The Gary Null Show

The Gary Null Show - 11.14.22

Video:
Commentary 
 Niall Ferguson – Woke Totalitarianism) (18:14)
13 stillborns in one hospital in 24 hours (1:54)
Nurse blows whistle: C19 Shots and Spike in Baby issues; Refuses to inject poison. (1:30)
 
Asthma Can Be Reduced By Increasing Vitamin D Levels And Consuming Ginger
Tel Aviv University (Israel) & Columbia University, November 13, 2022According to research published in the journal Allergy, Dr Ronit Confino-Cohen and colleagues at Tel Aviv University analysed data from more than four million Israeli’s that are members of the nation’s largest healthcare provider — finding that of the 21,000 with asthma, those with a vitamin D deficiency were 25% more likely than other asthmatics to have had at least one flare-up in the recent past.

The effect of the vitamin is strongest in people with asthma and other lung diseases who are predisposed to respiratory infections. People with the worst vitamin D deficiency were 36 percent more likely to suffer respiratory infections than those with sufficient levels, according to research in Archives of Internal Medicine.
“Vitamin D has significant immunomodulatory effects and, as such, was believed to have an effect on asthma — an immunologically mediated disease,” said Confino-Cohen. “But most of the existing data regarding vitamin D and asthma came from the pediatric population and was inconsistent. Our present study is unique because the study population of young adults is very large and ‘uncontaminated’ by other diseases.”
Professor Catherine Hawrylowicz from King’s College London explained that findings already suggest that supplementation with vitamin D may one day be used not only to treat people who don’t respond to medications but also to reduce the doses of dangerous steroids in other asthma patients – thus reducing the risk of harmful side effects.
Of the 21,000 asthmatics studied, the team reported that those with vitamin D deficiency were at a higher risk of an asthma attack.
Meanwhile, a team of US-based researchers have suggested that ginger compounds could also be effective in reducing the symptoms of asthma.
The study, led by Elizabeth Townsend from Columbia University, investigated whether purified extracts of ginger that contained specific components of the spicy root could help enhance the relaxing effects of bronchodilators in asthmatic people.
The research team explained that they studied the effects of three separate components of ginger: 6-gingerol, 8-gingerol or 6-shogaol when exposed to airway smooth muscle (ASM) tissue samples that were caused to contract by exposing them to acetylcholine.
“We demonstrated that purified components of ginger can work synergistically with Beta-agonists to relax ASM,” said Townsend – adding that tissues treated with the combination of purified ginger components and isoproterenol showed significantly greater relaxation than those treated only with isoprotereno.
Indeed, one of the three ginger components, 6-shogaol appeared most effective in increasing the relaxing effects of the Beta-agonist.
(NEXT)
Natural matcha green tea extract found to effectively kill breast cancer cellsUniversity of Salford (UK), November 05, 2022
A recent study carried out by the University of Salford has found that one kind of green tea in particular, matcha, can kill breast cancer cells effectively.
The scientists at the university’s Biomedical Research Center used a process known as metabolism phenotyping on breast cancer stem cell lines. They discovered that matcha “shifted cancer cells towards a quiescent metabolic state” while stopping them from spreading. Best of all, this was achieved using a rather low concentration of just 0.2 mg/mL.
In addition, they discovered evidence that matcha affects the signaling pathways that promote cancer stem cells in a way that may make it a viable alternative to chemical cancer drugs like rapamycin.
The scientist explained that the tea essentially suppresses oxidative mitochondral metabolism, preventing these cells from refueling. This causes them to become inactive and eventually die.
University of Salford Professor of Translational Medicine Michael Lisanti said: “Our results are consistent with the idea that Matcha may have significant therapeutic potential, mediating the metabolic reprogramming of cancer cells.”
(NEXT)
Inflammation in midlife linked to brain shrinkage laterJohns Hopkins University School of Medicine, November 11, 2022
People who show signs of inflammation in middle age are more likely to suffer from brain shrinkage later in life, a possible precursor to dementia or Alzheimer’s disease, researchers said Wednesday.
The findings in the journal Neurology are the latest to uncover an association between dementia and inflammation, in which the body’s immune cells rev up in response to harms like smoking, stress, illness or poor diet.
However, the findings stopped short of proving any cause-and-effect relationship.
“These results suggest that inflammation in mid-life may be an early contributor to the brain changes that are associated with Alzheimer’s disease and other forms of dementia,” said study author Keenan Walker of the Johns Hopkins University School of Medicine.
“Because the processes that lead to brain cell loss begin decades before people start showing any symptoms, it is vital that we figure out how these processes that happen in middle age affect people many years later.”
The study was based on 1,633 people with an average age of 53.
Researchers tested their blood for levels of five markers of inflammation—not in any specific part of the body but rather throughout it—including the white blood cell count.
An average of 24 years later, participants took a memory test and underwent brain scans.
Those who had higher levels of inflammation at midlife on three or more biomarkers had an average five percent lower brain volume in the hippocampus and other areas associated with Alzheimer’s disease, said the report.
The effect was similar to having one copy of a gene—called apolipoprotein E (APOE) e4—that predisposes people to Alzheimer’s, researchers said.
People with higher inflammation also performed slightly worse on a memory test, remembering on average five of 10 words they were asked to recall, compared to 5.5 in the non-inflammation group.
Outside experts described the study as large and rigorously conducted, but stressed that it did not study whether patients went on to develop Alzheimer’s disease, only that some showed signs of brain shrinkage and memory loss.
“This research points to inflammation as a potential early indicator of later brain degeneration, but we cannot say whether inflammation could be causing brain shrinkage or if it is a response to other damaging processes that might already be underway,” said Carol Routledge, director of Research at Alzheimer’s Research UK.
(NEXT)
Adult ADHD has become epidemic—experts explain whyUniversity of California at Berkeley, November 7, 2022
Attention-deficit/hyperactivity disorder is growing up. Stephen Hinshaw and Katherine Ellison authors of ADHD: What Everyone Needs to Know, confirm that adults—and particularly women—are reporting to clinics in record numbers, becoming the fastest-growing part of the population receiving diagnoses and prescriptions for stimulant medications.
“ADHD was never just for kids, and today many adults are getting the help they’ve needed for years,” says Hinshaw, a professor at the University of California at Berkeley and a respected global expert on ADHD.
Ellison, a Pultizer-prize winning journalist, notes, “At least half of all children diagnosed with ADHD will continue to be impaired by their symptoms as adults, suggesting that approximately 10 million U.S. adults qualify for the diagnosis. Adult ADHD can lead to suffering through commonly accompanying disorders such as anxiety, depression, substance abuse, antisocial behavior, and gambling or Internet addictions. Social ties may well be frayed, with high risk of difficulties in intimate relationships. And, people with ADHD are also more likely to have a bitter history of academic and professional failures.”
Indeed, researchers have found that adults who have been diagnosed with ADHD are up to 14 percent less likely than their peers to have a job. On average they also earn 33 percent less compared with people in similar lines of work and are 15 percent more likely to be receiving some form of government aid. The bottom line is that adult ADHD is not only real but has potentially devastating consequences, the experts agree.
Hinshaw and Ellison also reveal a recent rapid rise in adult prescriptions for ADHD medication. One of the biggest surprises is that women of child-bearing age have become the fastest-growing group of consumers of ADHD medications. The number of annual prescriptions of generic and brand-name forms of Adderall surged among women over 26 years old, from a total of roughly 800,000 to some 5.4 million.
(NEXT)
Study shows clear new evidence for mind-body connection
University of Calgary Department of Oncology, November 3, 2022
Impact of meditation, support groups seen at cellular level in breast cancer survivors
For the first time, researchers have shown that practising mindfulness meditation or being involved in a support group has a positive physical impact at the cellular level in breast cancer survivors.
A group working out of Alberta Health Services’ Tom Baker Cancer Centre and the University of Calgary Department of Oncology has demonstrated that telomeres – protein complexes at the end of chromosomes – maintain their length in breast cancer survivors who practise meditation or are involved in support groups, while they shorten in a comparison group without any intervention.
“We already know that psychosocial interventions like mindfulness meditation will help you feel better mentally, but now for the first time we have evidence that they can also influence key aspects of your biology,” says Dr. Linda E. Carlson, PhD, principal investigator and director of research in the Psychosocial Resources Department at the Tom Baker Cancer Centre.
“It was surprising that we could see any difference in telomere length at all over the three-month period studied,” says Dr. Carlson, who is also a U of C professor in the Faculty of Arts and the Cumming School of Medicine, and a member of the Southern Alberta Cancer Institute. “Further research is needed to better quantify these potential health benefits, but this is an exciting discovery that provides encouraging news.”
The study was published online in the journal Cancer.
A total of 88 breast cancer survivors who had completed their treatments for at least three months were involved for the duration of the study. The average age was 55 and most participants had ended treatment two years prior. To be eligible, they also had to be experiencing significant levels of emotional distress.
In the Mindfulness-Based Cancer Recovery group, participants attended eight weekly, 90-minute group sessions that provided instruction on mindfulness meditation and gentle Hatha yoga, with the goal of cultivating non-judgmental awareness of the present moment. Participants were also asked to practise meditation and yoga at home for 45 minutes daily.
In the Supportive Expressive Therapy group, participants met for 90 minutes weekly for 12 weeks and were encouraged to talk openly about their concerns and their feelings. The objectives were to build mutual support and to guide women in expressing a wide range of both difficult and positive emotions, rather than suppressing or repressing them.
The participants randomly placed in the control group attended one, six-hour stress management seminar.
All study participants had their blood analysed and telomere length measured before and after the interventions.
Scientists have shown a short-term effect of these interventions on telomere length compared to a control group, but it’s not known if the effects are lasting. Dr. Carlson says another avenue for further research is to see if the psychosocial interventions have a positive impact beyond the three months of the study period.
(NEXT)
Lion’s Mane Mushroom for Your Brain and Neuronal HealthGreen Med Info, November 8th 2022
Lion’s mane mushrooms (Hericium erinaceus), with their shaggy, mane-like spines, stand out among fungi not only for their appearance but for their mild, sweet, seafood-like flavor. Like other mushrooms, lion’s mane are multi-faceted healers, with antimicrobial, antihypertensive, antidiabetic and wound healing properties among their many therapeutic properties. Of the 68 diseases and conditions that lion’s mane mushroom may support, many of them relate to the nervous system, including cognitive function, memory, dementia, depression, anxiety and sleep disorders.
Lion’s mane mushroom contains more than 35 beneficial polysaccharides that may help prevent or treat cancer, gastric ulcers, diabetes, hyperlipidemia, liver injury and neurodegenerative diseases, according to a review published in the International Journal of Biological Macromolecules.
With a long history of use in Traditional Chinese Medicine, including for brain and neurological health, it’s now known that two terpenoid compounds– hericenones and erinacines — in these mushrooms and their mycelia may stimulate the synthesis of nerve growth factor (NGF).
Active compounds in lion’s mane mushrooms may also delay neuronal death in neurodegenerative diseases, including ischemic stroke, Parkinson’s disease, Alzheimer’s disease and depression, while promoting nerve regeneration in cases of neuropathic pain or age-related hearing loss (presbycusis). Some of their top therapeutic benefits include:
Regenerate Damaged Nerves – Lion’s mane has been shown to trigger neurite outgrowth in brain, spinal cord and retinal cells. It also stimulates the activity of nerve growth factor, which is important for the growth and differentiation of neurons.
Boost Cognitive Function – In adults with mild cognitive impairment , those who took lion’s mane powder three times a day for 16 weeks significantly increased their scores on a cognitive function scale compared with those who took a placebo.
Hericenones in lion’s mane are believed to be responsible for some of the mushroom’s beneficial effects on brain neural networks and improvements to cognitive function. This brain-boosting mushroom has also been found to improve memory in mice.[xi]
Fight Depression – Lion’s mane may ameliorate depressive disorder through a variety of mechanisms, including neurogenic/neurotrophic and anti-inflammatory pathways. Animal studies suggest that lion’s mane may reverse depressive behaviors caused by stress by modulating monoamine neurotransmitters and regulating BDNF pathways.
Support for Neurodegenerative Disease – neurotrophic compounds are known to pass through the blood-brain barrier and have been used to treat cognitive impairments, Alzheimer’s disease and Parkinson’s disease. In a study of patients with mild Alzheimer’s disease, those who took lion’s mane mycelia capsules for 49 weeks had improvements in their ability to carry out daily activities, such as personal hygiene and preparing food.
Improve Mood and Sleep Disorders – Among overweight or obese people with sleep disorders or mood disorders, lion’s mane was effective in relieving symptoms. Eight weeks of lion’s mane supplementation decreased depression, anxiety and sleep disorders in the study, while also improving mood disorders of a “depressive-anxious nature” and boosting the quality of sleep at night.

