The Gary Null Show
The Gary Null Show - 08.18.22

The Gary Null Show - 08.18.22

August 18, 2022


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Consuming green vegetables, supplements suppresses inflammatory bowel disease

Sichuan University in China and from Cedars Sinai Medical Center, August 17, 2022

The dietary supplement chlorophyllin alleviates inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers from the Center for Diabetes and Metabolism Research at Sichuan University in China and from Cedars Sinai Medical Center in Los Angeles. In addition, chlorophyllin significantly reduces mortality related to IBD, weight loss, diarrhea and hidden blood in the stool, intestinal epithelial damage and infiltration of inflammatory cells. The findings are published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology, and the study has been chosen as an APS select article for August. Current therapeutics for IBD include medications that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive treatments could result in severe adverse effects, including opportunistic infections and even organ failure. In this study, researchers found taking an oral chlorophyllin supplement—a compound derived from the green pigment found in plants—reduced colitis and abnormalities in the intestinal epithelia of mice. Also, consumption of green vegetables and chlorophyllin may be helpful for IBD recovery, in part through alleviation of inflammation and autolysosomal flux (a process that uses lysosome to degrade and remove toxic molecules and organelles). Green pigment found in these foods and supplements can initiate a feeding signaling to modulate autophagy in the cells, which suppresses IBD symptoms.


Coriander is a potent weapon against antibiotic resistant bacteria

University of Beira Interior (Portugal) August 10, 2022

The problem of antibiotic resistant bacteria has been deemed a public health crisis, with the Centers for Disease Control and Prevention (CDC) reporting that invasive MRSA – or methicillin-resistant S. aureus – infections affect 80,000 people globally a year, and claim over 11,000 lives. But, what the CDC will never tell you is how coriander can potentially save lives. Researchers in Portugal now say that that the oil from coriander – a common kitchen spice – is quite toxic to a wide range of harmful bacteria, leading to hopes that it may be enlisted in the fight against MRSA and other pathogens. The scientific research about coriander is promising
Researchers at University of Beira Interior used flow cytometry to study the effects of coriander oil on 12 different disease-causing types of bacteria, including E. coli, Salmonella, B. cereus and MRSA. In the study, published in Journal of Medical Microbiology, the oil significantly inhibited bacterial growth – especially that of MRSA and E. coli.


Tumour blood supply stopped in its tracks by modified natural compound

University of New South Wales (Australia), August 10, 2022

Researchers have discovered how the modified natural compound dextran-catechin disrupts formation of blood vessels that fuel growth in the childhood cancer neuroblastoma. Researchers have discovered how a modified natural compound disrupts angiogenesis, the formation of blood vessel networks, in neuroblastoma tumours, stopping them laying down the vital supply lines that fuel cancer growth and spread. Dextran catechin is a sugar based conjugated form of catechin commonly found in green tea, red wine, dark chocolate and apple peels. Lead author Dr Orazio Vittorio of Children’s Cancer Institute found that the natural polyphenol catechin slows tumour growth in the laboratory but breaks down too quickly in the body to be effective.


Researchers discover how DDT exposure contributes to Alzheimer’s disease risk

Florida International University and Rutgers University, August 17, 2022

A new study led by researchers from Florida International University and Rutgers reveals a mechanism linking the pesticide DDT to Alzheimer’s disease. Published in Environmental Health Perspectives, the study shows how the persistent environmental pollutant DDT causes increased amounts of toxic amyloid beta, which form the characteristic amyloid plaques found in the brains of those with Alzheimer’s disease. According to Jason Richardson, professor at FIU’s Robert Stempel College of Public Health & Social Work and corresponding author, the study further demonstrates that DDT is an environmental risk factor for Alzheimer’s disease.”The vast majority of research on the disease has been on genetics—and genetics are very important—but the genes that actually cause the disease are very rare,” Richardson says. “Environmental risk factors like exposure to DDT are modifiable. So, if we understand how DDT affects the brain, then perhaps we could target those mechanisms and help the people who have been highly exposed.” The study focused on sodium channels, which the nervous system uses to communicate between brain cells (neurons), as the potential mechanism. DDT causes these channels to remain open, leading to increased firing of neurons and increased release of amyloid-beta peptides. In the study, researchers demonstrate that if neurons are treated with tetrodotoxin, a compound that blocks sodium channels in the brain, the increased production of the amyloid precursor protein and toxic amyloid-beta species is prevented. “This finding could potentially provide a roadmap to future therapies for people highly exposed to DDT,” Richardson says.


Study shows how food preservatives may disrupt human hormones and promote obesity

Cedars-Sinai Medicine Institute, August 9, 2022

Can chemicals that are added to breakfast cereals and other everyday products make you obese? Growing evidence from animal experiments suggests the answer may be “yes.” But confirming these findings in humans has faced formidable obstacles – until now. A new study published in Nature Communications details how Cedars-Sinai investigators developed a novel platform and protocol for testing the effects of chemicals known as endocrine disruptors on humans. The three chemicals tested in this study are abundant in modern life. Butylhydroxytoluene (BHT) is an antioxidant commonly added to breakfast cereals and other foods to protect nutrients and keep fats from turning rancid; perfluorooctanoic acid (PFOA) is a polymer found in some cookware, carpeting and other products; and tributyltin (TBT) is a compound in paints that can make its way into water and accumulate in seafood. The investigators used hormone-producing tissues grown from human stem cells to demonstrate how chronic exposure to these chemicals can interfere with signals sent from the digestive system to the brain that let people know when they are “full” during meals. When this signaling system breaks down, people often may continue eating, causing them to gain weight.


Standing desks can improve well-being, reduce stress among office workers

University of Leicester (UK), August 17 2022

Standing desks can improve workers’ performance as well as cut their time sitting by an hour each day, according to new research. Study authors add that getting up from an office chair also boosts well-being and energy levels, while reducing stress. “High levels of sitting time are associated with several health related outcomes and premature mortality, with high levels of workplace sitting associated with low vigor and job performance and high levels of presenteeism.” Presenteeism is the practice of being present at one’s place of work for more hours than is required, especially as a manifestation of insecurity about one’s job. Sedentary lifestyles increase the risk of chronic conditions including cardiovascular disease, type 2 diabetes, depression, anxiety, and cancer.

The Gary Null Show - 08.17.22

The Gary Null Show - 08.17.22

August 17, 2022
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Study: Regular consumption of citrus fruits can reduce dementia risk by 15%

Tohoku University (Japan), August 4, 2022

Dementia continues to affect more people worldwide, and countries with aging populations like Japan are especially vulnerable. To address this matter, researchers from Tohoku University studied the health benefits of eating citrus fruits. According to the study findings, regular consumption of citrus fruits like oranges, grapefruits, lemons or limes could help reduce the risk of dementia among older adults by almost 15 percent. The research team hopes that the dietary approach could be both a simple and effective solution for dementia prevention. Findings from some cell and animal experiments have shown that citrus flavonoids can cross the blood-brain barrier and play a part in antioxidant and anti-inflammatory actions. Earlier studies suggest that this could help reverse and repair some forms of cellular damage.


Olive oil consumption found to reduce risk of death due to cancer, heart disease and Alzheimer’s

Harvard School of Public Health, August 14, 2022

According to a study, replacing butter or full-dairy fat with half a tablespoon or more of olive oil can help increase your chances of living longer. The study was conducted by experts from the Harvard T.H. Chan School of Public Health and published in the American Journal of Cardiology. The study revealed that people who used seven grams or more (at least half a tablespoon) of olive oil as a dressing or with bread had a reduced risk of dying from Alzheimer’s disease, cancer, heart disease or respiratory disease compared to those who rarely or never consumed olive oil. Findings also showed that replacing 10 grams a day (about 3/4 tablespoons ) of butter, margarine, mayo or dairy fat with the same amount of olive oil was linked to an impressive eight to 34 percent lower risk of disease-related death. For the study, the researchers analyzed data from 60,582 healthy adult women and 31,801 healthy adult men from the Nurses’ Health Study and the Health Professionals Follow-up Study. During the 28-year follow-up, the volunteers had a diet assessment every four years that asked them how often they consumed certain foods, fats and oils on average. The assessment also checked which brand or type of oils they used for cooking or at the table.


Cutting 1 gram from daily salt intake could ward off nearly 9 million cases of stroke/heart disease

British Medical Journal, August 16, 2022

A modest cut of just 1 gram in daily salt intake could ward off nearly 9 million cases of heart disease and strokes and save 4 million lives by 2030, suggest the estimates of a modeling study published in the open access journal BMJ Nutrition Prevention & Health. Salt intake in China is one of the highest in the world, averaging 11 g/day—over twice the amount recommended by the Chinese government. High salt intake drives up blood pressure and therefore the risk of cardiovascular disease, which accounts for 40% of all deaths in China every year. The researchers set out to estimate the health gains that could be achieved by reducing salt intake across the nation, with the aim of helping to inform the development of a doable salt reduction program.

Given that, on average, adults in China consume 11 g/day of salt, reducing this by 1 g/day should lower average systolic blood pressure by about 1.2 mmHg. And if this reduction were achieved in a year and sustained, some 9 million cases of heart disease and stroke could be prevented by 2030—4 million of them fatal.


Getting Adequate Amount Of Vitamin D Prevents Harmful Inflammation

University of South Australia, August 7, 2022

A little bit of inflammation is integral to the human body’s natural healing process. Chronic inflammation, however, can actually have the opposite effect. Constantly high levels increase one’s risk of various serious diseases including but not limited to Type 2 diabetes, heart disease, and various autoimmune conditions. Now, a study by scientists at the University of South Australia reports a direct link between low levels of vitamin D and high levels of inflammation. This is the world’s first ever genetic research project to focus on this topic. Study authors believe their work establishes an invaluable biomarker for identifying individuals at a higher risk of developing chronic illnesses with an inflammatory component. The research team used Mendelian randomization on the genetic data of 294 ,970 participants enrolled in the UK Biobank project. That analysis revealed a clear association between vitamin D and C-reactive protein levels, considered an indicator of inflammation.


Four Natural Options for Chronic Fatigue Syndrome

GreenMedInfo, August 16th 2022

Chronic fatigue syndrome (CFS) is a complex long-term disorder affecting over 2 million Americans that is characterized by extreme fatigue and malaise that doesn’t improve with rest.[i] A whopping 90% of chronic fatigue sufferers are undiagnosed[ii] and may find it difficult to carry on with normal activities such as work, school and household chores. At least 1 in 4 CFS patients are house-bound or bed-bound for long periods of time due to the disorder. While some studies demonstrate correlation between CFS and autoimmune system dysregulation,[v],[vi] the cause of CFS, also referred to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is still unknown. There is no known cure for CFS, with treatment generally focusing on symptom relief.We’ve identified four of the best natural options for chronic fatigue syndrome to provide safe, effective support to revitalize your body and spirit.

  1. Nicotinamide Adenine Dinucleotide (NADH)

An essential element in the production of energy, nicotinamide adenine dinucleotide (NADH) is a coenzyme found in every cell in the human body. NADH is a critical factor in hundreds of metabolic processes, including healthy cell turnover (antiaging), converting food into energy and maintaining the integrity of DNA,[ix] an important factor in disease prevention.

NADH has been studied extensively as a therapeutic for CFS, including a study comparing oral NADH with conventional therapy consisting of nutritional supplements and psychological therapy for a period of 24 months. To rule out specific comorbidities, immunological parameters and viral antibody titers were also evaluated at baseline and each trimester of therapy. Patients who received NADH had a dramatic and statistically significant reduction in symptoms during the first trimester.[x]

Another trial on the stabilized oral form of NADH examined 26 qualified patients over a 12-week double-blind, placebo-controlled study. Subjects were randomized to receive either 10 milligrams (mg) of NADH or placebo for a four-week period, followed by a four-week “washout” period, after which subjects were switched to the alternate treatment for a final four-week period.

Within this cohort of 26 subjects, eight patients, or 31%, responded favorably to NADH compared to just 8% (two patients) of the placebo group, with no severe adverse reactions related to treatment.[xi]

  1. Astragalus

Astragalus is a traditional herbal remedy known for its adaptogenic qualities, meaning it can help protect the body from damage due to oxidative stress. A powerful antioxidant, astragalus is used to protect and support immunity, as a preventative against colds and upper respiratory tract infections, and to regulate healthy blood pressure, among other uses.[xii] Astragalus can even be applied topically for wound care thanks to antiviral properties.

A 2009 study focused on the herbal formula Myelophil, a combination of two traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza, a member of the sage family. The Myelophil extract was given to the treatment cohort in either low- or high-dose groups of 3 or 6 grams of Myelophil daily. A control group was provided with a placebo and all groups were monitored for four weeks.

Patients were surveyed for symptom severity and blood antibody arrays were taken to measure inflammatory cytokines, an important marker of disease symptoms. Results showed that even at low dosage (3 grams), Myelophil significantly decreased fatigue severity compared with placebo, though no changes in cytokine expression were noted.[xiii]

  1. Probiotics

Probiotics have garnered the health spotlight in recent years, owing to their ability to support and protect the digestive tract. But probiotics can do more than improve gut health — they may also boost your brain and improve your mood.

Brain fog is a key side effect of CFS and a potentially devastating one when it comes to impact on daily functioning. The same can be said for depression, another common hallmark of CFS. Studies reflecting the mood-boosting, clarity-producing effects of probiotics are cause for optimism for sufferers of chronic fatigue.

A 2018 study in the journal Beneficial Microbes points to the role gut microbiota may play in CFS and fibromyalgia syndrome (FMS), which shares many features of CFS. A systematic review of studies was performed in this meta-analysis, encompassing randomized controlled trials and pilot studies of CFS or FMS conducted between 2006 and 2016. The administration of Lactobacillus casei for eight weeks was found to reduce anxiety scores, while treatment with Bifidobacterium infantis for the same period reduced inflammatory biomarkers.[xiv]

Unhealthful intestinal ecology may play a role in CFS, as it plays a part in the health of the immune system. A 2009 study on probiotics’ effects on energy level and symptomology for CFS patients found that, after four weeks of probiotic supplementation with strains of lactobacillus, acidophilus and Bifidobacterium, patients reported improved neurocognitive functions, though fatigue and physical activity scores were not significantly affected.[xv]

  1. Antioxidant Formulas

Supplementing with antioxidants is another way to boost your body’s defenses against the damaging effects of free radicals. By increasing the amount of antioxidant enzymes available to your cells, you may be able to prevent or even reverse the effects of oxidative stress that can cause systemic inflammation and fatigue.

Oxidative stress as a factor in CFS was studied by researchers using a mouse model that stressed mice via chronic swimming. Mice treated with melatonin — a hormone with antioxidant effects — carvedilol — a medication that is 10 times more potent than vitamin E[xvi] — were observed to have significantly reduced immobilityperiods each day.[xvii]

Similar results were observed when mice were administered an oral herbal compound (Withania somnifera (100 mg/kg), quercetin (50 mg/kg) and St. John’s wort (10 mg/kg).)[xviii] These treatments further caused a significant reduction in lipid peroxidation, a sign of oxidative stress, and restored the GSH (glutathione) levels decreased by chronic swimming.[xix]

The Gary Null Show - 08.16.22

The Gary Null Show - 08.16.22

August 16, 2022


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New study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes

University of California at Irvine, August 15, 2022

A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation. The team utilized a genetically engineered mouse model that develops obesity, insulin resistance and high blood sugar, similar to advanced human type 2 diabetes, to test whether Rhodiola rosea could improve glucose homeostasis. In the study, cohorts of age-matched male and female mice were randomly assigned to one of two groups: control, which received water, or experimental, which received Rhodiola rosea extract.


Meta-analysis concludes benefits for selenium supplementation in cognitively impaired individuals

Instituto de Pesquisa Pelé Pequeno Príncipe (Brazil), August 15 2022. 

A systematic review and meta-analysis published  in Nutrients found that supplementing with selenium was associated with improved levels of the mineral and the antioxidant enzyme glutathione peroxidase, as well as better cognitive function among patients with mild cognitive impairment (MCI) or Alzheimer disease (AD). 
“For the first time, our study demonstrated, through a systematic review and meta-analysis, the possible benefits of selenium supplementation on selenium levels in patients with MCI or AD, as well as on markers of oxidative stress and on cognitive test performance,” Meire Ellen Pereira and colleagues wrote. Among studies that evaluated the effects of selenium without other nutrients, selenium measured in plasma, serum, red blood cells or cerebrospinal fluid increased among participants who received the mineral while remaining essentially the same or lower in the control groups. The meta-analysis determined that supplementing with selenium increased selenium levels by an average of 4 times in plasma, 1.88 times in serum, 3.73 times in red blood cells and 2.18 times in cerebrospinal fluid. 


Skip the elevator: A 15-minute walk can help your brain fight off Alzheimer’s

German Center for Neurodegenerative Disease, August 15 2022

Older people can stave off Alzheimer’s disease with a daily 15-minute walk or other physical activities, according to new research. Researchers in Germany say moderate physical activity boosts all areas of the brain, especially those involved in memory. Staying active also benefits people over 70 the most. They see the biggest increase in grey matter, compared to their “couch potato” peers. “Our study results indicate that even small behavioral changes, such as walking 15 minutes a day or taking the stairs instead of the elevator, may have a substantial positive effect on the brain and potentially counteract age-related loss of brain matter and the development of neurodegenerative diseases. In particular, older adults can already profit from modest increases of low intensity physical activity.”


Antioxidants in fruit boosts immunity and protects thymus gland 
Scripps Research Institute, August 8, 2022

Eating fruit and vegetables or taking antioxidant supplements may combat one of the most harmful aspects of aging by protecting a vital immune system organ, research suggests. Scientists demonstrated how ageing sabotaged the thymus gland, weakening the immune system and putting the elderly at greater risk of infection. But the irreversible damage could be reduced by the action of antioxidants such as vitamin C. Experiments showed that antioxidants – which are abundant in many fruits and vegetables – cut down the destruction wrought by a highly reactive by-product of normal metabolism. In studies on mice, animals given vitamin C and another antioxidant used in human medicine experienced significantly less age-related deterioration of the thymus. US lead scientist Dr Howard Petrie, from the Scripps Research Institute in San Diego, California, said: “The thymus ages more rapidly than any other tissue in the body, diminishing the ability of older individuals to respond to new immunologic challenges, including evolving pathogens and vaccines. Its function is to manufacture T-cells, essential immune system cells in the front-line of the body’s defences against harmful foreign invaders and cancer.


