first-generation offspring had some exposure to the chemotherapy drug since their fathers’ sperm was exposed, but researchers found greater incidence of disease in not only the first- but also the second-generation, who had no direct exposure to the drug. While there were some differences by generation and sex, the associated problems included greater incidence of kidney and testis diseases as well as delayed onset of puberty and abnormally low anxiety, indicating a lowered ability to assess risk.
The results of the researchers’ analysis showed epigenetic changes in two generations linked to the chemotherapy exposure of the originally exposed rats. The fact that these changes could be seen in the grand-offspring, who had no direct exposure to the chemotherapy drug, indicates that the negative effects were passed down through epigenetic inheritance.
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Saffron can fight liver cancer, reveal UAE researchersUnited Arab Emirates University, November 20, 2022
It may be an expensive spice but you cannot put a label or price on health, said Professor Amr Amin who has researched a breakthrough in the properties of saffron in fighting liver cancer.
Professor Amin from Cellular & Molecular Biology at United Arab Emirates University said that researchers have investigated and found saffron to have anti-liver cancer properties.
“Safranal, a major biomolecule of the golden spice saffron arrests and stops the cancer cell division at two different stages,” he said.
The UAE researchers have been working on this project since 2011 when they first published the research in the Hepatology Journal.
The study suggests a novel mechanism of anti-proliferative activity of safranal against human liver cancer cells.
“This molecule could serve as a novel and/or adjuvant drug to treat liver cancer,” said Dr Amin.
The findings are now also published in a Nature journal Scientific Reports.
“The ingredient works in two ways; it stops cell division and promotes cell death,” he explained.
Prof Amin and colleagues concluded that safranal exerts its anticancer effect in HepG2 cells by inhibiting DNA repair, resulting in increased DNA damage.
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Japanese researchers say that ultrasound therapy can be used to treat patients with dementiaTohoku University (Japan), November 20, 2022
A new therapy based on ultrasound waves might be able to improve the cognitive powers of patients suffering from Alzheimer’s disease and other forms of dementia. According to an article on the Tohoku University news page, the approach improved the condition of mice with symptoms similar to human dementia.
In their experiment, the Tohoku University research team sent low-intensity pulsed ultrasound (LIPUS) waves through the brain of the mice. They found that the waves improved the creation of blood vessels and the rate of regeneration of nerve cells.
Furthermore, the treatment did not cause any notable side effects on the mice. The results led the researchers to believe that they can replicate their experimental success in actual human patients one day.
“The LIPUS therapy is a non-invasive physiotherapy that could apply to high-risk elderly patients without the need for surgery or anaesthesia, and could be used repeatedly,” explained TU researcher Hiroaki Shimokawa.
The Tohoku researchers applied LIPUS therapy to the whole brain of mice with symptoms that resemble those of Alzheimer’s disease or vascular dementia. They did this three times a day, with each session lasting for 20 minutes.The mice that simulated vascular dementia underwent surgery that reduced the amount of blood that reached the brain. These animals underwent LIPUS treatment on the first, third, and fifth days after that surgery. Meanwhile, the mice that modeled Alzheimer’s disease got 11 LIPUS treatments over a three-month-long trial period.
By the end of the experiment, the researchers found that LIPUS activated genes involved with the cells that made up the inner lining of blood vessels. Furthermore, an enzyme that promoted blood vessel formation displayed increased activity, as did a protein which helped nerve cells grow.
Based on their findings, whole-brain LIPUS therapy can help alleviate the symptoms of certain forms of dementia by encouraging the development of cells that are normally affected by the condition. The technique is currently undergoing initial clinical trials that will determine its efficacy and safety.

The Gary Null Show - 11.28.22

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Neil Oliver – ‘…it’s a toxic hell…’ (START @ 9:00)
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Pomegranate juice found to combat systemic inflammation throughout the bodyUniversity of Bologna (Italy) & University of Auckland (New Zealand), November 18, 2022
The researchers from the University of Bologna and the University of Auckland looked at the effects of the juice of the pomegranate in particular, which has already been shown to help conditions like diabetes, atherosclerosis and prostate cancer. Chronic inflammation, a response by the body to infection and tissue damage, has been linked to the development of disorders such as inflammatory bowel disease, asthma, rheumatoid arthritis, chronic obstructive pulmonary disease and psoriasis. After analyzing an extensive number of existing studies on pomegranate, they found plenty of evidence that shows pomegranate juice can indeed help inflammation-related diseases, although they pointed out that a definitive relationship has not been officially established. Most of the scientific research on pomegranate’s health benefits has been carried out on cell culture or animal models, they point out, and clinical trials with humans are generally lacking. They found that pomegranate seems to show the most promise in fighting cardiovascular diseases, metabolic syndrome and diabetes, but the researchers urge care, calling on further studies to determine its specific effects and explain why the fruit juice seems to help chronic inflammatory diseases. A Case Western study published in the Journal of Inflammation, for example, found that the extract of pomegranate significantly inhibited the buildup of damaging proteins associated with Alzheimer’s disease by as much as a half. This effect is being attributed to its ability to protect against the oxidative stress that leads to beta-amyloid deposits. Researchers have also demonstrated its potential to help those with prostate, colon and breast cancer. In studies where tumor cells were treated with pomegranate, cell migration dropped and the cancer was stopped from spreading to other areas of the body. Pomegranate juice came out on top in a study of beverages known for their antioxidant content carried out by the Center for Human Nutrition at the University of California – Los Angeles’s David Geffen School of Medicine. While all of the beverages examined – blueberry juice, acai berry juice, green tea, white tea, Concord grape juice, orange juice, pomegranate juice and red wine, had impressive amounts of antioxidants, pomegranate juice outperformed them all when it came to polyphenols and protective benefits. Its antioxidant potency composite index was a full 20 percent higher than any of the other drinks that were put through the rigorous testing.
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Handful of walnuts daily cuts risk of asthmaUniversity of North’s Carolina, November 20, 2022
Here’s another reason for you to eat more walnuts as a type of vitamin E, found in these nuts, may prevent the risk of asthma attacks by reducing airway inflammation. According to researchers, sufferers of a common breathing condition, taking it as part of the study, were also found to have less sticky mucus in their lungs. Gamma-tocopherol is a major form of vitamin E, which is abundant in nuts like walnuts and pecans and in the legume peanut, as well as seed oils such as corn, soybean and sesame. Senior study author Professor Michelle Hernandez from the University of North’s Carolina school of medicine said epidemiologic data suggested that people with high amounts of vitamin E in their diet were less prone to asthma and allergic disease. The team randomly analysed participants into two groups, one that received gamma tocopherol supplement and other that received a placebo for two weeks. After a three-week period break, the findings indicated that when people were taking the vitamin E supplement, they had less eosinophilic inflammation. In addition, those who were taking vitamin E were also found to have lower levels of proteins called mucins, which affect the stickiness of mucus. Mucins are often elevated in asthmatics.
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Using vapes may set the stage for dental decayTufts University, November 23, 2022
A vaping habit could end up leading to a tarnished smile, and more frequent visits to the dentist. Research by faculty from Tufts University School of Dental Medicine found patients who said they used vaping devices were more likely to have a higher risk of developing cavities. With CDC surveys reporting that 9.1 million American adults—and 2 million teenagers—use tobacco-based vaping products, that means a lot of vulnerable teeth. The findings of this study on the association between vaping and risk of caries—the dental term for cavities—serve as an alert that this once seemingly harmless habit may be very detrimental, says Karina Irusa, assistant professor of comprehensive care and lead author on the paper. The study was published in The Journal of the American Dental Association. Irusa says that the recent Tufts finding may be just a hint of the damage vaping causes to the mouth. “The extent of the effects on dental health, specifically on dental decay, are still relatively unknown,” she says. “At this point, I’m just trying to raise awareness,” among both dentists and patients. This study, Irusa says, is the first known specifically to investigate the association of vaping and e-cigarettes with the increased risk for getting cavities. She and her colleagues analyzed data from more than 13,000 patients older than 16 who were treated at Tufts dental clinics from 2019-2022. While the vast majority of the patients said they did not use vapes, there was a statistically significant difference in dental caries risk levels between the e-cigarette/vaping group and the control group, Irusa found. Some 79% of the vaping patients were categorized as having high-caries risk, compared to just about 60% of the control group. The vaping patients were not asked whether they used devices that contained nicotine or THC, although nicotine is more common. It’s also been observed that vaping seems to encourage decay in areas where it usually doesn’t occur—such as the bottom edges of front teeth. “It takes an aesthetic toll,” Irusa says.
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Study finds link between foods scored higher by new nutrient profiling system and better long-term health outcomesTufts University, November 22, 2022
The idea that what we eat directly affects our health is ancient; Hippocrates recognized this as far back as 400 B.C. But, identifying healthier foods in the supermarket aisle and on restaurant menus is increasingly challenging. Now, researchers at the Friedman School of Nutrition Science and Policy at Tufts have shown that a holistic food profiling system, Food Compass, identifies better overall health and lower risk for mortality. In a paper published in Nature Communications, researchers assessed whether adults who ate more foods with higher Food Compass scores had better long-term health outcomes and found that they did. Introduced in 2021, Food Compass provides a holistic measure of the overall nutritional value of a food, beverage, or mixed meal. It measures nine domains of each item, such as nutrient ratios, food-based ingredients, vitamins, minerals, extent of processing, and additives. Based on scores of 10,000 commonly consumed products in the U.S., researchers recommend foods with scores of 70 or above as foods to encourage; foods with scores of 31-69 to be eaten in moderation; and anything that scores 30 or below to be consumed sparingly. For this new study, Food Compass was used to score a person’s entire diet, based on the Food Compass scores of all the foods and beverages they regularly consume. For this validation study, researchers used nationally representative dietary records and health data from 47,999 U.S. adults aged 20-85 who were enrolled between 1999-2018 in the National Health and Nutrition Examination Survey (NHANES). Deaths were determined through linkage with the National Death Index (NDI). Overall, researchers found that the mean Food Compass score for the diets of the nearly 50,000 subjects was only 35.5 out of 100, well below ideal. “One of the most alarming discoveries was just how poor the national average diet is,” said O’Hearn. “This is a call for actions to improve diet quality in the United States.” A higher Food Compass diet score was associated with lower blood pressure, blood sugar, blood cholesterol, body mass index, and hemoglobin A1c levels; and lower prevalence of metabolic syndrome and cancer. A higher Food Compass diet score was also associated with lower risk of mortality: for each 10-point increase, there was a 7 percent lower risk of death from all causes. Food Compass also boosts scores for ingredients shown to have protective effects on health, like fruits, non-starchy vegetables, beans and legumes, whole grains, nuts and seeds, seafood, yogurt, and plant oils; and lowers scores for less healthful ingredients like refined grains, red and processed meat, and ultra-processed foods and additives. “We know Food Compass is not perfect,” said Mozaffarian. “But, it provides a more comprehensive, holistic rating of a food’s nutritional value than existing systems, and these new findings support its validity by showing it predicts better health.”
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Acupuncture can relieve lower back and pelvic pain often experienced during pregnancyGuangzhou University of Chinese Medicine, November 21, 2022
Acupuncture can significantly relieve the lower back and/or pelvic pain frequently experienced by women during their pregnancy, suggests a pooled data analysis of the available evidence, published in BMJ Open. And there were no observable major side effects for newborns whose moms opted for the therapy, the findings indicate, although only a few of the published studies included in the analysis evaluated outcomes, such as premature birth, note the researchers. To add to the evidence base, the researchers trawled research databases for relevant clinical trials that compared the pain relief afforded to pregnant womengiven acupuncture, alone or when combined with other therapies, with other/no/dummy treatments, as well as the potential impact on their newborns. The final analysis included 10 randomized controlled trials, involving 1,040 women. Every study was published between 2000 and 2020, and carried out variously in Sweden, the UK, the U.S., Spain and Brazil. The moms-to-be were all healthy, 17 to 30 weeks into their pregnancy on average, and had lower back and/or pelvic pain. Pooled data analysis of the trial results for nine studies suggested that acupuncture significantly relieved pain during pregnancy. Four of those studies reported on the potential of acupuncture to restore physical function, and the results showed that this was significantly improved. Quality of life was recorded in five studies. When the results of these were pooled, the findings suggested that acupuncture significantly improved this too. Pooled data analysis of four studies indicated that there was a significant difference in overall effects when acupuncture was compared with other or no interventions. The researchers conclude that acupuncture merits closer attention for its potential to ease pain at a time when it’s preferable to avoid drugs because of their potential side effects for mother and baby.
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6 Health Benefits Of Rutin, And Where To Find ItGreenMedInfo, November 24, 2022
Rutin is an antioxidant and anti-inflammatory powerhouse found in a variety of delicious food that may boost your health via multiple avenues, from promoting healthy circulation to providing pain relief.
Rutin is one of about 4,000 types of flavonoids that are found abundantly in plants. Also known as rutoside and vitamin P, rutin is a flavonol that acts as an active constituent in tea leaves, apples, buckwheat, most citrus fruits and passion flower, for example, with nutraceutical effects that have been valued since ancient times.
Medicinal plant compounds often have a range of biological activities that are both impressive and varied. Rutin is no exception, with a number of pharmacological activities that include:
Six Top Reasons to Try RutinRutin is perhaps best known for its ability to ward off oxidative stress via potent antioxidant properties. This makes it valuable in a number of disease conditions and even as a tool for healthy aging. Rutin, for instance, reduces skin aging by strengthening dermal density and elasticity, and is found in more than 130 registered therapeutic medicinal preparations.
GreenMedInfo.com has additionally compiled nearly 70 pharmacological actions related to rutin, along with 136 diseases that it may be useful for. Some of its top health benefits follow.
Protection From Neurodegenerative Disease
Rutin has demonstrated benefits to the central nervous system, including prevention of neuroinflammation, anticonvulsant activity and antidepressant effects. Rutin may be useful for recovery after stroke and also shows promise for Alzheimer’s disease.
With an ability to cross the blood-brain barrier, rutin may benefit the cognitive and behavioral symptoms of neurodegenerative diseases and helps to remove the inflammatory component of neurodegeneration.
Relieve Arthritis Pain
Rutin not only has analgesic and antinociceptive effects but also antiarthritic effects, making it an ideal natural option for arthritis.The plant compound has been found to suppress oxidative stress in people with rheumatoid arthritis,while also inhibiting both the acute and chronic phases of inflammation in an arthritis rat model.
Antidiabetic Effects
Rutin has beneficial effects on the endocrine system, including antidiabetic and anti-hypercholesterolemic effects. Rutin helps fight diabetes by decreasing carbohydrates absorption from the small intestine, increasing the uptake of glucose into tissues and stimulating the secretion of insulin from beta cells, leading to antihyperglycemic effects as well as protection against the development of diabetic complications.
Rutin is also useful for protecting against age-related metabolic dysfunction, with research suggesting it inhibits age-related mitochondrial dysfunction and oxidative stress, as well as endoplasmic reticulum, or ER, stress, which is related to proteins that are not properly folded.
Promote Healthy Circulation and Reduce Blood Clots
Consuming rutin, either from foods or supplements, may be an effective way to block the formation of blood clots. Research by Harvard Medical School researchers suggests that rutin is effective against both platelet-rich clots that form in arteries and fibrin-rich clots that form in veins.
Rutin was found to be a “champion compound” for inhibiting protein disulfide isomerase (PDI), which plays a role in the initial stages of clot formation. A nano-formulation of rutin was also found to exert powerful antithrombotic effects by inhibiting PDI,while rutin may also augment the production of nitric oxide in human endothelial cells, which is useful for blood pressure and cardiovascular system health.
In terms of improved circulation, rutin is a venoactive compound, which means it may be useful for symptoms of chronic venous diseases (CVD). The compound has been demonstrated to reduce severity of lower leg pain, leg cramps, heaviness and itching, as well as edema (swelling), in people with CVD.
Anticancer Effects
Rutin’s anticancer properties have been extensively studied. In human leukemia cells, rutin led to a significant reduction in tumor size, and it’s known to inhibit cancer cell growth by cell cycle arrest and apoptosis. It also inhibits proliferation and metastasis of colorectal cancer cell lines and shows promise for use in ovarian and color cancers, as well as neuroblastoma.
Support Gastrointestinal Health
Rutin has antiulcer effects, as it inhibits the gastric proton pump that sends acid to your stomach. It also has potential against inflammatory bowel disease, not only due to its antioxidant effects but also by suppressing the release of proinflammatory mediators and the expression of inflammatory proteins.
Top Sources of Rutin
As noted in the Saudi Pharmaceutical Journal, “An ancient saying ‘an apple a day, keeps doctor away’ seems to be true as rutin, one of the important constituents of apples, has a wide array of biological activities.”