The Gary Null Show - 11.11.22

Videos:
DR. SCOT YOUNGBLOOD AT SAN DIEGO CITY COUNCIL MEETING (12:36)
Edward Dowd Interviews (47:25)
Quercetin helps to reduce the risk of pancreatic cancerUniv. of Hawaii and Univ. of Southern California, November 1, 2022
Quercetin, which is found naturally in apples and onions, has been identified as one of the most beneficial flavonols in preventing and reducing the risk of pancreatic cancer. Although the overall risk was reduced among the study participants, smokers who consumed foods rich in flavonols had a significantly greater risk reduction.
This study, published in the American Journal of Epidemiology, is the first of its kind to evaluate the effect of flavonols – compounds found specifically in plants – on developing pancreatic cancer.
Researchers from the Univ. of Hawaii and Univ. of Southern California tracked food intake and health outcomes of 183,518 participants in the Multiethnic Cohort Study for eight years. The study evaluated the participants’ food consumption and calculated the intake of the three flavonols quercetin, kaempferol, and myricetin. The analyses determined that flavonol intake does have an impact on the risk for developing pancreatic cancer.
The most significant finding was among smokers. Smokers with the lowest intake of flavonols presented with the most pancreatic cancer. Smoking is an established risk factor for the often fatal pancreatic cancer, notes the research.
Among the other findings were that women had the highest intake of total flavonols and seventy percent of the flavonol intake came from quercetin, linked to apple and onion consumption.
It is believed that these compounds may have anticancer effects due to their ability to reduce oxidative stress and alter other cellular functions related to cancer development. Previously, the most consistent inverse association was found between flavonols, especially quercetin in apples and lung cancer, as pointed out in this study. No other epidemiological flavonol studies have included evaluation of pancreatic cancer.
While found in many plants, flavonols are found in high concentrations in apples, onions, tea, berries, kale, and broccoli. Quercetin is most plentiful in apples and onions.
Hops may help lower Alzheimer disease riskUniversity of Milano-Bicocca (Italy), November 9 2022.
Hops, the plant whose flowers are used to make beer, could have a future in the prevention of Alzheimer disease according to research reported in the journal ACS Chemical Neuroscience.
“The search for natural compounds, whose intake through diet can help prevent the main biochemical mechanisms responsible for Alzheimer disease onset, led us to screen hops,” Alessandro Palmioli of the University of Milano-Bicocca and colleagues wrote.
Acting on other positive findings for hops, the team identified feruloyl and p-coumaroylquinic acids, flavan-3-ol glycosides and procyanidins as compounds responsible for the plant’s neuroprotective action. These molecules interacted with amyloid-beta (a substance that forms sticky plaques in the brains of Alzheimer disease patients), to prevent it from forming fibrils and becoming toxic. Hops extracts were also found to prevent cell death by inhibiting oxidative stress and inducing autophagy, a process by which cells break down and destroy old or damaged proteins or other substances. The Tettnang variety of hops proved to be the most successful of the four varieties tested.
“The identification of natural compounds or natural mixtures, such as nutraceuticals, exploitable for the development of preventive strategies against Alzheimer disease (and other neurodegenerative diseases) appears as a better alternative to the treatment of symptoms, as the neuronal damage associated with the disease is irreversible,” the authors remarked. “Our results show that hop is a source of bioactive molecules with synergistic and multitarget activity against the early events underlying Alzheimer disease development. We can therefore think of its use for the preparation of nutraceuticals useful for the prevention of this pathology.”
Healthy plant-based diets better for the environment than less healthy plant-based dietsHarvard School of Public Health, November 10. 2022
Healthier plant-based dietary patterns are associated with better environmental health, while less healthy plant-based dietary patterns, which are higher in foods like refined grains and sugar-sweetened beverages, require more cropland and fertilizer, according to a new study led by researchers at Harvard T.H. Chan School of Health and Brigham and Women’s Hospital. The findings also showed that red and processed meat had the highest environmental impact out of all food groups in participants’ diets, producing the greatest share of greenhouse gas emissions and requiring the most irrigation water, cropland, and fertilizer.
“The differences between plant-based diets was surprising because they’re often portrayed as universally healthy and good for the environment, but it’s more nuanced than that,” said Aviva Musicus, postdoctoral research fellow in the Department of Nutrition at Harvard Chan School and corresponding author of the study.
Previous research has documented that different types of plant-based diets have various health effects. For example, plant-based diets higher in whole grains, fruits, vegetables, nuts, legumes, vegetable oils, and tea/coffee are associated with reduced chronic disease risk, while plant-based diets high in fruit juices, sugar-sweetened beverages, refined grains, potatoes, and sweets/desserts are associated with an increased risk of chronic disease. Yet little research has been conducted to determine the environmental impacts, such as greenhouse gas emissions, use of high-quality cropland, nitrogen from fertilizer, and irrigation water, of these dietary approaches.
The researchers analyzed the food intakes of more than 65,000 qualifying participants, and examined their diets’ associations with health outcomes, including relative risks of cardiovascular disease, and with environmental impacts. Higher scores on the unhealthy plant-based diet index indicated higher consumption of refined grains, sugary drinks, fruit juice, potatoes, and sweets/desserts; while higher scores on the healthy plant-based diet index indicated higher consumption of vegetables, fruits, whole grains, nuts, legumes, vegetable oils, and tea/coffee.
Participants who consumed healthy plant-based diets had lower cardiovascular disease risk, and those diets had lower greenhouse gas emissions and use of cropland, irrigation water, and nitrogenous fertilizer than diets that were higher in unhealthy plant-based and animal-based foods.
Participants who ate unhealthy plant-based diets experienced a higher risk of cardiovascular disease, and their diets required more cropland and fertilizer than diets that were higher in healthy plant-based and animal foods. The findings also reinforced earlier studies showing that diets higher in animal-based foods, especially red and processed meat, have greater adverse environmental impacts than plant-based diets.
Removing digital devices from the bedroom can improve sleep for children, teensPenn State University, November 4, 2022
Removing electronic media from the bedroom and encouraging a calming bedtime routine are among recommendations Penn State researchers outline in a recent manuscript on digital media and sleep in childhood and adolescence.
The recommendations, for clinicians and parents, are:
Make sleep a priority by talking with family members about the importance of sleep and healthy sleep expectations;
Encourage a bedtime routine that includes calming activities and avoids electronic media use;
Encourage families to remove all electronic devices from their child or teen’s bedroom, including TVs, video games, computers, tablets and cell phones;
Talk with family members about the negative consequences of bright light in the evening on sleep; and
If a child or adolescent is exhibiting mood or behavioral problems, consider insufficient sleep as a contributing factor.
“Recent reviews of scientific literature reveal that the vast majority of studies find evidence for an adverse association between screen-based media consumption and sleep health, primarily delayed bedtimes and reduced total sleep duration,” said Orfeu Buxton, associate professor of biobehavioral health at Penn State.
The reasons behind this adverse association likely include time spent on screens replacing time spent sleeping; mental stimulation from media content; and the effects of light interrupting sleep cycles, according to the researchers.
Black Sesame Seed Reduces High Blood Pressure
Mahidol University (Thailand), November 10, 2022
Research from Thailand’s Mahidol University has found that black sesame seeds can significantly reduce blood pressure among men and women.
The research tested 30 men and women with an average age of 50 years old. They were considered ‘pre-hypertensive’ as their blood pressure levels were high but not yet high enough to be prescribed medication. During the four week study, the patients did not take any medications or dietary supplements.
The volunteers were divided into two groups. One group was given six placebo capsules per day, and the other group was given six capsules of 420 milligrams of black sesame seed meal. Each person in the sesame seed group was given a total of 2,520 milligrams (2.5 grams) per day.
According to the USDA, a tablespoon of sesame seeds weighs about nine grams. This would mean that the subjects were given a little less than a quarter tablespoon per day.
The research found the sesame seed meal significantly decreased the blood pressure among the treated group. Their average systolic blood pressure after the four weeks was 121 mmHg, while the average blood pressure of the placebo group was 129 mmHg.
The sesame seed group also showed decreased levels of malondialdehyde and increases in their blood vitamin E levels.
Malondialdehyde is an indicator of the amount of lipid peroxidation taking place within the bloodstream. As other research has shown, lipid peroxidation is linked to the blood vessel damage seen in atherosclerosis. This is a relationship of free radical oxidation. When low-density lipoproteins are oxidized, they can damage blood vessels because they effectively steal electrons from blood vessel wall cells.
Conversely, higher vitamin E levels are typically linked with lower lipid peroxidation because vitamin E is an antioxidant.
The researchers analyzed the black sesame seed meal, and it was found to contain 105 micrograms per gram of tocopherols – primarily gamma tocopherol. By the way, this is a different configuration of synthetic vitamin E found in most supplements – rac-α-tocopheryl acetate – referred also as alpha-tocopherol.
The main medicinal constituents of black sesame seed include sesamol, sesamin and sesamolin, which are known to be antioxidants. They also contain catechins, known for their anticancer properties.
Is muscle weakness the new smoking? Grip strength tied to accelerated biological age, study showsUniversity of Michigan, November 10, 2022
Everyone ages at a different pace. That’s why two 50-year-olds, despite living the same number of years, may have different biological ages—meaning that a host of intrinsic and extrinsic factors have caused them to age at varying paces with different levels of risk for disease and early death. Lifestyle choices, such as diet, and smoking, and illness all contribute to accelerating biological age beyond one’s chronological age.
For the first time, researchers have found that muscle weakness marked by grip strength, a proxy for overall strength capacity, is associated with accelerated biological age. Specifically, the weaker your grip strength, the older your biological age, according to results published in the Journal of Cachexia, Sarcopenia and Muscle.
Researchers at Michigan Medicine modeled the relationship between biological age and grip strength of 1,274 middle aged and older adults using three “age acceleration clocks” based on DNA methylation, a process that provides a molecular biomarker and estimator of the pace of aging. The clocks were originally modeled from various studies examining diabetes, cardiovascular disease, cancer, physical disability, Alzheimer’s disease, inflammation and early mortality.
Results reveal that both older men and women showed an association between lower grip strength and biological age acceleration across the DNA methylation clocks.
“We’ve known that muscular strength is a predictor of longevity, and that weakness is a powerful indicator of disease and mortality, but for the first time, we have found strong evidence of a biological link between muscle weakness and actual acceleration in biological age,” said Mark Peterson, Ph.D., M.S. at University of Michigan.
“This suggests that if you maintain your muscle strength across the lifespan, you may be able to protect against many common age-related diseases. We know that smoking, for example, can be a powerful predictor of disease and mortality, but now we know that muscle weakness could be the new smoking.”
The real strength of this study was in the 8 to 10 years of observation, in which lower grip strength predicted faster biological aging measured up to a decade later, said Jessica Faul, Ph.D., M.P.H., a co-author of the study and research associate professor at the U-M Institute for Social Research.
Past studies have shown that low grip strength is an extremely strong predictor of adverse health events. One study even found that it is a better predictor of cardiovascular events, such as myocardial infarction, than systolic blood pressure—the clinical hallmark for detecting heart disorders. Peterson and his team have previously shown a robust association between weakness and chronic disease and mortality across populations.

