The Gary Null Show

The Gary Null Show - 05.10.22

Study finds Mediterranean diet improves depression symptoms in young men and women
University of Technology, Sydney, May 9, 2022
Young adults with a poor diet saw a significant improvement in their symptoms of depression when they switched to a healthy Mediterranean diet, a new study shows.
The 12-week randomized control trial, conducted by researchers from the University of Technology Sydney, was recently published in The American Journal of Clinical Nutrition.
The study contributes to the emerging field of nutritional psychiatry, which aims to explore the effect that specific nutrients, foods and dietary patterns can have on mental health. The diet used in the study was rich in colorful vegetables, legumes and wholegrains, oily fish, olive oil and raw, unsalted nuts. The primary focus was on increasing diet quality with fresh wholefoods while reducing the intake of 'fast' foods, sugar and processed red mea.
"There are lots of reasons why scientifically we think food affects mood. For example, around 90 percent of serotonin, a chemical that helps us feel happy, is made in our gut by our gut microbes. There is emerging evidence that these microbes can communicate to the brain via the vagus nerve, in what is called the gut-brain axis. To have beneficial microbes, we need to feed them fiber, which is found in legumes, fruits and vegetables," they said.
 
Amaranth extract goes head to head with beet as nitrate source
Arjuna Natural (India), May 6, 2022
 
A number of studies have established that nitrate, a nitric oxide metabolite, is beneficial for endurance during exercise. However, this bioavailability study, published in the journal Nutrition, was the first clinical trial to show that extract of amaranthus - one of the sources of nitrite in nature - can help athletes work out longer and harder. The researchers found that a single (2g) dose of amaranth extract was able to increase nitrate (NO3) and nitrite (NO2) levels in the body for at least eight hours.
 
Until now, sports nutrition manufacturers have typically incorporated beetroot powder and juice into formulations in order to support nitrate levels. These findings give this market a new, more potent form of nitrate to work with, according to botanical extracts manufacturer Arjuna, whose interest in amaranthus stems from its traditional use in Indian medicine and cooking. 
 
By comparison, he said that amaranthus was a far more “potent” form of nitrate for sports nutrition applications.
 
“It’s standardised to 9-10% nitrate content, whereas most beet-based ingredients contain less than 2% nitrate,” he told NutraIngredients.
 
Arjuna attributes this to its patent production process, which extracts 9,000mg per 100g of nitrate from the leaves of the amaranthus species.
Another advantage over its beet-based counterparts is that it doesn’t contain any reducing sugars and oxalates.
 
 
Study identifies exact amounts of extra vitamin C for optimal immune health
University of Otago (New Zealand), May 6, 2022
If you are carrying a few extra kilos in weight, an extra apple or two per day might make a difference in boosting your immune system and helping ward off COVID-19 and winter illnesses.
New University of Otago  research has identified, for the first time, exactly how much extra vitamin C humans need to ingest, relative to their body weight, to maximize their immune health.
The study has found that for every 10 kilograms of excess weight a person carries, their body needs an extra 10 milligrams of Vitamin C daily, which will help to optimize their immune health.
"Previous studies have already linked higher body weight with lower vitamin C levels," says lead author Associate Professor Carr. "We know obesity is a risk factor for getting COVID-19 and that obese patients are more likely to struggle to fight it off once infected. We also know that vitamin C is essential for good immune function and works by helping white blood cells fight infection. The results from this study therefore suggest that increasing your vitamin C intake if overweight might be a sensible response. Pneumonia is a major complication of COVID-19 and patients with pneumonia are known to be low in vitamin C.
The study determined how much vitamin C is required for people of higher body weight compared to a starting base weight of a 60 kilogram person consuming the average New Zealand dietary vitamin C intake of 110 milligrams per day, which most people achieve from a balanced diet. 
 
Vitamin A deficiency is detrimental to blood stem cells
German Cancer Research Center, May 5, 2022
Many specialized cells, such as in the skin, gut or blood, have a lifespan of only a few days. Therefore, steady replenishment of these cells is indispensable. They arise from so-called "adult" stem cells that divide continuously. In addition, there is a group of very special stem cells in the bone marrow that were first discovered in 2008 by a research team led by Andreas Trumpp, who is a division head at the DKFZ and director of HI-STEM. These cells remain in a kind of dormancy most of the time and only become active in an emergency such as bacterial or viral infections, heavy blood loss, or in the wake of chemotherapy. Once their work is done, the body sends its most potent stem cells back to sleep. The scientists assume that this protects them from dangerous mutations that may lead to leukemia.
The scientists have now identified retinoic acid, a vitamin A metabolite, as a crucial factor in this process. If this substance is absent, active stem cells are unable to return to a dormant state and mature into specialized blood cells instead. This means that they are lost as a reservoir. This was shown in studies with specially bred mice. "If we feed these mice on a vitamin A deficient diet for some time, this leads to a loss of the stem cells," said Nina Cabezas-Wallscheid, who is the first author of the publication. "Thus, we can prove for the first time that vitamin A has a direct impact on blood stem cells."
 
 
Exposure to wildfires increases risk of cancer
McGill University (Quebec), May 9, 2022
A new study from McGill University finds higher incidence of lung cancer and brain tumors in people exposed to wildfires. The study, which tracks over 2 million Canadians over a period of 20 years, is the first to examine how proximity to forest fires may influence cancer risk.
"Wildfires tend to happen in the same locations each year, but we know very little about the long-term health effects of these events. Our study shows that living in close proximity to wildfires may increase the risk of certain cancers," says Scott Weichenthal, at McGill University.
The study shows that people living within 50 kilometers of wildfires over the past 10 years had a 10% higher incidence of brain tumors and 4.9% higher incidence of lung cancer than people living further away.
 
Curcumin improves intestinal barrier function: modulation of intercellular signaling 
Virginia Commonwealth University, May 5, 2022
Studies from Virginia Commonwealth University Describe New Findings in Curcumin improves intestinal barrier function
According to news, research stated, "Association between circulating lipopolysaccharide (LPS) and metabolic diseases (such as type 2 diabetes and atherosclerosis) has shifted the focus from high-fat high-cholesterol containing Western- type diet (WD)-induced changes in gut microbiota per se to release of gut bacteria-derived products (e.g., LPS) into circulation due to intestinal barrier dysfunction as the possible mechanism for the chronic inflammatory state underlying the development of these diseases. We demonstrated earlier that oral supplementation with curcumin attenuates WD-induced development of type 2 diabetes and atherosclerosis."T
The research concluded: "The major site of action of curcumin is, therefore, likely the intestinal epithelial cells and the intestinal barrier, and by reducing intestinal barrier dysfunction, curcumin modulates chronic inflammatory diseases despite poor bioavailability."
Videos: 
1. Brazil’s Lula proposes creating Latin American currency to ‘be freed of US dollar’ dependency (part 2) (10:00)
 