The Gary Null Show - 11.25.22

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The ultimate stress buster: L-theanine
Columbia University Medical Center,  November 16, 2022
Honestly, who would have thought that stress can cause heart damage equivalent to smoking five cigarettes?
This is according to a study conducted by Columbia University Medical Center and published in the American Journal of Cardiology. 
The study reveals how an amino acid known as L-theanine reduces both stress levels and heart rate.  As a way to increase stress levels, scientists asked 12 participants to solve a mentally stressful task in four double blind trials.
L-theanine was given to participants in one of the four trials before dealing with the stressful task.  In the second group, study subjects took L-theanine midway through the work.  In the third and fourth variations, subjects were respectively given a placebo and nothing at all before attempting the task.
In comparison to the placebo group, there was a reduced amount of immunoglobulin (a stress marker in saliva released by the immune system after exposure to viruses, bacteria, and other foreign entities) and a lower heart rate in participants who took L-theanine.
The researchers explained that L-theanine works by suppressing the sympathetic nervous system responsible for the ‘fight or flight’ response during emergency situations.
This is achieved by blocking a chemical known as glutamate (L-glutamic acid) that carries electric signals transmitted from nerve cells to the rest of the body cells. The conclusion was that L-theanine plays a major role in terms of influencing psychology (mind) and physiology (body) function during stressful situation.
Greater flavonoid intake associated with less arterial calcification
Edith Cowen University (Australia), November 23 2022. 
The December 2022 issue of Arteriosclerosis, Thrombosis, and Vascular Biology reported a study that uncovered a relationship between greater consumption of plant compounds known as flavonoids and decreased calcification in the abdominal aorta, which supplies blood to the abdominal organs and lower limbs. 
Greater abdominal aortic calcification has been associated with an increased risk of stroke, heart attack and dementia. 
The study included 881 participants in the Perth Longitudinal Study of Ageing Women. Dietary questionnaire responses were analyzed to determine total and individual flavonoid intake. 
Women whose total flavonoid intake was among the top 25% of participants had a 36% lower risk of extensive abdominal aortic calcification than women whose intake was among the lowest 25%. Among women whose intake of individual flavonoids known as flavan-3-ols and flavonols was among the top 25%, respective risks were 39% and 38% lower. 
Those who consumed 2–6 cups per day of black tea (the main source of total flavonoid intake in this study), had a 16%–42% lower risk of extensive abdominal aortic calcification than women who were not tea drinkers. 
“In most populations, a small group of foods and beverages—uniquely high in flavonoids—contribute the bulk of total dietary flavonoid intake,” first author Ben Parmenter noted. “The main contributors are usually black or green tea, blueberries, strawberries, oranges, red wine, apples, raisins/grapes and dark chocolate.” 
“Out of the women who don’t drink black tea, higher total non-tea flavonoid intake also appears to protect against extensive calcification of the arteries,” he continued. “This implies flavonoids from sources other than black tea may be protective against abdominal aortic calcification when tea is not consumed.”
“Abdominal aortic calcification is a major predictor of vascular disease events, and this study shows intake of flavonoids, that could protect against abdominal aortic calcification, are easily achievable in most people’s diets,” he concluded.
Researchers discover that vitamin C improves health for children of pregnant smokers
Oregon Health & Science University, November 22, 2022
Researchers at Oregon Health & Science University have found that vitamin C supplementation to pregnant women unable to quit smoking significantly improves airway function and respiratory health in their offspring at 5 years of age.
While previous studies have shown that vitamin C improves airway function in infants, this is the first study to demonstrate that the improvement in airway function can be maintained through preschool age.
The study published this week in JAMA Pediatrics.
Despite anti-smoking efforts and a steady decrease of smoking among the adult population over the past decade, the addictive properties of tobacco products can make quitting smoking incredibly challenging for many individuals. Roughly 10% of American women continue to smoke in pregnancy, each year resulting in about 400,000 infants being exposed to smoke in-utero, or in the uterus.
In-utero smoke exposure from maternal smoking during pregnancy can be dangerous for a developing baby and is linked to poor health outcomes, including impaired fetal lung development, decreased airway function and an increased risk for wheezing and asthma. Additionally, decreased airway growth early in life causes increased risk for serious lifelong conditions, such as chronic obstructive pulmonary disease, which is now the third leading cause of death worldwide.
For this study, participating women were enrolled in a double-blind, randomized controlled trial to receive either vitamin C (500 mg/day) or a placebo.
Statistical analyses showed that the effect of vitamin C supplementation to pregnant smokers prior to 23 weeks of gestation consistently resulted in significantly better airway function in their offspring at 5 years old.
While the findings may improve the health of the many children who face in-utero smoke exposure, these findings may have even broader implications: The results may potentially lead to better understanding of—and treatments for—the health impacts of other smoke exposures, including indoor and outdoor air pollution, vaping and wildfires.
Decades of air pollution undermine the immune system, lymph nodes study finds
Columbia University Irving Medical Center, November 23, 2022
The diminished power of the immune system in older adults is usually blamed on the aging process. But a new study by Columbia immunologists shows that decades of particulate air pollution also take a toll.
The study found that inhaled particles from environmental pollutants accumulate over decades inside immune cells in lymph nodes associated with the lung, eventually weakening the cells’ ability to fight respiratory infections.
The findings—published Nov. 21 in Nature Medicine—offer a new reason why individuals become more susceptible to respiratory diseases with age.
The Columbia researchers weren’t initially looking at air pollution’s influence on the immune system. More than ten years ago, they began to collect tissues from deceased organ donors to study immune cells in multiple mucosal and lymphoid tissues. Such cells have been largely inaccessible to researchers studying the immune system where sampling is limited to peripheral blood.
“When we looked at people’s lymph nodes, we were struck by how many of the nodes in the lung appeared black in color, while those in the GI tract and other areas of the body were the typical beige color,” says Donna Farber, Ph.D., the George H. Humphreys II Professor of Surgical Sciences at Columbia University , who led the study.
And as the researchers collected more tissue from younger donors, they also noticed an age difference in the appearance of the lung’s lymph nodes: Those from children and teenagers were largely beige while those from donors over age 30 looked were tinged with black and got darker with increasing age.
“When we imaged the lung’s blackened lymph nodes and found they were clogged with particles from airborne pollutants, we started to think about their impact on the lung’s ability to fight infection as people age,” Farber says.
In the new study, she and her colleagues examined tissues from 84 deceased human organ donors ranging in age from 11 to 93, all nonsmokers.
They found that the pollutant particles in the lung’s lymph nodes were located inside macrophages, immune cells that engulf and destroy bacteria, viruses, cellular debris, and other potentially dangerous substances.
The macrophages containing particulates were significantly impaired: they were much less capable of ingesting other particles and producing cytokines—chemical “help” signals—that activate other parts of the immune system. Macrophages in those same lymph nodes that did not contain particulates were unimpaired.
“We do not know yet the full impact pollution has on the immune system in the lung,” Farber adds, “but pollution undoubtedly plays a role in creating more dangerous respiratory infections in elderly individuals and is another reason to continue the work in improving air quality.”
Biologist explains how cannabinoids cause tumor cells to commit suicide
Compultense University (Spain): November 17, 2018
A molecular biologist from Compultense University in Madrid, Christina Sanchez, has been studying the molecular activity of cannabinoids for over a decade. Through her studies, she and colleagues found that tetrahydrocannabinol , (THC) which is the main psychoactive part of cannabis, kills tumerous cells while allowing healthy cells to be. It was an unexpected discovery when Sanchez and crew were studying brain cancer cells to grasp a better understanding of how they function. They observed that when cells were exposed to THC, the tumeral cells stopped growing then destroyed themselves. This occurred both in lab tests and animal trials. Sanchez first reported her miraculous findings back in 1998.
According to Sanchez ,”After the discovery of this compound that is called THC, it was pretty obvious that this compound had to be acting on the cells, on our organism, through a molecular mechanism.” Research finds that the human body is designed to use cannabis compounds. In the eighties, research first showed the human body contains two targets for THC. One is the endocannabinoid system which processes THC through an endogenous framework. Then the various cannabinoid receptors throughout the body that use them. In conjunction, the body benefits from cannabinoids via these two natural systems. Cannabis is the only place in nature where some certain cannabinoids are found.
Sanchez continues, “The endocannabinoids, together with the receptors and the enzymes that synthesize, that produce, the endocannabinoids and that degrade the endocannabinoids, are what we call the endocannabinoid system. We now know that the endocannabinoid system regulates a lot of biological functions: appetite, food intake, motor behavior, reproduction, and many, many other functions. And that’s why the plant has such a wide therapeutic potential.”
Cannabis cannabinoids, when consumed, work with the body’s natural endocannabinoid system and bind to the receptors in the same manner as endogenous cannabinoids. The effects cancer-wise as demonstrated in animal models of breast and brain cancers is that the cancerous cells self destruct. A big advantage of cannabinoids is their unique ability to specifically target tumor cells with no effect on normal cells. This gives cannabinoids the advantage over chemotherapy which targets way more then the actual target
Spending Time in the Forest or the Field: Investigations on Stress Perception and Psychological Well-Being
University of Freiburg (Germany), November 16, 2022Research suggests that stays in a forest promote relaxation and reduce stress compared to spending time in a city. The aim of this study was to compare stays in a forest with another natural environment, a cultivated field. Healthy, highly sensitive persons  aged between 18 and 70 years spent one hour in the forest and in the field at intervals of one week. The primary outcome was measured using the Change in Subjective Self-Perception (CSP-14) questionnaire. Secondary outcomes were measured using the Profile Of Mood States (POMS) questionnaire and by analyzing salivary cortisol. The medicinal use of forests is of increasing interest worldwide. Forest air is refreshing because trees clean the air of pollutants such as nitrogen oxides and sulfur oxides, produce oxygen, and release volatile bioactive terpenes into the air . Research from Japan, South Korea], China, Taiwan, Australia, the United States, Italy, Norway, Iceland, Finland, and Austria suggests that spending time in the forest promotes relaxation, lowers stress hormones and blood pressure and strengthens the immune system. Most studies compared stays in the forest to stays in the city. Accordingly, forests potentially contribute to the prevention of stress-related diseases. Controlled studies have shown positive effects in high blood pressure, chronic heart failure, COPD and chronic neck pain. In addition, spending time in the forest seems to improve psychological well-being.Spending time in forests reduced adrenaline and noradrenaline in urine, cortisol in saliva and self-rated stress perception; it also induced relaxation in controlled trials. This indicates that forest stays can reduce stress.The available data also indicate that “forest bathing”, i.e., walking, standing or sitting in a forest with the purpose of relaxation, perceiving the environment and inhaling phytoncides stabilizes the autonomic nervous system by reducing the sympathetic and activating the parasympathetic tones. With regard to the immune system, which is linked to stress response and vegetative nerve system, an increase in the activity of natural killer cells and the expression of anti-cancer proteins such as perforin, granzyme A/B, granulysin could be demonstrated. In view of these findings, forests could make an important contribution to the prevention of stress-related diseases.As shown in previous studies, the stressful environment of a city was most often compared to a forest; it remains unclear whether forests have specific effects or are just acting as natural environments. Therefore, we wanted to compare two natural but polar-opposite environments. In cultivated fields, sensory impressions are different from the forest. In order to maximize profitability, fields are mostly structured into rectangular shapes and usually mainly one type of plant is found, while in a natural forest, different types of plants grow side by side. Accordingly, visual, auditory and olfactory impressions are less diverse in fields than in forestsThe play of light and shadow that characterizes the forest atmosphere is not found in fields. The plants are usually not tall enough to provide shade, whereas the height of the trees in the forest can provide a sense of shelter. Field paths are more often sealed than forest paths, which changes haptic perception when walking on them. Thus, there are significant differences in the types of sensory impressions between forests and fields.  Highly sensitive persons (HSP), due to their subtle perception, intensely perceive stimuli that others might not even consciously notice. These stimuli may consist of the behavior or moods of other people, the media, medications, pain, and hunger [32]. They perceive stimuli, positively or negatively, to a higher degree, which may, on the one hand, lead to a prolonged reaction time, and on the other hand to more intense feelings and emotional excitability.Our main outcome results show that, as soon as one hour after entering the forest, participants felt a sense of security, relaxation and inner connectedness. In summer, forest interventions had a better effect on vitality. Our study was the first to use the CSP-14 questionnaire, and the comparisons between field and forest interventions were also novel. Forest interventions significantly lowered perceptions of depression, anxiety, hostility, fatigue, confusion and total mood disturbance, and greatly increased vigor.This study shows that forests are not the only kind of natural environment that can promote psychological well-being. The characteristics and qualities of natural environments might influence people’s mood and well-being differently. There might also be differences dependent on the preferences of the respective individuals. We regard it as meaningful to study these different effects of nature on the human soul and body in more detail. In addition, future studies examining the effects of different natural environments on human health should respect seasonal aspects and weather conditions.

