The Gary Null Show

The Gary Null Show - 04.12.22

Polyphenol pills counter inflammation in women on hormonal contraceptives: RCT
 
Universidade Federal do Rio Grande do Sul (Brazil), April 7, 2022
 
Supplements containing a mixture of polyphenols may counter increases in pro-inflammatory markers in women of childbearing age using combined hormonal contraceptives, says a new study. The supplements, formulated with resveratrol, catechin, quercetin, chlorogenic acid and cyanidin, were also found to prevent the increases in markers of systemic oxidative stress like F2-isoprostane. “The increase in biomarkers of inflammation and oxidative stress observed in the present study were possibly caused by the use of hormonal contraceptives, as verified in the [control group], and this change was not observed in the group that used polyphenols,” wrote researchers from the Institute of Cardiology and the Universidade Federal do Rio Grande do Sul in Brazil. “Therefore, the results of this polyphenol supplementation showed that the antioxidant and anti-inflammatory effects observed in the studied population is due to the reduction in plasma levels of PGE2, supporting the conceptual hypothesis, by its action on the inflammatory cascade, probably by COX inhibition.”
 
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The power of kindness in improving brain health
 
Center for BrainHealth at The University of Texas, April 11, 2022
 
Kindness is powerful and does not just affect the recipient's feelings—kindness can also impact an entire family's brain health. A cross-disciplinary team of researchers and clinicians from Center for BrainHealth at The University of Texas at Dallas sought to understand whether an online kindness training program improves preschooler's prosocial behaviors and their parents' resilience during the COVID-19 pandemic.
 
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Omega-3 supplementation could offer MCI benefits: Pilot study
 
University of California-Los Angeles, April 10, 2022
 
Supplementation with a drink containing 2000 mg of omega-3 and mixed botanicals could have ‘significant’ immune and biochemical effects in people that have minor cognitive impairment (MCI), new research suggests. The pilot study, published in The FASEB Journal, investigated the immune and pro- and anti-inflammatory effects of nutritional supplementation with a drink (Smartfish) that combines high levels of the omega-3 fatty acids DHA and EPA with a mixture of vitamins and botanicals including resveratrol vitamin D3, “thus targeting several facets of AD [Alzheimer’s disease] pathogenesis.”
 
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Magic mushroom compound increases brain connectivity in people with depression after use
 
by Imperial College London, April 11, 2022
 
Psilocybin, the psychedelic compound found in magic mushrooms, helps to "open up" depressed people's brains, even after use, enabling brain regions to talk more freely to one another. These are the findings of a new analysis of brain scans from close to 60 people receiving treatment for depression, led by Imperial College London's Centre for Psychedelic Research. The team behind the study believes it may have untangled how psilocybin exerts its therapeutic effects on the brain.
 
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Regular cycling helps patients with 'accelerated aging' disease
 
McMaster University, April 11, 2022
 
A study led by McMaster University researchers has found that regular cycling can greatly improve mobility in patients with myotonic dystrophy (MD), a genetic disease that causes muscle degeneration. Senior author Mark Tarnopolsky said that cycling for 35 minutes three times a week for 12 weeks led to a 32 percent increase in overall fitness in people with MD. Patients who took part in the study also saw a 1.6-kilogram increase in their muscle massand a two percent reduction of body fat. They were also able to walk an extra 47 meters in six minutes, when tested by researchers at the end of the 12-week trial.
 

The Gary Null Show - 04.11.22

New study reveals that healthy plant-based diets are associated with a lower risk of developing diabetes
 
Harvard School of Public Health, April 8, 2022
 
New research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]) finds that the consumption of healthy plant-based foods, including fruits, vegetables, nuts, coffee, and legumes, is associated with a lower risk of developing type 2 diabetes (T2D) in generally healthy people and support their role in diabetes prevention. The study aimed to identify the metabolite profiles related to different plant-based diets and investigate possible associations between those profiles and the risk of developing T2D.
 
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Vitamin K2 brain benefit
 
Al-Maarefa University (Saudi Arabia), April 8 2022. 
 
Results from a study  suggest that vitamin K2 could help protect the brain from aging-associated disorders. The study’s investigators remarked that people with severe dementia and individuals at an early stage of Alzheimer’s disease have an increased risk of reduced serum vitamin K levels. Rats that received vitamin K2 had less cognitive impairment, depression and anxiety, and better spatial memory and learning ability compared to untreated animals. When the two groups’ maze performances at the end of the treatment period were compared with untreated young adult rats, older animals that received MK-7 performed similarly to the younger rats, while the performance of older untreated rats was significantly lower.
 