2. Elon Musk Blasts Soros 'Dark Money Groups' Threatening Twitter Advertisers (14:13)

The Gary Null Show - 05.09.22

Lower risk of dementia found among people with higher carotenoid levels
National Institutes of Health's National Institute on Aging, May 6 2022. 
An article appearing on in Neurology® reported an association between higher levels of several carotenoids and a lower risk of developing Alzheimer disease and other dementias during a 16 to 17-year average period.
Carotenoids are a family of yellow to red plant pigments, including beta-carotene, which have an antioxidant effect. 
Participants whose levels of the carotenoids lutein, zeaxanthin and beta-cryptoxanthin were highest were likelier to develop dementia later in life than individuals with lower levels. Among those aged 65 and older upon enrollment, each approximate 15.4 micromole per liter increase in lutein and zeaxanthin was associated with a 7% decrease in dementia risk during follow-up. For beta-cryptoxanthin, each 8.6 micromole per liter increase was associated with a 14% reduction among those older than 45 at the beginning of the study. 
“Further studies are needed to test whether adding these antioxidants can help protect the brain from dementia,” Dr Beydoun concluded.
 
 
A Mediterranean-style diet decreases the levels of the inflammatory marker called C-reactive protein
University of Bologna (Italy), May 3, 2022 
 
Sticking to a Mediterranean style diet decreases the levels of the inflammatory marker called C-reative protein, linked to ageing, finds the EU funded project NU-AGE.  Another positive effect of this diet was that the rate of bone loss in people with osteoporosis was reduced. Other parameters such as insulin sensitivity, cardiovascular health, digestive health and quality of life are yet to be analysed.
 
This is the first project that goes in such depths into the effects of the Mediterranean diet on health of elderly population. We are using the most powerful and advanced techniques including metabolomics, transcriptomics, genomics and the analysis of the gut microbiota to understand what effect, the Mediterranean style diet has on the population of over 65 years old" said prof. Claudio Franceschi, project coordinator from the University of Bologna, Italy.
 
The project was conducted in five European countries: France, Italy, the Netherlands, Poland and the UK and involved 1142 participants. There are differences between men and women as well as among participants coming from the different countries. Volunteers from five countries differed in genetics, body composition, compliance to the study, response to diet, blood measurements, cytomegalovirus positivity and inflammatory parameters.
 
 
 
Resveratrol’s blood pressure benefits may pass from mother to child
University of Alberta and University of Adelaide, May 4, 2022
 
Hereditary hypertension may not pass the generations if the mother is given resveratrol supplements during pregnancy, suggests a new study with lab rats. Offspring of spontaneously hypertensive rats were found to be protected from elevated blood pressure once they reached adulthood if their mothers had received resveratrol supplementation during pregnancy.
 
“Maternal perinatal resveratrol supplementation prevented the onset of hypertension in adult offspring  and nitric oxide synthase inhibition normalized these blood pressure differences, suggesting improved nitric oxide bioavailability underlies the hemodynamic alterations,” wrote the researchers in the journal Hypertension .
 
The new study supplemented the diets of spontaneously hypertensive female rats with 0 or 4 g/kg diet of resveratrol from gestational day 0.5 until postnatal day 21. The offspring of these rats were then followed to adulthood.
 
Results showed that the adult offspring had significantly lower blood pressure than their mothers. Additional tests indicated that the potential blood pressure lowering activity observed in the resveratrol-fed animals was not linked to nitric oxide
 
 
 
Krill oil may be beneficial to muscle function and size in healthy people over the age of 65
University of Glasgow (Scotland), May 6, 2022
 
The study—led by the University of Glasgow's Institute of Cardiovascular and Medical Sciences (ICAMS) and published in Clinical Nutrition—found that krill oil supplementation of four grams per day could have beneficial effects on skeletal muscle function and size in this age group.
The research found that healthy adult participants who had received daily krill oil supplementation for six months showed statistically and clinically significant increases in muscle function and size. Krill oil contains high concentrations of the omega-3 fatty acids DHA and EPA, which previous scientific studies have shown are important nutrients for the body as it ages.
The randomized, double blind, controlled trial included 102 men and women all above 65 years of age. The participants were relatively inactive to engaging in less than one hour of self-reported exercise each week on entry to the study.
The study found that participants receiving daily krill oil supplements showed the following improvements (from baseline) at the end of the study:
Increase in thigh muscle strength (9.3%), grip strength (10.9%) and thigh muscle thickness (3.5%), relative to control group.
Increase in red blood cell fatty acid profile for EPA 214%, DHA 36% and the omega-3 index 61%, relative to control group.
Increased M-Wave of 17% (relative to the control group), which shows the excitability of muscle membranes.
 
 
 
New research shows cannabis flower is effective for treating fatigue
University of New Mexico, May 6, 2022
Researchers at The University of New Mexico have used a mobile software app to measure the effects of consuming different types of common and commercially available cannabis flower products on fatigue levels in real-time. As part of the study, researchers showed that over 91 percent of people in the study sample that used cannabis flower to treat fatigue reported symptom improvement. 
In their recent study, titled "The Effects of Consuming Cannabis Flower for Treatment of Fatigue," published in the journal Medical Cannabis and Cannabinoids, the UNM researchers showed that using cannabis results in immediate improvement for feelings of fatigue in the majority of users. This was the first large-scale study to show that on average, people are likely to experience a 3.5 point improvement of feelings of fatigue on a 0-10 scale after combusting cannabis flower products
The study was based on data from 3,922 cannabis self-administration sessions recorded by 1,224 people.  "One of the most surprising outcomes of this study is that cannabis, in general, yielded improvements in symptoms of fatigue, rather than just a subset of products, such as those with higher THC or CBD levels or products characterized as sativa rather than indica," said co-author and Associate Professor Sarah Stith.
"We're excited to see real-world data and studies support the use of cannabinoids for helping individuals manage their fatigue and energy levels," says Tyler Dautrich. "This obviously has implications for patients experiencing fatigue as a symptom of their medical condition, but we also feel this can lead to healthier options to the current energy drink and supplement market."
 