The Gary Null Show - 11.23.22

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Greater niacin intake linked with lower mortality risk among cancer patients during 15-year period
First People’s Hospital in China, November 21 2022. 
A study reported  in BMC Cancer found that men and women with cancer who consumed a higher amount of niacin (vitamin B3) from food or supplements had a lower risk of dying from the disease during a 15-year follow-up period than patients with lower consumption. 
Researchers analyzed data from 3,504 cancer patients who participated in the National Health and Nutrition Examination Surveys (NHANES) between 1999 and 2014. 
Among participants whose niacin intake from food was among the top 25%, the adjusted risk of mortality from all causes was 27% lower, and the risk of dying from cancer was 49% lower during follow-up compared with participants whose intake was among the lowest 25%. Each 10 mg per day increase in dietary niacin was associated with an adjusted 11% lower risk of all-cause mortality and a 19% reduction in the risk of cancer mortality. 
Total daily niacin intake was 76.4 mg per day among participants who reported using niacin supplements compared to 21.4 mg per day among those who did not supplement. Cancer mortality was 52% lower among those who supplemented with niacin versus unsupplemented participants. 
“Our study found that higher intake of dietary niacin was associated with lower risk of mortality from all-causes and cancer mortality,” Hongyan Ying Taizhou of First People’s Hospital in China and colleagues concluded. “The consumption of niacin had a dose-effect relationship for all-cause mortality, but not for cancer mortality. This conclusion was verified by the data of supplemental niacin consumption.”
Study: Antioxidant flavonols linked to slower memory decline
Rush University Medical Center, November 22, 2022
People who eat or drink more foods with antioxidant flavonols, which are found in several fruits and vegetables as well as tea and wine, may have a slower rate of memory decline, according to a study published in Neurology.
“It’s exciting that our study shows making specific diet choices may lead to a slower rate of cognitive decline,” said study author Thomas M. Holland, MD, MS of Rush University Medical Center in Chicago. “Something as simple as eating more fruits and vegetables and drinking more tea is an easy way for people to take an active role in maintaining their brain health.”
The study involved 961 people with an average age of 81 without dementia. They filled out a questionnaire each year on how often they ate certain foods. They also completed annual cognitive and memory tests including recalling lists of words, remembering numbers and putting them in the correct order. They were also asked about other factors, such as their level of education, how much time they spent doing physical activities and how much time they spent doing mentally engaging activities such as reading and playing games. They were followed for an average of seven years.
The people were divided into five equal groups based on the amount of flavonols they had in their diet. While the average amount of flavonol intake in US adults is about 16 to 20 milligrams (mg) per day, the study population had an average dietary intake of total flavonols of approximately 10 mg per day. The lowest group had an intake of about 5 mg per day and the highest group consumed an average of 15 mg per day; which is equivalent to about one cup of dark leafy greens.
After adjusting for other factors researchers found that the cognitive score of people who had the highest intake of flavonols declined at a rate of 0.4 units per decade more slowly than people whose had the lowest intake. Holland noted this is probably due to the inherent antioxidant and anti-inflammatory properties of flavonols.
The study also broke the flavonol class down into the four constituents: kaempferol, quercetin, myricetin and isorhamnetin. The top food contributors for each category were: kale, beans, tea, spinach and broccoli for kaempferol; tomatoes, kale, apples and tea for quercetin; tea, wine, kale, oranges and tomatoes for myricetin; and pears, olive oil, wine and tomato sauce for isorhamnetin.
People who had the highest intake of kaempferol had a 0.4 units per decade slower rate of cognitive decline compared to those in the lowest group. Those with the highest intake of quercetin had a 0.2 units per decade slower rate of cognitive decline compared to those in the lowest group. And people with the highest intake of myricetin had a 0.3 units per decade slower rate of cognitive decline compared to those in the lowest group. Dietary isorhamnetin was not tied to global cognition.
Examining how poor diet damages blood vessels
Leipzig University & Helmholtz Institute for Metabolic, Obesity and Vascular Research (Germany), November 21, 2022
A research team led by Bilal Sheikh from the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) and Leipzig University’s Faculty of Medicine investigated how obesity impacts blood vessels’ structure at a molecular level.
The team’s research, now published in Nature Metabolism, illustrates that metabolic disease affects blood vessels in different organs of our body in a unique way. For instance, blood vessels in the liver and fat tissue struggle to process the excess lipids, kidney vessels develop metabolic dysfunction, lung vessels become highly inflammatory, and transport across the brain vessels is defective. 
“As vascular dysfunction drives all major pathologies, from heart failure to atherosclerosis and neurodegeneration, our research shows how bad eating habits molecularly promote the development of diverse diseases,” explains Dr. Olga Bondareva, the first author of the study.
“We want to elucidate molecular mechanisms of obesity in order to be able to offer patients tailor-made therapies in the future,” adds HI-MAG director Professor Matthias Blüher. Blüher has been conducting research on morbid obesity at Leipzig University for years. The present study also involves scientists from Leipzig who work in the fields of cardiology and laboratory medicine.
The researchers then asked whether a healthy diet could reduce the disease-causing molecular signatures induced by a bad diet. Their results show that a healthy diet can indeed improve the molecular health of blood vessels, albeit only partially. For instance, the blood vessels in the liver recovered nearly completely, but blood vessels in the kidneys retained the disease signature, despite a healthy diet and significant weight loss. This means that some of our blood vessels can develop a “memory” of metabolic disease, which is difficult to reverse.
Lab mice fed processed food found to fare worse against flu than those eating grains
University of Sydney & Shenzhen University School of Medicine (China), November 21, 2022
A team of researchers at the University of Sydney working with a colleague from Shenzhen University School of Medicine has found that lab mice are more likely to survive a flu infection if they are fed grain-based foods rather than processed food. The paper is published in Cell Reports.
In recent years, medical researchers have reported evidence that diet plays a larger role in illness recovery than was thought. Some studies have shown, for example, that caloric density and the concentration of nutrients consumed while recovering from an infection can have a major impact on the severity of the infection. In this new effort, the researchers found evidence suggesting that other characteristics of food can also play a role in illness recovery, at least in mice.
In this new effort, the researchers were studying how mammals such as mice fight off influenza infections. As part of that effort, they inadvertently fed two groups of lab mice slightly different meals that were thought to be equivalent in nutritional value and hence unlikely to have an impact on disease recovery. More specifically, they fed one group of mice a diet consisting mostly of grains. The other mice were fed a highly processed diet. 
Both groups were subsequently infected with the influenza virus and were kept on the same diets they had prior to being infected. The researchers note that prior studies had shown that mice fed either diet when not battling an infection displayed little difference in health or behavior. But when infected with influenza, the researchers found that all of those fed the highly processed diet died. They also found that those fed the highly processed diet failed to regain weight lost due to the illness. In sharp contrast, all of the mice on the grain-based diet began regaining weight within 10 days of initial infection, and all of them recovered.
The researchers note that the difference in survival was not due to differences in an immune response, but was instead due to recovery issues. They note that the mice on the highly processed food diet ate less than those given grains and wound up getting less nutrients. 
Study: Olive Leaf Extract as Effective as Typical Diabetes Drugs
University of Auckland  (New Zealand), November 17, 2022
Researchers from the University of Auckland have discovered that olive leaf extract has the ability to decrease insulin resistance and increase the production of insulin by the pancreas. This is one of the main problems that most diabetes patients suffer from – the lack of proper insulin balance in the body.
To test olive leaf extract’s effects on diabetes, the researchers conducted a randomized, double-blinded and placebo-controlled clinical study dividing 46 overweight men into two groups. One of the groups received olive leaf extract, while the other group was given a placebo. The olive leaf extract was standardized to contain its active ingredients – oleuropein and hydroxytyrosol.
After six weeks to allow the men’s bodies to return to their ‘normal levels,’ the groups were switched. The original placebo group then received the olive leaf extract, and vice versa.  None of the men knew which group they were in at which time.
The researchers found that the olive leaf extract lowered insulin resistance by an average of 15% and increased the productivity of the pancreas’ beta cells – which produce insulin – by 28%.
The researchers concluded: “Supplementation with olive leaf polyphenols for 12 weeks significantly improved insulin sensitivity and pancreatic β-cell secretory capacity in overweight middle-aged men at risk of developing the metabolic syndrome.”
This research also showed that olive leaf could possibly effectively treat both Diabetes 1 and Diabetes type 2. In addition, the olive leaf extract would likely help individuals with type 2 Diabetes the most.
Researchers also found that olive leaf extract may be just as effective as conventional drugs. They stated:
“Hence, compared to these drugs that only improve insulin secretion, olive leaf extract improves both insulin sensitivity and pancreatic β-cell secretory capacity. Remarkably, the observed effects of olive leaf extract supplementation in our study population is comparable to common diabetic therapeutics (particularly metformin)…”
Common Painkillers Like Ibuprofen And Naproxen Can Make Arthritis Inflammation Even Worse
University of California-San Francisco, November 20, 2022
Common painkillers can make the misery of osteoarthritis even worse, a new study warns.
Ibuprofen, naproxen, and diclofenac are among the many drugs for relieving aching joints. However, researchers say they may aggravate inflammation of the knee over time. They belong to a class of medications known as NSAIDS, or non-steroidal anti-inflammatory drugs. The study, based on a review of over 1,000 patients, is one of the first to investigate their long-term effects.
“NSAIDs are frequently used to treat pain, but it is still an open discussion of how NSAID use influences outcomes for osteoarthritis patients. In particular, the impact of NSAIDs on synovitis, or the inflammation of the membrane lining the joint, has never been analyzed using MRI-based structural biomarkers.”
The team found no benefit in 277 patients with moderate to severe osteoarthritis who also engaged in sustained NSAID use. In fact, joint inflammation and cartilage quality got worse over the next four years compared to a group of 793 controls who did not take the drugs.
Dr. Luitjens and her colleagues looked at the link between NSAIDs and synovitis and assessed how the therapy impacted joint structure over time.
“Synovitis mediates development and progression of osteoarthritis and may be a therapeutic target,” Dr. Luitjens continues. “Therefore, the goal of our study was to analyze whether NSAID treatment influences the development or progression of synovitis and to investigate whether cartilage imaging biomarkers, which reflect changes in osteoarthritis, are impacted by NSAID treatment.”
“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” the study author reports. “The use of NSAIDs for their anti-inflammatory function has been frequently propagated in patients with osteoarthritis in recent years and should be revisited, since a positive impact on joint inflammation could not be demonstrated.”