The Gary Null Show - 11.10.22

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Antioxidants may reduce oxidative stress in men with prostate cancer
Universities of Connecticut, Louisiana State, North Carolina, South Carolina, and California , November 3, 2022
This latest paper – which looked at men with prostate cancer from the North Carolina-Louisiana Prostate Cancer Project – came in light of a growing body of evidence suggesting oxidative stress plays a role in the development and progression of prostate cancer. The researchers looked at biomarkers of oxidative stress in the blood, urine and prostate tissue. 
They found a greater antioxidant intake was associated with lower urinary 8-isoprostane concentrations. 
A 10% increase in antioxidant intake saw an unadjusted 1.1% decrease in urinary 8-isoprostane levels. 
8-Isoprostane has been described as a “reliable marker”  and recognised  “gold standard” for lipid peroxidation – the oxidative degradation of lipids. 
“This study demonstrated that intake of antioxidants was associated with less oxidative stress among men with incident prostate cancer,” the researchers concluded in the British Journal of Nutrition.   
“The results of this study and others warrant additional research in humans on the mechanisms underlying the relationship between dietary antioxidants and prostate tissue redox status and carcinogenesis, as well as determining whether this relationship may influence disease severity, progression and recurrence.” 
High-intensity exercise changes how muscle cells manage calcium 
Karolinska Institute (Sweden) November 2, 2022
Researchers at Karolinska Institutet in Sweden have discovered a cellular mechanism behind the surprising benefits of short, high-intensity interval exercise. Their findings, which are published in the scientific journal PNAS, also provide clues to why antioxidants undermine the effect of endurance training. 
A few minutes of high-intensity interval exercise is enough to produce an effect at least equivalent to that achieved with traditional much more time-consuming endurance training. High-intensity exercise has become popular with sportspeople and recreational joggers alike, as well as with patients with impaired muscle function. However, one question has so far remained unanswered: how can a few minutes’ high-intensity exercise be so effective?
To investigate what happens in muscle cells during high-intensity exercise, the researchers asked male recreational exercisers to do 30 seconds of maximum exertion cycling followed by four minutes of rest, and to repeat the procedure six times. They then took muscle tissue samples from their thighs.
“Our study shows that three minutes of high-intensity exercise breaks down calcium channels in the muscle cells,” says Professor Håkan Westerblad, principal investigator at Karolinska Institutet’s Department of Physiology and Pharmacology. “This causes a lasting change in how the cells handle calcium, and is an excellent signal for adaptation, such as the formation of new mitochondria.”
Mitochondria are like the cell’s power plants, and changes that stimulate the formation of new mitochondria increase muscle endurance. What the researchers found was that the breakdown of calcium channels that was triggered by the high-intensity exercise was caused by an increase in free radicals, which are very reactive and oxidise cellular proteins.
The cells therefore have antioxidative systems for trapping and neutralising the radicals. Antioxidants, like vitamins E and C, are also present in food and are common ingredients in dietary supplements. In the present study, the researchers examined what happens when isolated mouse muscles are treated with an antioxidant before and after simulated high-intensity interval exercise.
“Our study shows that antioxidants remove the effect on the calcium channels, which might explain why they can weaken muscular response to endurance training,” says Professor Westerblad. “Our results also show that the calcium channels aren’t affected by the three minutes of high-intensity interval exercise in elite endurance athletes, who have built up more effective antioxidative systems.” 
8 Weeks Of Mindfulness Training Can Lower Blood Pressure For Months
Brown University, November 8, 2022
A custom mindfulness program which teaches people how to have healthy relationships with their diet, physical activity, alcohol use, and stress can help lower blood pressure for at least six months, a new study finds.
A team with the American Heart Association found that eight weeks of mindfulness training significantly lowers systolic blood pressure readings — the top number in a blood pressure measurement. The training focused on attention control, meditation, self-awareness, and emotion regulation, using weekly group sessions and daily mindfulness exercises.
“Mindfulness is non-judgmental, present-moment awareness of physical sensations, emotions and thoughts,” says lead study author Eric Loucks, Ph.D., an associate professor of epidemiology and director of the Mindfulness Center at Brown University, in a media release.
“It is almost like a scientist curiously and objectively observing the information coming in through the sense organs and the mind, and then responding skillfully to that information. Mindfulness also involves the concept of remembering, or in other words, remembering to bring one’s wisdom (wherever it was gained, such as from health care professionals or public health messages) into the present moment. Wisdom in the context of elevated blood pressure levels may include knowledge that evidence-based practices, such as physical activity, diet, limited alcohol consumption and antihypertensive medication adherence, can improve well-being.”The participant group included over 200 adults from the Providence, Rhode Island area who all had high blood pressure, meaning their readings were higher than 120 mm Hg systolic or 80 mm Hg diastolic blood pressure (the bottom number). Nearly six in 10 were women (59%) and had an average age of 59.
Results show the Mindfulness-Based Blood Pressure Reduction group saw their systolic blood pressure drop by an average of 5.9 mm Hg. Those using enhanced usual care only saw their blood pressure drop by 1.4 mm Hg. While systolic blood pressure changed, neither group saw their diastolic blood pressure drop.
In addition to improving their blood pressure, the mindfulness group also engaged in far fewer sedentary activities over the six months. Those in mindfulness training reduced their sedentary sitting by an average of 351 minutes each week. Those doing mindfulness training were also more likely to eat a heart-healthy diet and experienced less stress during the course of the study.
Grapefruit Juice Supports Healthy Arteries 
French National Institute for Agricultural Research, November 2022
Want to hydrate your way toward a healthier heart? Then you may want to consider adding grapefruit juice into your diet.Because a recent study found that grapefruit juice enriched with the flavonoid naringenin actually improved a marker associated with arterial function.The results of the study were published in the American Journal of Clinical Nutrition.
Previous research shows citrus bioflavonoids support blood vessel function. They strengthen blood vessel walls, decrease bruising, prevent bleeding, and heal hemorrhoids (hemorrhoids are swollen veins). Of the group of citrus bioflavonoids, naringenin stands out.
For the current study, 48 healthy post-menopausal women were recruited and assigned to drink grapefruit juice or a drink without flavonoids for 6 months. The grapefruit juice contained 210 mg of naringenin glycosides.
According to the results of the study, the women drinking the grapefruit juice showed a lower carotid femoral pulse wave velocity, indicating a reduction in arterial stiffening.
Naringenin is also found in oranges and tomatoes. It’s also available as a dietary supplement and is usually found in citrus bioflavonoid formulas.
Low levels of air pollution deadlier than previously thought
McGill University, November 7, 2022
The World Health Organization’s most recent estimates (2016) are that over 4.2 million people die prematurely each year due to long-term exposure to fine particulate outdoor air pollution (often referred to as PM2.5). A recent study involving McGill researchers now suggests that the annual global death toll from outdoor PM2.5 may be significantly higher than previously thought. That’s because the researchers found that mortality risk was increased even at very low levels of outdoor PM2.5, ones which had not previously been recognized as being potentially deadly. These microscopic toxins cause a range of cardiovascular and respiratory diseases and cancers.
“We found that outdoor PM2.5 may be responsible for as many as 1.5 million additional deaths around the globe each year because of effects at very-low concentrations that were not previously appreciated,” said Scott Weichenthal, an Associate Professor at McGill University and the lead author on the recent paper in Science Advances.
The researchers arrived at this conclusion by combining health and mortality data for seven million Canadians gathered over a twenty-five-year period with information about the levels of outdoor PM2.5 concentrations across the country.
The WHO recently set out ambitious new guidelines for annual average outdoor fine particulate air pollution, cutting its earlier recommendations in half, from concentrations of 10 to concentrations of 5 micrograms (ug) per cubic meter. The current United States Environmental Protection Agency standard of 12 (ug) per cubic meter is now more than double the value recommended by the WHO.
Highly processed foods can be considered addictive like tobacco products, study claims
University of Michigan & Virginia Tech University, November 9, 2022
Can highly processed foods be addictive?
A new University of Michigan and Virginia Tech analysis took the criteria used in a 1988 U.S. Surgeon General’s report that established that tobacco was addictive and applied it to food. 
Based on the criteria set for tobacco, the findings indicate that highly processed foods can be addictive, said lead author Ashley Gearhardt, U-M associate professor of psychology, and Alexandra DiFeliceantonio, assistant professor at Fralin Biomedical Research Institute at Virginia Tech. 
In fact, the addictive potential for food such as potato chips, cookies, ice cream and French fries may be a key factor contributing to the high public health costs associated with a food environment dominated by cheap, accessible and heavily marketed highly processed foods, the researchers said. 
The research, published in the current issue of Addiction, offers evidence that highly processed foods meet the same criteria used to identify cigarettes as an addictive substance: 
They trigger compulsive use where people are unable to quit or cut down (even in the face of life-threatening diseases like diabetes and heart disease)
They can change the way we feel and cause changes in the brain that are of a similar magnitude as the nicotine in tobacco products
They are highly reinforcing
They trigger intense urges and cravings 
DiFeliceantonio said the ability of highly processed foods to rapidly deliver unnaturally high doses of refined carbohydrates and fat appear key to their addictive potential.
Highly processed foods contain complex substances that cannot be simplified to a single chemical agent acting through a specific central mechanism. The same can be said for industrial tobacco products, which contain thousands of chemicals including nicotine, Gearhardt said.
Poor diets dominated by highly processed foods now contribute to preventable deaths on par with cigarettes. Similar to tobacco products, the food industry designs their highly processed foods to be intensely rewarding and hard to resist, the researchers said. 

The Gary Null Show - 11.09.22

VIDEO:
No Bill Maher, Democracy Is NOT On The Ballot (5:00)
Michael Moore’s Nonstop Lies & Gaslighting For Democrats – Jimmy Dore
Dem Party Turns On Anti-War Democratic Primary Winner (2:16 to 5:28)
Society is going to COLLAPSE -Neil Oliver ( 5:24)
Fear Psychosis and the Cult of Safety – Why are People so Afraid?  – Academy of Ideas (13:25)
The Great Reset and Transhumanism | Beyond the Cover (17:50)
 