Study: Coconut oil contains molecules found to be effective against coronavirus
Ateneo de Manila University (Philippines), May 2, 2022
New research out of the Philippines has uncovered yet another potentially viable candidate for treating and preventing the Wuhan coronavirus (COVID-19) without the need for pharmaceuticals or vaccines, and it is lovingly known to many of our readers as coconut oil.
Dr. Fabian M. Dayrit, PhD, from Ateneo de Manila University, along with the help of Dr. Mary T. Newport, MD, from Spring Hill Neonatology in Florida, looked at the known antiviral benefits of coconut oil to see if they may also apply to the Wuhan coronavirus (COVID-19).
Lauric acid (C12), along with its derivative monolaurin, has been known for many years to possess natural antiviral activity. A medium-chain fatty acid that comprises about 50 percent of coconut oil’s makeup, lauric acid is widely recognized as a “super” nutrient, as is monolaurin, which is produced by the body’s own enzymes upon ingestion of coconut oil.
These nutrients work in tandem to disintegrate the “envelopes” that surround viruses, and this includes the Wuhan coronavirus (COVID-19). These two nutrients can also inhibit late-stage maturation in the replicative cycle of viruses, as well as prevent the binding of viral proteins to the host cell membrane.
Another antiviral compound found in coconut oil that also plays a protective role is capric acid (C10), along with its derivative monocaprin. Though it only makes up about seven percent of coconut oil, capric acid has shown effectiveness against HIV-1, which is important because evidence has emerged to suggest that the Wuhan coronavirus (COVID-19) may contain HIV DNA.
Videos:
1. Brazil’s Lula proposes creating Latin American currency to ‘be freed of US dollar’ dependency (part 1)
 
2. Bonhoeffer‘s Theory of Stupidity (5:58)
 
3.  2022.05.08 Ihor Kolomoisky Is In Trouble (6:52)

The Gary Null Show - 05.06.22

Broccoli may beneficially affect microbiota diversity: Study
University of Illinois
Consuming broccoli may change the diversity and composition of the microbiota in the gastrointestinal tract, says a new study.
Two hundred grams per day of broccoli for 17 days resulted in 37% increase in the proportion of Bacteroidetes relative to Firmicutes, according to data presented at the Experimental Biology meeting in Chicago this week by scientists from the University of Illinois at Urbana-Champaign, ARS-USDA, and the National Cancer Institute.
“These novel results reveal that broccoli consumption affects the diversity and composition of the GI microbiota of healthy adults,” they wrote in the FASEB Journal . “These data help fill the gap in knowledge related to the role of bacterial hydrolysis of phytonutrients.
“The increase in Bacteroides spp. is particularly relevant because Bacteroides thetaiotaomicron has been shown in vitro to utilize glucosinolates.”
 
Acupuncture possible treatment for dental anxiety
University of York
Researchers have found evidence that acupuncture could help people who experience dental anxiety.
Dental anxiety affects up to an estimated 30% of the adult population in countries world-wide. Patients can experience nausea, difficulty breathing and dizziness at the thought of going to the dentist, during an examination, and following treatment.
In a review of six trials with 800 patients, researchers used a points scale to measure anxiety and studies show that anxiety reduced by eight points when dental patients were given acupuncture as a treatment. This level of reduction is considered to be clinically relevant, which means that acupuncture could be a possibility for tackling dental anxiety.
Studies that compared anxiety levels between patients that received acupuncture and those that did not, showed a significant difference in anxiety scores during dental treatment. A clinically relevant reduction in anxiety was found when acupuncture was compared with not receiving acupuncture.
 
Omega-3 may help protect against adverse cardiovascular effects of pollution
Case Western University
An article published in the Journal of the American College of Cardiology reported a protective effect for supplementation with omega-3 fatty acids against some of the harmful cardiovascular effects of exposure to air pollution in China.
The randomized, double-blinded trial included 65 healthy college students in Shanghai, China who received 2.5 grams fish oil as a source of omega-3 fatty acids or a placebo daily. During the last two months of the trial, the subjects participated in four health examinations that included blood pressure assessment and measurement of blood markers of inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, cardiometabolism and neuroendocrine stress response.
Campus levels of fine particulate matter air pollution (PM 2.5) measured during the course of the trial averaged 38 micrograms per cubic meter. The researchers observed greater stability of most biomarker levels in responses to changes in fine particulate matter exposure in the fish oil-treated group in comparison with the placebo group. Omega-3 fatty acid supplementation was associated with beneficial effects for five blood biomarkers of inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response. 
 
 
Snoring causes injuries and prevention of healing in the upper airways
Umea University (Sweden)
The recurrent vibrations caused by snoring can lead to injuries in the upper airways of people who snore heavily. This in turn, can cause swallowing dysfunction and render individuals more vulnerable for developing the severe condition obstructive sleep apnea. These findings are reported by researchers at Umeå University, Sweden. Their on-going research focuses on the processes behind vibratory damage and healing of the upper airway tract. The data generated will help identify people at high risk of developing sleep apnea and to find novel treatment strategies.
Researchers in Umeå have shown that snorers and sleep apnea patients have neuromuscular injuries in the upper respiratory tract. The injuries can be seen at both the structural and molecular level. Researchers could also observe a correlation between snoring and swallowing dysfunction as well as a relation between nerve damage and obstructive sleep apnea. Sleep apnea is characterized by repeated collapse of the upper respiratory tract leading to respiratory arrest during sleep, which increases the risk of cardiovascular disease.
The studies show that people who constantly snore heavily and have sleep apnea displayed a loss of nerves and muscle mass in the soft palate. Furthermore, the attempts by the body to heal damaged tissue were disturbed resulting in an abnormal muscle structure. Another interesting finding was that muscle fibres in the soft palate lacked or had a disturbed organization of certain structural proteins. These proteins stabilize the organelles of the muscle cell and support cellular structures related to energy production and muscle fibre contraction.
The researchers also found that a neurotransmitter that is normally associated with healing and regeneration of neurons was present in the muscle cells. This finding suggests that the body is trying to heal the injuries, but the recurrent snoring vibrations prevent proper healing. It becomes a vicious circle where snoring causes damage and at the same time disturb healing of injuries, which can lead to swallowing dysfunction and sleep apnea.
 
Study: Tai chi can reduce hypertension symptoms in young and middle-aged in-service staff
Zhei-jian Hospital (China)
Researchers from Zhejiang Hospital in China reported that practicing t’ai chi can help with hypertension. 
The treatment group practiced simplified t’ai chi for three months. On the other hand, the control group underwent general daily lifestyle intervention.
After one month of exercise, the participants who practiced t’ai chi experienced significant reductions in their systolic blood pressure, heart rate, triglycerides, total cholesterol, and low-density lipoprotein (LDL) cholesterol.
At the end of the intervention period, the t’ai chi group experienced substantial decreases in their BMI, heart rate, systolic blood pressure, diastolic blood pressure, pulse pressure, triglycerides, total cholesterol, LDL cholesterol, and blood sugar levels. Practicing t’ai chi also improved their quality of life.
 