The Gary Null Show - 11.22.22

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Almonds can help you cut calories
University of South Australia, November 20, 2022
Weight loss is never an easy nut to crack, but a handful of almonds could keep extra kilos at bay according to new research from the University of South Australia.
Examining how almonds can affect appetite, researchers found that a snack of 30-50 grams of almonds could help people cut back on the number of kilojoules they consume each day.
Published in the European Journal of Nutrition, the study found that people who consumed almonds – as opposed to an energy-equivalent carbohydrate snack – lowered their energy intake by 300 kilojoules (most of which came from junk food) at the subsequent meal.
“Our research examined the hormones that regulate appetite, and how nuts – specifically almonds – might contribute to appetite control. We found that people who ate almonds experienced changes in their appetite-regulating hormones, and that these may have contributed to reduced food intake (by 300kJ).”
The study found that people who ate almonds had 47 per cent lower C-peptide responses (which can improve insulin sensitivity and reduce the risk of developing diabetes and cardiovascular disease); and higher levels of glucose-dependent insulinotropic polypeptide (18 per cent higher), glucagon (39 per cent higher), and pancreatic polypeptide responses (44 per cent higher). Glucagon sends satiety signals to the brain, while pancreatic polypeptide slows digestion which may reduce food intake, both encouraging weight loss.
“Almonds are high in protein, fibre, and unsaturated fatty acids, which may contribute to their satiating properties and help explain why fewer kilojoules were consumed.”
The findings of this study show that eating almonds produce small changes to people’s energy intake, Dr Carter says this may have clinical effects in the long term.
Probiotics help maintain a healthy microbiome when taken with antibiotics
Texas Christian University, November 18 2022. 
A systematic review published in the Journal of Medical Microbiology helps answer the question concerning whether probiotics should be taken along with antibiotics to support gut health. 
Although probiotics decrease the adverse gastrointestinal effects caused by antibiotics, their ability to preserve intestinal microbial composition that is negatively impacted by antibiotic therapy is not well understood. 
“Like in a human community, we need people that have different professions because we don’t all know how to do every single job,” she explained. “And so, the same happens with bacteria. We need lots of different gut bacteria that know how to do different things.”
While it is well known that antibiotics destroy some beneficial intestinal microorganisms, some healthcare professionals have expressed a concern that administering probiotics to antibiotic-treated patients could further alter the established gut microbe balance.
The review included 29 studies published during a 7-year period. The authors concluded that consuming probiotics with antibiotics can prevent or reduce some changes caused by antibiotics to the microbiome. “When participants take antibiotics, we see several consistent changes in some bacterial species,” Dr Marroquin observed. “But when treatment was combined with probiotics, the majority of those changes were less pronounced and some changes were completely prevented.”
New study shows repeated stress accelerates aging of the eye
University of California, Irvine, November 21, 2022
New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma patients.
The study was published today in Aging Cell. Along with her colleagues, Dorota Skowronska‐Krawczyk, Ph.D., at the UCI School of Medicine, describes the transcriptional and epigenetic changes happening in aging retina. 
The team shows how stress, such as intraocular pressure (IOP) elevation in the eye, causes retinal tissue to undergo epigenetic and transcriptional changes similar to natural aging. And, how in young retinal tissue, repetitive stress induces features of accelerated aging including the accelerated epigenetic age.
Aging is a universal process that affects all cells in an organism. In the eye, it is a major risk factor for a group of neuropathies called glaucoma. Because of the increase in aging populations worldwide, current estimates show that the number of people with glaucoma (aged 40-80) will increase to over 110 million in 2040.
In humans, IOP has a circadian rhythm. In healthy individuals, it oscillates typically in the 12-21 mmHg range and tends to be highest in approximately two thirds of individuals during the nocturnal period. Due to IOP fluctuations, a single IOP measurement is often insufficient to characterize the real pathology and risk of disease progression in glaucoma patients. 
Long-term IOP fluctuation has been reported to be a strong predictor for glaucoma progression. This new study suggests that the cumulative impact of the fluctuations of IOP is directly responsible for the aging of the tissue.
Researchers now have a new tool to estimate the impact of stress and treatment on the aging status of retinal tissue, which has made these new discoveries possible. In collaboration with the Clock Foundation and Steve Horvath, Ph.D., from Altos Labs, who pioneered the development of epigenetic clocks that can measure age based on methylation changes in the DNA of tissues, it was possible for researchers to show that repetitive, mild IOP elevation can accelerate epigenetic age of the tissues.
What do people experience at the border between life and death?
University of London & New York University, November 20, 2022
A new study on near-death experiences featured 567 men and women whose hearts stopped while hospitalized in the United States and the United Kingdom.
Out of 28 survivors of cardiac arrest interviewed as part of the study, 11 recalled memories suggesting consciousness while undergoing CPR. 
Additional cardiac arrest survivors provided self-reports about what they experienced while their hearts stopped.
Reports included perceiving separating from their bodies and meaningful examinations of their lives. 
Researchers discovered spikes of brain activity up to an hour into CPR. 
Dr. Parnia, who served as lead investigator of the study, explained that he and the other researchers undertook this research in an attempt to scientifically explore something that health professionals have discussed anecdotally for decades: The similar stories people revived by cardiopulmonary resuscitation (CPR) often tell about the time when their hearts stopped.
“For decades now, millions of people who’ve gone through this have reported having lucid heightened consciousness, even though from the perspective of their doctors they were not conscious and they were in death,” Dr. Parnia told MNT.
The study centered around 567 men and women who received CPR after their hearts stopped beating while at one of 25 participating hospitals in the United States and the United Kingdom. 
When health practitioners began CPR on a patient whose heart stopped, researchers rushed to the scene, bringing along a portable electroencephalogram, or EEG, to monitor electrical activity in different parts of the brain, and near-infrared spectroscopy (NIRS) to measure oxygen saturation of superficial brain cortex regions. Taking care not to get in the way of health practitioners performing CPR, researchers also clamped a tablet computer above the patient’s head. The tablet was connected to Bluetooth headphones which were placed on the patient’s ears.
Of 567 subjects, 213 or about 38% experienced sustained return of spontaneous circulation, meaning their pulse was restored for 20 minutes or longer. Only 53, or fewer than 10% of the participants, lived to be discharged from the hospital.
Of those 53, 25 were unable to be interviewed by researchers due to poor health. The remaining 28 participants were interviewed 2 to 4 weeks after cardiac arrest depending on their recovery. 
Of the 28 participants interviewed, 11 — or 39% — reported having memories during cardiac arrest. Two of the 28 participants could hear the medical staff working while receiving CPR. One participant recalled seeing the medical staff working and could feel someone rubbing his chest. 
Using the near-death scale, six participants had transcendent experiences. Three participants reported dream-like experiences, which included a singing fisherman. 
Six of the 28 participants interviewed remembered the experience of dying. These recollections included one person who heard a deceased grandmother telling her to return to her body. 
“We characterize the testimonies that people had and were able to identify that there is a unique recalled experience of death that is different to other experiences that people may have in the hospital or elsewhere,” Dr. Parnia said, “and that these are not hallucinations, they are not illusions, they are not delusions, they are real experiences that emerge when you die.”
Fifty-three participants had interpretable EEG data. Researchers discovered spikes of brain activity, including so-called gamma, delta, theta, alpha, and beta waves emerging up to 60 minutes into CPR.
Some of these brain waves normally occur when people are conscious and performing functions like memory retrieval and thinking. According to the researchers, this is the first time such biomarkers of consciousness have been identified during CPR for cardiac arrest. 
“We found the brain electrical markers of heightened […] lucid consciousness, the same markers as you get in people who are having memory retrievals who are having […] high order cognitive processes, except that this was occurring when the brain had shut down.
Research suggests agmatine can boost brain health and uplift your mood naturally
Yonsei University College of Medicine (S Korea), October 28, 2022.
Athletes and bodybuilders are always eager to learn more about new products that can help enhance their workouts by promoting strength and stamina. Agmatine, a natural compound, is often used by health enthusiasts as a pre-workout supplement.
According to research, agmatine can also potentially be used to boost brain health and improve mood.
In one scientific review, researchers suggest that the compound can help prevent neurodegenerative diseases and assist in the recovery of brain injury patients.
Agmatine or 4-aminobutyl-guanidine is produced in your body from arginine, an amino acid found in foods like chickpeas, lentils, pork and poultry.
When used as a pre-workout supplement, experts recommend not taking it with protein since dietary protein can slow the absorption of agmatine. This then diminishes its benefits.
Agmatine is often listed on supplement labels as agmatine sulfate. Dosages range between 250 mg to 1,000 mg per scoop, with intake recommendations between one to two grams per day.
Agmatine has antioxidant and anti-inflammatory effects and can scavenge harmful free radicals that cause oxidative damage to your organs and tissues. Some people believe agmatine can help enhance workouts by increasing levels of beneficial nitric oxide. This then dilates blood vessels and promotes healthy circulation.
Data also suggests that agmatine may help activate the release of pain-killing, mood-lifting endorphins, which can boost motivation and mood. This suggests taking agmatine can help make you feel more inclined to exercise.
The compound may also help block aged glycation end products. Your body produces these potentially carcinogenic compounds after you eat charcoal-broiled or well-done meats.
Agmatine may also help down-regulate matrix metalloproteinases (MMPs), which are tissue-degrading enzymes that can facilitate the spread of malignant tumors. 
Studies show that agmatine works against the glutamate receptors that affect pain perception.
Data from preliminary studies have supported agmatine’s ability to reduce pain and strengthen the pain-killing effects of prescription opioids. Experts hope that agmatine can be used to help reduce the amount of medications needed and decrease the possibility of addiction to opioids.
Supplementation with agmatine may help activate serotonin, the “feel good” chemical in your body while also decreasing levels of cortisol, the “stress” hormone that builds up when you are under duress. In a review published in the European Journal of Neuropsychopharmacology, scientists suggest that agmatine has antidepressant effects.
According to a 2018 study published in the journal Human and Experimental Toxicology, agmatine can help protect brain cells from oxidative stress and inflammation caused by laboratory-induced Parkinson’s.
Prenatal phthalate exposure can significantly impact infant behavior and cognition, says study
University of Illinois Urbana-Champaign, November 16, 2022
Prenatal exposure to phthalates, a set of chemicals commonly found in plastics and personal care products, has been shown to significantly impact aspects of behavior and cognition in infants, according to a team of researchers at the University of Illinois Urbana-Champaign.
“Phthalates are widespread, and several well-known studies have reported that 100% of pregnant individuals had detectable levels of phthalates in their bodies,” said developmental neurotoxicologist Jenna Sprowles, a former postdoctoral research associate at the Beckman Institute for Advanced Science and Technology.
Children’s toys, cosmetics, and constructional materials are all potential sources of phthalate exposure, as are other materials made from polyvinyl chloride.
When individuals who are pregnant are exposed to phthalates, the chemical compound crosses the placental barrier to interact directly with the fetus. Phthalates can also be transferred to a newborn through breast milk.
Their study, reported in the journal Neurotoxicology and Teratology, investigated the neurobehavioral impacts of prenatal phthalate exposure in infants aged 4.5 and 7.5 months. Since many existing studies focus on individuals in early and middle childhood, providing attention to this age group is especially important.
“Phthalates are endocrine-disrupting chemicals, meaning they interact with and alter how hormones typically act in the body. Hormones play crucial roles in brain development, so when the activities of hormones are altered by chemicals like phthalates, adverse functional effects are possible,” Sprowles said. “While we do know that different phthalates can affect different hormone systems, we don’t yet know exactly how particular phthalates exert their specific effects.”
The researchers found that the impact of prenatal phthalate exposure was specific to each phthalate’s particular properties. For example, higher prenatal concentrations of a phthalate called MEP, which is commonly found in personal care products, were associated with lower ASQ scores (indicating below-average development) in certain domains.
Their results align with existing studies, some of which have been carried out in animal models, which indicate that both prenatal and neonatal exposure to phthalates alters neural structure and function, resulting in impaired cognition and altered behavior.