Modern Processed Diets Are Coding DNA and Gut Bacteria To Pass On Poor Immune Functions To Our Children

Yale University and Erlangen-Nuremberg University, August 6, 2022

A team of scientists from Yale University in the U.S and the University of Erlangen-Nuremberg, in Germany, has said that junk food diets could be partly to blame for the sharp increase in autoimmune diseases such as multiple sclerosis, including alopecia, asthma and eczema. The new stark warnings come in a review published in Nutrition Journal, which analysed the impact that the modern Western diet has on immune function and risk of ill-health related to poor immunity and inflammation."While today's modern diet may provide beneficial protection from micro- and macronutrient deficiencies, our over abundance of calories and the macronutrients that compose our diet may all lead to increased inflammation, reduced control of infection, increased rates of cancer, and increased risk for allergic and auto-inflammatory disease," warned Myles in his review. Each person harbors a unique and varied collection of bacteria that's the result of life history as well as their interactions with the environment, diet and medication use. Western diet and lifestyles consisting of fast and processed foods are leading to a lower diversity of bacteria in the gut, say researchers. Of potentially greatest concern, our poor dietary behaviours are encoded into both our DNA scaffolding and gut microbiome, and thus these harmful immune modifications are passed to our offspring during their most critical developmental window.


The aging heart accumulates mutations—while losing the ability to repair them

Children's Hospital Boston, August 12, 2022

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases. A first-of-its-kind study from Boston Children's Hospital now shows that the cells that make up our heart muscle accumulate new genetic mutations over time—while losing the ability to repair them.

The findings were published in the journal Nature Aging.

The research team, led by Sangita Choudhury, Ph.D., and August Yue Huang, Ph.D., in the Division of Genetics and Genomics at Boston Children's, sequenced the entire genomes of 56 individual heart muscle cells, known as cardiomyocytes, from 12 people across the age spectrum—from infancy to 82 years—who had died from causes unrelated to heart disease.


The Gary Null Show - 08.15.22

The Gary Null Show - 08.15.22

August 15, 2022

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Researchers propose new treatment to prevent kidney stones – HCA in Garcinia Cambogia

University of Houston, August 8, 2022 

 Researchers have found evidence that a natural fruit extract is capable of dissolving calcium oxalate crystals, the most common component of human kidney stones. This finding could lead to the first advance in the treatment of calcium oxalate stones in 30 years.Jeffrey Rimer, associate professor of chemical engineering at the University of Houston, was lead author of the study, published in the online edition of Nature. The work offers the first evidence that the compound hydroxycitrate (HCA) is an effective inhibitor of calcium oxalate crystal growth that, under certain conditions, is actually able to dissolve these crystals. Researchers also explain how it works. Doctors tell patients who are at risk of developing stones to drink lots of water and avoid foods rich in oxalate, such as rhubarb, okra, spinach and almonds. They often recommend taking citrate (CA), in the form of potassium citrate, a supplement that can slow crystal growth, but some people are unable to tolerate the side effects.


Pomegranate improves synaptic function in experimental model of Alzheimer's disease

University of New South Wales August 11, 2022. 

An article published in the journal Oncotarget reports improvement in the loss of synaptic proteins that occurs with aging in association with pomegranate intake in a mouse model of Alzheimer's disease. Synapses are the connections that enable the transmission of messages between neurons. Impairment of synaptic plasticity—the ability of synapses to strengthen or weaken over time in response to variation in their activity—is one of several neurologic changes observed in Alzheimer's disease that contributes to cognitive impairment.


Yoga May Boost Aging Brains

Hospital Israelita Albert Einstein (Brazil), August 9, 2022 

Older women who practice yoga may have greater "thickness" in areas of the brain involved in memory and attention, a small study suggests. Researchers found that even compared with other healthy, active women their age, yoga practitioners typically had greater cortical thickness in the brain's left prefrontal cortex.The findings are based on one-time brain scans of fewer than 50 women—and they do not prove that yoga, itself, altered anyone's brain structure, according to senior researcher Elisa Kozasa.

The study does add to a bigger body of evidence on yoga and brain function, said Dr. Helen Lavretsky, a researcher who was not involved in the work. "This contributes to the evidence that yoga practice has neuroplastic effects on the brain that may translate into other health benefits—like better mood and cognition," said Lavretsky, a professor-in-residence of psychiatry at the UCLA Geffen School of Medicine.


Resveratrol: The key to reducing elderly frailty?

Universidad Pablo de Olavide (Spain) , August 11, 2022

The so-called red wine nutrient resveratrol may help maintain muscle performance and reduce frailty in the elderly, research in mice has suggested.Using 48 young, mature and old mice models, the study found resveratrol improved muscle performance in the mature and old animals but not in the young. They found resveratrol – found in grapes, red wine, walnuts, peanuts and berries – “primed” the effect of exercise by increasing endurance, coordination and strength in the old animals as well as providing higher protection against oxidative damage and an increase in the mitochondrial mass responsible for the energy-generating process essential for cell metabolism.


Ginkgo may enhance performance, boost brain health for active men

Poznan University (Poland), August 10, 2022

Extracts of Ginkgo biloba leaves may offer body and mind benefits for young, active men, according to a small supplementation trial from Poland. A daily 160 mg dose of a standardized extract of Ginkgo biloba for six weeks was associated with improvements of VO2max (maximal oxygen uptake) and blood antioxidant capacity, report scientists from the Jerzy Kukuczka Academy of Physical Education and the Poznan University of Physical Education. Writing in Nutrients , the scientists also note that Ginkgo supplementation resulted in increased production of brain-derived neurotrophic factor (BDNF) during exercise. “BDNF is a molecular mediator of synaptic plasticity, hence, the BDNF signaling pathway is reduced in many neurodegenerative and psychiatric diseases,” they explained. Increasing BDNF levels, therefore, is considered beneficial. The results showed that VO2max increased in both groups, but the greatest increases were measured in the Ginkgo group. However, no statistical significance was found between the groups, which may be due to the dose – previous studies have shown benefits from higher doses.


Is corn silk beneficial for diabetes?

University in China study and University of Buffalo, August 2, 2022

Corn silk refers to the threads that grow on corn cobs. People have used corn silk as an herbal remedy for centuries in traditional Chinese and Native American medicine. Proponents suggest that it may have several medicinal applications, which may include reducing inflammation, blood pressure, and blood sugar.Corn silk, also known as Stigma Maydis, refers to a traditional Chinese medicine. 

Corn silk describes the thread-like strands that grow underneath the husk of a fresh ear of corn. These thin fibers contain plant compounds that may be responsible for various health benefits. Some evidence suggests that corn silk may possess antidiabetic properties.

A Jilin University in China study and University of Buffalo review suggest that corn silk, and its flavonoids, may possess antidiabetic benefits. The mouse study suggests that the antidiabetic properties of corn silk could make it a good candidate for a functional food or treatment for diabetes. Corn silk may help by slowing the absorption of starchy foods from the intestine. By slowing this process, blood glucose levels rise more steadily after meals, which avoids sudden blood sugar spikes. Corn silk has antioxidant and antiglycation properties that can provide protective effects for insulin-secreting cells.

A review of corn silk's medicinal benefits at Damietta University in Egypt suggests:

Antioxidant and anti-inflammatory: suggests that the compounds present in corn silk are rich in antioxidant and anti-inflammatory properties. This could provide a protective effect against different conditions. For example, a 2019 paper suggests it could protect against skin damage.

Antihyperlipidemia: Corn silk possesses anti-hyperlipidemic activity. It can help improve cholesterol levels and decrease the risk of cardiovascular conditions.

Lowering blood pressure: Corn silk can help lower blood pressure. Corn silk tea could help improve the effect of antihypertensive drugs and could offer a natural alternative treatment option.

Treating kidney stones: Researchers at Dalien Polytechnic University in China found that sugars present in corn silk can help reduce kidney damage and promote uric acid excretion. As such, corn silk could act as a dietary supplement to help reduce kidney stone formation.

Reduction of nephrotoxicity: Corn silk can help reduce kidney damage that may occur as a side effect of a certain anticancer drug. 

The Gary Null Show - 08.12.22

The Gary Null Show - 08.12.22

August 12, 2022

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Chili peppers for a healthy gut: Spicy chemical may inhibit gut tumors

How Tart Cherries Reduce Inflammation and Oxidative Stress

Uncovering the links between diet, gut health and immunity

Southern-style diet ‘increases death risk’ in kidney disease patients

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Can breast milk feed a love of vegetables?

Chili peppers for a healthy gut: Spicy chemical may inhibit gut tumors

University of California, San Diego   August 1, 2022

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

The receptor or ion channel, called TRPV1, was originally discovered in sensory neurons, where it acts as a sentinel for heat, acidity and spicy chemicals in the environment. TRPV1 was quickly described as a molecular ‘pain receptor.’ 

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR. EGFR is an important driver of cell proliferation in the intestines, whose epithelial lining is replaced approximately every four to six days.

“These results showed us that epithelial TRPV1 normally works as a tumor suppressor in the intestines,” said de Jong. In addition, molecular studies of human colorectal cancer samples recently uncovered multiple mutations in the TRPV1 gene, though Raz noted that currently there is no direct evidence that TRPV1 deficiency is a risk factor for colorectal cancer in humans.

The current study suggests one potential remedy might be spicy capsaicin, which acts as an irritant in mammals, generating a burning sensation in contact with tissue. 

The researchers fed capsaicin to mice genetically prone to developing multiple tumors in the gastrointestinal tract. The treatment resulted in a reduced tumor burden and extended the lifespans of the mice by more than 30 percent. The treatment was even more effective when combined with celecoxib, a COX-2 non-steroidal anti-inflammatory drug already approved for treating some forms of arthritis and pain.

“Our data suggest that individuals at high risk of developing recurrent intestinal tumors may benefit from chronic TRPV1 activation,” said Raz. “We have provided proof-of-principle.”

How Tart Cherries Reduce Inflammation and Oxidative StressNorthumbria University (UK),  August 4, 2022Michigan researchers had previously shown that a cherry-enriched diet not only reduced overall body inflammation, but also reduced inflammation at key sites (belly fat, heart) known to affect heart disease risk in the obese.This study offers further promise that foods rich in antioxidants, such as cherries, could potentially reduce inflammation and have the potential to lower disease risk.”

Two daily doses of the tart cherry concentrate was associated with significantly lower levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP), compared to placebo, according to findings published in Nutrients.

”This is the first study to investigate the impact of cherries on systemic inflammatory and oxidative stress induced by a series of metabolically challenging cycling bouts. Despite both groups demonstrating a similar drop off in performance and no differences in time trial performance, the results show that both oxidative stress and inflammatory responses were attenuated with Montmorency cherry concentrate supplementation versus placebo.” 

”With millions of Americans looking for ways to naturally manage pain, it’s promising that tart cherries can help, without the possible side effects often associated with arthritis medications,” said Kerry Kuehl, M.D, Dr.PH., M.S., Oregon Health & Science University, principal study investigator. “I’m intrigued by the potential for a real food to offer such a powerful anti-inflammatory benefit — especially for active adults.”

Darren E. Huxley, MD says that a natural alternatives to pain medications are proving effective without unwanted side effects. “In this case we have cherries, another potent, natural antioxidant proving to be as, if not more effective than pain medications because of the ability for sustained long-term use without side effects in common anti-inflammatory drugs.Tart cherries have also been shown to contain naturally high levels of melatonin, a key compound in the human sleep-and-wake cycle, and new research in the European Journal of Nutrition confirms that melatonin from tart cherries is absorbed by humans.

In 2001, Burkhardt et al. even observed that the Montmorency variety, in particular, contains about six times more melatonin than the Balaton variety. 

Uncovering the links between diet, gut health and immunity

University of Sydney, August 5, 2022

A preclinical study from the University of Sydney has found a high-protein diet can change the microbiota of the gut, triggering an immune response. Researchers say the study takes us a step closer to understanding the way diet impacts gut health and immunity.

“The focus of our work is on how the gut microbiota—the trillions of bacteria that inhabit the gut—affects the immune system,” said Associate Professor Laurence Macia from the University’s Charles Perkins Center and Faculty of Medicine and Health.

Traditionally, however, scientists have focused on the role of dietary fiber in maintaining a healthy gut.

In this first-of-its-kind study, published in Nature Communications, the team from the Charles Perkins Center used sophisticated modeling to explore the impact of 10 diets with a different makeup of macronutrients—protein, fats and carbohydrate in mice.

Mice fed a high protein diet increased their production of bacterial extracellular vesicles, complex cargo containing bacterial information such as DNA and protein. The body subsequently viewed this activity as a threat and triggered a sequence of events where immune cells traveled into the gut wall.

“Here we found protein had a huge impact on the gut microbiota and it was not so much about the type of bacteria that were there, but the type of activity. In essence, we discovered a new way of communication between the gut bacteria and the host which was mediated by protein,” said Associate Professor Macia.

While it is too early to say if this research might translate in humans, the researchers say activation of the immune system can prove either good or bad news.

“By increasing antibodies in the gut you may see strong protection against potential pathogens, for example salmonella, but on the downside, an activated immune system could mean you are at increased risk of colitis, an inflammatory bowel disease, or autoimmune conditions like Crohn’s,” said lead author and post-doctoral researcher Jian Tan.

The results appear consistent with the population impacts of modern-day diets, with the Western world seeing lower rates of gastrointestinal infection but higher rates of chronic disease. 

Southern-style diet ‘increases death risk’ in kidney disease patients

University of Alabama  1 August 2022

New research published in the National Kidney Foundation’s American Journal of Kidney Diseases suggests that eating a “Southern-style diet” is linked with higher death rates in kidney disease patients.

Investigating the influence of diet on kidney disease patients, the researchers studied  3,972 participants with stage 3-5 chronic kidney disease who had not started dialysis. Analyzing the dietary habits of the participants, the researchers found that those who regularly consumed foods familiar to Southern diets had a 50% increase in risk of death across the 6.5-year follow-up period.

Foods that the authors identify as being part of a Southern diet include processed and fried foods, organ meats and sweetened beverages.

Could Hibiscus Tea be Better than High Blood Pressure Drugs?

Tufts University,  August 4th, 2022

Naturally healing foods, including hibiscus, don’t carry the side effects of pharmaceuticals and can often offer similar (or better) benefits, without padding the pockets of Big Pharma companies. This is one example of a natural solution for high blood pressure.

When it comes to high blood pressure, a completely preventable condition, there are many natural solutions. Things like cayenne pepper, apple cider vinegar, and celery are just a few alternatives, along with broad dietary and lifestyle changes. But many people aren’t aware of the blood pressure lowering benefits of hibiscus.

Dr. Diane McKay presented her own research on hibiscus Dr. McKay, of Tufts University, conducted a study on 65 people between the ages of 30 and 70 who had been diagnosed with prehypertension or mild hypertension.

After receiving hibiscus tea daily for six weeks, participants experienced reduced diastolic, systolic, and mean arterial pressures when compared with those who received a placebo. The effects were most pronounced in those with the highest beginning baseline blood pressures.

In another study, scientists received a surprise when looking at the effects of hibiscus tea on blood sugar. The study compared the effects of hibiscus and black teas and found that both impacted cholesterol levels. While the black tea positively influenced HDL levels, hibiscus tea helped keep LDL, HDL, and overall cholesterol at healthy levels.

Can breast milk feed a love of vegetables?

 Monell Chemical Senses Center, August 4, 2022 

Want your preschooler to eat veggies without a fuss? Try eating veggies while you’re breast-feeding.

That’s the message from a new study of lactating mothers and their breast-fed babies. The study found that those infants who took in veggie-flavored breast-milk were less likely to turn away from similar-tasting cereal when they graduated to more solid food.

“Every baby’s sensory experience is unique, but the flavor of their first food, beginning in utero, is dependent on what mom is eating,” said Julie Mennella. She is a biopsychologist at the Monell Chemical Senses Center in Philadelphia, and led the study.

“The way I see it is: Mother’s milk is the ultimate in precision medicine,” Mennella said.

When an expectant mother eats vegetables, they flavor her amniotic fluid—and later, her breast-milk—and those flavors get passed along to her baby. As a result, the researchers said, if the baby learns early how veggies taste, he or she will be less apt to squawk when offered that first spoonful.

For her study, Mennella randomly assigned 97 breast-feeding mothers to one of five groups.

For a month, three groups drank a half-cup of carrot, celery, beet or vegetable juice before nursing. One group began when babies were two weeks old, another at 1-1/2 months of age and the third at 2-1/2 months.

A fourth group of moms drank juice for three months, starting when their babies were two weeks old. A fifth group—the “control” group—did not use juice.

The takeaway: Babies who’d been exposed to vegetable flavors in breast-milk preferred carrot-flavored cereal over plain cereal or cereal with the unfamiliar taste of broccoli. Only 8 percent rejected all of the foods, the findings showed.

The Gary Null Show - 08.11.22

The Gary Null Show - 08.11.22

August 11, 2022


Bernie Turns Pro-War & Votes To Expand NATO – Jimmy Dore

Ukrainian Terrorism: Firing Munitions Containing Petal Mines On Donbass Orphanage, Another War Crime

 The moral roots of liberals and conservatives – Jonathan Haidt



Vitamin K protects cells
3 grams of fresh salmon does wonders for high blood pressure, study reveals
Physical activity stimulates the generation of new heart muscle cells in aged mice
The Human Mind Is Not Meant to Be Awake After Midnight, Scientists Warn
Social Isolation, Loneliness Raise Risk Of Death From Heart Attack Or Stroke By Nearly A Third
Mushrooms of the Far East hold promise for the anti-cancer therapy

Vitamin K protects cells

Helmholtz Zentrum München (Germany), August 5 2022

An article appearing  in Nature reported that the reduced form of vitamin K has an antioxidant effect that inhibits cell death caused by ferroptosis: an iron-dependent type of programmed cell death characterized by the oxidative destruction of cell membranes. “We identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), is able to efficiently rescue cells and tissues from undergoing ferroptosis,” first author Eikan Mishima announced.