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Research finds that wisdom is a matter of both heart and mind
 
University of Waterloo (Canada) April 7, 2022 
 
The fluctuations of your heartbeat may affect your wisdom, according to new research from the University of Waterloo. The study suggests that heart rate variation and thinking process work together to enable wise reasoning about complex social issues. "Our research shows that wise reasoning is not exclusively a function of the mind and cognitive ability," says Prof. Grossmann. "We found that people who have greater heart rate variability and who are able to think about social problems from a distanced viewpoint demonstrate a greater capacity for wise reasoning." A growing consensus among philosophers and cognitive scientists defines wise judgment to include the ability to recognize the limits of one's knowledge, to be aware of the varied contexts of life and how they may unfold over time, to acknowledge others' points of view, and to seek reconciliation of opposing viewpoints.
 
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Too much sitting may shorten your life, study suggests
 
University of Sao Paulo School of Medicine April 7, 2022 
 
A new study finds that sitting less may extend your life. Brazilian researchers who analyzed data from 54 countries linked sitting for more than three hours a day to 3.8 percent of deaths from all causes. Limiting sitting time to less than three hours a day would increase a person's life expectancy by an average of 0.2 years—or more than two months, the researchers said. The study authors estimated the effects of less time spent sitting, regardless of moderate to vigorous physical activity. Even a modest, 10 percent reduction in sitting time—for instance, 30 fewer minutes a day—could have an immediate impact, the researchers said.
 
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Depressive disorders can lead to changes in immune cells
 
Dresden University of Technology and University of Zurich (Germany), April 9.2022
 
Loss of interest, joylessness, lack of drive and increased fatigability—all these complaints are among the main symptoms of depression, a mental illness affecting an estimated 5% of the population in Germany. Pathophysiological features of depressive disorders often include low-grade inflammation and elevated glucocorticoid output. In a new study published in the journal Translational Psychiatry, researchers establish for the first time a link between depressive disorders and mechanical changes in blood cells. 
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The Gary Null Show - 04.08.22

Zinc deficiency linked to chronic inflammation
 
Oregon State University April 6 2022. 
 
A report published in Molecular Nutrition and Food Research reveals how being deficient in the mineral zinc results in immune dysfunction and chronic inflammation, which is involved in cardiovascular disease and other conditions. Emily Ho of Oregon State University (OSU) and her colleagues examined the effects of zinc deficiency in cell cultures and aged mice. The team observed an increase in the responses of the cytokines interleukin 1beta and interleukin 6 following the administration of an inflammation-provoking substance to human white blood cells known as monocytes. In aged mice, zinc deficiency was also associated with an increase in interleukin 6 gene expression.
 
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Turmeric compound helps grow engineered blood vessels and tissues
 
University of California at Riverside, April 6, 2022
 
A finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues in human patients. Curcumin, a compound found in turmeric, has anti-inflammatory and antioxidant properties and is known to suppress angiogenesis in malignant tumors. Bioengineers at UC Riverside have now discovered that when delivered through magnetic hydrogels into stem cell cultures this versatile compound paradoxically also promotes the secretion of vascular endothelial growth factor, or VEGF, that helps vascular tissues grow. When cultured with stem cells derived from bone marrow, the magnetic hydrogel gradually released the curcumin without injuring the cells. Compared to hydrogels embedded with bare nanoparticles, the group of hydrogels loaded with curcumin-coated nanoparticles showed a higher amount of VEGF secretion.
 
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Exercise shown to release protein reducing bowel cancer risk
 
Newcastle University, April 7, 2022
 
Scientists at Newcastle University have shown that physical activity causes the cancer-fighting protein, interleukin-6 (IL-6), to be released into the bloodstream which helps repair the DNA of damaged cells. Previous scientific evidence suggests that more exercise is better for reducing bowel cancer risk as the more physical activitypeople do, the lower their chances of getting it. When exercise is repeated multiple times each week over an extended period, cancer-fighting substances—such as IL-6—released into the bloodstream have the opportunity to interact with abnormal cells, repairing their DNA and reducing growth into cancer."
 
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Ginkgo biloba Extract Improves ADHD Symptoms in Children
 
University of Tübingen's Center for Medicine (Germany), April 6, 2022
 
Ginkgo's usefulness for children with attention deficit/hyperactivity disorder has now been confirmed by a clinical study from Germany. This is supported by previous research showing Ginkgo's effects on cognition among the elderly. Researchers tested a Ginkgo biloba extract called EGb761 on 20 children diagnosed with ADHD in an open clinical protocol. The children were given the Ginkgo extract for three to five weeks at a dosage of up to 240 milligrams. This maximum dosage was given to those children who did not have immediate effective responses to a lower dose over the initial period of three weeks. The researchers found that the Ginkgo extract improved ADHD symptoms among the children. This improvement corresponded with improved Contingent negative variation (CNV) testing results.
 