Study shows eating prunes daily can help prevent bone lossPenn State University, November 3, 2022
People often eat prunes to boost their digestive health, but a study published in the American Journal of Clinical Nutrition shows that consuming a handful of prunes a day may also help prevent bone loss when you are older.
Researchers from Penn State University reported that women in their 60s who consumed prunes had significantly less bone loss in their hips in a year compared to those who didn’t eat the dried fruits. This suggests that prunes can help reduce inflammation in the body, which is a key driver of bone loss.
The researchers recruited 235 women for the study. The volunteers had an average age of 62 and had already gone through menopause.
The participants were split into three equal groups:
One group didn’t consume prunes.Another group consumed at least 50 grams (g) of prunes a day, or four to six pieces daily.The last group consumed 100g of prunes, or 10 to 12 pieces daily.The volunteers ate the “Improved French” prune variety. All of their diet included calcium and vitamin D3 supplements, which can also help prevent bone loss.
The research team used scans to measure bone density in the hip, neck and hip socket at the start of the study, after six months and after one year. They found that the hips of the non-eaters had an estimated 1.1 percent loss of bone density a year after the study began.
Meanwhile, the bone density of those who consumed four to six prunes a day barely shifted.
The result was similar for the group that ate more prunes, but the researchers noted that any protective effect could be masked because of its much higher dropout rate.
Blood tests also showed that the women who consumed prunes had significantly lower inflammation levels than those who did not. There was no significant documented difference in bone mass in the spine or hip socket between the groups one year after the study began.
Tracing tomatoes’ health benefits to gut microbesOhio State University, November 7, 2022
Two weeks of eating a diet heavy in tomatoes increased the diversity of gut microbes and altered gut bacteria toward a more favorable profile in young pigs, researchers found.
After observing these results with a short-term intervention, the research team plans to progress to similar studies in people, looking for health-related links between tomatoes in the diet and changes to the human gut microbiome – the community of microorganisms living in the gastrointestinal tract.
“It’s possible that tomatoes impart benefits through their modulation of the gut microbiome,” said senior author Jessica Cooperstone, assistant professor at The Ohio State University.
The tomatoes used in the study were developed by Ohio State plant breeder, tand co-author David Francis, and are the type typically found in canned tomato products.
Ten recently weaned control pigs were fed a standard diet and 10 pigs were fed the standard diet fine-tuned so that 10% of the food consisted of a freeze-dried powder made from the tomatoes.
Fiber, sugar, protein, fat and calories were identical for both diets. The control and study pig populations lived separately, and researchers running the study minimized their time spent with the pigs – a series of precautions designed to ensure that any microbiome changes seen with the study diet could be attributed to chemical compounds in the tomatoes.
Results showed two main changes in the microbiomes of pigs fed the tomato-heavy diet – the diversity of microbe species in their guts increased, and the concentrations of two types of bacteria common in the mammal microbiome shifted to a more favorable profile.
This higher ratio of the phyla Bacteroidota (formerly known as Bacteriodetes) compared to Bacillota (formerly known as Firmicutes) present in the microbiome has been found to be linked with positive health outcomes, while other studies have linked this ratio in reverse, of higher Bacillota compared to Bacteroidota, to obesity.
Tomatoes account for about 22% of vegetable intake in Western diets, and previous research has associated consumption of tomatoes with reduced risk for the development of various conditions that include cardiovascular disease and some cancers.
But tomatoes’ impact on the gut microbiome is still a mystery, and Cooperstone said these findings in pigs – whose gastrointestinal tract is more similar than rodents’ to the human GI system – suggest it’s an avenue worth exploring.
New study examines how breathing shapes our brainsAarhus University (Denmark), November 8, 2022
“Breathe in… Breathe out…” or “take a deep breath and count to ten.” The calming effect of breathing in stressful situations is a concept most of us have met before. Now Professor Micah Allen from the Department of Clinical Medicine at Aarhus University has come a step closer to understanding how the very act of breathing shapes our brain.
The researchers synthesized results from more than a dozen studies with rodent, monkey, and human brain imaging, and used it to propose a new computational model that explains how our breathing influences the brain’s expectations.
“What we found is that, across many different types of tasks and animals, brain rhythms are closely tied to the rhythm of our breath. We are more sensitive to the outside world when we are breathing in, whereas the brain tunes out more when we breathe out. This also aligns with how some extreme sports use breathing, for example professional marksmen are trained to pull the trigger at the end of exhalation,” explains Professor Micah Allen.
The study suggest that breathing is more than just something we do to stay alive, explains Micah Allen.
“It suggests that the brain and breathing are closely intertwined in a way that goes far beyond survival, to actually impact our emotions, our attention, and how we process the outside world. Our model suggests there is a common mechanism in the brain which links the rhythm of breathing to these events.”
Stabilizing our mind through breathing is a well-known and used tactic in many traditions such as yoga and meditation. The new study sheds light on how the brain makes it possible. It suggests that there are three pathways in the brain that control this interaction between breathing and brain activity. It also suggests that our pattern of breathing makes the brain more “excitable”, meaning neurons are more likely to fire during certain times of breathing
Close friends linked to a sharper memoryNorthwestern University School of Medicine, November 1, 2022
Maintaining positive, warm and trusting friendships might be the key to a slower decline in memory and cognitive functioning, according to a new Northwestern Medicine study.
SuperAgers—who are 80 years of age and older who have cognitive ability at least as good as people in their 50s or 60s—reported having more satisfying, high-quality relationships compared to their cognitively average, same-age peers, the study reports.
Previous SuperAger research at the Cognitive Neurology and Alzheimer’s Disease Center (CNADC) at Northwestern University Feinberg School of Medicine has focused on the biological differences in SuperAgers, such as discovering that the cortex in their brain is actually larger than their cognitively average, same-age peers.
“You don’t have to be the life of the party, but this study supports the theory that maintaining strong social networks seems to be linked to slower cognitive decline,” said senior author Emily Rogalski, associate professor at Northwestern’s CNADC.
Motivation is affected by oxidative stress, but nutrition can helpEcole Polytechnique Federale de Lausanne. Novembre 7. 2022
In life, motivation can be the difference between success and failure, goal-setting and aimlessness, well-being and unhappiness. And yet, becoming and staying motivated is often the hardest step, a problem which has prompted much research.
How does stress affect our capacity for motivation?” asks Professor Carmen Sandi at EPFL’s School of Life Sciences. “If that is the case, could nutritional interventions that can affect metabolite levels be an effective vehicle to improve motivated performance?”
The researchers focused on an area deep into the brain called the “nucleus accumbens”, which is known to play a major role regulating functions like reward, reinforcement, aversion, and not least, motivation.
The idea behind the study was that the brain itself—like all tissues in our body—is subjected to constant oxidative stress, as a result of its metabolism.
The brain then is often subjected to excessive oxidative stress from its neurometabolic processes—and the question for the researchers was whether antioxidant levels in the nucleus accumbens can affect motivation. To answer the question, the scientists looked at the brain’s most important antioxidant, a protein called glutathione (GSH), and its relationship to motivation.
What they found was that higher levels of GSH in the nucleus accumbens correlated with better and steady performance in the motivation tasks.
“N-acetylcysteine, the nutritional supplement that we gave in our study can also be synthesized in the body from its precursor cysteine,” says Sandi. “Cysteine is contained in ‘high-protein foods’, such as meat, chicken, fish or seafood. Other sources with lower content are eggs, whole-grain foods such as breads and cereals, and some vegetables such as broccoli, onions, and legumes.”
“Of course, there are other ways beyond N-acetylcysteine to increase GSH levels in the body, but how they relate to levels in the brain—and particularly in the nucleus accumbens—is largely unknown. Our study represents a proof of principle that dietary N-acetylcysteine can increase brain GSH levels and facilitate effortful behavior.”
Purple corn found to improve libido in malesUniversity of Tlaxcala (Mexico), November 1, 2022
Purple corn (Zea mays) has been used as an aphrodisiac since the time of ancient Mexico. A study published in the journal Journal of Evidence-Based Integrative Medicine sought to understand the mechanisms behind this plant’s effect.
The researchers suspected that purple corn extract stimulated the ejaculatory response in males.They used an animal model composed of male rats able to copulate and male rats whose spinal cord had been transected. Three doses of purple corn extract (25, 50, and 75 mg/kg) were administered to the animals.The rats’ copulating behavior was noted before and after the administration of the extracts. In the control group, the researchers noted no change in the animals’ mount latency and the number of mounts performed. All doses, however, increased the number of intromissions performed by male animals. Ejaculation latency was decreasedIn the spinal group, the researchers successfully used the extract to stimulate an increase in the number of discharges of the ejaculatory motor patterns.According to the researchers, these are proof that purple corn extract has aphrodisiac effects.

The Gary Null Show - 11.08.22

VIDEOS:
Dem Party Turns On Anti-War Democratic Primary Winner (2:16 to 5:28)
Society is going to COLLAPSE -Neil Oliver ( 5:24)
Fear Psychosis and the Cult of Safety – Why are People so Afraid?  – Academy of Ideas (13:25)
The Great Reset and Transhumanism | Beyond the Cover (17:50)
 
Zinc supplementation associated with higher levels of brain growth factorSoybean foods may protect menopausal women against osteoporosis Study finds diet high in saturated fat can reprogram immune cells in miceCoenzyme Q10 consumption reverses cholesterol transportStudy confirms that processed foods key to rising obesityViolence on TV: Effects from age 3 can stretch into the teen years
Zinc supplementation associated with higher levels of brain growth factor
Iran University of Medical Sciences, November 4 2022. 
A review and meta-analysis of randomized, controlled trials affirmed an association between supplementing with zinc and higher circulating levels of brain-derived neurotrophic factor (BDNF). Brain-derived neurotrophic factor plays a positive role in the survival of brain cells known as neurons. A reduction in BDNF expression occurs in Alzheimer and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis. Antidepressants and anthocyanin supplements have been shown to increase BDNF gene expression, and serum or plasma levels have been elevated by exercise and omega-3 fatty acid, resveratrol or zinc supplementation.
For their review and meta-analysis, Fahimeh Agh of Iran University of Medical Sciences and colleagues identified four trials that evaluated the effects of zinc supplements on serum or plasma BDNF levels among 185. Zinc dosages ranged from 25–30 milligrams per day given for 84–90 days. 
Pooled results of the trials found significantly higher BDNF levels among participants who received zinc compared with participants in the control groups. The increase in BDNF was significant at 30 milligram doses (which were used in 3 trials) and at all trial durations. Among the 3 trials that analyzed serum zinc levels, participants who were given zinc supplements had significantly increased zinc levels in comparison with the control participants. 
“A large body of evidence indicated BDNF as an important predictive factor for following the beginning, progress and cure of brain disorders due to its main role in brain neurogenesis and neuroplasticity,” Agh and her associates wrote. 
“Increased circulating levels of BDNF as a result of zinc supplementation suggest that zinc supplementation may be a safe and effective strategy to counteract neurodegenerative diseases that are correlated with low BDNF levels,” they concluded.
Soybean foods may protect menopausal women against osteoporosis 
University of Hull (UK), November 1, 2022
Eating a diet rich in both soy protein and isoflavones can protect menopausal women from bone weakening and osteoporosis, according to the results of a preliminary study presented today at the Society for Endocrinology annual conference in Edinburgh.
Soybean foods contain chemicals known as isoflavones that are similar in structure to oestrogen and so could theoretically protect women against osteoporosis by mimicking the action of oestrogen.
In this study, researchers from the University of Hull gave two hundred women in early menopause a daily supplement containing soy protein with 66mg of isoflavones or a supplement with soy protein alone for six months. The researchers investigated changes in the women’s bone activity by measuring certain proteins (βCTX and P1NP) in their blood. 
They found that the women on the soy diet with isoflavones had significantly lower levels of βCTX than the women on soy alone, suggesting that their rate of bone loss was slowing down and lowering their risk of developing osteoporosis. Women taking soy protein with isoflavones were also found to have decreased risk of cardiovascular disease than those taking soy alone.
“The 66 mg of isoflavone that we use in this study is equivalent to eating an oriental diet, which is rich in soy foods. In contrast, we only get around 2-16 mg of isoflavone with the average western diet.”
“Supplementing our food with isoflavones could lead to a significant decrease in the number of women being diagnosed with osteoporosis.”
Study finds diet high in saturated fat can reprogram immune cells in mice
Portland State University, November 7, 2022
A new study by Portland State University researchers is the first to show that eating a diet exclusively high in saturated fats can reprogram the mouse immune system, making it better able to fight off infection but more susceptible to systemic inflammatory conditions, including sepsis. Brooke Napier, assistant professor of biology at PSU, led the study, which was published in eLife.
The ketogenic or “keto” diet is a popular high-fat diet used for weight loss or to control epileptic seizures. This study shows that when mice eat a ketogenic diet that is high in saturated fats it can have a significant impact on their immune system. 
A previous study by Napier and colleagues found that mice fed a high-fat, high-sugar Western diet were more susceptible to sepsis and had a higher mortality rate than mice fed a standard diet. In the current study, the researchers found similar effects in mice fed a high-fat ketogenic diet, suggesting that dietary fat may play a role in sepsis. 
The researchers focused on one particular fat found in the blood of the mice fed a ketogenic diet: palmitic acid, which is commonly found in animal fats and dairy products. Remarkably, mice fed a normal diet who were injected with palmitic acid also became more susceptible to sepsis. 
“It was just exposure to this one saturated fat that made them more susceptible to sepsis mortality,” says Napier. “The idea that you could have a specific fat in your diet that would cause such a drastic outcome in disease is kind of incredible.” 
Napier and her team next probed just how exactly high levels of palmitic acid could initiate sepsis. Their first clue came when they noticed that mice fed the Western diet, mice fed the ketogenic diet, and mice treated with palmitic acid all had high levels of inflammatory cytokines, immunological hormones that can cause fever and systemic inflammation during sepsis. 
The presence of the inflammatory cytokines suggested that palmitic acid could be affecting the immune system by causing inflammation, but Napier soon discovered that the story was more complicated—and more interesting—than that.
Napier and colleagues also found that another type of fat may be able to counteract the harmful effects of palmitic acid. Oleic acid, a polyunsaturated fat found in many plant-based oils including olive oil, can block the synthesis of ceramide, a fatty substance that can initiate a stress response in cells and may play a role in the hyperinflammatory response that causes sepsis. When the researchers fed mice a ketogenic diet for two weeks but also gave them oleic acid for the final three days, they no longer showed an increased susceptibility to sepsis.
Coenzyme Q10 consumption reverses cholesterol transport
Sun Yat Sen University (Taiwan), October 31, 2022
According to news reporting out of Guangdong, People’s Republic of China, research stated, “We have recently shown that coenzyme Q10 (CoQ10) enhances macrophage reverse cholesterol transport via activator protein-1/miRNA-378/ABCG1 signal pathway in vivo and in vitro. Whether CoQ10 exerts similar beneficial effects in human is currently unknown.”
Our news journalists obtained a quote from the research from Sun Yat Sen University, “The present study evaluated the effect of CoQ10 on ABCG1-mediated macrophage cholesterol efflux in 20 healthy volunteers. Participants were given 100 mg CoQ10 twice daily or placebo for 1 week with a 1-week washout period. Human monocyte-derived macrophages (MDMs) were differentiated under pooled sera obtained before (preCoQ10) or after CoQ10 (postCoQ10) consumption. The CoQ10-induced inhibition of MDMs foam cell formation was blocked by ABCG1 silencing in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The cholesterol efflux to HDL, and mRNA as well as protein expressions of ATP-binding cassette transporter G1 (ABCG1) were augmented in postCoQ10 MDMs incubated with postCoQ10 sera compared to preCoQ10 sera. The change in the serum CoQ10 concentration positively correlated with cholesterol efflux to HDL and ABCG1 mRNA level in the CoQ10 group. MDMs treated with purified CoQ10 had an enhanced cholesterol efflux to HDL.”
According to the news editors, the research concluded: “CoQ10 consumption may have an atheroprotective property by inducing ABCG1 expression and enhancing HDL-mediated macrophage cholesterol efflux in healthyindividuals.”
Study confirms that processed foods key to rising obesity
University of Sydney (Australia), November 7, 2022
A year-long study of the dietary habits of 9,341 Australians has backed growing evidence that highly processed and refined foods are the leading contributor of rising obesity rates in the Western world.
“As people consume more junk foods or highly processed and refined foods, they dilute their dietary protein and increase their risk of being overweight and obese, which we know increases the risk of chronic disease,” said lead author Dr. Amanda Grech, a Postdoctoral Research Fellow at the CPC and the university’s School of Life and Environmental Sciences.
“It’s increasingly clear that our bodies eat to satisfy a protein target,” added Professor David Raubenheimer, the Leonard Ullmann Chair in Nutritional Ecology at the School of Life and Environmental Sciences. “But the problem is that the food in Western diets has increasingly less protein. So, you have to consume more of it to reach your protein target, which effectively elevates your daily energy intake.
The University of Sydney scientists analyzed data from a cross-sectional survey of nutrition and physical activity in 9,341 adults, known as the National Nutrition and Physical Activity Survey with a mean age of 46.3 years. They found the population’s mean energy intake was 8,671 kilojoules (kJ), with the mean percentage of energy from protein being just 18.4 percent, compared with 43.5 percent from carbohydrates and from 30.9 percent from fat, and just 2.2 percent from fiber and 4.3 percent from alcohol.
They also found a statistically significant difference between groups by the third meal of the day: those with a higher proportion of energy from protein at the start of the day had much lower total energy intake for the day. Meanwhile, those who consumed foods low in protein at the start of the day proceeded to increase consumption, indicating they were seeking to compensate with a higher consumption of overall energy. This is despite the fact the first meal was the smallest for both groups, with the least amount of energy and food consumed, whereas the last meal was the largest.
Participants with a lower proportion of protein than recommended at the first meal consumed more discretionary foods—energy-dense foods high in saturated fats, sugars, salt, or alcohol—throughout the day, and less of the recommended five food groups (grains; vegetables/legumes; fruit; dairy and meats). Consequently, they had an overall poorer diet at each mealtime, with their percentage of protein energy decreasing even as their discretionary food intake rose—an effect the scientists call ‘protein dilution’.
While many factors contribute to excess weight gain—including eating patterns, physical activity levels, and sleep routines—the University of Sydney scientists argue the body’s powerful demand for protein, and its lack in highly processed and refined foods, is a key driver of energy overconsumption and obesity in the Western world.
Violence on TV: Effects from age 3 can stretch into the teen years
University of Montreal, November 7, 2022
Watching violent TV during the preschool years can lead to later risks of psychological and academic impairment by the summer before middle school starts, according to a new study led by Linda Pagani, a professor at Université de Montréal’s School of Psycho-Education.
Before now, “it was unclear to what extent exposure to typical violent screen content in early childhood—a particularly critical time in brain development—can predict later psychological distress and academic risks,” said Pagani.
“The detection of early modifiable factors that influence a child’s later well-being is an important target for individual and community health initiatives, and psychological adjustment and academic motivation are essential elements in the successful transition to adolescence,” she added. “So, we wanted to see the long-term effect of typical violent screen exposure in preschoolers on normal development, based on several key indicators of youth adjustment at age 12.”
To do this, Pagani and her team examined the violent screen content that parents reported their children viewing between ages 3 1/2 and 4 1/2, and then conducted a follow-up when the children reached age 12.
“Compared to their same-sex peers who were not exposed to violent screen content, boys and girls who were exposed to typical violent content on television were more likely to experience subsequent increases in emotional distress,” said Pagani.
“They also experienced decreases in classroom engagement, academic achievement and academic motivation by the end of the sixth grade,” she added. “For youth, transition to middle school already represents a crucial stage in their development as adolescents. Feeling sadness and anxiety and being at risk academically tends to complicate their situation.”
In all, the parents of 978 girls and 998 boys participated in the study of violent TV viewing at the preschool age. At age 12 years, the children and their teachers rated the children’s psychosocial and academic achievement, motivation and participation in classroom activities.
“Preschool children tend to identify with characters on TV and treat everything they see as real,” Pagani said. “They are especially vulnerable to humorous depictions of glorified heroes and villains who use violence as a justified means to solve problems.
“Repeated exposure,” she added, “to rapidly paced, adrenaline-inducing action sequences and captivating special effects could reinforce beliefs, attitudes and impressions that habitual violence in social interactions is ‘normal.’ Mislearning essential social skills can make it difficult to fit in at school.”
Added Bernard, “Just like witnessing violence in real life, being repeatedly exposed to a hostile and violent world populated by sometimes grotesque-looking creatures could trigger fear and stress and lead these children to perceive society as dangerous and frightening. And this can lead to habitually overreacting in ambiguous social situations. In the preschool years, the number of hours in a day is limited, and the more children get exposed to aggressive interactions (on screens) the more they might think it normal to behave that way.”