Ferroptosis has been implicated in Alzheimer disease and other disorders. “Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation, has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant cancers,” the authors explained. “Here we show that the fully reduced forms of vitamin K—a group of naphthoquinones that includes menaquinone and phylloquinone—confer a strong anti-ferroptotic function, in addition to the conventional function linked to blood clotting.”

In the current investigation, they determined that the fully reduced form of vitamin K (vitamin K hydroquinone) is a strong antioxidant and prevents ferroptosis. “The reduced forms of Vitamin K and coenzyme Q10 are not very stable, so our finding that FSP1 can maintain them in their active (reduced) state is key to understanding how they are able to function to maintain cell viability,” coauthor Derek A. Pratt stated. 

The team found that vitamin E and three forms of vitamin K— phylloquinone, menaquinone-4 (MK4) and menadione (vitamin K3)—rescued cells that were genetically modified to undergo ferroptosis. 

3 grams of fresh salmon does wonders for high blood pressure, study reveals

Macau University of Science and Technology (China), August 9, 2022

Omega-3 carries many health benefits, and a new review suggests eating three grams of it per day is enough to lower your blood pressure. The findings include omega-3 fatty acids obtained from food or dietary supplements.

“According to our research, the average adult may have a modest blood pressure reduction from consuming about 3 grams a day of these fatty acids,” says Xinzhi Li, MD, PhD, assistant professor and program director of the School of Pharmacy at Macau University of Science and Technology in China.

The average fish oil supplement carries an average of 300 mg of omega-3 per pill. A four to five-ounce Atlantic salmon carries about three grams of omega-3 fatty acids.

“Most of the studies reported on fish oil supplements rather than on EPA and DHA omega-3s consumed in food, which suggests supplements may be an alternative for those who cannot eat fatty fish such as salmon regularly,” explains Dr. Li. “Algae supplements with EPA and DHA fatty acids are also an option for people who do not consume fish or other animal products.”

The National Institutes of Health recommends 1.1 to 1.6 grams of omega-3 fatty acids daily. The American Heart Association advises getting some of your omega-3 intake through two servings of three to four ounces of cooked fish per week.

The review combed through the data from 71 clinical trials studying the relationship between blood pressure and the omega-3 fatty acids DHA and EPA in adults with or without high blood pressure or cholesterol disorders. 

High blood pressure was lower in people who ate between two and three grams of combined DHA and EPA omega-3 fatty acids daily than adults who did not. Eating more than three grams of omega-3s made a tremendous difference in adults with high blood pressure or high blood lipids.

With three grams of daily omega-3s, the average blood pressure in people with hypertension decreased about 4.5 mm/Hg. Those without high blood pressure saw their blood pressure drop by 2.0 mm/Hg.

Eating five grams of omega-3s lowered the blood pressure by nearly 4.0 mm/Hg for people with hypertension. Those without high blood pressure who ate five daily grams of omega-3s saw an average decrease of less than 1.0 mm/Hg.

Physical activity stimulates the generation of new heart muscle cells in aged mice

Heidelberg University (Germany), August 8, 2022

Can physical activity support the generation of heart muscle cells (cardiomyocytes) even in aged animals? Researchers at Heidelberg University Hospital (UKHD) together with a team of international collaborators demonstrated positive effects on the formation of new heart muscle cells (cardiomyogenesis) in aged mice and investigated the underlying cellular and molecular mechanisms. The current research results have been published in the journal Circulation.

The heart of adult mammals has a very limited ability to generate new cardiomyocytes. With aging, this capacity continues to decrease, while at the same time the risk of cardiovascular disease increases. Dr. Carolin Lerchenmüller, head of the Cardiac Remodeling and Regeneration research group in the Department of Cardiology, Angiology and Pneumology at the UKHD, and her team have found evidence that physical activity stimulates the new formation of heart muscle cells in aging mice.

The researchers found that the calculated annual rate of newly generated heart muscle cells in the “exercising” group of older mice was 2.3 percent. In contrast, there were no new heart muscle cells in the “sedentary” control group. A previous study with young animals had already shown that mice had a calculated annual rate of 7.5 percent new heart muscle cells through exercise, compared to 1.63 percent in the corresponding “sedentary” control group.

The Human Mind Is Not Meant to Be Awake After Midnight, Scientists Warn 

Harvard University, August 4, 2022

In the middle of the night, the world can sometimes feel like a dark place. Under the cover of darkness, negative thoughts have a way of drifting through your mind, and as you lie awake, staring at the ceiling, you might start craving guilty pleasures, like a cigarette or a carb-heavy meal.

Plenty of evidence suggests the human mind functions differently if it is awake at nighttime. Past midnight, negative emotions tend to draw our attention more than positive ones, dangerous ideas grow in appeal and inhibitions fall away. A new paper summarizes the evidence of how brain systems function differently after dark.

Their hypothesis, called ‘Mind After Midnight’, suggests the human body and the human mind follow a natural 24-hour cycle of activity that influences our emotions and behavior.

In short, at certain hours, our species is inclined to feel and act in certain ways. In the daytime, for instance, molecular levels and brain activity are tuned to wakefulness. But at night, our usual behavior is to sleep.

According to the researchers, to cope with this increased risk, our attention to negative stimuli is unusually heightened at night. Where it might once have helped us jump at invisible threats, this hyper-focus on the negative can then feed into an altered reward/motivation system, making a person particularly prone to risky behaviors.

Add sleep loss to the equation, and this state of consciousness only becomes more problematic.

The authors of the new hypothesis use two examples to illustrate their point. The first example is of a heroin user who successfully manages their cravings in the day but succumbs to their desires at night.

The second is of a college student struggling with insomnia, who begins to feel a sense of hopelessness, loneliness and despair as the sleepless nights stack up.

Both scenarios can ultimately prove fatal. Suicide and self-harm are very common at nighttime. In fact, some research reports a three-fold higher risk of suicide between midnight and 6:00 am compared to any other time of day.

study in 2020 concluded that nocturnal wakefulness is a suicide risk factor, “possibly through misalignment of circadian rhythms.”

Social Isolation, Loneliness Raise Risk Of Death From Heart Attack Or Stroke By Nearly A Third

University of California, San Diego, August 9, 2022

Loneliness increases the risk of cardiovascular disease by almost a third, according to new research. Socially isolated individuals are about 30 percent more likely to suffer a stroke or heart attack — death from either.

Scientists at the University of California, San Diego also identified a lack of information on interventions that may boost the health of vulnerable individuals. The findings are based on data pooled from studies across the world over the past 40 years.

“Over four decades of research has clearly demonstrated social isolation and loneliness are both associated with adverse health outcomes,” says lead author Dr. Crystal Wiley Cené, a professor of clinical medicine and chief administrative officer for health equity, diversity and inclusion at the school, in a statement. “Given the prevalence of social disconnectedness across the U.S., the public health impact is quite significant.”

Risk increases with age due to life factors, such as widowhood and retirement. But the problem is increasingly affecting young people. The study finds social isolation and and loneliness increase the risk of death from heart disease or stroke by 29 and 32 percent, respectively.

People with heart disease who were socially isolated had a two to threefold increase in death during a six-year follow-up study. Socially isolated adults with three or fewer social contacts a month were up to 40 percent more likely to suffer recurrent strokes or heart attacks. In addition, five year heart failure survival rates were 60 and 62 percent lower for those who were socially isolated or both socially isolated and clinically depressed, respectively.

Isolation and loneliness are associated with elevated inflammatory markers, increasing symptoms of chronic stress. It becomes a vicious circle. Depression may lead to social isolation, and social isolation may increase the likelihood of experiencing depression. Social isolation during childhood can even lead to cardiovascular disease in adulthood, increasing the risk of obesity, high blood pressure and raised blood glucose levels.

Mushrooms of the Far East hold promise for the anti-cancer therapy

Far Eastern Federal University (Russia) & University of Lausanne (France), August 3, 2022

Mushrooms from the Far East area contain the natural chemical compounds, which could be used for the design of the novel drugs with highly specific anti-tumor activities and low-toxicity. These compounds may offer new avenues for oncology, providing us with either stand-alone alternatives to chemotherapy, chemopreventive medicines, or drugs to be used in combination with other therapies.

The international team of scientists from the Far Eastern Federal University (FEFU), University of Lausanne, and Federal Scientific Center of the East Asia Terrestrial Biodiversity FEB RAS describes the available body of research on four fungi species with high anti-cancer potential. The article is published in Oncotarget and contains the list of tumors, which were reported to be promising targets of the fungal compounds. Among them sarcoma, leukemia, rectum and colon cancer, stomach cancer, liver cancer, colon carcinoma and others.

For the purpose of the current study scientists chose mushrooms widely used in Asian and Far Eastern folk medicine: Fomitopsis pinicola (conk), Hericium erinaceus (Lion’s mane), Inonotus obliquus (Chaga), and Trametes versicolor (polypore). Each is also indigenous to North America. These species of fungi were shown to selectively target certain malignant tumors. The desired effect is achieved thanks to the various bioactive compounds contained in the mushrooms: polyphenols, polysaccharides, glucans, terpenoids, steroids, cerebrosides, and proteins. These substances are not only capable to hit different critical targets within cancer cells levels but also in certain cases to synergistically boost the chemo. Scientists emphasize that four species of fungi were chosen due to the fact that their medicinal properties are relatively well described. Some of them are already actively used for the anti-cancer drugs manufacturing in certain countires. Undoubtedly, there are many other species of fungi that contain chemical compounds to defeat cancer cells.

The scientists hope that the high potential of the fungi for the anti-cancer therapy showcased in their article will encourage the further research at the junction of oncology and mycology. Currently in the laboratories of the School of Biomedicine (FEFU) led by Vladimir Katanaev and Alexander Kagansky,the new experiments are conducted to reveal the anti-cancer activities of the mushrooms extracts. This work is aimed at creating the new generation of highly specific low-toxic drugs, which could be specifically targeted on different tumor types.

The Gary Null Show - 08.10.22

The Gary Null Show - 08.10.22

August 10, 2022


1. The Anti-Smartphone Revolution – (13:23) ColdFusion

2. Gravitas Plus: Explained: The China-Taiwan conflict (9:11)



Astonishing effects of grapes, remarkable potential for health benefits
Frequent nut consumption associated with less inflammation
Body posture affects how oral drugs absorbed by stomach [why not supplements too?] 
Lifting Weights Beats Out Cycling, Swimming For Vegans Wanting Stronger Bones
Perfectionism Linked To Burnout At Work, School And Sports, Research Finds 
Mindfulness Therapy Better Than Antidepressants

Astonishing effects of grapes, remarkable potential for health benefits

Western New England University, August 8, 2022

Recent studies released by Dr. John Pezzuto and his team from Western New England University show “astonishing” effects of grape consumption and “remarkable” impacts on health and on lifespans.

Published in the journal Foods, one study showed that adding grapes in an amount equal to just under two cups of grapes per day to a high-fat diet, typically consumed in western countries, yielded reductions in fatty liver and extended lifespans.  Noting that these studies add an entirely new dimension to the old saying ‘you are what you eat,’ Pezzuto, who has authored over 600 scientific studies, said that the work with grapes showed actual changes in genetic expression. “That is truly remarkable.”

Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death.  Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human.

Another study by Dr. Pezzuto and his team published in the journal Antioxidants, reported that grape consumption altered gene expression in the brain and had positive effects on behavior and cognition that were impaired by a high-fat diet. 

Frequent nut consumption associated with less inflammation

Brigham and Women’s Hospital, August 1, 2022

In a study of more than 5,000 people, investigators from Brigham and Women’s Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the health benefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition.

“Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH’s Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.”

In the current study, the research team performed a cross-sectional analysis of data from the Nurses’ Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2).

After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6.

Peanuts and tree nuts contain a number of healthful components including magnesium, fiber, L-arginine, antioxidants and unsaturated fatty acids such as α-linolenic acid. 

Body posture affects how oral drugs absorbed by stomach [why not supplements too?] 

Johns Hopkins School of Medicine, August 8, 2022

A common, economic, and easy method of administering drugs is orally, by swallowing a pill or capsule. But oral administration is the most complex way for the human body to absorb an active pharmaceutical ingredient, because the bioavailability of the drug in the gastrointestinal tract depends on the medication’s ingredients and the stomach’s dynamic physiological environment.

In Physics of Fluids, researchers from Johns Hopkins School of Medicine employ a biomimetic in-silico simulator based on the realistic anatomy and morphology of the stomach—a “StomachSim”—to investigate and quantify the effect of body posture and stomach motility on drug bioavailability.

“”When the pill reaches the stomach, the motion of the stomach walls and the flow of contents inside determine the rate at which it dissolves. The properties of the pill and the stomach contents also play a major role.

Stomach contents, motility, and gastric fluid dynamics all play a role in a drug’s bioavailability, and stomach contractions can induce pressure and generate complex pill trajectories. This results in varying rates of pill dissolution and nonuniform emptying of the drug into the duodenum and, sometimes, gastric dumping in the case of modified-release dosage.

The modeling appears to be the first of its kind to couple gastric biomechanics of posture with pill movement and drug dissolution to quantify an active pharmaceutical ingredientpassing through the pylorus into the duodenum. The model enabled the researchers to calculate and compare the emptying rate and the release of a dissolved active pharmaceutical ingredient into the duodenum for a variety of physiological situations.

Lifting Weights Beats Out Cycling, Swimming For Vegans Wanting Stronger Bones

Medical University of Vienna (Austria), August 2, 2022

When it comes to bone health, a new study finds people on a plant-based diet should grab the dumbbells. Researchers in Austria have found that lifting weights is the best form of exercise for vegans – trumping cycling and swimming.

The team found that vegans who do resistance training once a week – such as machine-work, free weights, or bodyweight resistance – have stronger bones than plant-based eaters who do other forms of exercise.

The new study, published in the Journal of Clinical Endocrinology & Metabolism, found vegans who did resistance training had similar bone structure to omnivores — people who eat both meat and vegetables.

For at least five years, authors followed 43 men and women on a plant-based diet and 45 men and women who eat meat as well.

“Our study showed resistance training offsets diminished bone structure in vegan people when compared to omnivores.”

Perfectionism linked to burnout at work, school and sports, research finds 

York St. John University (UK), July 31, 2022

Concerns about perfectionism can sabotage success at work, school or on the playing field, leading to stress, burnout and potential health problems, according to new research published by the Society for Personality and Social Psychology. 

In the first meta-analysis of the relationship between perfectionism and burnout, researchers analyzed the findings from 43 previous studies conducted over the past 20 years. It turns out perfectionism isn’t all bad. One aspect of perfectionism called “perfectionistic strivings” involves the setting of high personal standards and working toward those goals in a pro-active manner. These efforts may help maintain a sense of accomplishment and delay the debilitating effects of burnout, the study found. 

The dark side of perfectionism, called “perfectionistic concerns,” can be more detrimental when people constantly worry about making mistakes, letting others down, or not measuring up to their own impossibly high standards, said lead researcher Andrew Hill, an associate professor of sport psychology at York St. John University in England. Previous research has shown that perfectionistic concerns and the stress they generate can contribute to serious healthproblems, including depression, anxiety, eating disorders, fatigue and even early mortality. The study was published online in the Personality and Social Psychology Review.

The study found that perfectionistic concerns had the strongest negative effects in contributing to burnout in the workplace, possibly because people have more social support and clearly defined objectives in education and sports. A student can be rewarded for hard work with a high grade, or a tennis player can win the big match, but a stellar performance in the workplace may not be recognized or rewarded, which may contribute to cynicism and burnout. 

“People need to learn to challenge the irrational beliefs that underlie perfectionistic concerns by setting realistic goals, accepting failure as a learning opportunity, and forgiving themselves when they fail,” Hill said. “Creating environments where creativity, effort and perseverance are valued also would help.” 

Mindfulness Therapy Better Than Antidepressants

University of Exeter (UK), July 31, 2022 

Antidepressants are big business.  But for the same money, and without the side effects, a little mindfulness can do the same job. 

A new study from the University of Exeter in the UK suggests that mindfulness-based cognitive therapy (MBCT) is just as good as drugs – and maybe even better


MBCT is a structured training program for the mind and body.  It was developed to help people deal with repeated bouts of depression.  It teaches them skills to recognize and respond constructively to the thoughts and feelings associated with relapse.  In other words, it helps patients re-focus their thoughts as a way to avoid falling back into depression.

Prior studies have shown that MBCT reduces the risk of relapse or recurrence of depression by about 34% compared to usual care or placebo.  B

The research published in The Lancet  followed a group of 424 depressed patients for two years. The patients had all suffered three or more previous major depressive episodes.  And they were all taking a maintenance course of antidepressants.

The MBCT group attended eight group therapy sessions in which they learned mindfulness practices and cognitive-behavioral skills, and participated in group discussions.  

After two years, relapse rates were worse in the drug group.  The drug group relapsed at the rate of 47% compared to only 44% for the mindfulness group. 

The researchers concluded that MBCT may be an effective alternative to antidepressants for prevention of depressive relapse with no significant difference in cost. And it may be a good alternative for people who choose not to use drugs.  But they also suggested MBCT was more beneficial than drugs in preventing relapses in patients who were at highest risk of relapse especially those who reported severe childhood abuse.

The Gary Null Show - 08.09.22

The Gary Null Show - 08.09.22

August 9, 2022


The healthcare system is a giant SCAM (that you pay for) – Sorelle Amore Finance

Failure after failure: Private hospitals’ appalling treatment of pregnant mum | 60 Minutes Australia



  • B vitamins can potentially be used to treat advanced non-alcoholic fatty liver disease
  • Decreased acetyl-L-carnitine levels associated with depression
  • Skip the texts: Face-to-face meetings make college students happier
  • Eating more plant protein associated with lower risk of death
  • Heat therapy boosts mitochondrial function in muscles
  • Your soap and toothpaste could be messing with your microbiome


B vitamins can potentially be used to treat advanced non-alcoholic fatty liver disease

Duke University Medical School, August 6, 2022

Scientists at Duke-NUS Medical School have uncovered a mechanism that leads to an advanced form of fatty liver disease—and it turns out that vitamin B12 and folic acid supplements could reverse this process.