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Pomegranate-date cocktail a day keeps the doctor away
 
Technion-Israel Institute of Technology , April 6, 2022
 
Glorious, red pomegranates and their Middle Eastern sister, luscious toffee-like dates, are delicious, increasingly trendy, and healthy to boot. As it turns out, when consumed together they are a winning combination in the war against heart disease. Just half a glass of pomegranate juice a day with a handful of dates can do the trick! A team of researchers at the Technion-Israel Institute of Technology has discovered that the combination of pomegranate juice and dates along with their pits provide maximum protection against atherosclerosis (plaque buildup or hardening of the arteries), which can cause a heart attack or stroke. Pomegranate juice, rich in polyphenolic antioxidants (derived from plants), has been shown to most significantly reduce oxidative stress. Dates, which are rich sources of phenolic radical scavenger antioxidants, also inhibit the oxidation of LDL (the so-called "bad cholesterol") and stimulate the removal of cholesterol from lipid-laden arterial cells.
Dr. Richard Fleming
Dr. Richard Fleming is a cardiologist specializing in nuclear medicine who has proven a direct correlation between inflammation and heart disease.  Dr. Fleming holds a PhD in particle physics, graduated from the University of Iowa College of Medicine and later completed a law degree. He is the inventor of the Fleming Method for Tissue and Vascular Differentiation and Metabolism, a method that quantifies tissue activity due to inflammation and infection. In the past Richard has taught at the University of Texas and conducted cardiological research at Methodist College and Creighton University. Since the declaration of the Covid pandemic, he has put his attention on uncovering the health risks from both the SARS-2 virus and the Covid-19 vaccines, exposing the medical risks, and researching the genetic engineered origins of SARS-2.  He has published and edited several medical texts and has published over 60 peer-reviewed scientific papers. He recently released a new book "Is Covid-19 a Bioweapon: A Scientific and Forensic Investigation," which takes a hard critical look at the available evidence that identifies clear genetic anomalies that could only have occurred through gain of function research.  Dr Fleming's website is FlemingMethod.com.

The Gary Null Show - 04.07.22

Researchers look to licorice for promising cancer treatments
 
University of Illinois Chicago, April 6, 2022
 
Licorice is more than a candy people either love or hate—it may play a role in preventing or treating certain types of cancer, according to researchers at the University of Illinois Chicago. Gnanasekar Munirathinam and his research team are studying substances derived from the licorice plant Glycyrrhiza glabra to determine if they could be used to prevent or stop the growth of prostate cancer. "When we look at the research out there and our own data, it appears that glycyrrhizin and its derivative glycyrrhetinic acid have great potential as anti-inflammatory and anti-cancer agents," Munirathinam said. "We hope our research on prostate cancer cells advances the science to the point where therapies can be translated to help prevent or even cure prostate and other types of cancer."
 
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Not all dietary fiber is equal: Cereal fiber linked with lower inflammation, but not fruit or vegetable fiber
 
Columbia University, April 6, 2022
 
Researchers at Columbia University Mailman School of Public Health and colleagues evaluated whether dietary fiber intake was associated with a decrease in inflammation in older adults and if fiber was inversely related to cardiovascular disease. The results showed that total fiber, and more specifically cereal fiber but not fruit or vegetable fiber, was consistently associated with lower inflammation and lower CVD incidence. The research confirmed previously observed associations between dietary fiber and CVD and extended those investigations to include the source of the fiber, the relationship of fiber with multiple inflammatory markers, and to test whether inflammation mediated the relationship between dietary fiber and CVD.
 
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How to reduce loneliness: Meaningful activities can improve health, well-being
 
Pennsylvania State University
 
Free time is sometimes idealized, but research shows free time can sometimes be unhealthy by increasing loneliness. A new Penn State study demonstrated that engaging in meaningful, challenging activities during free time can reduce people's loneliness and increase their positive feelings. Across two different studies, the researchers found that people who had meaningful, challenging experiences were less lonely—even when higher levels of social contact and support were not available. Our research shows that both of these ideas are true. By engaging in meaningful activities during free time that demand focus, people can reduce loneliness and increase momentary happiness."  "Loneliness is very connected to our health," Dattilo explained. "Psychological, emotional, and cognitive health are all challenged when people are lonely. Loneliness is associated with depression and other mental health challenges."
 
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Curcumin Found To Outperform Pneumococcal Vaccines In Protecting Infants
 
UCLA, April 1, 2022
 
Now new research finds a substance in turmeric, curcumin, may outperform the vaccine in providing long lasting protection against potentially deadly lung damage in infants. Pneumococcal bacteria are the most common cause of bacterial infections in children and a frequent cause of infections in adults. Infection starts in the nose or throat where it may persist for weeks or months. Pneumococcal infections are also the most common complication of seasonal influenza. Researchers at Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), using disease models, found curcumin provided long-term protection against the damage caused by inadequate lung function. Their study, published online by the American Journal of Physiology, Lung Cellular and Molecular Physiology, found curcumin provided protection against bronchopulmonary dysplasia (BDP), a condition characterized by scarring and inflammation, and against hyperoxia, in which too much oxygen enters the body through the lungs.
 