The Gary Null Show - 11.07.22

Videos:
Michael Moore ‘Optimistic’ About Democratic Midterm Chances Because He Doesn’t ‘Live in a Bubble’ and Millions of Americans Aren’t ‘Very Bright’ (3:05)
Dem Party Turns On Anti-War Democratic Primary Winner (2:16 to 5:28)
Society is going to COLLAPSE -Neil Oliver ( 5:24)
Fear Psychosis and the Cult of Safety – Why are People so Afraid?  – Academy of Ideas (13:25)
Study reveals the powerful pain-relieving properties of ashwagandha
Nizam Institute of Medical Science (India), October 30, 2022
People experiencing knee joint pain and discomfort, particularly those with knee osteoarthritis, may find relief in an Ayurvedic medicine called ashwagandha(Withania somnifera). A study published in the Journal of Ayurveda and Integrative Medicine found that the root and leaf extracts of ashwagandha relieve knee pain and discomfort caused by osteoarthritis.
In the search for safe and effective natural pain relief treatments, researchers from Nizam’s Institute of Medical Sciences (NIMS)  evaluated the efficacy and safety of the root and leaf extracts of ashwagandha in patients with knee joint pain and discomfort. Ashwagandha is known to contain analgesic, anti-inflammatory, and chondroprotective properties.
In the study, the researchers recruited 60 patients with knee joint pain and discomfort. These participants received placebo capsules, 125 milligrams (mg) of ashwagandha extract, or 250 mg of ashwagandha extract twice a day for 12 weeks.
The results revealed that participants who received doses of ashwagandha extracts experienced great reductions in pain, stiffness, and disability. Those who received the higher dose of ashwagandha, which was 250 mg, experienced even greater and faster effects than those who received the 125 mg dose. In addition, the ashwagandha treatment did not cause any side effect. Overall, both doses of ashwagandha extract caused significant reductions in pain, stiffness, and disability of patients in a dose-dependent manner without causing any side effect.Ashwagandha Root Supports Thyroid Hormone Levels
Sudbhawana Hospital (India), October 31, 2022
Eight weeks of supplementation with Ashwagandha root extract were associated with normalization of the thyroid stimulating hormones (TSH), serum thyroxine (T4) and serum triiodothyronine (T3) in people with elevated TSH levels.
“The results of the present study are in accordance with previous studies,” wrote the researchers in the Journal of Alternative and Complementary Medicine. “The results indicate a possible role for ashwagandha in regulating HPT axis. The anti-stress and cortisol-lowering effect of ashwagandha may provide a suitable explanation for the current outcome.”
Ashwagandha has been used traditionally as an adaptogen to rejuvenate health, maintain homeostasis, sustain normal thyroid function and maintain hormonal balance in human body. However, very few modern published papers have reported ashwagandha’s beneficial effects on thyroid function. This is the first clinical study that supports the traditional claim of ashwagandha as a thyroid modulator.
The new double blind, randomized, placebo-controlled study involved 50 people with elevated TSH levels. So called subclinical hypothyroidism is described as a thyroid disorder with no obvious symptoms of thyroid deficiency. Participants were randomly assigned to receive either ashwagandha supplements (600mg daily) or placebo for eight weeks.
Results showed that ashwagandha significantly improved serum TSH, serum T4 and serum T3 levels, achieving change toward normalization of 19%, 45% and 21% respectively.
“The outcome of the present study highlights the beneficial role of ashwagandha root extract for normalizing thyroid hormone levels in subclinical hypothyroid patients; however, further studies are required to elucidate the underlying mechanisms of ashwagandha,” concluded the researchers.
Enzyme in Broccoli, Cucumbers and Avocados Reverses Aging In Cells
Washington University School of Medicine, October 31, 2022
Researchers have zeroed in on an enzyme — found in natural foods like broccoli and cucumbers — that can slow the chronic conditions that come with age.
Scientists at Washington University School of Medicine in St. Louis have shown that supplementing healthy mice with a natural compound called NMN can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity.
The compound, called nicotinamide mononucleotide (NMN), is involved in producing another compound that is critical for energy metabolism. When they gave normal aging mice infusions of NMN, they made more of that energy-fueling compound and some of the biological problems associated with aging went away. The NMN-treated animals did not gain as much weight, they were able to convert food into energy more efficiently, their blood sugar was better–even their eyesight improved. The mice receiving NMN were also able to prevent some of the genetic changes associated with aging.
“We have shown a way to slow the physiologic decline that we see in aging mice,” said Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine. “This means older mice have metabolism and energy levels resembling that of younger mice. Since human cells rely on this same energy production process, we are hopeful this will translate into a method to help people remain healthier as they age.”
With age, the body loses its capacity to make a key element of energy production called NAD (nicotinamide adenine dinucleotide). Past work by Imai and co-senior author Jun Yoshino, MD, PhD, an assistant professor of medicine, has shown that NAD levels decrease in multiple tissues as mice age. Past research also has shown that NAD is not effective when given directly to mice so the researchers sought an indirect method to boost its levels. To do so, they only had to look one step earlier in the NAD supply chain to the NMN compound.
“It’s clear that in humans and in rodents, we lose energy with age,” says Imai. “We are losing the enzyme NMN. But if we can bypass that process by adding NMN, we can make energy again. These results provide a very important foundation for the human studies.”
“Even though NAD synthesis was stopped only in the fat tissue, we saw metabolic dysfunction throughout the body, including the skeletal muscle, the heart muscle, the liver and in measures of the blood lipids,” Yoshino said. “When we gave NMN to these mice, these dysfunctions were reversed. That means NAD in adipose tissue is a critical regulator of whole body metabolism.”
Meta-analysis of the efficacy of acupuncture in the treatment of the vascular cognitive impairment associated with cerebral small vessel disease
Guangzhou Medical University (China), November 5, 2022
To systematically evaluate the efficacy and safety of acupuncture in the treatment of the vascular cognitive impairment (VCI) associated with cerebral small vessel disease (CSVD–VCI) and to provide a theoretical basis for clinical acupuncture treatment for CSVD–VCI.
Ten articles on RCTs were included, involving 761 patients, i.e., 381 in the acupuncture group and 380 in the control group. The meta-analysis results indicated that the use of acupuncture alone and acupuncture alongside other therapies for CSVD–VCI could improve the overall clinical response rate, increase the patients’ Montreal Cognitive Assessment scores, and activities of daily living scores.
Conclusion:  Acupuncture alone and acupuncture alongside other therapies are superior to non-acupuncture-based therapies in the treatment of CSVD–VCI. However, due to the small number of relevant available articles and their general low quality, this conclusion may be biased. More clinical RCTs with a larger sample size and higher quality are needed to support this theory.
Kids with vitamin D deficiency more likely to develop asthma: 10-year study
Telethon Kids Institute (Australia), November 1, 2022
The findings, published in the Journal of Allergy and Clinical Immunology, showed repeated bouts of vitamin D deficiency in early childhood were linked to higher rates of asthma at aged 10, as well as allergy and eczema. 
The study also found that allergic immune responses were more common in children with low vitamin D in the first few years, while children with vitamin D deficiency at 6 months of age were more likely to experience two conditions previously associated with heightened asthma risk: increased colonisation of the upper airways by harmful bacteria and increased susceptibility to severe lower respiratory infections involving fever.
“We know vitamin D plays an important role in regulating the immune system and promoting healthy lung development…But while it has been suggested that inadequate vitamin D may be a factor contributing to the surge in asthma rates over recent decades, previous studies investigating the relationship have yielded conflicting results. There has been a lack of research looking at whether vitamin D deficiency is more detrimental at certain periods in childhood.”
The study tracked vitamin D levels from birth to asthma onset, and it had shown a clear link between prolonged vitamin D deficiency in early childhood and the development of asthma. The paper states that the children were assessed at birth and at clinical follow-ups at the ages of 0.5, 1, 2, 3, 4, 5, and 10 years, and relationships with clinical outcomes were examined. 
“Vitamin D deficiency in early childhood is associated with increased risk for persistent asthma, potentially through modulating susceptibility to early allergic sensitization, upper respiratory tract colonization with bacterial pathogens, or both. These relationships are only evident if vitamin D status is monitored prospectively and longitudinally,” the study concluded.
“Australia is one of the few developed countries that does not fortify its food supply with Vitamin D and therefore it may not be a coincidence that we have the highest rates of allergic disease, including food allergies, in the developed world. We believe that Vitamin D supplementation trials in infancy are essential to answer this important public health question,” she said.
Boost Memory, Regenerate Neurons with This Ancient Plant
GreenMedInfo, November 1st 2022
Considering the fact that gingko biloba is the oldest known tree in existence (deemed for this reason a “living fossil“), isn’t it poetic how this plant has also been used to promote long life as both a food and medicine in traditional cultures as well?
A 2006 paper published in the European Journal of Neurology described a 24-week randomized, placebo-controlled, double-blind study showing an extract of this plant was as clinically effective as the blockbuster donepezil for mild-to-moderate Alzheimer’s disease
You will find gingko has been studied to have value in over 100 different diseases, and has been identified to have at least 50 distinct beneficial physiological actions. Isn’t this amazing? 
It has been known that gingko can stimulate brain-derived neutrophic factor (BDNF), a protein found in the brain and in the peripheral nervous system which is essential in the regulation, growth and survival of brain cells, and which is especially important for long-term memory. The ability to increase BDNF, therefore, implies it will improve brain and cognitive function.
Only recently a new mechanism behind gingko biloba’s brain and neurological tissue healing properties been revealed in the publication of an article in Cell and Molecular Neurobiology titled, “Ginkgo Biloba Extract Enhances Differentiation and Performance of Neural Stem Cells in Mouse Cochlea.”  
In the new study researchers tested the premise that ginkgo biloba’s wide range of benefits in the treatment of neural damage and disorders is due, in part, to its ability to positively modulate neural stem cells (NSC), a subpopulation of cells within the brain that as multipotent cells are capable of generating the many different types (phenotypes) of cells that make up the brain.  Their results, using mouse cochlea-derived neural stem cells, showed a number of ways that gingko biloba exact (GBE) resulted in a beneficial effect:
“Our data showed that GBE treatment promotes cell survival and NSC proliferation. In addition, GBE treatment also increases NSC differentiation to neurons and enhances the performance of mature neural networks evident by the increased frequency of calcium oscillation. Moreover, neurite outgrowth is also dramatically increased upon GBE treatment. Overall, our study demonstrates the positive regulatory role of GBE in NSC proliferation and differentiation into functional neurons in vitro, supporting the potential therapeutic use of GBE in hearing loss recovery.”
It is noted that neural stem cell stimulation and subsequent brain repair has also been observed in preclinical research with a little known component of turmeric known as ar-turmerone, which is found in whole turmeric but not in the increasingly popular 95% standardized curcumin extracts of turmeric.  