These findings could help people with non-alcoholic fatty liver disease, an umbrella term for a range of liver conditions affecting people who drink little to no alcohol, which affects 25% of all adults globally, and four in 10 adults in Singapore. 

Non-alcoholic fatty liver disease involves fat build-up in the liver and is a leading cause of liver transplants worldwide. When the condition progresses to inflammation and scar tissue formation, it is known as non-alcoholic steatohepatitis (NASH). 

Dr. Tripathi, study co-author Dr. Brijesh Singh and their colleagues in Singapore, India, China and the US confirmed the association of homocysteine with NASH progression in preclinical models and humans. They also found that  when homocysteine attached to a protein called syntaxin 17, it blocked the protein from performing its role of transporting and digesting fat (known as autophagy, an essential cellular process by which cells remove malformed proteins or damaged organelles) in fatty acid metabolism, mitochondrial turnover, and inflammation prevention. This induced the development and progression of fatty liver disease to NASH. 

Importantly, the researchers found that supplementing the diet in the preclinical models with vitamin B12 and folic acid increased the levels of syntaxin 17 in the liver and restored its role in autophagy. It also slowed NASH progression and reversed liver inflammation and fibrosis. 


Decreased acetyl-L-carnitine levels associated with depression

Stanford University, July 30 2022.

 An article that in the Proceedings of the National Academy of Sciences reported a link between low levels of acetyl-L-carnitine and a greater risk of depression.

Acting on the findings of animal research conducted by lead author Carla Nasca, PhD, the researchers recruited men and women between the ages of 20 and 70 years who had been admitted to Weill Cornell Medicine or Mount Sinai School of Medicine for treatment of acute depression. Clinical assessments were conducted upon enrollment and blood samples were analyzed for levels of acetyl-L-carnitine.

In comparison with levels measured in blood samples provided by 45 demographically matched healthy men and women, acetyl-L-carnitine blood levels in depressed subjects were substantially lower. Acetyl-L-carnitine levels were lowest among depressed patients who had severe symptoms, a history of treatment resistance, or early onset disease. Having a history of childhood abuse was also associated with low acetyl-L-carnitine levels.

“We’ve identified an important new biomarker of major depression disorder,” Dr Rasgon stated. What’s the appropriate dose, frequency, duration? We need to answer many questions before proceeding with recommendations, yet. 


Skip the texts: Face-to-face meetings make college students happier

University of Hamburg (Germany), August 5, 2022

In a world where everyone spends more and more time with eyes fixed on their phones, new research suggests young people feel happier after socializing with friends in person rather than virtually

The conclusion is an outgrowth of nearly four years spent analyzing how social habits of more than 3,000 college students affected their state of mind.

“The findings of this study suggest that talking to people face to face makes us feel better than texting back and forth, for example,” said James Maddux, senior scholar at the Center for the Advancement of Well-Being in Fairfax, Va., who reviewed the results.

Led by Lara Kroencke, of the University of Hamburg in Germany, the researchers noted that other studies have consistently shown that people tend to feel better after socializing with others.To better explore that question, Kroencke’s team conducted three studies between 2017 and 2020 with students from the University of Texas at Austin.

Researchers chose that age group because of the “intense” socializing that tends to take place during that phase of life. Participants between 18 and 24 years old; 37% were white, 23% were Asian, 23% were Hispanic, nearly 5% were Black, and the rest identified as multiracial.

The result: Students tended to feel best after interacting with others in person or through a mix of in person and virtual, versus entirely by computer or phone. Interacting only virtually was, however, better for well-being than no interaction at all, the team stressed.

They also found that socializing with close friends brought about a greater overall sense of well-being than engaging with either family or someone a person didn’t know so well. And those who tended towards high levels of neuroticism were likely to benefit the most from in-person interactions.


Eating more plant protein associated with lower risk of death

 Massachusetts General Hospital & Harvard Medical School, July 31, 2022

 Eating more protein from plant sources was associated with a lower risk of death and eating more protein from animals was associated with a higher risk of death, especially among adults with at least one unhealthy behavior such as smoking, drinking and being overweight or sedentary, according to an article published online by JAMA Internal Medicine.

Mingyang Song, M.D., Sc.D., of Massachusetts General Hospital and Harvard Medical School, Boston, and coauthors used data from two large U.S. studies that had repeated measures of diet through food questionnaires and up to 32 years of follow-up.  Among 131,342 study participants, 85,013 (64.7 percent) were women and the average age of participants was 49. Median protein intake, measured as a percentage of calories, was 14 percent for animal protein and 4 percent for plant protein.

The authors report:

After adjusting for major lifestyle and dietary risk factors, every 10 percent increment of animal protein from total calories was associated with a 2 percent higher risk of death from all causes and an 8 percent increased risk of death from cardiovascular disease death.

In contrast, eating more plant protein was associated with a 10 percent lower risk of death from all causes for every 3 percent increment of total calories and a 12 percent lower risk of cardiovascular death.

Increased mortality associated with eating more animal protein was more pronounced among study participants who were obese and those who drank alcohol heavily.

The association between eating more plant protein and lower mortality was stronger among study participants who smoked, drank at least 14 grams of alcohol a day, were overweight or obese, were physically inactive or were younger than 65 or older than 80.

Substituting 3 percent of calories from animal protein with plant protein was associated with a lower risk of death from all causes: 34 percent for replacing processed red meat, 12 percent for replacing unprocessed red meat and 19 percent for replacing eggs.


Heat therapy boosts mitochondrial function in muscles

Brigham Young University, August 2, 2022

A new study finds that long-term heat therapy may increase mitochondrial function in the muscles. The discovery could lead to new treatments for people with chronic illness or disease. The study–the first of its kind in humans–is published in the Journal of Applied Physiology.

Mitochondria, the “energy centers” of the cells, are essential for maintaining good health.  Exercise has been shown to create new mitochondria and improve function of existing mitochondria. However, some people with chronic illnesses are not able to exercise long enough–previous research suggests close to two hours daily–to reap the benefits. Rodent studies have suggested that heat exposure may also induce the production of more mitochondria.

Researchers from Brigham Young University in Utah studied 20 adult volunteers who had not participated in regular exercise in the three months prior to the study. The research team applied two hours of shortwave diathermy–a type of heat therapy generated by electrical pulses–to the thigh muscles of one leg of each person every day. The researchers based the six-day trial of heat on the minimum amount of exercise needed to measure changes in muscle, or about two hours each day. They designed the treatment to mimic the effects of muscle heating that occurs during exercise. The therapy sessions increased the temperature of the heated leg by approximately 7 degrees F. Each participant’s other leg served as a control, receiving no heat therapy or temperature change. The researchers looked at mitochondria content in the muscles on the first day of therapy and 24 hours after the last treatment.

Mitochondrial function increased by an average of 28 percent in the heated legs after the heat treatment. The concentration of several mitochondrial proteins also increased in the heated legs, which suggests that “in addition to improving function, [repeated exposure to heat] increased mitochondrial content in human skeletal muscle,” the research team wrote.



Your soap and toothpaste could be messing with your microbiome

University of Chicago, August 2, 2022

Antimicrobial chemicals found in common household products could be wreaking havoc with people’s guts, according to a research paper out this week in the journal Science.

Triclosan is an antibacterial compound used in soaps, detergent and toothpaste, as well as toys and plastics. It was originally only used in hospitals, but it found its way into homes as Americans became more germ-phobic. (However, recent studies have found it no more effective at killing bacteria than plain soap. )

Now, there are growing concerns about the possible negative effects of the chemical on human health and the environment. According to the US Food and Drug Administration (FDA), animal studies have shown that the chemical can act as a hormone disruptor. A study found traces of triclosan in the urine of 75% of the participants – some as young as six. The chemical has also been found in more than half of freshwater streams in the US.

The latest research paper, written by academics from the University of Chicago, focused on the lesser-known effects of triclosan exposure on the bacteria in people’s guts.

Disturbing the human microbiome has been “linked to a wide array of diseases and metabolic disorders, including obesity, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and behavioral and metabolic disorders,” wrote the paper’s authors, Alyson L Yee and Jack A Gilbert.

To test the chemical’s effect in humans, researchers from Stanford and Cornell universities gave seven volunteers triclosan-containing products, such as toothpaste and liquid soap, to use for four months. After that period, the same volunteers were switched to products without triclosan. The volunteers were compared with a second group who first used the non-triclosan products, then changed to those containing triclosan.

The results showed that more triclosan was found in the urine of all the participants during the periods when they were using triclosan-containing products.

Yee and Gilbert also suggested that exposure to triclosan could be even more detrimental to the health of developing fetuses and newborns than to adults. A 2014 New York University study found that gut disruptions in early infancy could have lasting negative effects on immune and brain development.

The Gary Null Show - 08.08.22

The Gary Null Show - 08.08.22

August 8, 2022



  • Cocoa flavanols may be able to reduce blood pressure
  • Cool room temperature inhibited cancer growth in mice
  • Smells experienced in nature evoke positive wellbeing
  • Healthy lifestyle may buffer against stress-related cell aging, study says
  • Zinc plus antioxidants: A cost-effective solution to macular degeneration?
  • Passive exercise offers same brain health benefits as active movements, study finds

Cocoa flavanols may be able to reduce blood pressure

University of Surrey (UK), July 23, 2022

A recent study found that cocoa flavanols can effectively lower blood pressure in people with ideal blood pressure, but not when it was already low, as well as reduce arterial stiffness. 

Researchers of the current study note that previous controlled clinical intervention studies have demonstrated the blood pressure-decreasing and arterial stiffness-reducing effects of cocoa flavanols (CF) in healthy humans.

However, as these studies were in tightly controlled settings, the researchers wanted to see how well this intervention played out in real-life scenarios. The researchers used an n-of-1 study design, where a small number of participants were exposed to the same intervention or the placebo multiple times. They then compared the results for each individual as well as between individuals. 

The study included eleven healthy adults who received alternating doses of cocoa flavanol capsules and placebo capsules for eight days. 

The results showed that cocoa flavanols were effective in lowering blood pressure and reducing arterial stiffness. 

One concern about using cocoa flavanols to lower blood pressure is the risk of the blood pressure dropping too low. However, in this study, researchers found that the cocoa had less impact when blood pressure was lower, indicating it was a potentially safe intervention. 

Prof. Christian Heiss, study author and professor of cardiovascular medicine, explained to MNT:  “The study confirms that cocoa flavanols can lower blood pressure and improve arterial stiffness. The new thing is that it does so in the normal life of healthy people and only lowers it if it is ‘high’ even in the ‘normal range.”

Cool room temperature inhibited cancer growth in mice

Karolinska Institutet, August 5, 2022

Turning down the thermostat seems to make it harder for cancer cells to grow, according to a study in mice by researchers at Karolinska Institutet in Sweden. The study, published in the journal Nature, found that chilly temperatures activate heat-producing brown fat that consumes the sugars the tumors need to thrive. Similar metabolic mechanisms were found in a cancer patient exposed to a lowered room temperature.

"We found that cold-activated brown adipose tissue competes against tumors for glucose and can help inhibit tumor growth in mice," says Professor Yihai Cao at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, and corresponding author. "Our findings suggest that cold exposure could be a promising novel approach to cancer therapy, although this needs to be validated in larger clinical studies."

The study compared tumor growth and survival rates in mice with various types of cancer, including colorectal, breast and pancreatic cancers, when exposed to cold versus warm living conditions. Mice acclimatized to temperatures of 4 degrees Celsius had significantly slower tumor growth and lived nearly twice as long compared with mice in rooms of 30 degrees Celsius.

They found that cold temperatures triggered significant glucose uptake in brown adipose tissue, also known as brown fat, a type of fat that is responsible for keep the body warm during cold conditions. At the same time, the glucose signals were barely detectable in the tumor cells.

When the researchers removed either the brown fat or a protein crucial for its metabolism called UCP1, the beneficial effect of the cold exposure was essentially wiped out and the tumors grew at a pace on par with those that were exposed to higher temperatures. Similarly, feeding tumor-bearing mice with a high sugar drink also obliterated the effect of cold temperatures and restored tumor growth.

"Interestingly, high sugar drinks seem to cancel out the effect of cold temperatureson cancer cells, suggesting that limiting glucose supply is probably one of the most important methods for tumor suppression," Yihai Cao says.


Smells experienced in nature evoke positive wellbeing

University of Kent (UK), August 5, 2022

Smells experienced in nature can make us feel relaxed, joyful, and healthy, according to new research led by the University of Kent's Durrell Institute of Conservation and Ecology (DICE).

Smells were found to play an important role in delivering well-being benefits from interacting with nature, often with a strong link to people's personal memories, and specific ecological characteristics and processes (e.g. fallen leaves rotting in the winter).

Researchers found that smells affected multiple types of human well-being, with physical well-being noted most frequently, particularly in relation to relaxation, comfort and rejuvenation. Absence of smell was also perceived to improve physical well-being, providing a cleansing environment due to the removal of pollution and unwanted smells associated with urban areas, and therefore enabling relaxation. Relaxation reduces stress and lowers cortisol levels, which is often linked to a multitude of diseases, and so these findings could be particularly significant to public health professionals.

The research, carried out in woodland settings across four seasons, also found that smells evoked memories related to childhood activities. Many participants created meaningful connections with particular smells, rather than the woodland itself, and associated this with a memorable event. This, in turn, appeared to influence well-being by provoking emotional reactions to the memory.


Healthy lifestyle may buffer against stress-related cell aging, study says

University of California at San Francisco  July 29, 2022


A new study from UC San Francisco is the first to show that while the impact of life's stressors accumulate overtime and accelerate cellular aging, these negative effects may be reduced by maintaining a healthy diet, exercising and sleeping well. 


"The study participants who exercised, slept well and ate well had less telomere shortening than the ones who didn't maintain healthy lifestyles, even when they had similar levels of stress," said lead author Eli Puterman, PhD, assistant professor in the department of psychiatry at UCSF. "It's very important that we promote healthy living, especially under circumstances of typical experiences of life stressors like death, caregiving and job loss."


In the study, researchers examined three healthy behaviors –physical activity, dietary intake and sleep quality – over the course of one year in 239 post-menopausal, non-smoking women. In women who engaged in lower levels of healthy behaviors, there was a significantly greater decline in telomere length in their immune cells for every major life stressor that occurred during the year. Yet women who maintained active lifestyles, healthy diets, and good quality sleep appeared protected when exposed to stress – accumulated life stressors did not appear to lead to greater shortening. 


"This is the first study that supports the idea, at least observationally, that stressful events can accelerate immune cell aging in adults, even in the short period of one year. Exciting, though, is that these results further suggest that keeping active, and eating and sleeping well during periods of high stress are particularly important to attenuate the accelerated aging of our immune cells," said Puterman. 

Zinc plus antioxidants: A cost-effective solution to macular degeneration?

University of Washington and University College London, July 30, 2022

A formula supplement containing anti-oxidants plus zinc appears to be cost-effective in slowing the progression of the ‘wet’ form of the most common degenerative eye disease, finds a new study in British Journal of Ophthalmology.

The cost savings and effectiveness of the supplement in advanced (category 4) cases of neovascular (wet-form) Age Related Macular Degeneration (nAMD) are such that their use should be considered in public health policy, recommend the multi-centre study team on behalf of the UK Electronic Medical Record (EMR) AMD Research Team.  Category 4 individuals who already had nAMD in one eye, showed a cost saving of nearly €3250 (£3000) per patient over the lifetime of treatment, compared to those not given supplements. The Age Related Eye Disease Study (AREDS) formula supplements also increased quality-adjusted life years (QALYs) by 0.16.

“AREDS supplements are a dominant cost-effective intervention for category 4 AREDS patients, as they are both less expensive than standard care and more effective, and therefore should be considered for public funding,” wrote lead researcher Dr. Adnan Tufail.

The study examined the use of AREDS formulation 1 and formulation 2 supplements.  AREDS 1 contained 80milligrams (mg) zinc, 2 mg copper, 500 mg vitamin C, 15 mg beta-carotene, 400 IU vitamin E.

AREDS 2 reduced the amount of zinc to 25 mg, excluded beta-carotene (due to potential higher cancer risk in smokers), and added 10 mg lutein, 2 mg zeaxanthin, 1000 mg omega-3 fatty acids (650 mg docosahexaenoic acid and 350 mg eicosapentaenoic acid).

These findings are consistent with previous research demonstrating the effectiveness of AREDS supplementss. Consequently, the researchers advocate the use of supplements to reduce the necessity for ranibizumab injections, which is the standard NHS treatment for AMD.


Passive exercise offers same brain health benefits as active movements, study finds

University of Western Ontario, August 4, 2022

A new study by kinesiology graduate students from Western has found passive exercise leads to increased cerebral blood flow and improved executive function, providing the same cognitive benefits as active exercise.

Published in Psychophysiology, the study is the first to look at whether there would be benefits to brain health during passive exercise where a person's limbs are moved via an external force—in this case, cycle pedals pushed by a mechanically driven flywheel. 

During a 20-minute session with healthy young adults, the team found an improvement in executive function of the same magnitude for both the passive and the active exercise conditions, without an increase in heart rate or diastolic blood pressure

Executive function is a higher-order cognitive ability that allows people to make plans and supports the activities of daily living. People who have mild cognitive impairments, such as people experiencing symptoms of early-stage Alzheimer's, can find their executive function negatively affected. 

Previous research has documented that active exercise, where a person activates their muscles of their own volition, can increase blood flow to the brain and improve executive function. Passive exercise also increases blood flow to the brain, but this is significantly less documented.  

During passive exercise, a person's limbs move and their muscle receptors are being stretched. That information is sent to the brain, indicating that more blood is needed in the moving areas of the body and in connected regions of the brain. This increase in cerebral blood flow, while significantly less than with active exercise, produced executive function improvements of a similar magnitude—an exciting result for the researchers. 

"The potential impact for people with limited or no mobility could be profound. If done regularly, the increase in blood flow to the brain and resultant improvement in executive function will, optimistically, become a compounding effect that has a significant impact on cognitive health and executive function," Heath explained. 