Scott Ritter
 
via ZOOM
 
Scott Ritter is a former US Marine Corp intelligence officer and military strategist during the Cold War with the Soviet Union and in the Middle East. He served as a lead analyst for Marine deployment during the Soviet invasion of Afghanistan and the Iran-Iraq war. During Operation Desert Storm, Scott was the ballistic missile advisor to General Schwarzkopf. Later he assumed the role of the lead United Nations weapons inspector for seven years overseeing the disarmament of Iraq's weapons of mass destruction and biological agents program. He was one of the most forceful critics of the Bush administration's claims that Sadaam Hussain possessed WMDs. Scott is now an author and lecturer who has been very public about the American media's misinformation campaign about Russia's incursion into Ukraine and the gross failure's of the Biden White House foreign affairs policies and actions. 

The Gary Null Show - 04.06.22

Vitamin K shows evidence of brain benefits 
Study suggests a biological pathway through which vitamin K may help ward off dementia 
AlMaarefa University(Saudi Arabia), April 5, 2022
In a new study conducted in rats, scientists report evidence that vitamin K could help protect against aging-related cognitive declines associated with Alzheimer’s disease and other forms of dementia. Vitamin K2 demonstrated very promising impact in hindering aging-related behavioral, functional, biochemical and histopathological changes in the senile aging brain. Vitamin K2 can be proposed to be a promising approach to attenuate age-related disorders and preserve cognitive functions in aging individuals. The researchers used validated tests including a maze, swim test and sociability test to assess the rats’ cognitive functioning and depressive-like and anxiety behavior. These tests revealed that rats that received MK-7 performed better than those that did not. Vitamin K supplementation was associated with reduced evidence of cognitive impairment, depression and anxiety, along with improved spatial memory and learning ability.
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Vegetarian Diet Reduces Risk Of Heart Disease By A Third
University of Oxford, March 30, 2022   
A vegetarian diet can reduce a person’s risk of heart disease by a third. Vegetarians have a 32% lower risk of hospitalization or death from cardiovascular disease than people who consume meat and fish. The study is the largest yet to compare cardiovascular disease rates between vegetarians and meat eaters. The experts analyzed nearly 45,000 participants (34% were vegetarian) from England and Scotland who signed up for the European Prospective Investigation into Cancer and Nutrition (EPIC)-Oxford study.
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Meditation builds brain cells, Harvard study shows proof
Harvard University, April 2, 2022
Research has now demonstrated that meditation builds brain cells and increases gray matter in the brain. Using magnetic imaging (MRI), Harvard researchers found that meditation produced physiological changes in the brain’s gray matter. Some areas in the brains of the study participants thickened after only eight weeks of mindfulness practice. Study participants reported feeling less stressed after the eight-week period. MRI scans revealed decreased gray matter in the amygdalae and increased gray matter in the hippocampus. The amygdalae are the parts of the brain that help the body deal with anxiety and stress and controls the “fight or flight” mechanism. The hippocampus, which showed an increase in gray-matter density, is the area of the brain that controls memory, learning, self-awareness, introspection and compassion.
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Artificial sweeteners linked with a 13% higher risk of cancer
Sorbonne Paris Nord University, March 31, 2022
A large new observational study has found an association between the consumption of artificial sweeteners, particularly aspartame and acesulfame-K, and cancer. The study found a 13% higher risk of cancer in general, with the highest likelihood of developing breast cancer and cancers related to obesity, for people consuming large quantities of artificial sweeteners. The researchers analyzed the histories of 102,865 adults participating in the ongoing NutriEnt-Santé studyTrusted Source that began collecting data in 2009. Participants were followed for the new research over an average of 7.8 years. Senior investigator and director of EREN Dr. Mathilde Touvier said to MNT: “We performed analyses for the ‘total of artificial sweeteners’ overall (i.e., the sum of acesulfame-K, aspartame, sucralose, cyclamates, saccharin, steviol glycosides, and salt of aspartame-acesulfame), and then separately for the most represented artificial sweeteners in the cohort (i.e., acesulfame-K, aspartame, and sucralose).” Looking deeper into the greater risk of Aspartame and acesulfame-K, Dr. Touvier explained, “It should be noted that aspartame and acesulfame-K were by far the most frequently consumed artificial sweeteners.”
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Israeli Study: Your Cell Phone Is Killing Your Sperm
Technion-Israel Institute of Technology and Carmel Medical Center (Israel), April 2, 2022
Over the years, science has thoroughly documented the global decline in male fertility, which has been ongoing since the 1940s. Several possible culprits have been blamed such exposure to pesticides, estrogen-mimicking chemicals, and sedentary lifestyles. However, a team of Israeli scientists has found another possible environmental cause. Researchers at Haifa’s Technion- Israel Institute of Technology and Carmel Medical Center, conducted a study involving 106 men who were given a semen analysis. They have found that men who wear their cell phones in their pants pockets, have significantly higher rates of abnormal sperm. 47% of men who stored their cell phones in their pants had abnormal sperm, compared to just 11% for the average male. But keeping a cell phone near the groin wasn’t the only contributing factor to poor fertility. Both talking on the phone for more than an hour a day and using it while it was charging, was also linked to abnormal sperm counts.
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The Gary Null Show - 04.05.22