Lemongrass essential oil protects the liver from acetaminophen-induced injury
State University of Maringa (Brazil)
A study published in The American Journal of Chinese Medicine found that the essential oil extracted from lemongrass (Cymbopogon citratus) can protect the liver from damage caused by acetaminophen intake. 
They pretreated mice with 125, 250, or 500 milligrams per kilogram (mg/kg) of lemongrass essential oil or 200 mg/kg of a standard drug per day for seven days.
Then, they induced liver toxicity by administering 250 mg/kg dose of acetaminophen.
The researchers found that pretreatment with lemongrass essential oil significantly reduced the levels of liver disease markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP).
Inflammation in the liver was also reduced by lemongrass essential oil.
Liver lesions in mice were also improved after pretreatment with lemongrass essential oil.
Pretreatment with lemongrass essential oil increased antioxidant activity in the liver.
Videos:
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The Gary Null Show - 05.05.22

Omega-3 and cancer recovery: How supplementation helps reduce hospital stays after operations
Capital Medical University (China)
Omega-3 supplementation boosts immunity and helps reduce inflammation among gastrointestinal cancer patients after surgery, new meta-analysis reports.
Recent studies have indicated that nutritional intervention can reduce these problems, with omega-3 polyunsaturated fatty acids (n-3 PUFAs) particularly promising because of their inflammation benefits.
Results showed that patients on an n-3 PUFAs regime had lower levels of inflammation markers.
The academics, from China’s Capital Medical University, stated: “The results of our study showed that n-3 PUFAs significantly decreased the level of inflammation and increased immune function.
“Thus modulation of immune responses and reduction of inflammatory responses together lessens postoperative hospital stay for GI cancer patients.”
 
 
Vitamin D levels higher in exercisers
 
Johns Hopkins University
The Journal of Clinical Endocrinology & Metabolism published the finding of researchers at Johns Hopkins University of a correlation between increased physical activity and higher levels of vitamin D. Higher levels of vitamin D and exercise was also associated with a lower risk of cardiovascular disease.
The study included 10,342 men and women who were free of coronary heart disease and heart failure upon enrollment in the Atherosclerosis Risk in Communities study between 1987 to 1989. Physical activity levels were assessed during follow-up visits that took place over a 19.3-year period. Stored serum samples obtained at the second visit were analyzed for 25-hydroxyvitamin D3.
Following adjustment for lifestyle and other factors, those who met the recommended levels had a 31% lower risk of being deficient in vitamin D than those with poor activity levels. Subjects in the recommended activity group with levels of vitamin D of 30 ng/mL or more had a 24% lower risk of cardiovascular disease.
 
Gingko biloba helps protect against the toxic cognitive effects of aluminium chloride
Atomic Energy Authority (Egypt)
Ginkgo biloba extract helped protect the brain from the toxic effects of aluminium chloride, exposure to which has been linked to diseases such as Alzheimer's.
Researchers found its antioxidant properties were key in protecting the brain neurons of rats from oxidative stress caused by aluminium chloride (AlClʒ) intake.
“The toxic effect of AlClʒ caused significant histologic changes in brain and testis tissues which is in agreement with other data that found accumulation of Al metal in neurons which cause ultra-structural changes,” wrote researchers from the Atomic Energy Authority in Egypt wrote in Nutrition Journal.
“Administration of Ginkgo biloba extract (GbE) with aluminium chloride improved some biochemical and histologic changes observed in the brain and testis of male rats.”
Overexposure to aluminium, a potent neurotoxin, could be a possible factor in several neurodegenerative disorders including Alzheimer’s disease, say researchers.
GbE on the other hand, has antioxidant and free radical scavenging properties. It has been used to help treating cerebral disorders that result from ageing and hypoxia. Previous studies also highlighted its ability to regulate neurotransmitters and exert neuprotective effects.
 
New data shows avocado consumers have improved nutrient intakes
USDA and Haas Avocado Board
A new analysis of the National Health and Nutrition Examination Survey (NHANES) data, compared avocado consumers to non-consumers and found that consuming avocados may be associated with an overall better diet, higher intake of essential nutrients, lower body weight, lower Body Mass Index (BMI) and smaller waist circumference.
Insulin and homocysteine levels were lower in the avocado group, as well as a significantly reduced incidence of metabolic syndrome. Homocysteine, when elevated, has been associated with an increased risk of cardiovascular disease.i Metabolic syndrome is the name for a group of risk factors that raises the risk for heart disease and other health problems, such as diabetes and stroke.ii The analysis, "Avocado consumption by adults is associated with better nutrient Intake, diet quality, and some measures of adipositywas published in the journal Internal Medicine Review.
SUMMARY OF KEY FINDINGS:
* Compared to non-consumers, avocado consumers have:
 
Higher intakes of dietary fiber, total fat, good fats (monounsaturated fatty acids and polyunsaturated fatty acids), vitamins E and C, folate, magnesium, copper and potassium.
 
Lower intakes of total carbohydrates, added sugars and sodium.
* Improved physiologic measures include:
 
On average, avocado consumers weighed 7.5 lbs less, had a mean BMI of 1 unit less and 1.2 in. smaller waist circumference compared to non-consumers.
 
Avocado consumers were 33% less likely to be overweight or obese and 32% less likely to have an elevated waist circumference compared to non-consumers.
 
Incidence of metabolic syndrome was significantly reduced for avocado consumers.
 
 
 
Better quality relationships associated with reduced dementia risk
University of East Anglia (UK)
Positive social support from adult children is associated with reduced risk of developing dementia, according to a new research published today.
Conversely, negative social support is linked with increased risk, according to the 10-year follow-up study carried out by a team of researchers from the University of East Anglia (UEA), University College London (UCL), London Metropolitan University and the University of Nottingham.
The researchers analysed a decade of data that followed 10,055 core participants from ELSA who were dementia-free at the start of the study. Participants were interviewed every two years and incidence of dementia was identified from self-reports by participants or information given by nominated informants.
Positive support was characterised by having a reliable, approachable and understanding relationship with spouses or partners, children and other immediate family.
But negative support scores showed stronger effects - an increase of one point in the negative support score led to up to 31 per cent rise in the risk. Negative support was characterised by experiences of critical, unreliable and annoying behaviours from spouses or partners, children and other immediate family.
 
After spouse passes, death risk from ‘broken heart’ rises
Rice University
In the three-month period following a spouse’s death, widows and widowers are more likely to exhibit risk factors linked to cardiovascular illness and death, according to a new study This could make a bereaved spouse more likely to “die of a broken heart,” the researchers say.
The study, which appears in Psychoneuroendocrinology, found that individuals who have lost a spouse within the last three months have higher levels of pro-inflammatory cytokines (immune markers that indicate inflammation in the bloodstream) and lower heart rate variability (HRV) compared with non-bereaved individuals who share the sex, age, body mass index, and educational level. Both are factors that increase an individual’s risk for cardiac events, including death. The study is the first to demonstrate that bereavement is associated with elevated levels of ex vivo cytokines and lower HRV.
“In the first six months after the loss of a spouse, widows/widowers are at a 41 percent increased risk of mortality,” says lead author Chris Fagundes, an assistant professor of psychology in Rice University’s School of Social Sciences.
“Importantly, 53 percent of this increased risk is due to cardiovascular disease. This study is an important step toward understanding why this is the case by identifying how bereavement gets under the skin to promote morbidity and mortality.”
Finally, the bereaved spouses reported 20 percent higher levels of depressive symptoms than the control group. Participants ranged in age from 51 to 80 (average 67.87) and included 22 percent men and 78 percent women. The sex and age of the control group was comparable, and the results were the same when accounting for slight differences in weight and health behaviors.