The Gary Null Show - 08.05.22

The Gary Null Show - 08.05.22

August 5, 2022



  • Hyaluranic acid, a naturally occurring compound, awakens stem cells to repair damaged muscle
  • 'A banana a day': Starch supplement may reduce the risk of some hereditary cancers
  • Running reduces risk of death regardless of duration, speed
  • Eating processed foods is hurting your brain, study says: Even '2 cookies' can affect health
  • Sharing memories with toddlers helps their well-being into adulthood
  • What the Amish can teach us about health and happiness


Hyaluranic acid, a naturally occurring compound, awakens stem cells to repair damaged muscle

University of Ottawa (Ontario), August 4 2022

A new study published in the journal Science reveals a unique form of cell communication that controls muscle repair. In damaged muscle, stem cells must work together with immune cells to complete the repair process, yet how these cells coordinate to ensure the efficient removal of dead tissue before making new muscle fibers has remained unknown. The scientists have now shown that a natural substance called hyaluronic acid, which is used in cosmetics and injections for osteoarthritis, is the key molecule that manages this fundamental interaction.

"When muscles get damaged, it is important for immune cells to quickly enter the tissue and remove the damage before stem cellsbegin repair," said Dr. Jeffrey Dilworth, senior scientist at the University of Ottawa and senior author on the study. "Our study shows that muscle stem cells are primed to start repair right away, but the immune cells maintain the stem cells in a resting state while they finish the cleanup job. After about 40 hours, once the cleanup job is finished, an internal alarm goes off in the muscle stem cells that allows them to wake up and start repair."

Dr. Dilworth and his team identified hyaluronic acid as the key ingredient in this internal alarm clock that tells muscle stem cells when to wake up. When muscle damage occurs, stem cells start producing and coating themselves with hyaluronic acid. Once the coating gets thick enough, it blocks the sleep signal from the immune cells and causes the muscle stem cells to wake up.

"Interestingly, aging is associated with chronic inflammation, muscle weakness and a reduced ability of muscle stem cells to wake up and repair damage,. "If we could find a way to enhance hyaluronic acid production in the muscle stem cells of older people it might help with muscle repair."

'A banana a day': Starch supplement may reduce the risk of some hereditary cancers

Universities of Newcastle and Leeds (UK), August 4, 2022

Resistant starches (RS) are carbohydrates that pass undigested through the small intestine and are digested, or fermented, in the large intestine. They are present in plant-based foods including beans, oats, breakfast cereals, rice, cooked and cooled pasta, peas, and slightly unripe bananas. RS forms part of dietary fiber, which is known to reduce the risk of colorectal cancer and many other non-communicable diseases.

Researchers at Newcastle University and the University of Leeds in the United Kingdom found that a RS powder supplement may help prevent cancer in people with Lynch syndrome.

Lynch syndrome, an inherited condition, predisposes people to colon cancer, gastric cancer, and several other cancers.

The experts ran a multinational trial involving almost 1,000 people with Lynch syndrome. They gave the participants a 30g dose of RS for an average of two years.

The supplementation did not affect colorectal cancers as expected. However, unexpectedly, its protective potential was most apparent in the upper digestive tract, where cancers are aggressive and not usually caught early.The  trial analyzed the long-term effects of aspirin and RS on cancer onset in patients with Lynch syndrome.

The dose used was equivalent to eating one slightly unripe banana daily. Bananas at this stage resist breakdown in the small intestine, reaching the large intestine and feeding the microbiome there.

They found no difference in the number of colorectal cancer cases. However, fewer participants receiving the supplement developed non-colorectal LS cancers compared to those taking the placebo.


Running reduces risk of death regardless of duration, speed

Iowa State University,  July 29, 2022


Running 5 minutes daily can reduce risk of cardiovascular disease-related death


Running for only a few minutes a day or at slow speeds may significantly reduce a person's risk of death from cardiovascular disease compared to someone who does not run, according to a study published in the Journal of the American College of Cardiology


Researchers studied 55,137 adults between the ages of 18 and 100 over a 15-year period to determine whether there is a relationship between running and longevity. In the study period, 3,413 participants died, including 1,217 whose deaths were related to cardiovascular disease. In this population, 24 percent of the participants reported running as part of their leisure-time exercise. 


Compared with non-runners, the runners had a 30 percent lower risk of death from all causes and a 45 percent lower risk of death from heart disease or stroke. Runners on average lived three years longer compared to non-runners. Also, to reduce mortality risk at a population level from a public health perspective, the authors concluded that promoting running is as important as preventing smoking, obesity or hypertension. The benefits were the same no matter how long, far, frequently or fast participants reported running. Benefits were also the same regardless of sex, age, body mass index, health conditions, smoking status or alcohol use.


The study showed that participants who ran less than 51 minutes, fewer than 6 miles, slower than 6 miles per hour, or only one to two times per week had a lower risk of dying compared to those who did not run. Runners who ran less than an hour per week have the same mortality benefits compared to runners who ran more than three hours per week. Thus, it is possible that the more may not be the better in relation to running and longevity. 



Eating processed foods is hurting your brain, study says: Even '2 cookies' can affect health

Yale University, August 3, 2022

Although it's obvious that a diet of hot dogs and ice cream won't lead to a healthy physical life, new research illuminates how ultra-processed foods can also cause a significant decrease in brain function.

Research presented at the Alzheimer's Association International Conference in San Diego outlined how foods such as instant noodles, sugary drinks and frozen meals all play a factor in a faster rate of cognitive decline.

"Just 100 calories of processed foods can affect your physical health. So, that's two cookies."

Research has linked ultra-processed food consumption to health problems like obesity, cardiovascular disease, diabetes and cancers.  That's because they cause inflammation, which can affect neurotransmitters in the brain. Processed foods also operate on a micro level with billions and billions of bacteria cells that (impair) functioning."

The findings found that participants who were getting 20% or more of their daily calories from ultra-processed foods saw a far faster decline in cognitive performance over the span of six to 10 years versus people with diets containing few processed foods.


Sharing memories with toddlers helps their well-being into adulthood

University of Otago (New Zealand), August 3 2022

How mothers share memories with their children during toddlerhood impacts mental health and well-being in early adulthood, a University of Otago study has shown.

Researchers found 21-year-olds told more coherent stories about turning points in their lives if their mothers were taught new conversational techniques two decades earlier.

These adults also reported fewer symptoms of depression and greater self-esteem compared to adults in the study whose mothers interacted with them as usual.

The study, published in Journal of Research in Personality, is a long-term follow-up of a reminiscing intervention in which 115 mothers of toddlers were assigned to either a control group or taught to use elaborative reminiscing for a year.

Elaborative reminiscing involves open, enriched, and responsive conversations with children about shared experiences of everyday events. This is the first study to show long-term benefits of mother-child reminiscing for emerging adult development.


What the Amish can teach us about health and happiness

University of Tennessee, July 29, 2022

 Often viewed as outcasts by mainstream society, the Amish may seem downright bizarre to the average American. Foregoing technological advancements that many of us would be lost without, the Amish have created a way of life that fosters a connection with the land and environment, while also cultivating an impressive sense of community. And they are healthy -- exceedingly so. The Amish rarely experience disorders like cancer or cardiovascular disease, seemingly able to bypass illness altogether. What's their secret?


One of the most striking aspects of the Amish is how they lead their lives, free from modern inventions like electricity, telephones, cars and the myriad of gadgets most of us consider so essential for our productivity and happiness.

This high level of daily physical activity helps to keep their obesity rates low and cardiovascular health in top form. 


"The Amish were able to show us just how far we've fallen in the last 150 years or so in terms of the amount of physical activity we typically perform. Their lifestyle indicates that physical activity played a critical role in keeping our ancestors fit and healthy." 

\One of the main contributors to stress is the speed at which we move, think and process. We are bombarded with sensory information at every turn. 


Not so with the Amish. Their communities are based on patience and a slower way of being. Competition is frowned upon, while cooperation and harmony are respected. Social support is strong. Through traditional gender roles, each person has a valued part to play within the community.


The study published in Scientific Research discovered that mental health is enhanced by the structure of Amish society. Martial stability, mutual support, a secure parental base and care for the elderly were found to be contributing factors in cultivating happiness and contentment.


Moreover, the Amish tend to have low vaccination rates. Instead, they rely on clean living and a healthy diet of homegrown, organic produce, raw dairy and nourishing fats to keep immunity strong.

The Gary Null Show - 08.04.22

The Gary Null Show - 08.04.22

August 4, 2022


  1. Neil Oliver – ‘…they’re herding people like sheep…
  1. Large Observational Study On COVID-19 Vaccines Impact of Women’s Menstrual Cycles Post Vaccination – Trial Site News
  1. The Dark Side of Electric Cars – Jhonny Harris 

4.How The US Stole The Philippines – Jhonny Harris 


Cardamonin shows promise for treating aggressive breast cancer

Florida A&M University, August 3, 2022

Cardamonin—a natural compound found in the spice cardamom and other plants—could have therapeutic potential for triple-negative breast cancer, according to a new study using human cancer cells. The findings also show that the compound targets a gene that helps cancer cells elude the immune system

About 10-15% of breast cancers are triple-negative, which means they don’t have receptors for estrogen or progesterone and don’t make excess amounts of a protein called HER2. These tumors are difficult to treat because they don’t respond to the hormone-based therapies used for other types of breast cancer. They also tend to be more aggressive and have a higher mortality rate than other breast cancers.

“The fact that cardamonin has been used for centuries as a spice and, more recently, as a supplement shows that its intake is safe and may bring health benefits,” said Mendonca. “Our research shows that cardamonin holds potential for improving cancer therapy without as many side effects as other chemotherapeutic agents.”

For the new study, the researchers investigated how cardamonin affected the expression of the programmed cell death ligand 1 (PD-L1) gene, which is found in tumor cells. PD-L1 is overexpressed during breast cancer progression and plays a critical role in helping breast cancer cells evade the body’s immune system.

They found that cardamonin treatment caused a dose-dependent decrease in cell viability in both cell lines. It also reduced PD-L1 expression in the Caucasian cell line but not the African American cell line, indicating that cells from different races may respond differently to cardamonin because of genetic variations among races. 

Persistent Low Wages Linked to Faster Memory Decline in Later Life
Columbia University’s Mailman School of Public Health, August 2 2022Sustained low wages are associated with significantly faster memory decline, according to a new study by Columbia University Mailman School of Public Health. While low-wage jobs have been associated with health outcomes such as depressive symptoms, obesity, and hypertension, which are risk factors for cognitive aging, until now no prior studies had examined the specific relationship between low wages during working years and later-life cognitive functioning. The findings are published in the American Journal of Epidemiology.”Our research provides new evidence that sustained exposure to low wages during peak earning years is associated with accelerated memory decline later in life,” said Katrina Kezios, Ph.D., postdoctoral researcher in the Department of Epidemiology at Columbia University Mailman School of Public Health and first author. “This association was observed in our primary sample as well as in a validation cohort.”The researchers found that, compared with workers never earning low wages, sustained low-wage earners experienced significantly faster memory decline in older age. They experienced approximately one excess year of cognitive aging per a 10-year period; in other words, the level of cognitive aging experienced over a 10-year period by sustained low-wage earners would be what those who never earned low wages experienced in 11 years.”Our findings suggest that social policies that enhance the financial well-being of low-wage workers may be especially beneficial for cognitive health,” said senior author Adina Zeki Al Hazzouri, Ph.D., assistant professor of epidemiology at Columbia Mailman School and the Columbia Butler Aging Center. “Future work should rigorously examine the number of dementia cases and excess years of cognitive aging that could be prevented under different hypothetical scenarios that would increase the minimum hourly wage.”Research links red meat intake, gut microbiome, and cardiovascular disease (ASCVD) in older adultsTufts University, August 3, 2022Over the years, scientists have investigated the relationship between heart disease and saturated fat, dietary cholesterol, sodium, nitrites, and even high-temperature cooking, but evidence supporting many of these mechanisms has not been robust. Recent evidence suggests that the underlying culprits may include specialized metabolites created by our gut bacteria when we eat meat. 
A new study led by researchers at the Friedman School of Nutrition Science and Policy at Tufts University and Cleveland Clinic Lerner Research Institute quantifies the risk of ASCVD associated with meat intake and identifies underlying biologic pathways that may help explain this risk. The study of almost 4,000 U.S. men and women over age 65 shows that higher meat consumption is linked to higher risk of ASCVD—22 percent higher risk for about every 1.1 serving per day—and that about 10 percent of this elevated risk is explained by increased levels of three metabolites produced by gut bacteria from nutrients abundant in meat. Higher risk and interlinkages with gut bacterial metabolites were found for red meat but not poultry, eggs, or fish. The study, published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) on August 1, is the first to investigate the interrelationships between animal source foods and risk of ASCVD events, and the mediation of this risk by gut microbiota-generated compounds as well as by traditional ASCVD risk pathways such as blood cholesterolblood pressure, and blood sugar. Highlights In this community-based cohort of older U.S. men and women, higher intakes of unprocessed red meat, total meat (unprocessed red meat plus processed meat), and total animal source foods were prospectively associated with a higher incidence of ASCVD during a median follow-up of 12.5 years. The positive associations with ASCVD were partly mediated (8-11 percent of excess risk) by plasma levels of TMAO, gamma-butyrobetaine, and crotonobetaine. The higher risk of ASCVD associated with meat intake was also partly mediated by levels of blood glucose and insulin and, for processed meats, by systematic inflammation but not by blood pressure or blood cholesterol levels. Intakes of fish, poultry, and eggs were not significantly associated with ASCVD. The 3,931 study subjects were followed for a median of 12.5 years, and their average age at baseline was 73. The study adjusted for established risk factors such as age, sex, race/ethnicity, education, smoking, physical activity, other dietary habits, and many additional risk factors. Diets higher in calcium and potassium may help prevent recurrent symptomatic kidney stones, study findsMayo Clinic, August 2, 2022Kidney stones can cause not only excruciating pain but also are associated with chronic kidney disease, osteoporosis and cardiovascular disease. If you’ve experienced a kidney stone once, you have a 30% chance of having another kidney stone within five years.Changes in diet are often prescribed to prevent recurrent symptomatic kidney stones. However, little research is available regarding dietary changes for those who have one incident of kidney stone formation versus those who have recurrent incidents.Mayo Clinic findings show that enriching diets with foods high in calcium and potassium may prevent recurrent symptomatic kidney stones.The findings, which were published in Mayo Clinic Proceedings, show that lower dietary calcium and potassium, as well as lower intake of fluids, caffeine and phytate, are associated with higher odds of experiencing a first-time symptomatic kidney stone.Of the patients who had first-time stone formation, 73 experienced recurrent stones within a median of 4.1 years of follow-up. Further analysis found that lower levels of dietary calcium and potassium predicted recurrence.Fluid intake of less than 3,400 milliliters per day, or about nine 12-ounce glasses, is associated with first-time stone formation, along with caffeine intake and phytate, the study finds. Daily fluid intake includes intake from foods such as fruits and vegetables.
Low fluid and caffeine intake can result in low urine volume and increased urine concentration, contributing to stone formation. Phytate is an antioxidant compound found in whole grains, nuts and other foods that can lead to increased calcium absorption and urinary calcium excretion.Low dietary calcium and potassium was a more important predictor than fluid intake of recurrent kidney stone formation, says Api Chewcharat, M.D., the article’s first author. The study concludes that diets with daily intake of 1,200 milligrams of calcium may help prevent first-time and recurrent kidney stones.Dr. Chewcharat says the takeaway is that patients should add more fruits and vegetables that are high in calcium and potassium to their diets. Fruits that are high in potassium include bananas, oranges, grapefruits, cantaloupes, honeydew melons and apricots. Vegetables include potatoes, mushrooms, peas, cucumbers and zucchini.Could acupuncture help ward off diabetes?Edith Cowan University, August 2, 2022
A new study from Edith Cowan University has found acupuncture therapy may be a useful tool in avoiding type 2 diabetes.
The research team investigated dozens of studies covering the effects of acupuncture on more than 3600 people with prediabetes, a condition which sees higher-than-normal blood glucose levels without being high enough to be diagnosed as diabetes.The findings showed acupuncture therapy significantly improved key markers, such as fasting plasma glucose, two-hour plasma glucose, and glycated haemoglobin, plus a greater decline in the incidence of prediabetes.There were also no reports of adverse reactions among patients.
Green tea helps support healthy glucose in metabolic syndrome patients Ohio State University, August 1 2022. Findings from a trial reported in the supplement of Current Developments in Nutrition revealed that consuming green tea extract improved glucose levels in adults with metabolic syndrome: a cluster of factors that increase the risk of diabetes and cardiovascular disease. Supplementation with green tea extract was also associated with improvement in intestinal health, including a reduction in leaky gut.  The trial was a follow-up to a study published in 2019 that found protective effects for green tea against inflammation induced by nonalcoholic steatohepatitis (NASH) in mice. In the current crossover trial, 21 individuals with metabolic syndrome and 19 healthy participants received 1 gram of green tea extract or a placebo for 28 days. This period was followed by another treatment period in which participants who previously received the extract were given a placebo and those who received a placebo received the extract. Fasting blood glucose, insulin and lipid levels were measured at the beginning of each treatment period and at days 14 and 28.  
Supplementation with green tea extract was associated with lower fasting glucose and markers of intestinal inflammation in comparison with the placebo. In separately published findings, green tea extract was associated with decreases in small intestinal permeability (leaky gut).  
The Gary Null Show - 08.03.22

The Gary Null Show - 08.03.22

August 3, 2022


How the US Stole Central America (With Bananas) – Johnny Harris



Black cardamom bioactives effective against lung cancer cells
Soybean oil causes more obesity than coconut oil and fructose
Why breast-fed premature infants have healthier guts than formula-fed ones
Even simple exercise may help aging brain, study hintsSmall daily portion of Jarlsberg cheese may help to stave off bone thinning
Body fat can send signals to brain, affecting stress response

Black cardamom bioactives effective against lung cancer cells

National University of Singapore, August 1, 2022

The main challenges associated with existing lung cancer drugs are severe side effects and drug resistance. There is hence a constant need to explore new molecules for improving the survival rate and quality of life of lung cancer patients.