The Gary Null Show - 11.04.22

VIDEOS:
EXCLUSIVE: UNDERTAKER EXPLAINS “MYSTERIOUS” CLOTTING PHENOMENON! | Louder with Crowder (part 2)
Society is going to COLLAPSE -Neil Oliver ( 5:24)
Fear Psychosis and the Cult of Safety – Why are People so Afraid?  – Academy of Ideas (13:25)
 
Dietary supplement found to improve concentration levelsUniversity of Granada, November 3, 2022
The research group from the University of Granada (UGR) has tested the effects of a multi-ingredient dietary nootropic on concentration levels and cognitive performance. Nootropics are cognitive enhancers that have traditionally been used in the treatment of cognitive pathologies.
Leading this study was Lucas Jurado Fasoli—a researcher from the Scientific Unit of Excellence in Exercise, Nutrition and Health (UCEENS) at the Sport and Health Joint University Institute (iMUDS). He explains that, traditionally, nootropics have been drugs, with their corresponding side-effects.
“To address the issue of potential side-effects, different dietary nootropics have emerged as an alternative way to enhance cognitive performance. And these, as is the case in this study, are used by healthy individuals in activities such as preparing for competitive exams or video-game competitions,” explains Jurado Fasoli.
The results of the study showed that the acute intake of this multi-ingredient nootropic decreases the response time across different cognitive tests: in processing speed, inhibitory control, working memory, and cognitive flexibility. It also increases accuracy in tests involving processing speed, inhibitory control, and cognitive flexibility. The supplement contains L-tyrosine, acetyl L-carnitine, sodium citicoline, alpha-GPC, taurine, caffeine, mango leaf extract and huperzia serrata leaf.
These results were accompanied by an increase in positive emotions and a decrease in negative emotions and depression. And, importantly, the favorable effects of this nootropic did not appear to have any effect on the heart-rate of participants.
Previous studies have shown that supplementation with the combination of caffeine and taurine, L-theanine, tyrosine, and mango leaves extract can improve the RT in different cognitive and computerized tests. In this study, we showed that a dietary multi-ingredient nootropic improves the processing speed of information in young healthy adults. This effect could be due to the synergic effects of different dietary ingredients included in the nootropic. Also, it could be partially explained by the central nervous system activation and alertness enhancement effect of caffeine, which could increase the processing speed and decrease the RT. The inclusion of L-theanine as a dietary ingredient in the nootropic counteracts the potential effects derived from a high dose of caffeine on anxiety, psychological stress, blood pressure, and HR, which completely agrees with our results.
A sample comprising 26 young adults (50:50 male/female, with an average age of 25) participated in the study. They were required to undertake various cognitive tests twice, separated by 48 hours, having ingested either the multi-ingredient dietary nootropic or a placebo (randomized and triple-blinded across the sample).
Thirty minutes after ingestion, measurements were taken of processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency. Different emotions were also evaluated and the participants’ heart-rate was recorded while they undertook the tests.
Consuming more magnesium associated with lower risk of mortality during years following heart attackWageningen University and Research (Netherlands), October 31, 2022
A study of people with a history of heart attack found that those who consumed more magnesium lived longer than those whose intake was low. Having a high magnesium intake, defined as greater than 320 milligrams (mg) per day, was associated with a 28% lower risk of dying from cardiovascular disease and a 22% lower risk of death from any cause compared to a low intake, defined as less than 283 mg per day.
The protective effect of magnesium was even stronger in patients who were being treated with diuretic drugs. In this group, the risk of mortality from cardiovascular disease was 45% lower among those with high magnesium compared to those with low magnesium.
“Little is known about magnesium intake and long-term mortality risk in cardiovascular disease patients,” authors Ilse Evers and colleagues noted. “Magnesium requirements may be different in cardiovascular disease patients because of alterations in the cardiovascular system, comorbidities and/or medication use.”
The study included 4,365 participants in the Alpha Omega Cohort, an ongoing follow-up of participants in the earlier 40-month Alpha Omega Trial. The Alpha Omega Trial included men and women between the ages of 60 and 80 years who had experienced a heart attack within 10 years prior to enrolling between 2002 and 2006. Dietary questionnaire responses obtained at enrollment provided information concerning magnesium intake from food and non-food sources. Mortality was ascertained through 2018. The findings were published in Frontiers in Cardiovascular Medicine.
Calorie restriction promotes longevity through effects on mitochondrial networkHarvard School of Public Health, October 27 2022.
Research reported in Cell Metabolism helps explain the effects of calorie restriction and activation of AMP-activated protein kinase (AMPK, an energy-sensing protein) on longevity. Harvard researchers have determined that AMPK and calorie restriction promote homeostasis and plasticity of networks formed by the cells’ power plants known as mitochondria.
Mitochondria networks change shape according to energy demand, however, this ability declines with age. “Dynamic remodeling of mitochondrial networks by fusion and fission promotes maintenance of cellular homeostasis,” explain Heather J. Weir and colleagues at the Harvard T. H. Chan School of Public Health. “Dysregulation of mitochondrial dynamics and aberrant mitochondrial morphology are hallmarks of aging and are thought to contribute to the pathology of numerous age-related pathologies including Alzheimer’s and Parkinson’s disease.”
By restricting calories in the diet of roundworms or using a strain of roundworm in which an AMPK subunit is activated, the researchers found that the roundworms maintained a youthful fused mitochondrial network shape with age. The youthful networks lengthen life by communicating with peroxisomes within the cells to alter fat metabolism.
“Low-energy conditions such as dietary restriction and intermittent fasting have previously been shown to promote healthy aging,” Dr Weir commented.
“Our work shows how crucial the plasticity of mitochondria networks is for the benefits of fasting. If we lock mitochondria in one state, we completely block the effects of fasting or dietary restriction on longevity.”
Electroacupuncture found to ease nausea and vomiting in ICU patients recovering from chemotherapyNarbonne Hospital (France), October 28, 2022
Refractory vomiting is just one of many complications endured by patients confined to intensive care units (ICU) due to chemotherapy and other major medical treatments. But relief may be coming in the form of transcutaneous electroacupuncture (TEA) therapy that can alleviate the worst symptoms of persistent vomiting.
Earlier studies have shown that TEA can reduce episodes of nausea and vomiting attributed to chemotherapy treatments, recently concluded medical operations, and pregnancy. It is growing popular as an alternative to anti-emetic medication.
The TEA treatment consisted of two electrodes attached on either side of the Neiguan (PC 6) pressure point, also known as the pericardium meridian. The researchers employed a standard neuromuscular transmission monitor to stimulate the acupuncture point for 30 minutes.
The overall incidence of nausea or vomiting within the first 24 hours after TEA was 50 percent. After the 24-hour mark, 30 percent of the patients perceived nausea, and 20 percent experienced vomiting.
Ninety percent of patients reported suppression of nausea/vomiting immediately after undergoing TEA. During a six-hour period after TEA, 60 percent of patients did not sense nausea or experience vomiting.
Between six to 24 hours after TEA, 60 percent of patients remained free from nausea or vomiting episodes. Two patients who experienced nausea were given a second TEA session that remedied all symptoms.TEA itself was free from any complication and side effects.
The Mindfulness Skill That Is Crucial for StressA new study suggests that practicing acceptance helps reduce our stress more than simple mindful awareness.Carnegie Mellon University, October 28, 2022
In this study, researchers randomly assigned 137 stressed adults of various ages and ethnicities to one of three programs: an eight-week Mindfulness-Based Stress Reduction (MBSR) course, where they learned to mindfully pay attention to their present-moment experiences in an accepting, nonjudgmental way; an MBSR course without instructions on acceptance; or no course. The courses included many lessons—for example, how to pay attention to your breath and your body sensations, and how to eat food or take a walk mindfully—as well as practice time outside of class. Before, during, and afterwards, participants reported five times daily about how stressed they felt in the moment and whether they’d experienced a stressful event since their last report.In response to stress, many people today are turning to meditation or mindfulness apps (myself included). But not all mindfulness practice is equally effective for combating stress, a new study suggests. It’s possible that some of our practices may be missing a vital ingredient: acceptance.
Though all of the groups experienced less stress and fewer incidents of feeling stressed over time, the people who took the full MBSR course had a significantly steeper improvement than the other two groups.
“Learning how to accept your present-moment experience is really important for reducing stress,” says Emily Lindsay, one of the study’s coauthors. “It seems to be a key element of mindfulness training.”
Mindfulness practices that specifically emphasize acceptance teach us a nonjudgmental attitude toward our experiences—meaning, learning not to label our thoughts, feelings, or experiences as good or bad, and trying not to change or resist them in any way. While many mindfulness courses include instructions in acceptance as par for the course, those that don’t may not be as effective.
People who learn to accept and not just notice their experiences become less prone to mind-wandering, which has been tied to well-being, and less reactive to stress—meaning, they show reductions in systolic blood pressure, the stress hormone cortisol, and feelings of stress in a stressful situation. Her recent study adds to these results by monitoring participants daily, helping to show that acceptance makes a difference in everyday life situations and not just in the laboratory.
Accepting stress helps people to stop focusing only on what’s wrong and to notice other feelings, sensations, and thoughts occurring at the same time, enabling them to see the “bigger picture.”
Acceptance is not about acquiescing to your fate, though —like getting a diagnosis of a terminal illness and just accepting that you’re going to die. That kind of “acceptance” leads to worse outcomes. Nor is it about accepting poor treatment from other people. It’s more about accepting your internal experience—your thoughts and feelings—which informs you about how to respond to your external circumstances in a wiser way. For example, if you feel angry and accept your anger in the moment, it may prevent you from lashing out at someone and help you see that your feelings aren’t their fault
Eat more trifoliate oranges to keep your prostate healthyKorean Institute of Oriental Medicine, October 26, 2022
Compared to younger individuals, older men are at a higher risk of developing benign prostatic hyperplasia (BPH) or an enlarged prostate. A study published in the journal BMC Complementary and Alternative Medicine reveals a compelling reason for men to eat trifoliate oranges, as extracts from the fruit were proven effective in preventing the onset of BPH and cease its progression.
The trifoliate orange (Poncirus trifoliata), also known as the hardy orange, is a citrus fruit native to China. It is grown in parts of the US and Europe for use in jellies, marmalades, and jams despite its notoriously bitter taste. It has been used as an ingredient in Traditional Chinese Medicine since ancient times, and current studies have shown its importance in maintaining prostate health.
As the word “benign” in its name implies, BPH is relatively harmless. In fact, some consider it a normal part of the aging process among males. It can, however, be extremely inconvenient as its symptoms can make the vital act of urinating difficult. It can also cause a constant feeling of needing to pee even at night; in most cases, sufferers may find themselves unable to sleep properly because of this particular symptom.
The researchers in the aforementioned looked at the trifoliate orange as a possible treatment for BPH. In particular, the study investigated the extract from Ponciri Fructus (PFE), the young fruit of the trifoliate orange, and its protective effects on the development of the BPH.
In the study, the researchers induced BPH in a rat model by injecting testosterone propionate (TP) and corn oil every day for four weeks. PFE was administered via oral gavage at a dose level of 200 mg/kg, one hour before these injections over the same duration.
At the end of the study, the rats were sacrificed and examined for markers of BPH. Specifically, the researchers took note of relative prostate weight, the levels of testosterone and dihydrotestosterone (DHT), common factors influencing the development of BPH.
At the end of the study, the researchers noticed reductions in relative prostate weight, the level of testosterone and DHT in serum and prostatic tissue, prostatic hyperplasia, and the expression of PCNA. They also noted higher levels of antioxidant enzymes.