The Gary Null Show - 05.04.22

Videos : 
2. Fake Cases: The Fraudulent PCR Test Is at the Heart of This Entire Plandemic – Dr. Reiner Fuellmich With Judy Mikovits & More
 
3.  Over 17,000 Physicians and Scientists Agree: “There Is No Medical Emergency” – Dr. Robert Malone
 
4. Honest Government Ad | Julian Assange
 
Cranberry juice may slash cardiometabolic risk factors: RCT study
USDA Agriculture Research Center, April 30, 2022
Daily consumption of a low-calorie cranberry juice may improve certain risk factors of heart disease, including blood pressure and triglycerides, says a new study from the Agricultural Research Service at the USDA.
Eight weeks of supplementing the diet with a cranberry juice containing 173 mg of phenolic compounds per serving was associated with significant reductions in C-reactive protein (CRP), diastolic blood pressure, and blood sugar levels, according to findings published in the Journal of Nutrition .
While the majority of the science supporting the health benefits of cranberries is for urinary tract health, a growing body of data supports the cardiovascular potential of the berries.
For example, a study by scientists at the Mayo Clinic and College of Medicine found that two glasses of cranberry juice a day may protect against the development of hardening of the arteries. Writing in the European Journal of Nutrition (Vol. 52, pp 289-296), the Mayo Clinic researchers reported that no effect was observed on the function of the cells lining the arteries (endothelial cells), but cranberry juice may reduce the number of endothelial cells that produce a compound called osteocalcin, which has been linked to hardening of the arteries.
 
 
Vitamin D toxicity rare in people who take supplements, researchers report
Mayo Clinic, April 30, 2022
 
Over the last decade, numerous studies have shown that many Americans have low vitamin D levels and as a result, vitamin D supplement use has climbed in recent years. In light of the increased use of vitamin D supplements, Mayo Clinic researchers set out to learn more about the health of those with high vitamin D levels. They found that toxic levels are actually rare.
A vitamin D level greater than 50 nanograms per milliliter is considered high. Vitamin D levels are determined by a blood test called a serum 25-hydroxyvitamin D blood test. A normal level is 20-50 ng/mL, and deficiency is considered anything less than 20 ng/mL, according the Institute of Medicine (IOM).
The researchers analyzed data collected over 10 years from patients in the Rochester Epidemiology Project, a National Institutes of Health-funded medical records pool , one of the few places worldwide where scientists can study virtually an entire geographic population to identify health trends.
Of 20,308 measurements, 8 percent of the people who had their vitamin D measured had levels greater than 50 ng/mL, and less than 1 percent had levels over 100 ng/mL.
"We found that even in those with high levels of vitamin D over 50 ng/mL, there was not an increased risk of hypercalcemia, or elevated serum calcium, with increasing levels of vitamin D," says study co-author Thomas D. Thacher, M.D., a family medicine expert at Mayo Clinic.
Only one case over the 10-year study period was identified as true acute vitamin D toxicity; the person's vitamin D level was 364 ng/mL. The individual had been taking 50,000 international units (IU) of vitamin D supplements every day for more than three months, as well as calcium supplements. The IOM-recommended upper limit of vitamin D supplementation for people with low or deficient levels is 4,000 IU a day.
 
 
Reducing sedentary time mitigates the risk of type 2 diabetes and cardiovascular diseases
University of Turku (Finland), May 2, 2022
A new study suggests that reducing daily sedentary time can have a positive effect on the risk factors of lifestyle diseases already in three months. Spending just one hour less sitting daily and increasing light physical activity can help in the prevention of these diseases.
In an intervention study of the Turku PET Centre and the UKK Institute in Finland, the researchers investigated whether health benefits can be achieved by reducing daily sedentary time during a three-month intervention period. The research participants were sedentary and physically inactive working-age adults with an increased risk of type 2 diabetes and cardiovascular diseases.
The intervention group managed to reduce sedentary time by 50 minutes per day on average, mainly by increasing the amount of light- and moderate-intensity physical activity. In the three-month period, the researchers observed benefits in health outcomes related to blood sugar regulation, insulin sensitivity and liver health in the intervention group.
 
 
Study Finds Cannabis May Be A “Miracle” Treatment For Autistic Kids
Shaare Zedek Medical Center (Israel), April 26, 2022
Autism could now be added to the lengthy and perpetually-expanding list of afflictions and symptoms treatable with the one product of nature shamefully prohibited by the federal government — the “miracle” palliative, cannabis.
In a recent article titled, “Marijuana may be a miracle treatment for children with autism,” Israeli researchers began a new study comprised of 120 children ranging in age from five to 29 years, who have been diagnosed with mild to severe autism.
Study participants are given one of two cannabis oil treatments or a placebo, drops of which can be mixed into a meal — none contain high levels of THC, the ingredient which gives users a ‘high.’
Myriad scientific studies and innumerable anecdotal cases have proven cannabis to treat everything from PTSD to ADHD, various cancers to the painful pressure of glaucoma — but the plant’s miraculous quality has been most apparent in treating severe seizures of childhood epilepsy. Now, it appears, cannabis — specifically, the non-psychoactive compound, cannabidiol or CBD — may offer improved quality of life for children with autism, and the families providing their care.
In an observational study, the doctor found 70 patients with autism experienced positive results from cannabis — so the clinical trial was launched for in-depth study.
 
 
Resveratrol and pinostilbene provide neuroprotectoin against age-related deficits.
Duquesne University, April 27, 2022
According to news, research stated, "Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice."
The news reporters obtained a quote from the research from Duquesne University, "Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds."
"These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways."
Study sheds light on the benefits of exercise in fatty liver disease
University of Eastern Finland, May 3, 2022
Exercise supports the treatment of non-alcoholic fatty liver (NAFLD) disease by impacting on several metabolic pathways in the body, a new study from the University of Eastern Finland shows
Regular high-intensity interval training (HIIT) exercise over a period of 12 weeks significantly decreased the study participants' fasting glucose and waist circumference, and improved their maximum oxygen consumption rate and maximum achieved workload. These positive effects were associated with alterations in the abundance of a number of metabolites. In particular, exercise altered amino acid metabolism in adipose tissue. The study was published in Scientific Reports.
Exercise had a beneficial effect on fasting glucose concentrations, waist circumference, maximum oxygen consumption rate, and maximum achieved workload. These factors were also associated with many of the observed alterations in the abundance of various metabolites in the exercise intervention group. The most significant alterations were observed in amino acids and their derivatives, lipids, and bile acids.
In particular, exercise increased the levels of amino acids, which are the building blocks of proteins, in adipose tissue. According to the researchers, their higher accumulations in adipose tissue may be associated with improved lipid and glucose metabolism, as well as with reduced insulin resistance.
The levels of various gut microbial metabolites were altered as a result of exercise, which is suggestive of changes in the composition of gut microbes, or in their function. Among these metabolites, increased amount of indolelactic acid, for example, can strengthen the intestinal mucosa, immune defense, and glucose balance.
 