In Indian Ayurvedic medicine, black cardamom has been used in formulations to treat cancer and lung conditions. A team of researchers from the NUS Faculty of Science studied the scientific basis behind this traditional medicinal practice and provided evidence of the cytotoxic effect of black cardamom on lung cancer cells. The research highlighted the spice as a source of potent bioactives, such as cardamonin and alpinetin, which could be used in the treatment or prevention of lung cancer. The study is the first to report the association of black cardamom extract with oxidative stress induction in lung cancer cells, and compare the spice’s effects on lung, breast and liver cancer cells.

The findings could potentially lead to the discovery of safe and effective new bioactives which can prevent or cure cancer formation. The research was first published in the Journal of Ethnopharmacology.

Black cardamom is typically used in Asian households in rice preparations, curries and stews either as a whole spice or in powdered form. The spice is also prescribed in Indian Ayurvedic medicine in powder form where it is used for conditions such as cough, lung congestion, pulmonary tuberculosis, and throat diseases. 

In the NUS study, black cardamom fruits were powdered and sequentially extracted with five types of solvents, including organic solvents and water. This allowed the researchers to evaluate the best solvents to extract the most potent actives in the fruit. The various types of black cardamom extracts were then tested for their cytotoxicity against several types of cancer cells. These included cancer cells from the lung, liver and breast. Among the three types of cells, lung cancer cells were least likely to survive when tested with the black cardamom extracts.

Soybean oil causes more obesity than coconut oil and fructose

University of California at Riverside, July 22, 2022

A diet high in soybean oil causes more obesity and diabetes than a diet high in fructose, a sugar commonly found in soda and processed foods, according to a published paper by scientists at the University of California, Riverside.

The scientists fed male mice a series of four diets that contained 40 percent fat, similar to what Americans currently consume. In one diet the researchers used coconut oil, which consists primarily of saturated fat. In the second diet about half of the coconut oil was replaced with soybean oil, which contains primarily polyunsaturated fats and is a main ingredient in vegetable oil. That diet corresponded with roughly the amount of soybean oil Americans currently consume.

The other two diets had added fructose, comparable to the amount consumed by many Americans. All four diets contained the same number of calories and there was no significant difference in the amount of food eaten by the mice on the diets. Thus, the researchers were able to study the effects of the different oils and fructose in the context of a constant caloric intake.

Compared to mice on the high coconut oil diet, mice on the high soybean oil diet showed increased weight gain, larger fat deposits, a fatty liver with signs of injury, diabetes and insulin resistance, all of which are part of the Metabolic Syndrome. Fructose in the diet had less severe metabolic effects than soybean oil although it did cause more negative effects in the kidney and a marked increase in prolapsed rectums, a symptom of inflammatory bowel disease (IBD), which like obesity is on the rise.

The mice on the soybean oil-enriched diet gained almost 25 percent more weight than the mice on the coconut oil diet and 9 percent more weight than those on the fructose-enriched diet. And the mice on the fructose-enriched diet gained 12 percent more weight than those on a coconut oil rich diet.

Soybean oil now accounts for 60 percent of edible oil consumed in the United States. That increase in soybean oil consumption mirrors the rise in obesity rates in the United States in recent decades.

During the same time, fructose consumption in the United States significantly increased, from about 37 grams per day in 1977 to about 49 grams per day in 2004.

The UC Riverside researchers also did a study with corn oil, which induced more obesity than coconut oil but not quite as much as soybean oil. They are currently doing tests with lard and olive oil. They have not tested canola oil or palm oil.

Why breast-fed premature infants have healthier guts than formula-fed ones

University of Maryland School of Medicine, August 2, 2022

Human breastmilk has long been considered “liquid gold” among clinicians treating premature infants in a newborn intensive care unit (NICU). Breastmilk-fed “preemies” are healthier, on average, than those fed formula. Why is that true, however, has remained a mystery.

New research from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS), found it is not just the content of breastmilkthat makes the difference. It is also the way the babies digest it.

The research, led by Bing Ma, Ph.D., Assistant Professor of Microbiology and Immunology at UMSOM and a researcher at IGS, discovered a strain of the Bifidobacterium breve bacteria or B. breve in the guts of breastfed babies who received higher volumes of breastmilk than their counterparts. Those preemies had better nutrient absorptionbecause they developed an intact intestinal wall one week after birth. B. breve was much less prevalent in both formula-fed babies and breastfed babies with “leaky gut.” Babies with leaky gut do not develop a barrier to protect against bacteria and digested food from getting into the bloodstream. For the first time, the team also found that the way B. breve metabolizes breastmilk keeps breastfed babies healthier and allows them to gain weight by strengthening their underdeveloped intestinal barrier.

An immature or “leaky” gut can lead to necrotizing enterocolitis (NEC), which is the third leading cause of newborn death in United States and worldwide. In fact, NEC impacts up to 10 percent of premature babies with a devastating mortality rate as high as 50 percent.

At the most basic level, the gut microbiome in these breastfed preemies with more B. breve metabolizes carbohydrates differently than it does formula. The researchers say they hypothesize that this process of metabolism then strengthens and matures the intestinal barrier faster, protecting fragile newborns from disease.

Even simple exercise may help aging brain, study hints

Wake Forest School of Medicine, August 1, 2022

New research hints that even a simple exercise routine just might help older Americans with mild memory problems.

Researchers recruited about 300 sedentary older adults with hard-to-spot memory changes called mild cognitive impairment or MCI—a condition that’s sometimes, but not always, a precursor to Alzheimer’s. Half were assigned aerobic exercises and the rest stretching-and-balance moves that only modestly raised their heart rate.

After a year, cognitive testing showed overall neither group had worsened, said lead researcher Laura Baker, a neuroscientist at Wake Forest School of Medicine. Nor did brain scans show the shrinkage that accompanies worsening memory problems, she said.

By comparison, similar MCI patients in another long-term study of brain health—but without exercise—experienced significant cognitive decline over a year.

But the results suggest “this is doable for everybody”—not just seniors healthy enough to work up a hard sweat, said Baker, who presented the data Tuesday at the Alzheimer’s Association International Conference. “Exercise needs to be part of the prevention strategies” for at-risk seniors.

Small daily portion of Jarlsberg cheese may help to stave off bone thinning

Norwegian Research Council, August 2, 2022

A small (57 g) daily portion of Jarlsberg cheese may help to stave off bone thinning (osteopenia/osteoporosis) without boosting harmful low density cholesterol, suggest the results of a small comparative clinical trial, published in the open access journal BMJ Nutrition Prevention & Health.

The effects seem to be specific to this type of cheese, the findings indicate.

Jarlsberg is a mild and semi-soft, nutty-flavored cheese made from cow’s milk, with regular holes. It originates from Jarlsberg in eastern Norway.

Previous research indicates that it may help boost levels of osteocalcin, a hormone that is associated with strong bones and teeth, but it’s not clear if this effect is specific to Jarlsberg or any type of cheese.

In a bid to find out, the researchers studied 66 healthy women (average age 33; average BMI of 24) who were randomly allocated to adding either a daily 57 g portion of Jarlsberg (41) or 50 g of Camembert cheese (25) to their diet for 6 weeks. 

At the end of this period, the group eating Camembert was switched to Jarlsberg for another six weeks. 

Jarlsberg and Camembert have similar fat and protein contents, but unlike Camembert, Jarlsberg is rich in vitamin K2, also known as menaquinone (MK), of which there are several varieties.

Every six weeks blood samples were taken from all the participants to check for key proteins, osteocalcin, and a peptide (PINP) involved in bone turnover. Vitamin K2 and blood fat levels were also measured.

Blood sample analysis showed that the key biochemical markers of bone turnover, including osteocalcin, and vitamin K2 increased significantly after 6 weeks in the Jarlsberg group. 

Glycated hemoglobin (HbA1c)—-the amount of glucose stuck in red blood cells—fell significantly (by 3%) in the Jarlsberg group, while it rose sharply (by 2%) in those eating Camembert. But after switching to Jarlsberg HbA1c fell significantly in this group too.

Calcium and magnesium fell significantly in the Jarlsberg group but remained unchanged in the Camembert group. After switching cheese, calcium levels dropped in this group too, possibly reflecting increased uptake of these key minerals in bone formation, say the researchers. 

“Daily Jarlsberg cheese consumption has a positive effect on osteocalcin, other [markers of bone turnover], glycated hemoglobin and lipids,” write the researchers, concluding that the effects are specific to this cheese.

Body fat can send signals to brain, affecting stress response

University of Florida, July 23, 2022

The brain’s effect on other parts of the body has been well established. Now, a group that includes two University of Florida researchers has found that it’s a two-way street: Body fat can send a signal that affects the way the brain deals with stress and metabolism.

While the exact nature of those signals remains a mystery, researchers say simply knowing such a pathway exists and learning more about it could help break a vicious cycle: Stress causes a desire to eat more, which can lead to obesity. And too much extra fat can impair the body’s ability to send a signal to the brain to shut off the stress response.

The findings are important and unique because they show that it’s not simply the brain that drives the way the body responds to stress, said James Herman, Ph.D., a co-author of the paper and a professor in the department of psychiatry and behavioral neuroscience at the University of Cincinnati,.

“It moved our understanding of stress control to include other parts of the body. Before this, everyone thought that the regulation of stress was mainly due to the brain. It’s not just in the brain. This study suggests that stress regulation occurs on a much larger scale, including body systems controlling metabolism, such as fat,” Herman said.

Researchers found that a glucocorticoid receptor in fat tissue can affect the way the brain controls stress and metabolism. Initially, such signals from the receptor can be lifesavers, directing the brain to regulate its energy balance and influencing stress responses in a beneficial way.

The Gary Null Show - 08.02.22

The Gary Null Show - 08.02.22

August 2, 2022

Videos: All Found on Youtube

  1. TikTok Is Worse Than You Thought
  2. Joe Reviews TikTok’s Crazy Terms of Service



Lutein may counter cognitive aging, study finds
A stable gut helps elite athletes perform better
Could Spirulina modify the microbiome to protect against age-related damage?
It doesn’t matter much which fiber you choose—just get more fiber
Plant-based meat ‘healthier and more sustainable than animal products,’ according to new study
Pine Bark Extract Treats Meniere’s Disease

Lutein may counter cognitive aging, study finds

University of Illinois, July 25, 2022

Spinach and kale are favorites of those looking to stay physically fit, but they also could keep consumers cognitively fit, according to a new study from University of Illinois researchers.

The study, which included 60 adults aged 25 to 45, found that middle-aged participants with higher levels of lutein – a nutrient found in green leafy vegetables such as spinach and kale, as well as avocados and eggs — had neural responses that were more on par with younger individuals than with their peers. The findings were published in the journal Frontiers in Aging Neuroscience.

“Now there’s an additional reason to eat nutrient-rich foods such as green leafy vegetables, eggs and avocados,” said Naiman Khan, a professor of kinesiology and community health at Illinois. “We know these foods are related to other healthbenefits, but these data indicate that there may be cognitive benefits as well.”

Lutein is a nutrient that the body can’t make on its own, so it must be acquired through diet. Lutein accumulates in brain tissues, but also accumulates in the eye, which allows researchers to measure levels without relying on invasive techniques.

The Illinois researchers measured lutein in the study participants’ eyes by having participants look into a scope and respond to a flickering light. Then, using electrodes on the scalp, the researchers measured neural activity in the brain while the participants performed a task that tested attention.

“The neuro-electrical signature of older participants with higher levels of lutein looked much more like their younger counterparts than their peers with less lutein,” Walk said. “Lutein appears to have some protective role, since the data suggest that those with more lutein were able to engage more cognitive resources to complete the task.”

Next, Khan’s group is running intervention trials, aiming to understand how increased dietary consumption of lutein may increase lutein in the eye, and how closely the levels relate to changes in cognitive performance.

A stable gut helps elite athletes perform better

Anglia Ruskin University, July 29, 2022

New research has found that microbial instability in the gut could hinder the performance of elite endurance athletes, and that short-term, high-protein diets are associated with this type of imbalance.

Researchers from across the UK analyzed the performance and gut health of a group of well-matched, highly trained endurance runners, to explore the impact of both high-protein and high-carbohydrate diets.

The study found that in those following a high-protein regime, this resulted in a disturbance in the stability of the gut microbiome. This was also accompanied by a 23.3% reduction in time trial performance.

Analysis found a significantly reduced diversity and altered composition of the gut phageome, as well as higher levels of certain types of virals and bacterial compartments. Those participants whose gut microbiome was more stable performed better during time trials.

Those following a high-carbohydrate diet resulted in an improved time trial performance of 6.5%.

Could Spirulina modify the microbiome to protect against age-related damage?

Louvain Drug Research Institute (Belgium), July 28, 2022

Spirulina might help protect against age-related liver inflammation by modifying pathways in the microbiome, say researchers.

Consumption of spirulina could help protect against hepatic inflammation in the elderly, according to the new animal research published in Nutrients.

Belgian researchers carried out tests on mice, which suggest that the algae Spirulina has an impact on the gut microbiota, which in turn activates the immune system in the gut and improves inflammation in the liver that is associated with ageing.

Led by senior author Professor Nathalie Delzenne from the Louvain Drug Research Institute in Belgium, the team said oral feeding of Spirulina was found to modulates several immunological functions involving, among others, the TLR4 pathway in old mice.

“The fact that its oral consumption can influence both gut immunity and systemic sites, such as the liver, suggests that its immune action is not confined to the gut immune system,” wrote the team – who said the findings open the way to new therapeutic tools “in the management of immune alterations in aging, based on gut microbe-host interactions.”

Furthermore, they suggested that improvement of the homeostasis in the gut ecosystem ‘could be essential’ during the aging process, “and, in this perspective, dietary manipulation of the gut microbiota of the elderly with Spirulina, may represent a tool for preserving a healthy gastrointestinal microbial community in addition to its beneficial effects on immune function.”

It doesn’t matter much which fiber you choose—just get more fiber

Duke University, July 30, 2022

That huge array of dietary fiber supplements in the drugstore or grocery aisle can be overwhelming to a consumer. They make all sorts of health claims too, not being subject to FDA review and approval. So how do you know which supplement works and would be best for you?

A rigorous examination of the gut microbes of study participants who were fed three different kinds of supplements in different sequences concludes that people who had been eating the least amount of fiber before the study showed the greatest benefit from supplements, regardless of which ones they consumed.

“The people who responded the best had been eating the least fiber to start with,” said study leader Lawrence David, an associate professor of molecular genetics and microbiology at Duke University.

When your gut bugs are happily munching on a high-fiber diet, they produce more of the short-chain fatty acids that protect you from diseases of the gut, colorectal cancers and even obesity. And in particular, they produce more of a fatty acid called butyrate, which is fuel for your intestinal cells themselves. Butyrate has been shown to improve the gut’s resistance to pathogens, lower inflammation and create happier, healthier cells lining the host’s intestines.

“We didn’t see a lot of difference between the fiber supplements we tested. Rather, they looked interchangeable,” David said during a tour of his sparkling new lab in the MSRB III building

Plant-based meat ‘healthier and more sustainable than animal products,’ according to new study

University of Bath (UK), July 30, 2022

Plant-based dietary alternatives to animal products are better for the environment and for human health when compared with the animal products they are designed to replace, say the authors of a new study.

A new paper published in Future Foods argues that because these foods are “specifically formulated to replicate the taste, texture, and overall eating experience of animal products,” they are a much more effective way of reducing demand for meat and dairy than simply encouraging people to cook vegetarian whole foods.

The study, conducted by psychologists at the University of Bath, concludes that plant-based meat and dairy alternatives “offer a healthier and more environmentally sustainable solution which takes into account consumer preferences and behavior.”

The review examined 43 studies into the health and environmental impacts of plant-based foods, as well as consumer attitudes. One study found that almost 90% of consumers who ate plant-based meat and dairy were in fact meat-eaters or flexitarians; another found that plant-based products with a similar taste, texture, and price to processed meat had the best chance of replacing meat.

The paper also found that these plant-based products caused lower levels of greenhouse gas emissions than the animal products they were replacing. One paper found replacing 5% of German beef consumption with pea protein could reduce CO2emissions by up to eight million tons a year. Another found that compared to beef burgers, plant-based burgers were associated with up to 98% less greenhouse gas emissions.

Studies focusing on the healthiness of plant-based products also found they tend to have better nutritional profiles compared to animal products, with one paper finding that 40% of conventional meat products were classified as ‘less healthy’ compared to just 14% of plant-based alternatives based on the UK’s Nutrient Profiling Model.

Others found plant-based meat and dairy were good for weight loss and building muscle mass, and could be used to help people with specific health conditions. Food producers may be able to add ingredients such as edible fungi, microalgae or spirulina to plant-based foods, boosting properties such as amino acids, vitamins B and E and antioxidants. Future innovations in processing and ingredients are likely to lead to further nutritional improvements.

Pine Bark Extract Treats Meniere’s Disease

University of Chieti-Pescara (Italy), July 17, 2022 

Research from Italy’s University of Chieti-Pescara has found that a patented pine bark extract significantly treats Meniere’s disease.

Ménière’s disease is a type of vertigo caused by a condition of the inner ear, discovered by the French doctor, Prosper Ménière in the mid-nineteenth century.

Dr. Ménière found the vertigo disorder, which produces a low-pitched tinnitus of varying intensity depending upon the person and the degree of the condition; can eventually result in a complete loss of hearing. Symptoms include periodic headaches, dizziness, nausea and vomiting along with vertigo attacks that can last hours to weeks.

The researchers studied 107 patients with Ménière’s disease – each with varying intensity of symptoms.

The researchers split the 120 patients into two groups and for six months, and both groups were given conventional treatment.

In addition, one group was given 150 milligrams per day of Pycnogenol – a patented pine bark extract from the French Maritime pine tree.

They found that after three months of treatment, the pine bark extract group showed significantly better improvement than the control group. A full 45 percent of the pine bark extract group had a complete recovery after three months compared to 23 percent of the placebo group.

After six months, a full 87 percent of the pine bark extract group experienced recovery – became asymptomatic. Meanwhile, 34 percent of the control group (conventional treatment) recovered after six months.

The patients were given 200 milligrams per day of Pycnogenol for 8 weeks and crossed over with a placebo.