The Gary Null Show - 11.21.22

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Heather Mac Donald On How The Delusion of Diversity Destroys Our Common Humanity(11:02)
Potatoes can be part of a healthy dietLouisiana State University, November 18, 2022
When we think of healthy vegetables, we don’t think of potatoes, but we should. Potatoes have developed a reputation for causing weight gain and an increased risk for type 2 diabetes, and often find themselves on a list of foods to avoid, especially for individuals with insulin resistance. However, a new study from Pennington Biomedical Research Center at Louisiana State University, published in the Journal of Medicinal Food, says that potatoes actually did not increase that risk, are filled with key nutrients, and packed with health benefits. Candida Rebello, PhD, an assistant professor at Pennington Biomedical, said, “We demonstrated that contrary to common belief, potatoes do not negatively impact blood glucose levels. In fact, the individuals who participated in our study lost weight.” “People tend to eat the same weight of food regardless of calorie content in order to feel full,” Rebello explained. “By eating foods with a heavier weight that are low in calories, you can easily reduce the number of calories you consume. The key aspect of our study is that we did not reduce the portion size of meals but lowered their caloric content by including potatoes. Each participant’s meal was tailored to their personalized caloric needs, yet by replacing some meat content with potato, participants found themselves fuller, quicker, and often did not even finish their meal. In effect, you can lose weight with little effort.” The study involved 36 participants between the ages of 18 and 60 who were overweight, had obesity, or insulin resistance. Insulin resistance refers to a health condition in which the body’s cells do not respond well to insulin and glucose does not enter into the cells to make energy. Insulin resistance is linked to obesity, high blood pressure, high cholesterol, and type 2 diabetes Participants were fed precisely-controlled diets of widely available common foods including either beans, peas, and meat or fish, or white potatoes with meat or fish. Both diets were high in fruit and vegetable content and substituted an estimated 40% of typical meat consumption with either beans and peas or potatoes. Previous studies have shown that eating beans and peas improves blood glucose levels in individuals with newly diagnosed type 2 diabetes. To increase the dietary fiber component of the potatoes, they were boiled with the skin intact and then refrigerated between 12 and 24 hours. Potatoes were incorporated into the main lunch and dinner entrées, and served together with sides such as mashed potatoes, oven-roasted potato wedges, potato salad, and scalloped potatoes with lunch and dinner entrees. “We prepared the potatoes in a way that would maximize their fiber content. When we compared a diet with potatoes to a diet with beans and peas, we found them to be equal in terms of health benefits,” Rebello said. “People typically do not stick with a diet they don’t like or isn’t varied enough. The meal plans provided a variety of dishes, and we showed that a healthy eating plan can have varied options for individuals striving to eat healthy. In addition, potatoes are a fairly inexpensive vegetable to incorporate into a diet.”
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Celery Seed Extract Lowers High Blood Pressure in Human Study
University of Chicago Medical Center, November 8, 2022
Drugs to lower blood pressure are among the most commonly prescribed medicines in the U.S. More than 678 million blood pressure prescriptions were filled in 2010. All of the current classes of blood pressure lowering drugs possess significant side effects.A recent study with a special extract of celery seed extract indicates that it may produce clinical results without producing the side effects that plague current drug treatment. Celery seed extract contains an important compound known as 3-n-butylphthalide, or 3nB for short, that is also responsible for the characteristic flavor and odor of celery. 3nB was discovered as the active component of celery in response to investigations by researchers seeking to explain some of the medicinal effects of celery, including the lowering of blood pressure and the relief of arthritis. 3nB first drew significant scientific attention when researchers identified it as the factor in celery responsible for the blood pressure lowering effect of celery. The research was prompted by one of the researcher’s father, who after eating a quarter-pound of celery every day for one week observed his blood pressure dropped from 158 over 96 to a normal reading of 118 over 82. A recent human study evaluated the efficacy of a standardized extract of celery seed supplying 85 percent 3nB in 30 patients with mild to moderate hypertension. The dosage was 150 mg per day. The results showed a statistically significant decrease in both systolic (SBP) and diastolic blood pressure (DBP) compared to baseline measurements. The change at week six for the SBP was 8.2 mmHg and for the DBP was 8.5 mmHG. No side effects were reported. These results indicate that celery seed extract may produce the greatest blood pressure-lowering effects in natural products available on health food store shelves. A major advantage of celery extract over conventional drugs used in high blood pressure is that drugs like beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and calcium channel blockers tend to significantly lower the blood flow to the brain While this effect is helpful in reducing the likelihood of stroke, it often leaves patients taking these drugs feeling tired, depressed, dizzy, and forgetful. Celery extract on the other hand has actually been shown to not only help prevent stroke in animal studies, but also improve blood flow as well and act to protect the brain and enhance energy production with the brain.
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Exercise during pregnancy gives newborn brain development a head start
University of Montreal, November 10, 2022
As little as 20 minutes of moderate exercise three times per week during pregnancy enhances the newborn child’s brain development, according to researchers at the University of Montreal and its affiliated CHU Sainte-Justine children’s hospital. This head-start could have an impact on the child’s entire life. “Our research indicates that exercise during pregnancy enhances the newborn child’s brain development,” explained Professor Dave Ellemberg, who led the study. “While animal studies have shown similar results, this is the first randomized controlled trial in humans to objectively measure the impact of exercise during pregnancy directly on the newborn’s brain.We hope these results will guide public health interventions and research on brain plasticity. Most of all, we are optimistic that this will encourage women to change their health habits, given that the simple act of exercising during pregnancy could make a difference for their child’s future.” Not so long ago, obstetricians would tell women to take it easy and rest during their pregnancy. Recently, the tides have turned and it is now commonly accepted that inactivity is actually a health concern. “While being sedentary increases the risks of suffering complications during pregnancy, being active can ease post-partum recovery, make pregnancy more comfortable and reduce the risk of obesity in the children,” Curier explained. “Given that exercise has been demonstrated to be beneficial for the adult’s brain, we hypothesized that it could also be beneficial for the unborn child through the mother’s actions.” To verify this, starting at the beginning of their second trimester, women were randomly assigned to an exercise group or a sedentary group. Women in the exercise group had to perform at least 20 minutes of cardiovascular exercise three times per week at a moderate intensity, which should lead to at least a slight shortness of breath. Women in the sedentary group did not exercise. The brain activity of the newborns was assessed between the ages of 8 to 12 days, by means of electroencephalography, which enables the recording of the electrical activity of the brain. “We used 124 soft electrodes placed on the infant’s head and waited for the child to fall asleep on his or her mother’s lap. We then measured auditory memory by means of the brain’s unconscious response to repeated and novel sounds,” Labonté-LeMoyne said. “Our results show that the babies born from the mothers who were physically active have a more mature cerebral activation, suggesting that their brains developed more rapidly.”
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Keeping indoor humidity levels at a ‘sweet spot’ may reduce the spread of COVID-19Massachusetts Institute of Technology, November 14, 2022
We know proper indoor ventilation is key to reducing the spread of COVID-19. Now, a study by MIT researchers finds that indoor relative humidity may also influence transmission of the virus. Relative humidity is the amount of moisture in the air compared to the total moisture the air can hold at a given temperature before saturating and forming condensation. In a study appearing in the Journal of the Royal Society Interface, the MIT team reports that maintaining an indoor relative humidity between 40 and 60% is associated with relatively lower rates of COVID-19 infections and deaths, while indoor conditions outside this range are associated with worse COVID-19 outcomes. To put this into perspective, most people are comfortable between 30 and 50% relative humidity, and an airplane cabin is at around 20% relative humidity. The findings are based on the team’s analysis of COVID-19 data combined with meteorological measurements from 121 countries, from January 2020 through August 2020. Their study suggests a strong connection between regional outbreaks and indoor relative humidity. In general, the researchers found that whenever a region experienced a rise in COVID-19 cases and deaths prevaccination, the estimated indoor relative humidity in that region, on average, was either lower than 40% or higher than 60% regardless of season. Nearly all regions in the study experienced fewer COVID-19 cases and deaths during periods when estimated indoor relative humidity was within a “sweet spot” between 40 and 60%.“There’s potentially a protective effect of this intermediate indoor relative humidity,” suggests lead author Connor Verheyen, a Ph.D. student in medical engineering and medical physics in the Harvard-MIT Program in Health Sciences and Technology. “However, we find that maintaining an indoor relative humidity in that sweet spot—of 40 to 60%—is associated with reduced COVID-19 cases and deaths.”In all, they focused on 121 countries where COVID-19 outbreaks occurred. For each country, they also tracked the local COVID-19 related policies, such as isolation, quarantine, and testing measures, and their statistical association with COVID-19 outcomes. In warmer times, both outdoor and indoor relative humidity for each country was about the same, but they quickly diverged in colder times. While outdoor humidity remained around 50% throughout the year, indoor relative humidity for countries in the Northern and Southern Hemispheres dropped below 40% in their respective colder periods, when COVID-19 cases and deaths also spiked in these regions.
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Why Are Kids So Great at Learning? GABA
Brown University, November 16, 2022
GABA is the abbreviation for the neurotransmitter γ-aminobutyric acid. In the study, published in the journal Current Biology, researchers explain GABA’s crucial role in helping children process new information and prepare their brains to learn and store even more. “What we found is a rapid increase in GABA in children, associated with learning,” says lead study author Takeo Watanabe, a professor of cognitive and linguistic sciences at Brown University. The neurotransmitter GABA plays an important role in helping the brain consolidate new info, Watanabe says. It “stabilizes” the network so that subsequent learning doesn’t override what was already there and defends knowledge against retrograde interference. Yet this kind of GABA inhibitory processing is not fully matured in children, he says. Kids have lower levels of GABA—it’s why they have less inhibitory abilities and weaker impulse control than adults. So if GABA is necessary to set the brain up to learn consecutive items, and children have less GABA than adults, then how are children able to, as Watanabe puts it, “learn and learn and learn and learn?”Using an advanced imaging technique called functional MRS, they measured the concentration of GABA in early visual cortical areas before, during and after learning sessions. They then compared the concentrations between children (ages 8 to 11) and adults (ages 18 to 35). They found that before learning begins, the overall amount of GABA in children is indeed smaller than in adults, Watanabe says. However, the researchers found that children exhibited a rapid boost in GABA concentration in the second round of learning, while the concentration of GABA in adults did not change.The results of the experiments suggest that compared with adults, children exhibit more dynamic GABA-associated inhibitory processing, which more rapidly adapts to stabilize learning than in adults, the researchers conclude.
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Being comfortable with aging can benefit sex lifeUniversity of Missouri, November 17, 2022
Researchers have long known that having a positive outlook can benefit a person’s health.Now, a new study by the University of Missouri has found older adults who feel positively about aging have a healthier sex life—a finding that didn’t surprise the researcher, who’s been studying the benefits of the positive perceptions of aging.”We know positive perceptions of aging can be really beneficial, but when they are negative, they can be really detrimental. Negative perceptions of aging are linked to higher likelihood of cognitive decline, higher likelihood of cardiovascular disease and even shorter lifespans. We wanted to see how it would affect people’s sexual relationships. As expected, thinking positively about the way you age can also lead to a healthy sex life.” “We found this relationship to be strong with both men and women,” Skoblow said. “With data from more than 1,100 couples, we were able to find that participants with a more positive perception of aging also had sex more frequently as well as increased satisfaction.” “It’s possible that if people expect a steep physical decline as an inevitable part of aging, they could have anticipatory inhibitions. They stop enjoying themselves in the moment and could have less satisfying sexual encounters,” Skoblow said. “We also know that western cultures often have many youthful beauty ideals, so maybe people with more positive perceptions of aging don’t buy into them as much, leading to a more satisfying sex life as their body begins to change.”