Vegan diet eases arthritis pain, finds new study
 
Physicians Committee for Responsible Medicine, April 4, 2022
 
A low-fat vegan diet, without calorie restrictions, improves joint pain in patients with rheumatoid arthritis, according to a new study conducted by researchers at the Physicians Committee for Responsible Medicine. Study participants also experienced weight loss and improved cholesterol levels. “A plant-based diet could be the prescription to alleviate joint pain for millions of people suffering from rheumatoid arthritis,” says Neal Barnard, MD, lead author of the study and president of the Physicians Committee. “And all of the side effects, including weight loss and lower cholesterol, are only beneficial.”
 
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Researchers Discover Cannabis-Mushroom Combination That “Kills Over 90% Of Colon Cancer Cells”
 
Cannabotech Integrative (Israel), April 1, 2022
 
For the last several years, scientists with Cannabotech, a biomedical company developing oncological products using cannabis, have been developing an “Integrative-Colon” product they say kills over 90% of colon cancer cells. According to Cannabotech, they have concluded a study using not only cannabis, but a unique combination of cannabinoids and mushroom extracts, which they tested on various colon cancer subtypes, representing different molecular changes common in these colon cancer subtypes. Their results of the cell model study were astounding, showing that its “Integrative-Colon” products killed over 90% of colon cancer cells — and they attribute this to to the mushroom and cannabis combination. Given the fact that the survival rate for colorectal cancer is just 65%, the idea that an easily grown plant and fungus could be used to save hundreds of thousands of lives, is inspiring to say the least. Humans share more DNA with mushrooms than we do with plants, a lot more.
 
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Vitamin C could help reduce toxic side effects of common cancer treatment 
 
University Nove de Julho (Brazil), April 4, 2022
 
A study conducted in rats suggests that taking vitamin C may help to counteract the muscle atrophy that is a common side effect of the chemotherapy drug doxorubicin. Although clinical studies would be needed to determine the safety and effectiveness of taking vitamin C during doxorubicin treatment, the findings suggest vitamin C may represent a promising opportunity to reduce some of the drug’s most debilitating side effects. “Our results suggest vitamin C as a potential adjunct therapy to assist in the management of peripheral muscle disorders after treatment with doxorubicin, thereby improving functional capacity and quality of life and reducing mortality,” said Antonio Viana do Nascimento Filho, a master’s student in medicine at University Nove de Julho (UNINOVE) in Brazil, first author of the study. Nascimento Filho will present the findings at the American Physiological Societyannual meeting during the Experimental Biology (EB) 2022 meeting, held in Philadelphia April 2–5.
 
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Stress markers high, antioxidants low in breast cancer patients
 
University of Lahore (Pakistan), April 4 2022. 
 
Research revealed blood inflammatory and stress marker variations between women with breast cancer and those who did not have the disease. The study compared 498 women with breast cancer with an equal number of age-matched women without the disease. Serum samples were analyzed for matrix metalloproteinases, interleukins, heat shock proteins, tumor necrosis factor-alpha (TNF-a, a proinflammatory cytokine), nitric oxide, inducible nitric oxide synthase, malondialdehyde (MDA, a marker of oxidative stress), vitamins A, C and D, the antioxidant glutathione, and antioxidant enzymes superoxide dismutase (SOD) and catalase. Compared to women who did not have breast cancer, breast cancer patients exhibited overexpression of the inflammatory marker matrix metalloproteinase 9, the proinflammatory protein interleukin-1, heat shock protein 27 (which can be protective as well as destructive), TNF-a, nitric oxide, inducible nitric oxide synthase and MDA. Women with breast cancer had low levels of vitamins A, C and D, glutathione, catalase and SOD.
 