The Gary Null Show - 08.01.22

The Gary Null Show - 08.01.22

August 1, 2022

Videos : Found on Youtube

1. BlackRock: The Most Evil Business In The World

2. This company owns the world (and it’s our fault) – BlackRock


Canadian Study Gives More Evidence Cancer Is A Lifestyle Disease Largely Caused By Food

Cancer Control Alberta, Alberta Health Services and University of Calgary, July 22, 2022

Shockingly, worldwide cancer rates are predicted to rise to 1-in-2 women and 1-in-3 men will be diagnosed with some form of cancer. It is so common already, in fact, that it getting cancer is more common than getting married or having a first baby.

In reality, one can significantly reduce the likelihood of getting cancer by making lifestyle changes. According to a recently published study out of Canada, the total proportion of cancer rates which can be attributed to lifestyle and environmental factors is quite high, nearing 41%.

Regarding the methods used in the study:

We estimated summary population attributable risk estimates for 24 risk factors (smoking [both passive and active], overweight and obesity, inadequate physical activity, diet [inadequate fruit and vegetable consumption, inadequate fibre intake, excess red and processed meat consumption, salt consumption, inadequate calcium and vitamin D intake], alcohol, hormones [oral contraceptives and hormone therapy], infections [Epstein-Barr virus, hepatitis B and C viruses, human papillomavirus, Helicobacter pylori], air pollution, natural and artificial ultraviolet radiation, radon and water disinfection by-products) by combining population attributable risk estimates for each of the 24 factors that had been previously estimated. 

The list above essentially outlines the wide range of personal choices we know can increase the risk of cancer, mainly pointing out that food causes cancer. Along with exercise, and common avoidable environmental factors, cancer is somewhat preventable.

Overall, we estimated that 40.8% of incident cancer cases were attributable to exposure to the 24 factors included in the analysis (Table 2). Tobacco smoking was responsible for the greatest cancer burden, accounting for an estimated 15.7% of all incident cancer cases (2485 cases), followed by physical inactivity and excess body weight, which were responsible for an estimated 7.2% and 4.3% of incident cancer cases, respectively. All other exposures of interest were estimated to be responsible for less than 4.0% of incident cancer cases each.

Brain imaging reveals how mindfulness program boosts pain regulation

University of Wisconsin-Madison, July 28, 2022

Research at the University of Wisconsin–Madison’s Center for Healthy Minds has isolated the changes in pain-related brain activity that follow mindfulness training—pointing a way toward more targeted and precise pain treatment.

The study, published in The American Journal of Psychiatry, identified pathways in the brain specific to pain regulation on which activity is altered by the center’s eight-week Mindfulness Based Stress Reduction course.

These changes were not seen in participants who took a similar course without the mindfulness instruction—important new evidence that the brain changes are due to the mindfulness training itself, according to Joseph Wielgosz. The study is the first to demonstrate pain-related brain changes from a standardized mindfulness course that is widely offered in clinical settings.

Around one-third of Americans experience pain-related problems, but common treatments—like medications and invasive procedures—don’t work for everyone and, according to Wielgosz, have contributed to an epidemic of addiction to prescription and illicit drugs.

Popular with patients and promising in its clinical outcomes, mindfulness training courses like MBSR have taken a central place in the drive for a more effective approach to pain management.

By practicing nonjudgmental, “present-centered” awareness of mind and body, participants can learn to respond to pain with less distress and more psychological flexibility—which can ultimately lead to reductions in pain itself.

The study also looked at longer-term mindfulness training. Intriguingly, practice on intensive meditation retreats was associated with changes in the neural signature for influences that shape pain indirectly—for example, differences in attention, beliefs and expectations, factors that often increase the perceived levels of distress in non-meditators.

These findings help show the potential for mindfulness practice as a lifestyle behavior.

Optimistic Women More Likely to Live Past 90

Harvard University, July 23, 2022

Turns out that focusing on the good things really is the recipe for a longer life. A new study from Harvard University, published in the Journal of the American Geriatrics Society, found that higher levels of optimism were positively associated with longer lifespan, with the most optimistic women even living past 90 years old across a variety of racial and ethnic groups.

This study included over 150,000 postmenopausal women across a variety of diverse socio-economic and ethnic groups in the United States. These women, aged 50-79, enrolled in the study and were followed for a period of up to 26 years. The results of this study found that the 25% of subjects who were the most optimistic were more likely to have a 5.4% longer lifespan, and a 10% greater likelihood of living beyond 90 years of age compared to the 25% who were the least optimistic.

The authors noted that while social structure factors can affect optimism, there is still reason to look on the bright side of life, regardless of these factors, finding that being optimistic is scientifically significant for longer lifespan and overall longevity. According to Hayami Koga, a PhD candidate in the Department of Social and Behavioral Sciences at Harvard T.H. Chan School of Public Health, this new research concluded that “There’s value to focusing on positive psychological factors, like optimism, as possible new ways of promoting longevity and healthy aging across diverse groups.”

The research from Harvard noted that women who were the most optimistic were 10% more likely to celebrate their 90th birthday than the least optimistic. Based on total demographics, however, the highest vs. lowest optimism quartile in the Women’s Health Initiative study is broken down as follows:

  • Overall – Associated with 5.4% longer lifespan
  • White women – 5.1% longer lifespan
  • Black women – 7.6% longer lifespan
  • Hispanic/Latina women – 5.4% longer lifespan
  • Asian women – 1.5% longer lifespan

This data shows that Black women have the highest longevity rates (at 7.6%) compared to other demographics specifically when optimism is brought into play.

Maintaining a positive outlook and optimism are undeniably large parts of the equation when it comes to living a long life, but there are other factors and lifestyle choices that come into play to ensure not only healthy lifespan, but healthy quality of life. These factors include:

  • A healthy diet —It has always been important to maintain a healthy diet to benefit overall health. While the Mediterranean diet, which emphasizes fruits and vegetables along with healthy fats and whole grains, is known for its health benefits, the Japanese diet is also a great option, with adherence to this diet being associated with a longer lifespan. 
  • Maintaining a healthy weight—Keeping the number on the scale in a healthy range with a combo of diet and exercise is a large aspect of staying healthy.
  • Nutrients—Targeted nutrients can also help support your longevity efforts. These nutrients include:
    • Nicotinamide riboside: A precursor of NAD+, and a form of vitamin B3 that can fight general fatigue, support cellular energy production, and even contribute to anti-aging.
    • Resveratrol: Skip the wine! Resveratrol has potent anti-aging properties, including fighting free radicals and mimicking calorie restricting diets that are key to longevity.
    • Curcumin: The golden spice is knowing for its anti-inflammatory benefits, and with that, its ability to benefit whole-body health. Working to keep your joints and your brain healthy, it’s a no brainer that this extract will keep you as young as you feel.
  • Managing stress—Keeping stress at bay is crucial to living a long and healthy life. There’s even evidence that managing stress can “un-gray” your hair! And who wouldn’t feel optimistic about that?

Is Vitamin E Good for PCOS?

Nanjing University of Chinese Medicine, July 25, 2022

Can women with polycystic ovary syndrome (PCOS) get pregnant? The answer is: yes…but it can be more challenging than for women without this hormone imbalance condition. For reproductive-age women, the hallmark of PCOS is high androgen levels (the “male” hormone), which can lead to irregular periods and difficulty getting pregnant. But, as daycares full of babies conceived with a little “help” can attest, there are options.

A new study published in BMC Women’s Health suggests that vitamin E may be helpful for women with PCOS undergoing ovulation induction.

According to the study, women with polycystic ovary syndrome undergoing ovulation induction who received vitamin E had lower levels of oxidative stress and required lower doses of human menopausal gonadotropin.

In addition to potentially supporting fertility, vitamin E has many other health benefits for women with PCOS: it also helps maintain healthy levels of insulin, triglycerides and LDL.

In addition to the BMC Women’s Health publication, placebo-controlled studies have shown the benefits of vitamin E for women with PCOS, especially regarding their reproduction and fertility.

In the retrospective study from BMC Women’s Health, 321 women with PCOS underwent ovulation induction.

  1. 105 received 100 mg/d of vitamin E during the follicular phase
  2. 106 received 100 mg/d of vitamin E during the luteal phase
  3. 110 did not receive vitamin E

The results? Those who took vitamin E showed improved resistance to oxidative damage, healthy endometrium thickness, and decreased hMG dosage for healthy ovulation.

Total darkness at night is key to success of breast cancer therapy — Tulane study

Tulane University, July 25, 2022

Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, “Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer,” published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer.

“In the first phase of the study, we kept animals in a daily light/dark cycle of 12 hours of light followed by 12 hours of total darkness (melatonin is elevated during the dark phase) for several weeks,” says Hill. “In the second study, we exposed them to the same daily light/dark cycle; however, during the 12 hour dark phase, animals were exposed to extremely dim light at night (melatonin levels are suppressed), roughly equivalent to faint light coming under a door.”

Melatonin by itself delayed the formation of tumors and significantly slowed their growth but tamoxifen caused a dramatic regression of tumors in animals with either high nighttime levels of melatonin during complete darkness or those receiving melatonin supplementation during dim light at night exposure.

These findings have potentially enormous implications for women being treated with tamoxifen and also regularly exposed to light at night due to sleep problems, working night shifts or exposed to light from computer and TV screens.

“High melatonin levels at night put breast cancer cells to ‘sleep’ by turning off key growth mechanisms. These cells are vulnerable to tamoxifen. But when the lights are on and melatonin is suppressed, breast cancer cells ‘wake up’ and ignore tamoxifen,” Blask says.

A Cup of Cranberries a Day Keeps Dementia Away

University of East Anglia (UK), July 26, 2022

While aging is inevitable, cognitive decline doesn’t have to be. A recent study from the University of East Anglia found some “berry” good news about a way to help support and maintain brain function: cranberry intervention.

According to the study, having the equivalent of one cup of fresh cranberries a day can improve memory, neuronal functioning, and vascular health, enhancing blood flow to the brain. And as a sweet bonus, researchers found the red fruit also helps lower LDL (low-density lipoprotein) cholesterol levels, which can build up in the arteries and result in a higher risk for cardiovascular disease and Alzheimer’s.

“Cranberries are rich in these micronutrients [flavonoids, anthocyanins and proanthocyanidins] and have been recognized for their antioxidant and anti-inflammatory properties,” the authors said.

The researchers from the University of East Anglia performed a placebo-controlled study of parallel groups of healthy 50 to 80-year-olds adults to assess the effects of freeze-dried cranberry powder on cognition, brain function and biomarkers for brain cell signaling.

The results revealed that taking cranberry extract for 12 weeks improved memory of everyday events (visual episodic memory) and enhanced blood circulation to certain parts of the brain (regional brain perfusion) compared to the placebo group. Better blood flow means essential nutrients such as oxygen and glucose reach areas of the brain associated with memory consolidation and retrieval.

The Gary Null Show - 07.29.22

The Gary Null Show - 07.29.22

July 29, 2022

Strawberries may fend off Alzheimer's

Rush University Medical Center, July 28, 2022


Could strawberries as a snack or in your cereal, salads or smoothie help protect your brain from Alzheimer's? Maybe so, according to a new study from researchers at RUSH.

RUSH researchers found that a bioactive compound found in strawberries called pelargonidin may be associated with fewer neurofibrillary tau tangles in the brain. Tau tangles are one of the hallmarks of Alzheimer's disease, which is caused by abnormal changes with tau proteins that accumulate in the brain. The study was published in the Journal of Alzheimer's Disease.

"We suspect the anti-inflammatory properties of pelargonidin may decrease overall neuroinflammation, which may reduce cytokine production," said Dr. Julie Schneider, author of the study. Schneider is associate professor and neuropathologist in the Rush Alzheimer's Disease Center at Rush University Medical Center in Chicago.

Among berries, strawberries are the most abundant source of pelargonidin.


Florida Seaweed may Hold Promise as Protector Against Cancer

 University of Florida College of Pharmacy, July 24, 2022


Among all cancers, new cases of prostate cancer are the most prevalent in the United States. While there are numerous tips for preventing and even reversing prostate cancer, one new study suggests a seaweed found off the coast of Florida could hold the key to preventing this and other forms of cancer.

The news potentially brings the U.S. closer to Asian countries in prostate cancer prevalence—countries that incidentally have high rates of seaweed consumption. Researchers with the University of Florida screened several different seaweeds, searching for one with the most cancer-protective promise. They found it in a common green algae known as sea lettuce.

“We now have scientific evidence that this seaweed raises the body’s antioxidant defense system and therefore might potentially prevent a number of diseases, including cancer,” said Hendrik Luesch, Ph.D., lead research and associate professor of medicinal chemistry in the UF College of Pharmacy. “This mechanism appears to be most relevant to prostate cancer.”

“Antioxidant-rich fruits and vegetables protect the body against these free radicals, mostly through a scavenging process of elimination. Rather than simply removing the damaging free radicals through this direct reaction, compounds in sea lettuce worked through an indirect mechanism, Luesch found. This process increases the levels of a suite of antioxidant enzymes and boosts antioxidants in cells, producing longer-lasting protection. Regulated by stretches of DNA called antioxidant response elements, the enzymes prevent oxidative damage and inflammation.”

Luesch compares the possibilities of sea lettuce compounds to the proven benefits of sulforaphane in broccoli, an enzyme that works through similar methods to prevent damage from oxidative stress and cancer.


Fast food diet before pregnancy can impact breast milk and baby's health, say scientists

University of Cambridge, July 27, 2022

A diet high in sugar and fat such as burgers, fries and fizzy drinks can negatively affect a new mother's breast milk and baby's health even before the child is conceived.

The new study using lab mice has found that even relatively short-term consumption of a fast food diet impacts women's health, reducing their ability to produce nutritional breast milk after giving birth. This can affect the newborn's well-being, as well as increasing the risk of both mother and child developing potentially fatal conditions such as heart disease, stroke and diabetes in later life.

Even mothers who appear to be a healthy weight can be suffering from hidden issues such as a fatty liver—which may be seen in people who are overweight or obese—from eating a diet heavy in processed foods, which tend to be high in fat and sugar. This can lead to advanced scarring (cirrhosis) and liver failure.

In this new study, a group of mice was fed a diet of processed high fat pellet with sweetened condensed milk for just three weeks before pregnancy, during the three-week pregnancy itself, and following birth. This diet was designed to mimic the nutritional content of a fast food burger, fries and sugary soft drink. The aim was to determine the impacts on fertility, fetus growth and neonatal outcomes. 

The researchers discovered that even a short-term high fat, high sugar diet impacted on the survival of the mice pups in the early period after birth, with an increased loss during the time the mother was feeding her offspring. Milk proteins are hugely important for newborn development but the quality was found to be poor in mouse mothers eating the high fat, high sugar diet.

"They ended up with fatty livers, which is really dangerous for the mum, and there was altered formation of the placenta. The weight of the fetus itself wasn't affected. They seemed lighter, but it wasn't significant. But what was also apparent was that the nutrition to the fetus was changed in pregnancy. Then when we looked at how the mum may be supporting the baby after pregnancy, we found that her mammary gland development and her milk protein composition was altered, and that may have been the explanation for the greater health problems of the newborn pups."


Meditation And Yoga Change Your DNA To Reverse Effects Of Stress, Study Shows

Coventry University (UK), July 25, 2022

Many people participate in practices such as meditation and yoga because they help us relax. At least those are the immediate effects we feel. But much more is happening on a molecular level, reveal researchers out of Coventry University in England.

Published in the journal Frontiers in Immunology, this new research examined 18 studies on mind-body interventions (MBIs). These include practices such as mindfulness meditation and yoga. Comprehensively, these studies encompassed 846 participants over 11 years. The new analysis reveals that MBIs result in molecular changes in the human body. Furthermore, researchers claim that these changes are beneficial to our mental and physical health.

To elaborate, consider the effect that stress has on the body. When we are under stress, the body increases the production of proteins that cause cell inflammation. This is the natural effect of the body’s fight-or-flight response.

It is widely believed that inflammation in the body leads to numerous illnesses, including cancer. Moreover, scientists also deduct that a persistent inflammation is more likely to cause psychiatric problems. Unfortunately, many people suffer from persistent stress, therefore they suffer from pro-inflammatory gene expression.

According to this new analysis out of Coventry, people that practice MBIs such as meditation and yoga can reverse pro-inflammatory gene expression. This results in a reduced risk of inflammation-related diseases and mental conditions.


EGCG in Green Tea inhibits the growth of breast cancer cells

Chonbuk National University School of Medicine (S Korea), July 21, 2022

According to news reporting originating in Chonbuk, South Korea, research stated, "Epigallocatechin gallate (EGCG), a major constituent of green tea, has potential as a treatment for a variety of diseases, including cancer. EGCG induces apoptosis and inhibits tumorigenesis through multiple signaling pathways in breast cancer cells. b-catenin signaling modulators could be useful in the prevention and therapy of breast cancer."

Research from the Chonbuk National University School of Medicine states, "However, the precise anticancer effect of EGCG through the b-catenin signaling pathway in breast cancer is unclear. The present study investigated the association between b-catenin expression and clinicopathological factors of breast cancer patients, and the effect of EGCG on b-catenin expression in breast cancer cells. b-catenin expression was analyzed according to the clinicopathological factors of 74 patients with breast cancer. Western blot analysis revealed that b-catenin was expressed at higher levels in breast cancer tissue than in normal tissue. b-catenin expression was associated with lymph node metastasis, tumor-node-metastasis stage and estrogen receptor status. EGCG dsignificantly downregulated the expression of b-catenin, phosphorylated Akt and cyclin D1. 

The present results suggest that EGCG inhibits the growth of MDA-MB-231 cells through the inactivation of the b-catenin signaling pathway."


According to the news reporters, the research concluded: "Based on these promising results, EGCG may be a potential treatment for triple negative breast cancer patients."



Turmeric eye drops could treat glaucoma

University College London, July 264, 2022

A derivative of turmeric could be used in eye drops to treat the early stages of glaucoma, finds a new study led by UCL and Imperial College London researchers.

In the new Scientific Reports paper, the researchers report a new method to deliver curcumin, extracted from the yellow spice turmeric, directly to the back of the eye using eye drops, overcoming the challenge of curcumin's poor solubility.