The Gary Null Show - 11.18.22

Videos :
Niall Ferguson – Woke Totalitarianism (0:19 to 18:14)
Heather Mac Donald On How The Delusion of Diversity Destroys Our Common Humanity (11:14)
Elon Musk: “Klaus Schwab Is LYING!!!” (9:45)
Lycopene, lutein supplements show skin protection from within against UV radiationLeibniz Research Institute for Environmental Medicine (Germany), November 10, 2022
The study’s findings, published in the British Journal of Dermatology , indicated that oral supplementation with the carotenoids changed the expression of genes that are indicators of oxidative stress, photo-dermatoses and photo-aging. “To the best of our knowledge we show here for the 1st time that (i) tomato nutrient complex as well as lutein do not only protect healthy human skin against UVB/A, but also against long wave UVA1 radiation, and (ii) that oral photo-protection of healthy human skin can be demonstrated at the level of HO-1, ICAM-1 and MMP-1 gene expression,” wrote researchers from IUF – Leibniz Research Institute for Environmental Medicine in Dusseldorf. Heme oxygenase-1 (HO-1), intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-1 (MMP-1) are reported to be UVA1/UVB radiation-inducible genes.“On top of that, as part of the photo-aging process we have evidence of the effect of our ingredients on the levels of expression of genes involved in collagen degradation, suggesting a link not only to skin health but also to skin appearance. This study suggests an effect of natural antioxidants on overall skin wellness, which is relevant for men and women in all age groups.” The new study included 65 healthy volunteers aged between 18 and 60. The participants were randomly assigned to randomly consume 20 mg per day of the tomato nutrient complex or placebo for 12 weeks, or 20 mg per day of lutein or placebo for 12 weeks. A two-week washout period separated the placebo and active intervention periods. At the beginning and at the end of each phase the skin was irradiated.Results of the placebo-controlled, double blinded, randomized cross-over study indicated that the tomato nutrient complex (TNC) totally inhibited the upregulation of HO-1, ICAM-1 and MMP1 mRNA by both UVA1 and UVA/B. On the other hand, lutein only completely inhibited gene expression if taken during the first 12 weeks (ie. prior to placebo), while a significantly smaller effect was observed if it was taken during the second 12 week phase (ie. after placebo), compared to TNC.
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Diallyl trisulfide in garlic induces apoptosis in primary effusion lymphomaKyoto Pharmaceutical University (Japan), November 7, 2022
Reports from Kyoto Pharmaceutical University stated, “The allyl sulfides, including diallyl sulfide (DAS), diallyl disulfide (DAD), and diallyl trisulfide (DAT), contained in garlic and members of the Allium family, have a variety of pharmacological activities. Therefore, allyl sulfides have been evaluated as potential novel chemotherapeutic agents.” Our news editors obtained a quote from the research, “Here, we found that DAT inhibited nuclear factor-kB (NF-kB) signaling and induced apoptosis in primary effusion lymphoma (PEL), a subtype of non-Hodgkin’s B-cell lymphoma caused by Kaposi’s sarcoma-associated herpesvirus (KSHV). We examined the cytotoxic effects of DAS, DAD and DAT on PEL cells. DAT significantly reduced the viability of PEL cells compared with uninfected B-lymphoma cells, and induced the apoptosis of PEL cells by activating caspase-9. DAT induced stabilization of IkBa, and suppressed NF-kB transcriptional activity in PEL cells. We examined the mechanism underlying DAT-mediated IkBa stabilization. The results indicated that DAT stabilized IkBa by inhibiting the phosphorylation of IkBa by the IkB kinase (IKK) complex. Furthermore, DAT induced proteasomal degradation of TRAF6, and DAT suppressed IKKb-phosphorylation through downregulation of TRAF6. It is known that activation of NF-kB is essential for survival of PEL cells. In fact, the NF-kB inhibitor BAY11-7082 induced apoptosis in PEL cells. In addition, DAT suppressed the production of progeny virus from PEL cells. The administration of DAT suppressed the development of PEL cells and ascites in SCID mice xenografted with PEL cells.” According to the news editors, the research concluded: “These findings provide evidence that DAT has antitumor activity against PEL cells in-vitro and in-vivo, suggesting it to be a novel therapeutic agent for the treatment of PEL.”
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PTSD May Speed Up Cellular AgingBoston University, November 13, 2022
From birth to death, a lot may change, but our DNA—the long, double-helix molecule that contains all of a person’s genetic code—stays the same. The instructions for reading that code can shift, however, as the chemical tags on and around a DNA sequence change throughout our lives, depending on our age, environment, and behavior. This outside influence on how our genes are read and expressed by cells is called epigenetics—and researchers studying it have discovered clues that may show why some veterans live longer than others. In a new study of military veterans published in Translational Psychiatry, researchers report findings that suggest former service personnel with PTSD are at greater risk of early death. “Our study found that PTSD and comorbid conditions, like substance misuse, are associated with a cellular marker of early death found in DNA methylation patterns,” says Erika Wolf, a professor of psychiatry at the Boston University School of Medicine and senior author of the study. The study included two samples of veterans that had representative levels of trauma and other psychiatric conditions, like substance use and personality disorders. One group included 434 veterans in their early 30s, who had served in post-9/11 conflicts; the other group included 647 middle-age veterans and their trauma-exposed spouses. Both groups were assessed for a range of psychological conditions, and had blood drawn to obtain genetic information and to test for levels of a variety of inflammatory molecules. The results indicate PTSD symptoms were a factor in faster cellular aging—.36 of a year faster. So, for every year that the cells of someone without PTSD age, the cells of someone with more severe PTSD symptoms age a year and a third.
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Higher sense of purpose in life may be linked to lower mortality riskBoston University, November 14, 2022
Growing research indicates that one’s purpose—i.e., the extent to which someone perceives a sense of direction and goals in their life—may be linked to health-protective benefits such as better physical functioning and lower risks of cardiovascular disease or cognitive decline. Now, a new study led by a Boston University School of Public Health (BUSPH) researcher found that people with higher levels of purpose may have a lower risk of death from any cause, and that this association is applicable across race/ethnicity and gender. Published in the journal Preventive Medicine, the study results did suggest that this association is slightly stronger among women than it is among men, but there was no significant difference by race/ethnicity. “In another study I led, we found that the effect of purpose on lowering all-cause mortality may differ by socioeconomic status. In this study, we extended the prior evidence and found that the beneficial effect of purpose persisted regardless of gender and race/ethnicity.” For the study, the team assessed self-reported sense of purpose among more than 13,000 people, based on the “purpose in life” of the Ryff Psychological Well-being Scales, a widely used tool that measures different aspects of well-being and happiness. The researchers also examined mortality risk over an eight-year period beginning between 2006-2008. The results showed that people with the highest sense of purpose indicated the lowest risk of death (15.2 percent mortality risk), compared to people with the lowest sense of purpose (36.5 percent mortality risk). The team also gathered data on additional factors that can influence health, such socioeconomic status, other demographic characteristics, baseline physical health, and depression, and found that an increase in these factors was also associated with increases in a higher sense of purpose.
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Hibiscus compound shows anti-Alzheimer disease activityPohang University of Science and Technology,
November 16 2022.
A report published in Alzheimer’s Research & Therapy revealed that gossypetin, a flavonoid occurring in the calyx of the hibiscus flower, activates a process that reduces brain accumulation of amyloid beta, a protein that clumps to form toxic brain plaques in people with Alzheimer disease. Gossypetin has been reported to have antioxidant, antiatherosclerotic and anticancer effects. Earlier research had suggested a benefit for gossypetin, which is structurally similar to quercetin, against the aggregation of amyloid beta and tau proteins that occurs in Alzheimer disease. However, gossypetin’s action in animal models of the disease had not been evaluated.Researchers at Pohang University of Science and Technology administered gossypetin or a control substance to mice that were bred to develop a condition similar to that of Alzheimer disease in humans. After 13 weeks of daily treatment, mice that received the flavonoid had less amyloid beta in the brain’s hippocampus (an area involved in memory and learning) and cortex in comparison with the control mice. Gossypetin-treated animals also demonstrated better spatial learning and memory than untreated mice.Rather than affecting the production of amyloid beta, the research team found that gossypetin helped clear it by enhancing the scavenging ability of the brain’s immune cells, which are known as microglia. Microglia normally consume amyloid beta but can become exhausted by continual exposure, which leads to a chronic damaging inflammatory reaction.
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Over a billion young people are potentially at risk of hearing loss from headphones, earbuds, loud music venuesMayo Clinic, November 15, 2022
More than 1 billion teens and young people are potentially at risk of hearing loss because of their use of headphones and earbuds and attendance at loud music venues, concludes a pooled data analysis of the available evidence, published in the open access journal BMJ Global Health. The World Health Organization (WHO) estimates that over 430 million people worldwide currently have disabling hearing loss. Young people are particularly vulnerable because of their use of personal listening devices (PLDs), such as smartphones, headphones and earbuds, and attendance at loud music venues, amid poor regulatory enforcement. Previously published research suggests that PLD users often choose volumes as high as 105 dB while average sound levels at entertainment venues range from 104 to 112 dB, exceeding permissible levels (80 dB for adults; 75 dB for children) even if for very short periods of time. A group of 33 studies, corresponding to data from 35 records and 19,046 participants, was included; 17 records focused on PLD use and 18 focused on loud entertainment venues. The pooled data analysis indicates that the prevalence of unsafe listening practices from PLD use and attendance at loud entertainment venues is common worldwide—24% and 48%, respectively, among teens and young people. Based on these figures, the researchers estimate that the global number of teens and young adults who could potentially be at risk of hearing loss as a result ranges from 0.67 to 1.35 billion.

The Gary Null Show - 11.17.22

Videos :
The Anti-Smartphone Revolution (8:00)
Heather Mac Donald On How The Delusion of Diversity Destroys Our Common Humanity (11:14)
The Strange Connections of Sam Bankman-Fried & FTX (9:11)
The TRUTH about IVERMECTIN (13:00)
 