The Gary Null Show - 04.04.22

A prune—or six—a day may keep inflammation at bay
 
Pennsylvania State University, April 1, 2022
 
A study in postmenopausal people suggests eating nutrient-rich prunes every day may be beneficial to bone health, reducing inflammatory factors that contribute to osteoporosis. Previous research has shown that polyphenol extracts—plant compounds that act as antioxidants and reduce inflammation—in prunes promote lower levels of oxidative stress and inflammation in a type of bone cell called osteoclasts. In a new study, researchers explored the effects of prunes on bone health after menopause. Postmenopausal women with a bone mineral density score that was defined as low—a marker of osteoporosis—were divided into three groups: One group ate 50 grams (g) of prunes (about six prunes) daily for 12 months. A second group ate 100 g of prunes (about 12 prunes) daily for 12 months. A control group ate no prunes.
 
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Cardamonin shows promise for treating aggressive breast cancer
 
Study shows that compound from cardamom spice can kill triple-negative breast cancer cells 
 
Florida A&M University, April 3, 2022
 
Cardamonin — a natural compound found in the spice cardamom and other plants — could have therapeutic potential for triple-negative breast cancer, according to a new study using human cancer cells. The findings also show that the compound targets a gene that helps cancer cells elude the immune system. About 10-15% of breast cancers are triple-negative, which means they don’t have receptors for estrogen or progesterone and don’t make excess amounts of a protein called HER2. These tumors are difficult to treat because they don’t respond to the hormone-based therapies used for other types of breast cancer. They also tend to be more aggressive and have a higher mortality rate than other breast cancers.
 
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Mineral supplement could stop fatty liver disease progression
 
University of Michiganm April 3, 2022
 
Results from a preclinical study add new evidence that a multi-mineral dietary supplement known as Aquamin could be a simple and effective way to reduce the long-term health consequences of non-alcoholic fatty liver disease. Aquamin, which is derived from calcified red marine algae, is rich in calcium, magnesium and 72 other minerals and trace elements. Most people living in Western society do not meet the USDA daily intake guidelines for the intake of calcium and magnesium and, presumably, other minerals nutritionally associated with these minerals. In preliminary studies, the researchers fed mice a high-fat diet to induce the development of non-alcoholic fatty liver disease and NASH. They studied these mice for 15 to 18 months to observe the full spectrum of liver disease, including advanced fibrotic changes and liver cancer.
 
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Half of older adults now die with a dementia diagnosis, up sharply from two decades ago
 
University of Michigan, April 2, 2022
 
Nearly half of all older adults now die with a diagnosis of dementia listed on their medical record, up 36% from two decades ago, a new study shows. The study, published in JAMA Health Forum by a University of Michigan team, uses data from 3.5 million people over the age of 67 who died between 2004 and 2017. It focuses on the bills their providers submitted to the traditional Medicare system in the last two years of the patients' lives. In 2004, about 35% of these end-of-life billing claims contained at least one mention of dementia, but by 2017 it had risen to more than 47%. Even when the researchers narrowed it down to the patients who had at least two medical claims mentioning dementia, 39% of the patients qualified, up from 25% in 2004.

The Gary Null Show - 04.01.22

Resveratrol supplementation associated with improved glucose regulation in diabetics
 
National University of Medical Sciences (Pakistan) March 30 2022. 
 
The June 2022 issue of Complementary Therapies in Medicine reported findings from a randomized trial that uncovered positive effects for supplementing with resveratrol in the regulation of glucose and the maintenance of healthy levels of inflammation and oxidative stress in type 2 diabetics. The trial included men and women who were being treated with orally administered drugs for type 2 diabetes.  Forty-five participants received 200 milligrams resveratrol per day and 46 received a daily placebo for 24 weeks. Blood samples collected at the beginning and end of the trial were analyzed for plasma glucose, insulin, hemoglobin A1c (a marker of long-term glucose control), lipids, malondialdehyde (a marker of oxidative stress), circulatory microRNAs associated with diabetes, and markers of inflammation that included tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP).
 
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Eating peanuts may lead to supple arteries and healthy hearts
 
Pennsylvania State University, March 29, 2022
 
Eating peanuts with a meal may help protect against cardiovascular diseases which can lead to heart attacks and stroke, according to an international team of researchers. In the study, overweight and obese but otherwise healthy men who ate about three ounces of peanuts with a high-fat meal had a blunted increase of lipids in their bloodstream. According to the researchers eating peanuts can keep the cells that line the arteries healthy, helping them stay more elastic. The researchers showed that when peanuts are eaten with a meal the typical post-meal increase of triglycerides -- a type of fat found in the bloodstream -- is blunted. According to the researchers, there was a 32 percent reduction in the triglyceride levels after the consumption of the peanut meal compared to the control group. Three ounces of peanuts is about three times the amount of an average serving size, according to the researchers.
 