 

The Gary Null Show - 05.03.22

Inadequate vitamin intake linked with insulin resistance
University of Alabama, May 2 2022. 
 
A greater risk of insulin resistance was revealed among women with acceptable calorie consumption whose folate and vitamin C intake were below the Dietary Reference Intake (DRI) values in a study reported  in Nutrition, Metabolism and Cardiovascular Diseases. Adequate dietary intakes of essential micronutrients are critical to prevent the development of insulin resistance and insulin resistance-related diseases. However, since excess calorie intake linked with obesity is also associated with those diseases, it is important to meet the Dietary Reference Intake (DRI) of those micronutrients without exceeding recommended daily calorie intakes. Among women whose calorie intake was categorized as acceptable and who met the Food and Nutrition Board’s DRI of folate and vitamin C, the respective risks of insulin resistance were 59% and 66% lower than women who did not meet the DRIs. The study also showed that even with the consumption of over the recommended calorie intake, only 2% of women met the DRI of vitamin D and approximately only 30% met the DRIs of vitamins A and E, further emphasizing the fact that a significant proportion of women consume calorie-dense food rather than micronutrient-dense food.”
 
(NEXT)
 
Ingesting soy protein may ease severity of inflammatory bowel disease
 
Penn State University, April 26, 2022
 
A diet supplemented with soy protein may be an effective adjunct therapy for inflammatory bowel diseases, Penn State researchers reported after completing a study that included mice and cultured human colon cells. The findings are significant because inflammatory bowel diseases -- including ulcerative colitis and Crohn's disease -- are characterized by either continuous or periodic inflammation of the colon and represent a significant risk factor for colon cancer. The team found that soy-protein concentrate can exert antioxidant and cytoprotective effects in cultured human bowel cells and can moderate the severity of inflammation in mice that have an induced condition similar to ulcerative colitis. Researchers, substituted soy-protein concentrate into the diet of the mice and removed corresponding amounts of the other protein sources, equaling about 12 percent. They kept human equivalents in mind as they determined the amount. The dietary soy-protein concentrate at the 12-percent dose level ameliorated body-weight loss and swelling of the spleen in the mice with induced inflammatory bowel disease. Soy-protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in the mice with induced IBD.
 
(NEXT)
 
Study finds children with vegetarian diet have similar growth and nutrition compared to children who eat meat
 
St. Michael's Hospital (Toronto), May 2, 2022
 
A study of nearly 9,000 children found those who eat a vegetarian diet had similar measures of growth and nutrition compared to children who eat meat. The study, published in Pediatrics and led by researchers at St. Michael's Hospital of Unity Health Toronto, also found that children with a vegetarian diet had higher odds of underweight weight status, emphasizing the need for special care when planning the diets of vegetarian kids. The findings come as a shift to consuming a plant-based diet grows in Canada. In 2019, updates to Canada's Food Guide urged Canadians to embrace plant-based proteins, such as beans and tofu, instead of meat. Researchers found children who had a vegetarian diet had similar mean body mass index (BMI), height, iron, vitamin D, and cholesterol levels compared to those who consumed meat. The findings showed evidence that children with a vegetarian diet had almost two-fold higher odds of having underweight, which is defined as below the third percentile for BMI. There was no evidence of an association with overweight or obesity. Underweight is an indicator of undernutrition, and may be a sign that the quality of the child's diet is not meeting the child's nutritional needs to support normal growth. For children who eat a vegetarian diet, the researchers emphasized access to healthcare providers who can provide growth monitoring, education and guidance to support their growth and nutrition.
 
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Blackcurrant extract triggers same process as statin drugs
 
University of Connecticut , April 29, 2022
 
Polyphenol-rich blackcurrant extract may prevent metabolic dysfunctions induced by diets high in fat and cholesterol, according to research in mice.
 
The results, published in the British Journal of Nutrition, found the extract reduced the percentage of mice with diet-induced severe steatosis (fatty liver), hypercholesterolaemia and hyperglycaemia.  Total plasma cholesterol and glucose levels were significantly lower in the blackcurrant group compared to the control, yet plasma triglyceride (TAG) level were not significantly different.
 
The extract contained 25% anthocyanins and 40% polyphenols and the dose equated to a daily human consumption of about 540 mg of the extract and 135 mg anthocyanins.
 
The researchers said such an ingredient could help reduce disease risk since dyslipidaemia and hyperglycaemia were likely to contribute to metabolic diseases.
 
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The Gary Null Show - 05.02.22

Ashwagandha root extract may improve memory and cognitive functions
 
Institute of Pharmacological Technology (India), April 25, 2022
 
Compared to a placebo, adults supplemented with ashwagandha root extract had improved memory test scores, researchers in India found. Ashwagandha root has been a part of the medicinal traditions of Ayurveda as a memory aid, wrote researchers of a study published in the Journal of Dietary Supplements. In this current study, the researchers conducted what they claimed to be the first trial that looked at “the clinical impact of ashwagandha on the cognitive deficits seen in mild cognitive impairment.” The study was conducted over eight weeks using a random-assignment, parallel-group, double-blind, placebo-controlled design. To be included in the study, participants had to be aged 35 or older, have subjective sumptoms of memory impairment, a previous diagnosis of early dementia or a score a certain amount in a mini-mental state examination, and the ability and willingness to provide informed consent. The ashwagandha root extract used in this study delivered in capsule form containing 300 mg of the aqueous extract. Study outcomes revealed that the ashwagandha group fared significantly better than baseline and the placebo group participants in terms of immediate and general memory test scores. There was also a great uptick in executive function, sustained attention, and information-processing speed.
 
(NEXT)
 
Sulforaphane Ameliorates Neurobehavioral Deficits and Protects Brain from Amyloid Beta Deposits
 
China Medical University and Hospital (Shenyang China), April 25, 2022
 
Research stated, "Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly individuals and its effective therapies are still unavailable. This study was designed to investigate the neuroprotection of sulforaphane (SFN) in AD-lesion mice induced by combined administration of d-galactose and aluminium." Research from China Medical University and Hospital stated "SFN ameliorated spatial cognitive impairment and locomotor activity decrease in Morris water maze and open field test, respectively. And attenuated numbers of amyloid (A) plaques in both hippocampus and cerebral cortex of AD-lesion mice were detected by immunohistochemistry. According to spectrophotometry and quantitative reverse-transcriptase polymerase chain reaction results, a significant increase in carbonyl group level and obvious decreases in both activity and messenger RNA expression of glutathione peroxidase were found in brain of AD-lesion mice compared with control, but not in SFN-treated AD-lesion mice." According to the news editors, the research concluded: "SFN ameliorates neurobehavioral deficits and protects the brain from A deposits and peroxidation in mice with Alzheimer-like lesions, suggesting SFN is likely a potential phytochemical to be used in AD therapeutics."
 