Korean ginseng prevents oxidative stress caused by workOhiol State University, November 07, 2022
People who are stressed may find relief from taking Korean ginseng. A study published in the Journal of Medicinal Food has revealed that the Korean ginseng called GINST15 can help reduce stress, mentally and physically. In the study, researchers from The Ohio State University in the U.S. found that Korean ginseng prevents damage caused by intense work stress due to its antioxidants. For the study, the researchers aimed to determine the effects of GINST15 supplement on hormonal and inflammatory responses to physical stress in humans. They recruited 10 women and nine men to participate in the study. The participants were tasked to complete three two-week treatment cycles with 960 milligrams (mg) of the Korean ginseng supplement, 160 mg of the Korean ginseng supplement, or a placebo, separated by a one-week washout period. After the treatment, the participants underwent an intense resistance exercise to induce physical stress. The participants also provided blood samples at rest and at various points after the exercise, particularly immediately, 30 minutes, 60 minutes, and 24 hours after exercise. Then, the researchers measured the levels of cortisol, superoxide dismutase, total glutathione, nonspecific antioxidant activity, total antioxidant power, and creatine kinase. The results showed that the supplementation of Korean ginseng reduced cortisol and increased enzymatic and nonspecific antioxidant activity. In addition, the high dose of the Korean ginseng supplement (960 mg) greatly reduced muscle damage and hypothalamic pituitary adrenal (HPA) responses to physical stress 24 hours after the intense exercise. Based on the findings of the study, the researchers concluded that taking Korean ginseng supplements can help ward off mental and physical stress by reducing cortisol levels and muscle damage.
When low-income families can meet their basic needs, children are healthierBoston Medical Center, November 8, 2022
A series of reports from five cities across the US found that young children and their parents are healthier when they are able to afford basic needs. New research published by Children’s HealthWatch, headquartered at Boston Medical Center, highlights the need for policymakers to improve access to and effectiveness of programs that enable all families with low incomes to afford basic needs such as food, shelter, utilities, medical care, prescription medicines and childcare.Researchers surveyed more than 18,000 families of children under age 4 in the emergency departments and primary care clinics at urban hospitals in Baltimore, Boston, Minneapolis, Philadelphia, and Little Rock. The study team created a composite measure of hardships that included a family’s ability to afford food, utilities, and health care, and maintain stable housing. All hardships described in the study have previously been associated with poor child and caregiver health. This study, however, examined the differences between children living in hardship-free families versus those in families with any or multiple hardships. In all cities, living in a hardship-free family was associated with good overall health for children and caregivers, positive developmental outcomes for young children, and positive mental healthamong mothers. Nearly half of families interviewed at Hennepin County Medical Center in Minneapolis reported that they were hardship-free. At Boston Medical Center, only about one quarter of the families surveyed reported zero hardships, which may be due to higher housing costs. The reports also examine the link between childcare constraints, when parents are unable to work or attend school because of an inability to afford childcare, and hardships. In each city, parents who reported being able to access affordable childcare were more likely to be hardship free. The research teams advocate for implementing policies to increase wages, along with ensuring access to programs that support low-income families being able to meet basic needs, such as food and housing security and medical care. Further, the authors suggested screening for hardships in health care settings and connecting patients and their families to resources that promote health.
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Vitamin D vs. Flu ShotsAlliance for Natural Health & Queen Mary University, November 8, 2022
New research shows vitamin D helps prevent infection. Will the crony medical establishment listen? We at ANH-USA have been beating the drum about vitamin D and its well-documented anti-viral capabilities for years, and there is new evidence demonstrating vitamin D’s role in preventing respiratory infections. When faced with the choice of a cheap, safe, and effective natural immune defense against the flu, or an expensive, dangerous, and ineffective vaccine that makes drug companies billions of dollars—which will our crony health officials choose? The Queen Mary University of London study, which pooled data from 25 studies that included more than 10,000 participants, found that vitamin D supplementation reduced the risk of respiratory infections (cold and flu) by 10 percent overall—and there are reasons to think this figure greatly understates the degree of protection. The protective effect of the sunshine vitamin was even more dramatic in those who were deficient. For the deficient, which about 40% of Americans are, the risk of infection was reduced by half with vitamin D supplementation. This builds upon earlier findings from a 2010 Japanese study which found that vitamin D supplementation was as effective as the vaccine at preventing colds and flu. Predictably, the media tries to diminish these findings, stating that “not everyone is convinced that this study should lead us to the supplement aisle.” We’re then told that the Institute of Medicine (IOM) has determined that adults need only 600 IU of vitamin D—an amount that most Americans do not get from sun exposure or their diet alone. The IOM also said that a vitamin D blood level of 20 ng/mL was adequate This is nonsense. The Vitamin D Council, for example, recommends 5,000 IU of vitamin D per day to achieve at least 40 ng/mL; other integrative doctors we respect advise that the D serum level needs to be around 70 in order to avoid viral infection. Other calculations have shown that IOM recommendations are only about one-tenth of what is needed to cut the incidence of diseases related to vitamin D deficiency. What this means is that most Americans are not getting the vitamin D they need, in part because health authorities at the IOM and elsewhere in the government are mistaken when telling Americans how much to take. That we do not get enough vitamin D in our diet or through sun exposure to meet a paltry 600 IU means that the number of Americans who are deficient must be staggering. It is a crime that health authorities are not telling people to take vitamin D supplements. The good news is that this study shows that those who are deficient in vitamin D—likely most Americans, given how wrong the IOM is about how much vitamin D we really need—can reduce their risk of cold or flu by 50 percent. That is more effective than the flu vaccine usually is.
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The therapeutic power of Indian frankincense for multiple sclerosis patientsAhvaz Jundishapur University of Medical Sciences (Iran), November 07, 2022
Boswellia serrata, the plant from which Indian frankincense is derived, can improve cognitive performance in people with multiple sclerosis (MS). This finding, from a study published in the Journal of Herbal Medicine, promises a new and natural way of delaying the complications and effects of MS. Neurons, the special cells that make up the nerves and the different parts of the nervous system, have what is called the myelin sheath. This is a layer that coats and protects the nerve fiber or axon, a long, thin projection that carries electrical impulses from one end of the neuron to the other. The myelin sheath insulates the axon and enhances its function, allowing it to more efficiently deliver messages between the brain and the different parts of the body. In multiple sclerosis, the immune system attacks the cells that make up the myelin sheath. This causes the nerves to “short circuit” and creates problems in the way that messages are delivered from or to the brain. With time, multiple sclerosis can result in permanent nerve impairment and damage. Researchers say B. serrata can help remedy certain symptoms and effects of multiple sclerosis, in particular, the cognitive impairment that occurs in 40 to 65 percent of patients. This usually entails problems with complex attention, a slower information processing speed, and episodic lapses in memory and executive functions. MS-related cognitive impairment has been known to affect patients quality of life, personal relationships, and vocational potential.
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Social media use increases depression and lonelinessUniversity of Pennsylvania, November 8, 2022
The link between the two has been talked about for years, but a causal connection had never been proven. For the first time, University of Pennsylvania research based on experimental data connects Facebook, Snapchat, and Instagram use to decreased well-being. Psychologist Melissa G. Hunt published her findings in the December Journal of Social and Clinical Psychology. “We set out to do a much more comprehensive, rigorous study that was also more ecologically valid,” says Hunt, associate director of clinical training in Penn’s Psychology Department. To that end, the research team designed their experiment to include the three platforms most popular with a cohort of undergraduates, and then collected objective usage data automatically tracked by iPhones for active apps, not those running the background. Each of 143 participants completed a survey to determine mood and well-being at the study’s start, plus shared shots of their iPhone battery screens to offer a week’s worth of baseline social-media data. Participants were then randomly assigned to a control group, which had users maintain their typical social-media behavior, or an experimental group that limited time on Facebook, Snapchat, and Instagram to 10 minutes per platform per day.”Here’s the bottom line,” she says. “Using less social media than you normally would leads to significant decreases in both depression and loneliness. These effects are particularly pronounced for folks who were more depressed when they came into the study.” “It is a little ironic that reducing your use of social media actually makes you feel less lonely,” she says. But when she digs a little deeper, the findings make sense. “Some of the existing literature on social media suggests there’s an enormous amount of social comparison that happens. When you look at other people’s lives, particularly on Instagram, it’s easy to conclude that everyone else’s life is cooler or better than yours.”
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Acupuncture at these specific points alleviates pain in cancer patientsGuangzhou University of Chinese Medicine, November 07, 2022
Cancer causes many adverse complications, including constant pain. A study published in the journal BMC Complementary and Alternative Medicinelooked into the viability of using acupuncture to soothe this pain and cause relief to cancer patients. Although cancers are named after the body part where the tumor – or tumors, in some cases – is located, its effects can be felt in other parts of the body. In the case of bone and testicular cancers, pain is one of the first signs. In others, such as pancreatic cancer, discomfort may be a sign that the disease has progressed or metastasized. The authors of the study wanted to know if acupuncture’s pain relieving properties extended to cancer patients. In a single-blind, randomized controlled pilot trial, they recruited 42 patients going through moderate to severe cancer pain. The participants were randomly assigned to one of three groups. Each group had 14 members. The first group had acupuncture at the acupoints si guan xue, while the second group combined si guan xue with commonly used acupoints. The third group served as the control and was treated only on the most frequently used acupoints.The researchers’ analysis showed that the second group experienced the most cancer pain reduction at around day five. This was compared to the control group. Scores in the PGIC, EORTC QLQ-C30, or KPS did not indicate much variance among the three groups. They concluded that acupuncture at the si guan xue, combined with commonly used acupoints, was the most effective at treating pain caused by cancer. However, a larger study needed to be performed owing to the small sample size employed by the present study.

The Gary Null Show - 11.16.22

Videos :
Did Joe Biden Just Say That Out Loud (0:23)
Bill Maher Gets B*tch Slapped By Jimmy Dore (6:00)
Why the economy really sucks (blame Goldman Sachs) (10:26)
Niall Ferguson – Woke Totalitarianism (0:19 to 18:14)
Just in case: Is Government the New God? – The Religion of Totalitarianism (13:27)
Taurine Supplementation Benefits Diabetes PatientsCapital Medical University (China), October 6, 2022
People with diabetes who received taurine supplements experienced improvements in glucose and other factors, according to the results of a review and meta-analysis of clinical trials, published in Food Chemistry: Molecular Sciences.Researchers analyzed five controlled trials including 209 participants, that evaluated the effects of taurine on individuals with type I or type II diabetes. Taurine doses ranged from 500 mg daily to 1,000 mg three times per day.Participants who received taurine had lower fasting blood glucose, hemoglobin A1c (HbA1c, a marker of long-term glucose control), and insulin resistance, compared to those given a placebo.“Taurine emerges as a new option for the management of patients with diabetes,” the scientists asserted.
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Vitamin D Deficiency Linked to Breast CancerAnkara Numune Research Oncology Clinic (Turkey), November 1, 2022
Most women with breast cancer were found to be deficient in vitamin D, according to the results of a study published in the journal Progress in Nutrition.Researchers analyzed the vitamin D status of 561 women, average age 55, with non-metastatic breast cancer.In this group, 81% of the women were deficient in vitamin D, and 11% had insufficient levels of the vitamin.Median 25-hydroxyvitamin D blood levels were only 13.91 ng/mL in this group of Turkish women.Optimal ranges by U.S. standards are 30-80 ng/mL. Life Extension’s minimal target for 25-hydroxyvitamin D is around 50 ng/mL.The researchers concluded that vitamin D levels should be measured in breast cancer patients and low levels should be corrected whenever diagnosed.
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Marijuana smokers show higher rates of emphysema, airway diseases than tobacco smokersUniversity of Ottawa (Ontario), November 15, 2022
Researchers from the University of Ottawa and The Ottawa Hospital have found marijuana smokers have a higher rate of emphysema and airway diseases compared to cigarette smokers.The findings, published in Radiology, examined the chest CT examinations of 56 marijuana smokers, 57 non-smokers and 33 tobacco-only smokers between 2005 and 2020. They determined higher rates of paraseptal emphysema and airway inflammatory changes, such as bronchiectasis, bronchial wall thickening, and mucoid impaction, in the marijuana smokers.”What’s unique about this study is that there hasn’t been anything comparing the imaging findings in tobacco smokers to marijuana smokers before. In fact, there is a lack of imaging research in marijuana, probably because it’s still illegal in many parts of the world, and in many U.S. states, which is why I think we were the first to do a project like this.” Despite the small sample size, Revah’s findings suggest that marijuana smokers saw additional effects on the lungs above tobacco alone, including more instances of large and small airways diseases.
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Morning physical activity is associated with the lowest risk of heart disease and strokeLeiden University Medical Centre (Netherlands), November 14, 2022
Morning physical activity is associated with the lowest risk of heart disease and stroke, according to a study in more than 85,000 individuals published today in the European Journal of Preventive Cardiology. The findings were consistent regardless of the total amount of daily activity.The study included 86,657 adults aged 42 to 78 years who were free of cardiovascular disease at baseline. The average age was 62 years and 58% were women. Participants wore an activity tracker on their wrist for seven consecutive days. During six to eight years of follow up, 2,911 participants developed coronary artery disease and 796 had a stroke. Comparing peak activity times across a 24 hour period, being most active between 8 am and 11 am was linked with the lowest risks of both heart disease and stroke. In a second analysis, the investigators divided participants into four groups based on the peak time of physical activity: 1) midday; 2) early morning (~8 am); 3) late morning (~10 am); and 4) evening (~7 pm). The categories were selected according to peak times of activity in the study population, rather than being pre-determined before the study began.Participants who were most active in the early morning or late morning had 11% and 16% lower risks of incident coronary artery disease, respectively, compared to the reference group. In addition, those who were most active in the late morning had a 17% decreased risk of incident stroke compared with the reference group.When the results were analyzed separately according to sex, the investigators found that the results were particularly prominent in women but no longer significant in men. Women who were most active in the early morning or late morning had 22% and 24% lower risks of incident coronary artery disease, respectively, compared to the reference group. In addition, women who were most active in the late morning had a 35% decreased risk of incident stroke compared with the reference group.
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New study shows astaxanthin is effective against daily mental and physical fatigue
AstaReal Research (Japan), November 7, 2022
Japanese nutraceutical firm AstaReal says its astaxanthin has been found to be simultaneously effective against both mental and physical fatigue in a new published study. The research, published in the Journal of Clinical Therapeutics & Medicines, states that individuals were treated with astaxanthin for eight weeks in a double-blind, placebo-controlled study. The study was designed to induce fatigue and stress, similar to that encountered in daily life. There was a mental challenge, where individuals were subjected to a number of timed calculations (the Uchida-Kraepelin test), and a physical test with a bicycle ergometer. Metrics of fatigue were assessed both before and after the stressor tests. The study states: “Thirty-nine healthy subjects reporting awareness of fatigue were divided onto two groups. The subjects in one group (Astaxanthin group) ingested 12mg of astaxanthin and 20mg of tocotrienols for eight weeks. The other group (control group) ingested 20mg of tocotrienols for eight weeks.” Analysis showed that astaxanthin significantly reduced perceived symptoms of mental and physical fatigue compared to the placebo. These included improvements in clarity of thinking, concentration, motivation, and mood. Irritation and feeling of body heaviness were reduced. In the calculation test, an increase in errors observed in the placebo during the second half of the test was almost eliminated in the astaxanthin group. Supplementation with astaxanthin also significantly reduced salivary cortisol, a biomarker for stress. The study concludes: “The results suggest that astaxanthin supplementation has beneficial effects on fatigue encountered in daily life.”
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High-fat diet can provoke pain sensitivity without obesity or diabetesUniversity of Texas at Dallas, November 14, 2022
A new study in mice from researchers at The University of Texas at Dallas suggests that a short-term exposure to a high-fat diet may be linked to pain sensations even in the absence of a prior injury or a pre-existing condition like obesity or diabetes. The study, published in the journal Scientific Reports, compared the effects of eight weeks of different diets on two cohorts of mice. One group received normal chow, while the other was fed a high-fat diet in a way that did not precipitate the development of obesity or high blood sugar, both of which are conditions that can result in diabetic neuropathy and other types of pain. The researchers found that the high-fat diet induced hyperalgesic priming—a neurological change that represents the transition from acute to chronic pain—and allodynia, which is pain resulting from stimuli that do not normally provoke pain.