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NIH Study confirms: Turkey Tail mushrooms boost immunity in women with breast cancer
 
University of Minnesota and Bastyr University, March 28, 2022
 
Turkey Tail mushrooms can boost your immune system so significantly that it may even shrink breast cancer tumors. A $2 million, seven-year clinical study funded by the National Institutes of Health and jointly conducted by the University of Minnesota and Bastyr University showed that Trametes versicolor, or turkey tail mushroom, in freeze-dried form, dramatically boosts immune function for women with Stage I-III breast cancer─ possibly shrinking tumors. One theory is that when patients ingest Turkey Tail mycelium, the immune system’s increased populations of NK cells and their associated CD8 glycoproteins are better able to discover and bind to receptor sites on the stroma of tumors, thus allowing NK invasion. If true, then the use of this medicinal mushroom as an adjunct or preventative therapy may help many patients better fight the battle when challenged with tumor-forming cancers.”
 
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Too Much Screen Time is Really Bad for Teen Well-Being
 
University of Queensland School of Health, March 31, 2022 
 
Whether it’s watching TV or playing games, teens experience serious physical and mental health consequences after just two hours of screen time, according to new research The global study of more than 400,000 adolescents is the first to provide evidence that both passive and mentally active screen time adversely affects teens’ mental well-being. Teens are more likely to report psychosomatic symptoms, a combination of physical and psychological complaints, if they exceed two hours of screen time and these effects were similar regardless of physical activity levels. Psychological complaints from teens included feeling low, irritable, nervousness, and sleeping difficulty, and somatic complaints included headaches, abdominal pain, backache, and dizziness.
 
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The Gary Null Show - 03.31.22

Eating two servings of avocados a week linked to lower risk of cardiovascular disease
 
Harvard School of Public Health, March 30, 2022 
 
Eating two or more servings of avocado weekly was associated with a lower risk of cardiovascular disease, and substituting avocado for certain fat-containing foods like butter, cheese or processed meats was associated with a lower risk of cardiovascular disease events. Researchers believe this is the first, large, prospective study to support the positive association between higher avocado consumption and lower cardiovascular events, such as coronary heart disease and stroke. “Our study provides further evidence that the intake of plant-sourced unsaturated fats can improve diet quality and is an important component in cardiovascular disease prevention,” said Lorena S. Pacheco, Ph.D. in the nutrition department at the Harvard T.H. Chan School of Public Health.”
 
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Exercise may reduce depression symptoms, boost effects of therapy
 
Iowa State University, March 30, 2022
 
Exercising for half an hour may reduce symptoms of depression for at least 75 minutes post-workout and amplify the benefits of therapy, according to two new studies led by researchers at Iowa State University. For the first study, the researchers recruited 30 adults who were experiencing major depressive episodes. The participants filled out electronic surveys immediately before, half-way-through and after a 30-minute session of either moderate-intensity cycling or sitting, and then 25-, 50- and 75-minutes post-workout. Those who cycled during the first lab visit came back a week later to run through the experiment again with 30-minutes of sitting, and vice versa. During the cycling experiment, participants' depressed mood state improved over the 30 minutes of exercise and consistently up to 75 minutes afterward. The improvement to anhedonia started to drop off at 75 minutes post-exercise, but still was better than the participants' levels of anhedonia in the group that did not exercise.
 
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Mindful People Often Have Better Blood Sugar Levels
 
Brown University, February 25, 2022
 
“Everyday” mindfulness is an awareness of your thoughts and feelings. And people who have it tend to have healthy glucose levels, new research shows. They also are less likely to be obese and they’re more likely to believe they can change many of the important things in their life—two factors that scientists suspect may contribute to the healthy glucose levels. Their overarching hypotheses are that people practicing higher degrees of mindfulness may be better able to motivate themselves to exercise, to resist cravings for high-fat, high-sugar treats, and to stick with diet and exercise regimens recommended by their doctors. Participants with high levels of mindfulness were about 20 percent less likely to have type 2 diabetes, but the total number of people in the study with the condition may have been too small to allow for definitive findings.
 
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Being overweight linked to poorer memory
 
University of Cambridge (UK), March 26, 2022
 
Overweight young adults may have poorer episodic memory - the ability to recall past events - than their peers, suggests new research from the University of Cambridge, adding to increasing evidence of a link between memory and overeating. In a preliminary study published in The Quarterly Journal of Experimental Psychology, researchers found an association between high body mass index (BMI) and poorer performance on a test of episodic memory. Although only a small study, its results support existing findings that excess bodyweight may be associated with changes to the structure and function of the brain and its ability to perform certain cognitive tasks optimally. In particular, obesity has been linked with dysfunction of the hippocampus, an area of the brain involved in memory and learning, and of the frontal lobe, the part of the brain involved in decision making, problem solving and emotions, suggesting that it might also affect memory; however, evidence for memory impairment in obesity is currently limited.