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New article outlines the characteristics of a 'longevity diet'
 
University of Southern California, April 29, 2022
 
Examining a range of research from studies in laboratory animals to epidemiological research in human populations gives scientists a clearer picture of what kind of nutrition can offer the best chance for a longer, healthier life, said USC Leonard Davis School of Gerontology Professor Valter Longo. Longo and Anderson reviewed hundreds of studies on nutrition, diseases and longevity in laboratory animals and humans and combined them with their own studies on nutrients and aging. The analysis included popular diets such as the restriction of total calories, the high-fat and low-carbohydrate ketogenic diet, vegetarian and vegan diets, and the Mediterranean diet. The article also included a review of different forms of fasting, including a short-term diet that mimics the body's fasting response, intermittent fasting (frequent and short-term) and periodic fasting (two or more days of fasting or fasting-mimicking diets more than twice a month). In addition to examining lifespan data from epidemiological studies, the team linked these studies to specific dietary factors affecting several longevity-regulating genetic pathways shared by animals and humans that also affect markers for disease risk, including levels of insulin, C-reactive protein, insulin-like growth factor 1, and cholesterol.
 
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Yoga may have health benefits for people with asthma
 
Cochrane Collaborative, April 26, 2022
 
A new Cochrane Review suggests that yoga may have a beneficial effect on symptoms and quality of life in people with asthma, but effects on lung function and medication use are uncertain. The Review summarizes the results of randomised trials and has found evidence that practicing yoga might be able to improve asthma quality of life and symptoms to some extent. They found 15 randomised controlled trials which involved 1,048 men and women. Most of the trials were conducted in India, followed by Europe and the United States. The majority of participants had mild to moderate asthma for six months to more than 23 years. Six studies looked into the effects of breathing alone during yoga exercise, whilst the other studies assessed the effects of yoga that included breathing, posture and meditation.
 
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The Gary Null Show - 04.29.22

Mushrooms boost immunity, suggests research
 
University of Florida Institute of Food and Agricultural Sciences, April 16, 2022
 
A new University of Florida study shows increased immunity in people who ate a cooked shiitake mushroom every day for four weeks. In a study led by UF Food Science and Human Nutrition , 52 healthy adults, age 21 to 41, came to the Gainesville campus, where researchers gave them a four-week supply of dry shiitake mushrooms. Participants took the mushrooms home, cleaned and cooked them. Then they ate one, 4-ounce serving of mushrooms each day during the experiment. Through blood tests before and after the experiment, researchers saw better-functioning gamma delta T-cells and reductions in inflammatory proteins. If you eat a shiitake mushroom every day, you could see changes in their immune system that are beneficial. "We're enhancing the immune system, but we're also reducing the inflammation that the immune system produces."
 
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Oral milk thistle extract stops colorectal cancer stem cells from growing tumors
 
University of Colorado, April 22, 2022
 
In results presented at the American Association for Cancer Research, a University of Colorado Cancer Center study shows that orally administering the chemical silibinin, purified from milk thistle, slows the ability of colorectal cancer stem cells to grow the disease. When stem cells from tumors grown in silibinin-fed conditions were re-injected into new models, the cells failed to develop equally aggressive tumors even in the absence of silibinin. "It's very simple: tumors from mice that were initially fed silibinin had fewer cancer stem cells, were smaller, had lower metabolisms and showed decreased growth of new blood vessels. Importantly, when these cancer stem cells from tumors in mice fed silibinin were re-injected into new mice, we found these stem cells had lost their potential to repopulate even in the absence of silibinin exposure. Silibinin is a non-toxic, potentially chemopreventive agent derived from milk thistle seeds.
 
(NEXT)
 
Chilli peppers hold promise of preventing liver damage and progression
 
European Association for the Study of the Liver (Austria), 23 April 2015 
 
Results revealed  that the daily consumption of capsaicin, the active compound of chilli peppers, was found to have beneficial effects on liver damage. In the study, capsaicin was found to reduce the activation of hepatic stellate cells (HSCs) in mice models. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. The study demonstrates that capsaicin partially improved liver damage in the BDL mice and inhibited further progression of the injury. In the second group of CCl4-treated mice, capsaicin prevented livers from injury development but did not reduce the fibrosis when it was already established.
 
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Compassion meditation reduces 'mind-wandering,' research shows 
 
Stanford University, April 23, 2022 
 
The practice of compassion meditation may be a powerful antidote to a drifting mind, new Stanford research shows.
 
Compassion meditation focuses on benevolent thoughts toward oneself and others, as the researchers noted. It is different in this aspect than most forms of meditation in the sense that participants are "guided" toward compassionate thoughts. This is the first report that demonstrates that formal compassion training decreases the tendency for the mind to wander, while increasing caring behavior not only towards others but towards oneself. "Mind-wandering" is the experience of having your thoughts not remain on a single topic for long. Prior research suggests that people spend as much as 50 percent of their waking hours in mind-wandering, often without realizing it. Doty said that mindfulness is extremely useful in today's world with its myriad of distractions, as humans are often overwhelmed and can find it difficult to attend to necessary tasks. "By closing one's eyes and engaging in attention training through a mindfulness practice, not only does it diminish the negative physiologic effects of distraction, which can result in anxiety and fear, but it can increase one's ability to attend to important tasks and not have an emotional response to the often negative dialogue which is frequent in many individuals," he said. As the researchers noted, compassion is defined by an awareness of suffering, sympathetic concern and a wish to see the relief of that suffering, and a responsiveness or readiness to help relieve that suffering. The study examined 51 adults during a compassion meditation program, measuring their various states of mind-wandering (neutral, pleasant, and unpleasant topics) and caring behaviors for themselves and others.  They were encouraged to meditate at least 15 minutes daily and, if possible, 30 minutes. The results indicated that compassion meditation decreased mind-wandering to neutral topics and increased caring behaviors toward oneself.
 