The Gary Null Show - 11.03.22

Videos:
Did Julian Assange’s lawyers just EXPOSE this CIA scheme? Redacted with Natali and Clayton Morris (3:23 to 6:46)
EXCLUSIVE: UNDERTAKER EXPLAINS “MYSTERIOUS” CLOTTING PHENOMENON! | Louder with Crowder (8:17 – 26:00)
 
Green tea and resveratrol reduce Alzheimer’s plaques in lab testsTufts University, November 2, 2022
Tufts researchers are working to understand what might slow progression of Alzheimer’s disease. They have tested 21 different compounds in Alzheimer’s-afflicted neural cells in the lab, measuring the compounds’ effect on the growth of sticky beta amyloid plaques. These plaques develop in the brains of people with Alzheimer’s.
The researchers found that two common compounds—green tea catechins and resveratrol, found in red wine and other foods—reduced the formation of plaques in those neural cells. And they did so with few or no side effects. The researchers reported their findings in the journal Free Radical Biology and Medicine.
Some of the 21 compounds tested reduced the disease progression by acting as anti-viral agents—slowing Alzheimer’s induced by the herpes virus. But finding a compound “that could diminish the plaques regardless of the virus component would be ideal, because that would show that regardless of the cause of Alzheimer’s, you might still see some kind of improvement,” says Dana Cairns, GBS12. Cairns is a research associate in the Kaplan Lab in the School of Engineering and led the research.
The initial screen found five compounds had “really robust prevention of these plaques,” she says. In addition to the green tea compounds and resveratrol, they found curcumin from turmeric, the diabetic medication Metformin, and a compound called citicoline prevented plaques from forming and did not have anti-viral effects.
“We hoped to find compounds that would be harmless and show some level of efficacy,” she said. Green tea compounds and resveratrol met that standard. “We got lucky that some of these showed some pretty strong efficacy,” Cairns said. “In the case of these compounds that passed the screening, they had virtually no plaques visible after about a week.”
The discovery is significant because there is no cure for Alzheimer’s or a way to prevent its progression, aside from several potential drugs developed by pharmaceutical companies that are still in trials, Cairns says. Compounds like these two that show some efficacy and are known to be safe and easily accessible could be taken as a supplement or consumed as part of one’s diet, she adds.
High fiber, yogurt diet associated with lower lung cancer riskVanderbilt University Medical School, October 28, 2022
A diet high in fiber and yogurt is associated with a reduced risk for lung cancer, according to a study by Vanderbilt University Medical Center researchers published in JAMA Oncology.
The benefits of a diet high in fiber and yogurt have already been established for cardiovascular disease and gastrointestinal cancer. The new findings based on an analysis of data from studies involving 1.4 million adults in the United States, Europe and Asia suggest this diet may also protect against lung cancer.
Participants were divided into five groups, according to the amount of fiber and yogurt they consumed. Those with the highest yogurt and fiber consumption had a 33% reduced lung cancer risk as compared to the group who did not consume yogurt and consumed the least amount of fiber.
“This inverse association was robust, consistently seen across current, past and never smokers, as well as men, women and individuals with different backgrounds,” she added. Shu said the health benefits may be rooted in their prebiotic (nondigestible food that promotes growth of beneficial microorganisms in the intestines) and probiotic properties. The properties may independently or synergistically modulate gut microbiota in a beneficial way.
Yoga Practice Beneficial to Patients With COPD
All India Institute of Medical Sciences Oct. 28, 2022
Patients with COPD who practice yoga can improve their lung function, according to a study by researchers at the All India Institute of Medical Sciences, Department of Pulmonary Medicine and Sleep Disorders. The study found that lung function, shortness of breath, and inflammation all showed significant improvement after patients completed 12 weeks of training.
An estimated 24 million Americans may have COPD, which includes chronic bronchitis, emphysema, or both. Patients with COPD have trouble pushing used air out of their lungs, making it difficult to take in healthy new air. Although there is no cure for COPD, a patient’s quality of life can be improved by controlling symptoms, such as shortness of breath.
The study included 29 stable patients with COPD who received yoga training in a format that included the use of physical postures (asanas), breathing techniques (pranayama), cleansing techniques, (kriyas), meditation, and a relaxation technique (shavasan) for 1 hour, twice a week, for 4 weeks. Following the 4-week period, patients were trained for 1 hour every 2 weeks, with the remaining sessions completed at home. Patients were evaluated on assessment of lung function, breathing, quality of life, and inflammation status. A repeat assessment was done at the end of the 12-week training session. All parameters showed significant improvement at the end of the 12-week period.
“We found that yoga can be a simple, cost-effective method that can help improve quality of life in patients with COPD,” stated Dr. Guleria.
Iron proposed as cause of heart failure in many heart attack patientsIndiana University School of Medicine, November 2 2022.
A study published in Nature Communications revealed the discovery of a cause for chronic heart failure that occurs in approximately half of the people who experience a heart attack.
“For the first time, we have identified a root cause of chronic heart failure following a heart attack,” lead researcher Rohan Dharmakumar of Indiana University School of Medicine’s Cardiovascular Institute announced.
Using large animal models, the research team found that in heart attacks in which bleeding within the heart muscle occurs upon restoration of circulation, scar tissue is gradually replaced by fat. The inability of fat to effectively propel blood from the heart can lead to heart failure in survivors of this type of heart attack. “Using noninvasive imaging, histology and molecular biology techniques, and various other technologies, we have shown that iron from red blood cells is what drives this process,” Dr Dharmakumar reported. “When we removed the iron, we reduced the amount of fat in the heart muscle. This finding establishes a pathway for clinical investigations to remedy or mitigate the effects associated with iron in hemorrhagic myocardial infarction patients.”
The finding led to a clinical trial to determine the effect of iron chelation therapy to remove excess iron in patients with hemorrhagic heart attack.
“While advances across populations have made survival after a heart attack possible for most, too many survivors suffer long-term complications like heart failure,” Indiana University’s Cardiovascular Institute physician director Subha Raman, MD noted. “Dr Dharmakumar’s breakthrough science illuminates who is at risk and why and points to an effective way to prevent these complications.”
DHEA supplementation associated with improved sexual function in womenCenter for Human Reproduction (New York), October 6, 2022A report published in the journal Endocrine revealed improvements in sexual function among older premenopausal women who supplemented with the hormone dehydroepiandrosterone (DHEA).
In their introduction to the article, authors Vitaly A. Kushnir of the Center for Human Reproduction in New York and colleagues describe their use of DHEA in the treatment of infertile women who had low levels of androgen hormones. “In the process of treating thousands of so-affected infertile women, we noticed that many spontaneously reported improvements in libido, sexual desire and, sometimes, even pain status, leading to the paradoxical situation of women refusing to discontinue DHEA supplementation once they conceived,” they remarked. “When we, in a review of the literature, were unable to find a study that investigated the effectiveness of DHEA on female sexuality in older premenopausal women, this study was developed.”
The study included 50 infertile premenopausal women whose age averaged 41 years. The participants supplemented with oral DHEA for a minimum of six weeks prior to starting any other fertility treatments.
Serum androgen hormone levels, including DHEA and testosterone, were shown to increase following DHEA supplementation. In comparison with pretreatment scores, FSFI index scores improved by 7%, including a 17% increase in desire, a 12% increase in arousal, and an 8% increase in lubrication. However, among women whose scores were among the lowest 25% of the group, total FSFI scores increased by 34%, which included a 40% increase in desire, a 46% increase in arousal, and a 33% increase in lubrication. Women in this group also experienced a 54% increase in orgasm, greater satisfaction, and less pain in comparison with pretreatment values.
Trauma during childhood triples the risk of suffering a serious mental disorder in adulthood, study findsHospital del Mar Medical Research Institute (Spain), November 2, 2022
A study led by researchers at the Hospital del Mar Medical Research Institute links psychological trauma in childhood with an increased risk of developing some kind of mental disorder years later.
Suffering psychological trauma during childhood significantly increases the risk of developing a mental disorder in adulthood. Specifically, as much as three times, according to a recent study, published in the journal European Archives of Psychiatry and Clinical Neuroscience. The study analyses the fourteen reviews and meta-analyses published to date in specialized journals on this issue, and is the first to take into account the full range of existing mental disorders.
In total, the studies analyzed incorporate more than 93,000 cases, revealing a direct link between suffering psychological trauma at a pediatric age and the risk of developing a mental pathology later in life. “It is the strongest evidence to date that psychological trauma really is a risk factor for suffering a mental disorder later on,” says Dr. Benedikt Amann, lead author of the study
The most common childhood traumas are emotional, physical and sexual abuse, as well as emotional or physical neglect and bullying, although there are many others. Suffering one of these situations damages the brain, causing physical as well as psychological consequences in the form of various disorders. In the case of emotional abuse, the most frequent trauma is associated with the most prevalent disorder in the population, that of anxiety. But there is also a relationship between childhood trauma and other pathologies, such as psychosis, which is linked to all traumas, obsessive-compulsive disorder or bipolar disorder. The risk of suffering from borderline personality disorder increases up to fifteen times in the case of having experienced trauma during childhood.
Trauma in adulthood is also associated with a four-fold increase in the risk of a later mental disorder. The researchers point out, however, that there is less evidence for this type of pathology.