The Gary Null Show - 11.15.22

VIDEOS:
Niall Ferguson – Woke Totalitarianism (0:19 to 18:14)
How Ukraine – Not Russia – Floods Social Media With War Propaganda (0:00 to 1:20)
Here’s why no one trusts CNN (3:35)
The Green New Deal’s Bad Science (8:14)
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Neil Oliver asks why we should be expected to sweep Covid hysteria under the rug? (0:36 to 5:32)
Jimmy Dore – Tim Robbins Apologizes To Unvaccinated For Being Wrong On Covid Policy (0:00 to 9:13)
Grape Powder Could Extend Lifespan by 4-5 Years
Long Island University, November 3, 2022
In a study the authors called “remarkable,” researchers found that giving grape powder to mice reduced the risk of non-alcoholic fatty liver disease and extended lifespan.
To see if grape powder could modulate the harmful effects of a high-fat diet, researchers fed mice a typical Western (high-fat) diet. Half then received 5% standardized grape powder while the other half didn’t.
Compared to mice not fed the grape powder, the mice given grape powder saw beneficial increases in antioxidant genes, reductions in fatty liver, and extended lifespans.
The lead author estimated that when translated to humans, the extended lifespan would correspond to an additional 4-5 years in the life of a human.
The grape powder used in this study was composed of fresh red, green and black grapes that were freeze-dried to retain their bioactive compounds.
The researchers concluded: “These results suggest the potential of dietary grapes to modulate hepatic gene expression, prevent oxidative damage, induce fatty acid metabolism, ameliorate NAFLD (non-alcoholic fatty liver disease), and increase longevity when co-administered with a high-fat diet.”
Study: Neuroprotective Effect of Virgin Coconut Oil Helps Relieve ALS 
Katholieke University (Belgium), November 6, 2022  An animal study looked into the potential of coconut oil for preventing or reducing ALS symptoms.Coconut oil has already demonstrated safe efficacy for treating Alzheimer’s disease symptoms, which is also a neurodegenerative disease for which mainstream medicine has no answer. 1H-magnetic resonance spectroscopy is ideal for ALS treatment diagnostics and research. It is used for many animal and human studies to isolate minute molecular changes in brain and nervous system studies without having to procure tissue and blood samples. Thus, it is non-invasive.[The study results] revealed that the coconut oil supplementation together with the regular diet delayed disease symptoms, enhanced motor performance, and prolonged survival in the SOD1G93A mouse model. Furthermore, MRS data showed stable metabolic profile at day 120 in the coconut oil diet group compared to the group receiving a standard diet without coconut oil supplementation.  In addition, a positive correlation between survival and the neuronal marker NAA was found. … this is the first study that reports metabolic changes in the brainstem using in vivo MRS and effects of coconut oil supplementation as a prophylactic treatment in SOD1G93A mice.One of the major metabolites NAA (N-acetylaspartate), has been observed as an integral part of neuron loss, which is a major factor of onset ALS when it is diminished from the central nervous system.  NAA reduction was greater in the non-coconut oil fed group of rats, indicating those on coconut oil were experiencing less neurodegeneration and neuronal destruction.
Aerobic activity can reduce the risk of metastatic cancer by 72%
Tel Aviv University (Israel), November 14, 2022
A new study at Tel Aviv University found that aerobic exercise can reduce the risk of metastatic cancer by 72%. According to the researchers, intensity aerobic exercise increases the glucose (sugar) consumption of internal organs, thereby reducing the availability of energy to the tumor.
The study was led by two researchers from TAU’s Sackler Faculty of Medicine.
Prof. Levy and Dr. Gepner said, “Studies have demonstrated that physical exercise reduces the risk for some types of cancer by up to 35%. This positive effect is similar to the impact of exercise on other conditions, such as heart disease and diabetes. In this study we added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been ‘be active, be healthy,’ now we can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.”
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study that monitored 3,000 individuals for about 20 years, indicated 72% less metastatic cancer in participants who reported regular aerobic activity at high intensity, compared to those who did not engage in physical exercise.
They found that aerobic activity significantly reduced the development of metastatic tumors in the lymph nodes, lungs, and liver. The researchers hypothesized that in both humans and model animals, this favorable outcome is related to the enhanced rate of glucose consumption induced by exercise.
Prof. Levy stated, “Our study is the first to investigate the impact of exercise on the internal organs in which metastases usually develop, like the lungs, liver, and lymph nodes.
“Consequently, if cancer develops, the fierce competition over glucose reduces the availability of energy that is critical to metastasis. Moreover, when a person exercises regularly, this condition becomes permanent: the tissues of internal organs change and become similar to muscle tissue. We all know that sports and physical exercise are good for our health. Our study, examining the internal organs, discovered that exercise changes the whole body, so that the cancer cannot spread, and the primary tumor also shrinks in size.”
Dr. Gepner adds, “Our results indicate that unlike fat-burning exercise, which is relatively moderate, it is a high-intensity aerobic activity that helps in cancer prevention. If the optimal intensity range for burning fat is 65–70% of the maximum pulse rate, sugar burning requires 80–85%—even if only for brief intervals. For example: a one-minute sprint followed by walking, then another sprint. 
Vegan diet best for weight loss even with carbohydrate consumption, study finds
University of South Carolina, November 6, 2022
The month of November often brings about a sense of dread at the thought of food filled holiday parties and gatherings, but those who consume a plant based diet have little need for concern. A newstudy by the University of South Carolina confirms one big draw of saying no to all animal products: the ability to shed weight faster than those who consume a diet that contains meat and dairy. 
The study compared the amount of weight lost by those on vegan diets to those on a mostly plant-based diet, and those eating an omnivorous diet with a mix of animal products and plant based foods. At the end of six months, individuals on the vegan diet lost more weight than the other two groups by an average of 4.3%, or 16.5 pounds.
The study followed participants who were randomly assigned to one of five diets on the dietary spectrum: vegan which excludes all animal products, semi-vegetarian with occasional meat intake; pesco-vegetarian which excludes all meat except seafood; vegetarian which excludes all meat and seafood but includes animal products, and omnivorous, which excludes no foods.
Participants followed their assigned dietary restrictions for six months, with all groups except the omnivorous participating in weekly group meetings. Those who stuck to the vegan diet showed the greatest weight loss at the two and six month marks.
The lead authornotes that the diet consumed by vegan participants was high in carbohydrates that rate low on the glycemic index. “We’ve gotten somewhat carb-phobic here in the U.S. when it comes to weight loss. This study might help alleviate the fears of people who enjoy pasta, rice, and other grains but want to lose weight,” she said.
Weight loss was not the only positive outcome for participants in the strictly vegan group. They also showed the greatest amount of decrease in their fat and saturated fat levels at the two and six month checks, had lower BMIs, and improved macro nutrients more than other diets. Eschewing all animal products appears to be key for these positive results. 
Uterine fibroid growth activated by chemicals found in everyday products
Northwestern University, November 14, 2022
For the first time, scientists at Northwestern Medicine have demonstrated a causal link between environmental phthalates (toxic chemicals found in everyday consumer products) and the increased growth of uterine fibroids, the most common tumors among women.
Manufacturers use environmental phthalates in numerous industrial and consumer products, and they’ve also been detected in medical supplies and food. Although they are known to be toxic, they are currently unbanned in the U.S. 
“These toxic pollutants are everywhere, including food packaging, hair and makeup products, and more, and their usage is not banned,” said corresponding study author Dr. Serdar Bulun, chair of the department of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine physician. “These are more than simply environmental pollutants. They can cause specific harm to human tissues.”
Up to 80% of all women may develop a fibroid tumor during their lifetime, Bulun said. One-quarter of these women become symptomatic with excessive and uncontrolled uterine bleeding, anemia, miscarriages, infertility and large abdominal tumors necessitating technically difficult surgeries.
The new study found women with a high exposure to certain phthalates such as DEHP (used as a plasticizer to increase the durability of products such as shower curtains, car upholstery, lunchboxes, shoes and more) and its metabolites have a high risk for having a symptomatic fibroid.
The scientists discovered exposure to DEHP may activate a hormonal pathway that activates an environmentally responsive receptor (AHR) to bind to DNA and cause increased growth of fibroid tumors.
Immune cells mistake heart attacks for viral infections
University of California San Diego and Harvard University, November 12, 2022 
A study led by Kevin King, a bioengineer and physician at the University of California San Diego, has found that the immune system plays a surprising role in the aftermath of heart attacks. The research could lead to new therapeutic strategies for heart disease.
The team, which also includes researchers from the Center for Systems Biology at Massachusetts General Hospital (MGH), Brigham and Women’s Hospital, Harvard Medical School, and the University of Massachusetts, presents the findings in Nature Medicine. Ischemic heart disease is the most common cause of death in the world and it begins with a heart attack. During this process, heart cells die, prompting immune cells to enter the dead tissue, clear debris and orchestrate stabilization of the heart wall.
But what is it about dying cells in the heart that stimulates the immune system? To answer this, researchers looked deep inside thousands of individual cardiac immune cells and mapped their individual transcriptomes using a method called single cell RNA-Seq. This led to the discovery that after a heart attack, DNA from dying cells masquerades as a virus and activates an ancient antiviral program called the type I interferon response in specialized immune cells. The researchers named these “interferon inducible cells (IFNICs).”
When investigators blocked the interferon response, either genetically or with a neutralizing antibody given after the heart attack, there was less inflammation, less heart dysfunction, and improved survival. Specifically, blocking antiviral responses in mice improved survival from 60 percent to over 95 percent. These findings reveal a new potential therapeutic opportunity to prevent heart attacks from progressing to heart failure in patients.
“We are interested to learn whether interferons contribute to adverse cardiovascular outcomes after heart attacks in humans,” said King, who did most of the work on the study while he was a cardiology fellow at Brigham and Women’s Hospital and at the Center for Systems Biology at MGH in Boston.
Investigators found that surprisingly, the antiviral interferon response is also turned on after a heart attack despite the absence of any infection. Their results point to dying cell DNA as the cause of this confusion because the immune system interprets it as the molecular signature of a virus.
Surprisingly, the immune cells participating in the interferon response were a previously unrecognized subset of cardiac macrophages. These cells could not be identified by conventional flow sorting because unique markers on the cell surface were not known. By using single cell RNA Seq, an emerging technique that combines microfluidic nanoliter droplet reactors with single cell barcoding and next generation sequencing, the researchers were able to examine expression of every gene in over 4,000 cardiac immune cells and found the specialized IFNIC population of responsible cells.