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The Gary Null Show - 04.28.22

Broccoli sprout extract promising for head and neck cancer prevention
University of Pittsburgh , April 19, 2022
Broccoli sprout extract protects against oral cancer in mice and proved tolerable in a small group of healthy human volunteers. “People who are cured of head and neck cancer are still at very high risk for a second cancer in their mouth or throat, and, unfortunately, these second cancers are commonly fatal,” said lead author Julie Bauman, co-director of the UPMC Head and Neck Cancer Center of Excellence. So we’re developing a safe, natural molecule found in cruciferous vegetables to protect the oral lining where these cancers form.” Previous studies, including large-scale trials in China, have shown that cruciferous vegetables that have a high concentration of sulforaphane – such as broccoli, cabbage and garden cress – help mitigate the effects of environmental carcinogens. For several months, Dr. Johnson and his team gave sulforaphane to mice predisposed to oral cancer and found that it significantly reduced the incidence and number of tumors. “The clear benefit of sulforaphane in preventing oral cancer in mice raises hope that this well-tolerated compound also may act to prevent oral cancer in humans who face chronic exposure to environmental pollutants and carcinogens,” said Dr. Johnson.
(NEXT)
Living in areas with more greenery may boost cognitive function: study
Boston University School of Public Health, April 27, 2022
Cognitive function at middle age is a strong predictor of whether a person may develop dementia later in life. Now, a new study led by a Boston University School of Public Health (BUSPH) researcher has found that increasing greenspace in residential areas could help improve cognition function in middle-aged women and that this association might be explained by a reduction in depression, which is also a risk factor for dementia. Published in the journal JAMA Network Open, the study found that exposure to greenspace around one’s home and surrounding neighborhood could improve processing speed and attention, as well as boost overall cognitive function. The results also showed that lowered depression may help explain the association between greenspace and cognition, bolstering previous research that has linked exposure to parks, community gardens, and other greenery with improved mental health.
(NEXT)
Could a natural compound spare our livers?
Texas A&M University, April 20, 2022
Spermidine—a compound in foods like aged cheese, mushrooms, soy products, legumes, corn, and whole grains—may prevent liver fibrosis and hepatocellular carcinoma, the most common type of liver cancer. There is also some evidence that it may prolong lifespan, according to a study in the journal Cancer Research. Researchers gave animal models an oral supplement of spermidine and found that they lived longer and were less likely than untreated individuals to have liver fibrosis and cancerous liver tumors, even when predisposed for those conditions.Even if people didn’t begin taking spermidine until later in life, they still might be able to get these liver and heart benefits. The animal models exposed to spermidine showed reductions in both liver lesions and intensity of liver fibrosis, a condition that often leads to liver cancer.
(NEXT)
Poor diet associated with increased diabetes risk across all gradients of genetic risk
Massachusetts General Hospital, April 26, 2022 
Genetic risk factors and diet quality are independently associated with type 2 diabetes; a healthy diet is linked to lower diabetes risk across all levels of genetic risk. That’s the conclusion of a study of more than 35,000 US adults published in PLOS Medicine The team found that, irrespective of genetic risk, a low diet quality, as compared to high diet quality, was associated with a 30% increased risk of type 2 diabetes. The joint association of low diet quality and increased genetic risk was similar to the sum of the risk for each factor alone, further supporting independent associations. That said, one limitation of the study was that the cohort sampling might not necessarily generalize to other populations. Merino adds, “This study provided evidence that the risk of type 2 diabetes attributed to increased genetic risk and low diet quality is similar to the sum of the risks associated with each factor alone. Such knowledge could serve to inform and design future strategies to advance the prevention of diabetes.”
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The Gary Null Show - 04.27.22

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Being in nature: Good for mind, body and nutrition
Researchers from Drexel University investigated how feeling connected with the natural world benefits dietary diversity and fruit and vegetable intake.
Drexel University, April 25, 2022
In late 2020, Canadian doctors made headlines for “prescribing nature,” or recommended time outdoors based on research that suggests people who spent two or more hours in nature per week improved their health and wellbeing. Knowing this, transdisciplinary researchers from Drexel University investigated how nature relatedness – simply feeling connected with the natural world – benefits dietary diversity and fruit and vegetable intake, in a study recently published the American Journal of Health Promotion. “Nature relatedness has been associated with better cognitive, psychological and physical health and greater levels of environmental stewardship. Our findings extend this list of benefits to include dietary intake,” said Brandy-Joe Milliron, PhD, at Drexel’s College of Nursing and Health Professions and lead author of the publication. “We found people with higher nature relatedness were more likely to report healthful dietary intake, including greater dietary variety and higher fruit and vegetable consumption.” The research team surveyed over 300 adults in Philadelphia to measure their self-reported connection to nature, including their experience with and perspective of nature, and the foods and beverages they had consumed the previous day to assess their dietary diversity and estimate their daily fruit and vegetable consumption.
(NEXT)
Overnight fasting may reduce breast cancer risk in women
 University of California at San Diego, April 20, 2022
A decrease in the amount of time spent eating and an increase in overnight fasting reduces glucose levels and may reduce the risk of breast cancer among women, report University of California, San Diego School of Medicine researchers in the journal Cancer Epidemiology, Biomarkers & Prevention. "Increasing the duration of overnight fasting could be a novel strategy to reduce the risk of developing breast cancer. This is a simple dietary change that we believe most women can understand and adopt. It may have a big impact on public health without requiring complicated counting of calories or nutrients." Women who fasted for longer periods of time overnight had significantly better control over blood glucose concentrations. The data shows that each three hour increase in nighttime fasting was associated with a 4 percent lower postprandial glucose level, regardless of how much women ate. Women in the study reported eating five times per day with a mean nighttime fasting of 12 hours. Those who reported longer fast durations also indicated they consumed fewer calories per day, ate fewer calories after 10 p.m. and had fewer eating episodes.
(NEXT)
Micronutrients (vitamins + minerals) show benefit for children with ADHD and emotional dysregulation
Evidence from a randomized clinical trial shows broad-spectrum micronutrient supplementation with all known vitamins and essential minerals resulted in global improvement of attention and mood based on blinded clinician ratings
Oregon Health & Science University, April 26, 2022 
 A study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) reports that children with ADHD and emotional regulation randomized to take a micronutrient formula were three times more likely to show symptomatic improvement on blinded clinician ratings, compared to those in the placebo group (54% versus 18%). The micronutrient formula, consisting of all known vitamins and essential minerals, was administered for eight weeks.
(NEXT)
Raspberry, a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias
University of Guadajara (Mexico), 11 April 2022
Raspberry production and consumption have increased in recent years due to its polyphenol content such as anthocyanins and ketones, bioactive compounds that have been studied to reduce blood glucose levels and stabilize the blood lipid profile. Original articles from in vitro and in vivo enzyme inhibition studies, animal models, and human clinical studies were compiled in PubMed, Web of Science, and Science Direct databases. Studies showed satisfactory results regarding blood glucose level reduction after consumption of frozen or lyophilized raspberry, infusion of raspberry leaves, seed oil, as well as compounds, extracted from the fruit by inhibiting enzymes such as α-glucosidase and dipeptidyl peptidase-4 (DPP-4) and other mechanisms that increase insulin production and insulin sensitivity. A reduction in cholesterol and low-density lipoprotein levels is reported, as well as an increase in high-density lipoproteins. A According to the results, raspberry can be included in the nonpharmacological treatment of hyperglycemia and dyslipidemias; however, further research is considered necessary.