The Gary Null Show - 11.02.22

VIDEOS:
Mark Dolan: Covid has been the biggest “I told you so” in history (4:41)
Society is going to COLLAPSE (5:24)
Fear Psychosis and the Cult of Safety – Why are People so Afraid? (13:25)
MSNBC Midterm PANIC꞉ ‘It’s Going To Be a BLOODBATH’!!! (0:18 – 3:32)
Pycnogenol, gotu kola supplementation associated with decreased progression of atherosclerosisD’Annunzio University (Italy), October 23, 2022
The results of studies published in Minerva Cardioangiologica suggest a benefit for supplementation with extracts of pine bark and the herb gotu kola in atherosclerosis.
In one study, participants with arterial wall atherosclerotic lesions and intima-media thickening (thickening of the artery walls’ innermost layers) received standard management, standard management plus aspirin, or standard management, aspirin and Pycnogenol® pine bark extract plus gotu kola extract daily for three years, after which atherosclerotic lesion progression, carotid artery intima-media thickness and oxidative stress were assessed.
At the end of the trial, 5.3% of those who received Pycnogenol and gotu kola had experienced atherosclerotic lesion progression in comparison with over 20% of the remainder of the participants. Cardiovascular events that required hospital admission were less than 4% in the supplemented group compared to over 12% in the rest of the subjects. Carotid artery intima thickness and oxidative stress were also lower in association with supplementation.
In the second study, 90 men with coronary artery calcifications received standard management alone, standard management and daily Pycnogenol, or standard management with daily Pycnogenol plus gotu kola. All participants received daily aspirin. Calcification was assessed at the beginning of the study and after one year.
While Pycnogenol plus standard management was more effective than standard management alone, men who received Pycnogenol plus gotu kola experienced a 10% decline in the number of calcifications by the end of the study, in contrast with a 34.9% increase in the standard management group. “This indicates that supplementation with the combined supplements blocks the increase in calcified areas and, possibly, in time may decrease the number of calcified spots,” Shu Hu and colleagues write.
Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study.Pennsylvania State University, October 22, 2022Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms.
We evaluated the effects of 2 doses of pistachios, added to a lower-fat diet, on lipids and lipoproteins, apolipoprotein (apo)-defined lipoprotein subclasses, and plasma fatty acids. To investigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).
In a randomized crossover controlled-feeding study, 28 individuals with LDL cholesterol > or = 2.86 mmol/L consumed 3 isoenergetic diets for 4 wk each. Baseline measures were assessed after 2 wk of a typical Western diet. The experimental diets included a lower-fat control diet with no pistachios [25% total fat; 8% saturated fatty acids (SFAs), 9% monounsaturated fatty acids (MUFAs), and 5% polyunsaturated fatty acids (PUFAs)], 1 serving/d of a pistachio diet (1 PD; 10% of energy from pistachios; 30% total fat; 8% SFAs, 12% MUFAs, and 6% PUFAs), and 2 servings/d of a pistachio diet (2 PD; 20% of energy from pistachios; 34% total fat; 8% SFAs, 15% MUFAs, and 8% PUFAs).
Inclusion of pistachios in a healthy diet beneficially affects CVD risk factors in a dose-dependent manner, which may reflect effects on SCD.
Poor quality sleep may be linked to heightened risk of glaucoma, irreversible sight lossSichuan University (China), November 1, 2022
Poor quality sleep, including too much or too little shuteye, daytime sleepiness, and snoring, may be linked to a heightened risk of developing irreversible sight loss (glaucoma), suggests a large UK Biobank study published in the open access journal BMJ Open.
The findings underscore the need for sleep therapy in people at high risk of the disease as well as eye checks among those with chronic sleep disorders to check for early signs of glaucoma, conclude the researchers.
While population screening may not be cost-effective, targeted screening of high-risk groups might be, suggest the researchers. And previously published research suggests that sleep disorders may be an important risk factor.
To explore these issues further, the researchers set out to ascertain the risk of glaucoma among people with different sleep behaviors: insomnia; too much or too little sleep; night or morning chronotypes (“owls” or “larks”); daytime sleepiness; and snoring.
They drew on 409,053 participants in the UK Biobank, all of whom were aged between 40 and 69, and who had provided details of their sleep behaviors.
Sleep duration of 7 to less than 9 hours per day was defined as normal, and as too little or too much outside this range. Chronotype was defined according to whether the person described themselves as more of a morning lark or night owl.
During an average monitoring period of just over 10.5 years, 8690 cases of glaucoma were identified.
Those with glaucoma tended to be older and were more likely to be male, chronic smokers, and to have high blood pressure or diabetes than those who weren’t diagnosed with the disease.
Short or long sleep duration was associated with a heightened risk of 8%; insomnia, 12%; snoring, 4%; and frequent daytime sleepiness, 20%.
Compared to those with a healthy sleep pattern, snorers and those who experienced daytime sleepiness were 10% more likely to have glaucoma, while insomniacs and those with a short/long sleep duration pattern were 13% more likely to have it.
Could a Japanese mushroom extract eradicate HPV?
University of Texas Health Science Center October 29, 2022
A study by researchers from The University of Texas Health Science Center suggests that an extract from a Japanese mushroom has potential to eradicate human papillomavirus – the leading cause of cervical cancer.
HPV is also accountable for around 95% of anal cancers, 65% of vaginal cancers, 60% of oropharyngeal cancers, 50% of vulvar cancers and 35% of penile cancers. .
As such, the team set out to assess the effects of active hexose correlated compound (AHCC) against HPV. AHCC is a substance produced by the shiitake mushroom, also called the Japanese mushroom, native to Asia.
AHCC is already available as a nutritional supplement, hailed for its immune-boosting properties. Previous studies, however, have suggested that the compound may improve the growth and function of cells that ward off infections and prevent tumor growth.
To reach their findings, Smith and colleagues enrolled 10 women to their study who had tested positive for HPV infection. Once a day for up to 6 months, each woman took an oral formulation of AHCC.
Five of these women tested negative for HPV infection after 3 months of AHCC use. Among three of the participants, it was confirmed that HPV had been completely eradicated after AHCC use had ceased. The remaining two women needed to take AHCC for the full 6 months to see results.
The team’s findings are “very encouraging,” according to Smith. “We were able to determine that at least 3 months of treatment is necessary, but some need to extend that to 6 months,” she says, adding:
“Since AHCC is a nutritional supplement with no side effects and other immune-modulating benefits, we will be planning on using 6 months of treatment in our phase 2 clinical study to have a consistent study treatment plan. This confirms our earlier preclinical research.”
Research suggests higher testosterone reference range for young menUniversity of Michigan, October 31 2022.
In an article appearing in the Journal of Urology, Alex Zhu , of University of Michigan and his associates asserted that the standard cutoff for testosterone deficiency of 300 nanograms per deciliter (ng/dL) is too low for men younger than 45 years of age. The study is “the first evaluation of normative, population-based testosterone levels for young men in the United States,” according to Dr Zhu and colleagues.
“There is an age-related decline in male testosterone production,” they wrote. “It is therefore surprising that young men are evaluated for testosterone deficiency with the same cutoff of 300 ng/dL that was developed from samples of older men.”
The investigation included 1,486 men between the ages of 20 to 44 years who participated in the National Health and Nutrition Examination Surveys (NHANES) of United States residents. Men who were receiving hormone replacement therapy were excluded from the study. The men’s testosterone levels were evaluated according to 5-year age groups. Testosterone levels that fell in the middle one-third of each group were categorized as normal.
For every 1-year increase in age, a 4.3 ng/dL decline in testosterone was observed. Normal levels of testosterone for men aged 20 to 24 years were categorized as 409-558 ng/dL, for those 25-29 as 413-575 ng/dL, for men 30 to 34 as 359-498 ng/dL, for 35-39-year-olds as 352-478 ng/dL and for 40 to 44-year-olds as 350-473 ng/dL. This resulted in age-specific cutoffs for low testosterone levels of 409, 413, 359, 352 and 350 ng/dL for each age group.
“Young men have different testosterone reference ranges than older men,” Dr Zhu, remarked. “Our findings suggest we should be using age-specific cutoffs when assessing testosterone levels in younger men.”
Why 80% of Us Are Deficient In MagnesiumDr Mark Sircus, October 31st 2022
Magnesium deficiency is often misdiagnosed because it does not show up in blood tests – only 1% of the body’s magnesium is stored in the blood
Most doctors and laboratories don’t even include magnesium status in routine blood tests. Thus, most doctors don’t know when their patients are deficient in magnesium, even though studies show that the majority of Americans are deficient in magnesium.
Consider Dr. Norman Shealy’s statements, “Every known illness is associated with a magnesium deficiency” and that, “magnesium is the most critical mineral required for electrical stability of every cell in the body. A magnesium deficiency may be responsible for more diseases than any other nutrient.”
Few people are aware of the enormous role magnesium plays in our bodies. Magnesium is by far the most important mineral in the body. After oxygen, water, and basic food, magnesium may be the most important element needed by our bodies; vitally important, yet hardly known. It is more important than calcium, potassium or sodium and regulates all three of them. Millions suffer daily from magnesium deficiency without even knowing it
Symptoms of Magnesium Deficiency
The first symptoms of deficiency can be subtle – as most magnesium is stored in the tissues, leg cramps, foot pain, or muscle ‘twitches’ can be the first sign. Other early signs of deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur.
Symptoms involving impaired contraction of smooth muscles include constipation; urinary spasms; menstrual cramps; difficulty swallowing or a lump in the throat-especially provoked by eating sugar; photophobia, especially difficulty adjusting to oncoming bright headlights in the absence of eye disease; and loud noise sensitivity from stapedius muscle tension in the ear.
Continuing with the symptoms of magnesium deficiency, the central nervous system is markedly affected. Symptoms include insomnia, anxiety, hyperactivity and restlessness with constant movement, panic attacks, agoraphobia, and premenstrual irritability.
“Symptoms or signs of the cardiovascular system include palpitations, heart arrhythmias, and angina due to spasms of the coronary arteries, high blood pressure and mitral valve prolapse. Be aware that not all of the symptoms need to be present to presume magnesium deficiency; but, many of them often occur together.
One of the principle reason doctors write millions of prescriptions for tranquilizers each year is the nervousness, irritability, and jitters largely brought on by inadequate diets lacking magnesium. Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent.
If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given.
Another good list of early warning symptoms suggestive of magnesium insufficiency:
Physical and mental fatiguePersistent under-eye twitchTension in the upper back, shoulders and neckHeadachesPre-menstrual fluid retention and/or breast tendernessPossible manifestations of magnesium deficiency include:
Low energyFatigueWeaknessConfusionNervousnessAnxiousnessIrritabilitySeizures (and tantrums)Poor digestionPMS and hormonal imbalancesInability to sleepMuscle tension, spasm and crampsCalcification of organsWeakening of the bonesAbnormal heart rhythmSigns of severe magnesium deficiency include:
Extreme thirstExtreme hungerFrequent urinationSores or bruises that heal slowlyDry, itchy skinUnexplained weight lossBlurry vision that changes from day to dayUnusual tiredness or drowsinessTingling or numbness in the hands or feetFrequent or recurring skin, gum, bladder or vaginal yeast infectionsMagnesium deficiency is a predictor of diabetes and heart disease both; diabetics both need more magnesium and lose more magnesium than most people. In two new studies, in both men and women, those who consumed the most magnesium in their diet were least likely to develop type 2 diabetes

The Gary Null Show - Interview With Michael Hudson

Dr. Michael Hudson is one of our nation’s finest and most important economists and Wall Street financial analysts. Dr. Paul Craig Roberts has called Michael “the world’s best economist.” He is the President of The Institution for the Study of Long-Term Economic Trends, and a distinguished research professor of economics at the University of Missouri. He was the Chief Economic Policy Advisor for the Rep. Dennis Kucinich’s 2008 presidential campaign and has served as an adviser to the White House, State and Defense departments and served as an economic advisor to other governments including Iceland, Latvia and China.  Michael has written many books and important papers and articles. His most recent must-read book is "The Destiny of Civilization: Finance Capitalism, Industrial Capitalism or Socialism" which explains the reason for crisis in the US and other Western nations due to a drainage o income, indebtedness and a collapse of industrialization. His website is Michael-Hudson.com