The Gary Null Show Notes - 03.30.22

Global diets are harming human and planetary health
 
University of Sao Paulo (Brazil) and Harvard School of Public Health, March 29, 2022
 
A global diet that increasingly includes ultra-processed foods is having a negative impact on the diversity of plant species available for human consumption while also damaging human and planetary health, according to a commentary published in the journal BMJ Global Health. Ultra-processed foods such as sweetened or salty snacks, soft drinks, instant noodles, reconstituted meat products, pre-prepared pizza and pasta dishes, biscuits and confectionery, are made by assembling food substances, mostly commodity ingredients, and 'cosmetic' additives (notably flavors, colors and emulsifiers) through a series of industrial processes. These products are the basis of a 'globalized diet' and are becoming dominant in the global food supply, with sales and consumption growing in all regions and almost all countries. Currently, their consumption is growing fastest in upper-middle-income and lower-middle income countries.
 
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People with fibromyalgia are substituting CBD for opioids to manage pain
 
The cannabis-derived substance provides fewer side effects, with less potential for abuse
University of Michigan, March 24, 2022
 
As the ravages of the opioid epidemic lead many to avoid these powerful painkillers, a significant number of people with fibromyalgia are finding an effective replacement in CBD-containing products, finds a new Michigan Medicine study. Previous research shows that some people substitute medical cannabis (often with high concentrations of THC) for opioids and other pain medications, reporting that cannabis provides better pain relief and fewer side effects. Kevin Boehnke, Ph.D., a research investigator in the Chronic Pain and Fatigue Research Center surveyed people with fibromyalgia about their use of CBD for treatment of chronic pain. The U-M team found that more than 70% of people with fibromyalgia who used CBD substituted CBD for opioids or other pain medications. Of these participants, many reported that they either decreased use or stopped taking opioids and other pain medications as a result.
 
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Sleep Increases Chromosome Dynamics that Clear Out DNA Damage Accumulated During Waking Hours
 
Bar-Ilan University (Israel), 03-28-22
 
In a new study, published in the journal Nature Communications, researchers at Bar-Ilan University in Israelbreveal a novel and unexpected function of sleep that they believe could explain how sleep and sleep disturbances affect brain performance, aging, and various brain disorders. Using 3D time-lapse imaging techniques in live zebrafish, the researchers were able to define sleep in a single chromosome resolution and show that single neurons require sleep to perform nuclear maintenance. DNA damage can be caused by many processes including radiation, oxidative stress, and even neuronal activity. DNA repair systems within each cell correct this damage. The current work shows that during wakefulness, when chromosome dynamics are low, DNA damage consistently accumulates and can reach unsafe levels. The role of sleep is to increase chromosome dynamics, and normalize the levels of DNA damage in each single neuron. Apparently, this DNA maintenance process is not efficient enough during the online wakefulness period and requires an offline sleep period with reduced input to the brain in order to occur. Their discovery was achieved thanks to the characteristics of the zebrafish model. With their absolute transparency, and a brain very similar to humans, zebrafish are a perfect organism in which to study single cell within a live animal under physiological conditions. Using a high resolution microscope, the movement of DNA and nuclear proteins within the cell—inside the fish—can be observed while the fish are awake and asleep. The researchers were particularly surprised to find that chromosomes are more active at night, when the body rests, but this increased activity enables the efficiency of the repair to DNA damage.
 
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Tai chi can mirror healthy benefits of conventional exercise
 
University of Hong Kong and University of California at Los Angeles, March 21, 2022
 
A new study shows that tai chi mirrors the beneficial effects of conventional exercise by reducing waist circumference in middle-aged and older adults with central obesity. Central obesity is a major manifestation of metabolic syndrome, broadly defined as a cluster of cardiometabolic risk factors, including central obesity, dyslipidemia, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C) level, and high blood pressure, that all increase risk for type 2 diabetes and cardiovascular disease. 543 participants were randomly assigned in a 1:1:1 ratio to a control group with no exercise intervention (n= 181), conventional exercise consisting of aerobic exercise and strength training (EX group) (n= 181), and a tai chi group (TC group) (n= 181). Interventions lasted 12 weeks.
 
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Improvement of vitamin D levels linked to longer life
 
Second Medical Centre & National Clinical Research Centre (China), March 28 2022.
 
The investigation included 1,362 participants aged 60 to 113 who had their serum vitamin D levels measured in 2012 and 2014. Mortality data was collected in 2018. Deficient vitamin D levels of less than 20 ng/mL were detected among 67.5% of the participants in 2012 and 68.4% in 2014. During follow-up, 420 deaths occurred. Men and women who were deficient in vitamin D in 2012 and 2014 had a 2.33 times greater risk of mortality than those who maintained nondeficient levels. Among participants who maintained sufficient vitamin D or were deficient in 2012 and not deficient in 2014, the risk of dying was 30% and 53% lower than participants who were deficient at both time points. Women and participants who among the oldest old at 80 years of age or older experienced the greatest benefit.