The research team found the eye drops can reduce the loss of retinal cells in rats, which is known to be an early sign of glaucoma.

"Curcumin is an exciting compound that has shown promise at detecting and treating the neurodegeneration implicated in numerous eye and brain conditions from glaucoma to Alzheimer's disease, so being able to administer it easily in eye drops may end up helping millions of people," said the study's lead author, Professor Francesca Cordeiro.

Curcumin has previously been shown to protect retinal ganglion cells when administered orally. For the current study, the researchers were seeking to find a more reliable method to deliver curcumin. Oral administration is difficult because curcumin has poor solubility, so it does not easily dissolve and get absorbed into the bloodstream, and would require people to take large amounts of tablets (up to 24 a day) that may cause gastrointestinal side effects.

The team developed a novel nanocarrier, wherein the curcumin is contained within a surfactant combined with a stabiliser, both of which are known to be safe for human use and are already in existing eye products. The nanocarrier can be used in eye drops to deliver much higher loads of curcumin than other products in development, increasing the drug's solubility by a factor of almost 400,000, and localises the curcumin in the eyes instead of throughout the body.

After twice-daily use of eye drops in the rats for three weeks, retinal ganglion cell loss was significantly reduced compared to matched controls, and the treatment was found to be well-tolerated with no signs of eye irritation or inflammation.

The Gary Null Show - 07.28.22

The Gary Null Show - 07.28.22

July 28, 2022


Stunning AI shows how it would remove humans. w Elon Musk.

Elon Musk’s Last Warning 2022 – “I Tried To Warn You The Last Few Years” (BEFORE IT’S TOO LATE!!!)

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Diets high in N-3 polyunsaturated fats may help decrease risk of breast cancer

A new study evaluates associations between breast cancer risk and intake of n-3 polyunsaturated fatty acids, based on menopause status

North American Menopause Society, July 27, 2022

Diet has long been reported to potentially affect breast cancer risk. Growing evidence suggests that n-3 polyunsaturated fatty acids (PUFAs) may play a role in the pathogenesis of breast cancer. A new study documents an inverse association between breast cancer risk and n-3 PUFA consumption, especially in premenopausal women who are obese. 

Previous studies have been conducted to investigate the association of n-3 PUFAs with breast cancer risk but have shown mixed results. Many of these studies were performed only in postmenopausal women because the peak age for breast cancer is 60 to 70 years in western countries, whereas it is age 40 to 50 years in Asian countries.

In this latest hospital-based, case-control study including nearly 1,600 cases, researchers not only examined the association between the intake of n-3 PUFAs in general with breast cancer, but they also looked at the effect of individual n-3 PUFAs. Good sources of n-3 PUFAs include fish, vegetable oil, nuts (especially walnuts), flax seeds and flaxseed oil, and leafy vegetables. Because the human body does not produce n-3 fatty acids naturally, these food sources are essential.

The study concluded that a higher intake of marine n-3 PUFAs and total n-3 PUFAs was associated with a lower risk of breast cancer. Dietary a-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid also were inversely associated with breast cancer risk. Such inverse associations were more evident in premenopausal women and women with certain types of breast tumors. In addition, a decreased risk of breast cancer was significantly associated with increasing n-3 PUFA intake in women who were overweight or obese but not in women of normal weight. There was a significant interaction between linoleic acid and marine n-3 PUFAs.

Zinc can halt the growth of cancer cells, study reveals

University of Texas Arlington,  July 22, 2022 

Research out of the University of Texas at Arlington has found that zinc is integral in cancer prevention, particularly cancer of the esophagus. By the way, previous research had determined the importance of zinc and its protective effect for the esophagus; however, scientists were never sure exactly why this was so.

Researchers out of the UTA College of Nursing and Health Innovation partnered with an experienced esophageal cancer researcher. Their efforts determined that zinc actually targets esophageal cancer cells while leaving normal cells alone.

It seems that it works by impeding overactive calcium signaling in the cancer cells, which isn’t a problem in normal cells. In this way, zinc inhibits cancer selectively, only in the cells that are exhibiting this behavior.

Supplementation of just 15 mg of zinc daily has been found to improve T-cell functioning and increase the body’s ability to fight infection, according University of Florida researchers. 

Harm from blue light exposure increases with age, research suggests

Oregon State University, July 27, 2022

The damaging effects of daily, lifelong exposure to the blue light emanating from phones, computers and household fixtures worsen as a person ages, new research by Oregon State University suggests.

The study, published today in Aging, involved Drosophila melanogaster, the common fruit fly, an important model organism because of the cellular and developmental mechanisms it shares with other animals and humans.

Jaga Giebultowicz, a researcher in the OSU College of Science who studies biological clocks, led a collaboration that examined the survival rate of flies kept in darkness and then moved at progressively older ages to an environment of constant blue light from light-emitting diodes, or LEDs.

The darkness-to-light transitions occurred at the ages of two, 20, 40 and 60 days, and the study involved blue light’s effect on the mitochondria of the flies’ cells.

“The novel aspect of this new study is showing that chronic exposure to blue light can impair energy-producing pathways even in cells that are not specialized in sensing light,” Giebultowicz said. “We determined that specific reactions in mitochondria were dramatically reduced by blue light, while other reactions were decreased by age independent of blue light. You can think of it as blue light exposure adding insult to injury in aging flies.”

The scientists note that natural light is crucial for a person’s circadian rhythm—the 24-hour cycle of physiological processes such as brain wave activity, hormone production and cell regeneration that are important factors in eating and sleeping patterns. But there is evidence suggesting that increased exposure to artificial light is a risk factor for sleep and circadian disorders, Giebultowicz said. And with the prevalent use of LED lighting and device displays, humans are subjected to increasing amounts of light in the blue spectrum since commonly used LEDs emit a high fraction of blue light.

In the earlier research, flies subjected to daily cycles of 12 hours in light and 12 hours in darkness had shorter lives compared to flies kept in total darkness or those kept in light with the blue wavelengths filtered out. The flies exposed to blue light showed damage to their retinal cells and brain neurons and had impaired locomotion—the flies’ ability to climb the walls of their enclosures, a common behavior, was diminished.

Amla Extract May Boost Endotheial Function, Immune Response and More

Nizam Institute of Medical Sciences (India), July 18, 2022

Endothelial dysfunction (ED) has been observed in individuals with metabolic syndrome (MetS) and contributes to the initiation and progression of atherosclerosis. The primary management of MetS involves lifestyle modifications and treatment of its individual components with drugs all of which have side effects. Thus, it would be of advantageous if natural products would be used as adjuncts or substitutes for conventional drugs. The aim of the present study was to evaluate the effect of standardized aqueous extract of fruits of amla (P. emblica) 250 mg and 500 mg twice daily on ED, oxidative stress, systemic inflammation and lipid profile in subjects with MetS.

Out of 65 screened subjects all 59 enrolled completed the study. Amla aqueous extract (PEE), 250 mg and 500 mg twice daily dosing, showed significant reduction in mean RI, measure of endothelial function, at 8 and 12 weeks compared to baseline and placebo. PEE 500 mg twice daily was significantly more efficacious than the 250 mg twice daily and placebo. No participant discontinued the study because of adverse events.

Amla aqueous extract significantly improved endothelial function, oxidative stress, systemic inflammation and lipid profile at both dosages tested, but especially at 500 mg twice daily. Thus, this product may be used as an adjunct to conventional therapy (lifestyle modification and pharmacological intervention) in the management of metabolic syndrome.

Histamine-producing gut bacteria can trigger chronic abdominal pain

McMaster University and Queen’s University (Ontario), July 27 ,2022

Researchers from McMaster University and Queen’s University have discovered a gut bacterial “super-producer” of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS).

The culprit is what has now been named Klebsiella aerogenes, identified in up to 25 percent of gut microbiota samples from patients with IBS. Researchers examined stool microbiota samples from both Canadian and American patient cohorts.

“We followed up these patients for several months and found high levels of stool histamine at the time when the patients reported severe pain, and low stool histamine when they were pain-free,” said senior author Premysl Bercik, professor of medicine of McMaster’s School of Medicine.

The McMaster-Queen’s research team pinpointed the bacterium Klebsiella aerogenes as the key histamine producer by studying germ-free mice colonized with gut microbiota from patients with IBS. They also colonized some mice with gut microbiota from healthy volunteers as a control group.

The study found that the bacterium Klebsiella aerogenes converts dietary histidine, an essential amino acid present in animal and plant protein, into histamine, a known mediator of pain. The bacterial histamine then activates the gut immune system through histamine-4 receptor, which draws immune mast cells into the intestines. These activated mast cells produce even more histamine and other pain-signaling mediators, triggering inflammation and pain.

The study found that when the mice colonized with histamine producing bacteria were fed a diet low in fermentable carbohydrates, bacterial histamine production dramatically decreased. This was due to change in bacterial fermentation and acidity within the gut, which inhibited the bacterial enzyme responsible for histamine production.

Bercik said that these results explain the beneficial effects of a low fermentable diet observed in patients with IBS.

Eating more ultra-processed foods associated with increased risk of dementia

Tianjin Medical University (China), July 27, 2022

People who eat the highest amounts of ultra-processed foods like soft drinks, chips and cookies may have a higher risk of developing dementia than those who eat the lowest amounts, according to a new study published in the online issue of Neurology. Researchers also found that replacing ultra-processed foods in a person’s diet with unprocessed or minimally processed foods was associated with a lower risk. The study does not prove that ultra-processed foods cause dementia. It only shows an association.

Ultra-processed foods are high in added sugar, fat and salt, and low in protein and fiber. They include soft drinks, salty and sugary snacksice cream, sausage, deep-fried chicken, yogurt, canned baked beans and tomatoes, ketchup, mayonnaise, packaged guacamole and hummus, packaged breads and flavored cereals.

For the study, researchers identified 72,083 people from the UK Biobank, a large database containing the health information of half a million people living in the United Kingdom. Participants were age 55 and older and did not have dementia at the start of the study. They were followed for an average of 10 years. By the end of the study, 518 people were diagnosed with dementia.

Researchers determined how much ultra-processed food people ate by calculating the grams per day and comparing it to the grams per day of other foods to create a percentage of their daily diet. They then divided participants into four equal groups from lowest percentage consumption of ultra-processed foods to highest.

After adjusting for age, gender, family history of dementia and heart disease and other factors that could affect risk of dementia, researchers found that for every 10% increase in daily intake of ultra-processed foods, people had a 25% higher risk of dementia.

Researchers also used study data to estimate what would happen if a person substituted 10% of ultra-processed foods with unprocessed or minimally processed foods, like fresh fruit, vegetables, legumes, milk and meat. They found that such a substitution was associated with a 19% lower risk of dementia.

“Our results also show increasing unprocessed or minimally processed foods by only 50 grams a day, which is equivalent to half an apple, a serving of corn, or a bowl of bran cereal, and simultaneously decreasing ultra-processed foods by 50 grams a day, equivalent to a chocolate bar or a serving of fish sticks, is associated with 3% decreased risk of dementia,” said Li. “It’s encouraging to know that small and manageable changes in diet may make a difference in a person’s risk of dementia.”

The Gary Null Show - 07.27.22

The Gary Null Show - 07.27.22

July 27, 2022

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Green tea extract promotes gut health, lowers blood sugar

Ohio State University, July 26, 2022New research in people with a cluster of heart disease risk factors has shown that consuming green tea extract for four weeks can reduce blood sugar levels and improve gut health by lowering inflammation and decreasing “leaky gut.”Researchers said this is the first study assessing whether the health risks linked to the condition known as metabolic syndrome, which affects about one-third of Americans, may be diminished by green tea’s anti-inflammatory benefits in the gut.”There is much evidence that greater consumption of green tea is associated with good levels of cholesterol, glucose and triglycerides, but no studies have linked its benefits at the gut to those health factors,” said Richard Bruno, senior study author and professor of human nutrition at The Ohio State University.In the new study, green tea extract also lowered blood sugar, or glucose, and decreased gut inflammation and permeability in healthy people—an unexpected finding.

“What this tells us is that within one month we’re able to lower blood glucose in both people with metabolic syndrome and healthy people, and the lowering of bloodglucose appears to be related to decreasing leaky gut and decreasing gut inflammation—regardless of health status,” Bruno said.”We did not attempt to cure metabolic syndrome with a one-month study,” he said. “But based on what we know about the causal factors behind metabolic syndrome, there is potential for green tea to be acting at least in part at the gut level to alleviate the risk for either developing it or reversing it if you already have metabolic syndrome.”

Blood vessels can actually get better with age 

Study finds that arteries adapt to oxidative stress caused by agingUniversity of Missouri, July 21, 2022Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.”Molecules known as reactive oxygen species, or ROS, play an important role in regulating cellular function,” said Steven Segal, a professor of medical pharmacology and physiology at the MU School of Medicine and senior author of the study. “However, the overproduction of ROS can help create a condition referred to as oxidative stress, which can alter the function of cells and interfere with their growth and reproduction.””We studied the endothelium from resistance arteries of male mice at 4 months and 24 months of age, which correspond to humans in their early 20s and mid-60s,” Segal said. “We first studied the endothelium under resting conditions and in the absence of oxidative stress. We then simulated oxidative stress by adding hydrogen peroxide. When oxidative stress was induced for 20 minutes, the endothelial cells of the younger mice had abnormal increases in calcium when compared to the endothelial cells of the older mice. This finding is important because when calcium gets too high, cells can be severely damaged.” 

When oxidative stress was extended to 60 minutes, Segal’s team found that the death of endothelial cells in the younger mice was seven times greater than those from the older mice. These findings indicated that with advancing age, the endothelium had adapted to preserve cellular integrity when confronted with oxidative stress.Our study suggests that blood vessels adapt during the aging process to regulate ROS and minimize cell death when subjected to an abrupt increase in oxidative stress. This adaptation helps to ensure that the arteries of older individuals can still do their jobs.” 

Elevated tween screen time linked to disruptive behavior disorders

University of California, San Francisco, July 26, 2022Tweens who spend more time on screens have a higher likelihood of developing disruptive behavior disorders, with social media having an especially strong influence, a new UC San Francisco-led study published in the Journal of Child Psychology and Psychiatry found.Social media use was most likely to be linked to conduct disorder, while other forms of screen use—such as watching videos and television, playing video games, and texting—were more likely to be associated with oppositional defiant disorder (ODD).Conduct disorder is characterized by violating others’ basic rights or societal rules with actions such as bullying, vandalism and stealing, while ODD is marked by a pattern of angry or irritable mood, argumentative or defiant behavior, and vindictiveness.Researchers collected data on screen use, then evaluated for behavior disorders one year later. Each hour of social media was linked with a 62% higher prevalence of conduct disorder, while television, video games, video chat, and texting were linked with a 14% to 21% higher prevalence of ODD.In another recent study, Nagata and colleagues found that adolescents are so attached to their phones—the main vehicle for screen time—that they report losing track of time when using their phone (47.5%) and will interrupt whatever they are doing when contacted by phone (31%).The average amount of screen time was four hours per day, with the most time spent watching/streaming TV shows/movies (1.3 hours on average), playing videogames (1.1 hours), and watching/streaming videos (1 hour).  In fact, four hours a day was a threshold, with time above four hours associated with a 69% higher prevalence of conduct disorder and a 46% higher prevalence of ODD.

Cocoa shown to reduce blood pressure and arterial stiffness in study

University of Surrey (UK), July 26, 2022

Cocoa flavanols have previously been found to lower blood pressure and arterial stiffnessas much as some blood pressure medication. However, how effective flavanols are in everyday life in reducing blood pressure has remained unknown, as previous studies in this area have been performed in tightly controlled experimental settings.

Surrey’s new research reduces concerns that cocoa as a treatment for raised blood pressure could pose health risks by decreasing blood pressure when it is not raised, paving the way for it to be potentially used in clinical practice.

In the first study of its kind study, researchers set out to investigate the use of flavanols, a compound found in cocoa, in lowering blood pressure and arterial stiffness in individuals outside of clinical settings.

For several days, eleven healthy participants consumed, on alternating days, either six cocoa flavanol capsules or six placebo capsules containing brown sugar. Participants were provided with an upper arm blood pressure monitor and a finger clip measuring pulse wave velocity (PWV) which gauges levels of arterial stiffness.

Measurements of blood pressure and PWV were taken prior to consumption of the capsules and every 30 minutes after ingestion for the first three hours, and then hourly for the remaining nine hours. Researchers found that blood pressure and arterial stiffness were only lowered in participants if it was high, and there was no effect when the blood pressure was low in the morning.

Professor Heiss added, “The positive impact cocoa flavanols have on our cardiovascular system, in particular, blood vessel function and blood pressure, is undeniable. Doctors often fear that some blood pressure tablets can decrease the blood pressure too much on some days.

Greater potassium intake linked to lower blood pressure in women

Amsterdam University Medical Center, July 25 2022. 

A study  in European Heart Journal found an association between consuming a higher amount of potassium and lower blood pressure among women with a high intake of sodium. “It is well known that high salt consumption is associated with elevated blood pressure and a raised risk of heart attacks and strokes,” noted study author Liffert Vogt, MD, PhD, of Amsterdam University Medical Center. “Health advice has focused on limiting salt intake but this is difficult to achieve when our diets include processed foods. Potassium helps the body excrete more sodium in the urine.”

The study included 11,267 men and 13,696 women who enrolled in England’s EPIC-Norfolk study between 1993 and 1997. Some participants were being treated for hypertension. Sodium and potassium intake were estimated from urinary levels of these minerals and categorized as low, medium or high. 

Increased potassium intake was associated with declining blood pressure among women with high sodium intake. In this group, each 1 gram increase in potassium consumption was associated with a 2.4 mmHg decrease in systolic blood pressure. 

During a median follow-up of 19.5 years, 54.5% of the men and women experienced cardiovascular disease events. Men whose potassium intake was among the top one-third of participants had a 7% lower risk of hospitalization or death caused by cardiovascular disease compared to men whose intake was among the lowest third. Among women whose potassium intake was highest, the risk was 11% lower. 

Elderberry benefits air travelers 

Griffith University, July 21, 2022

The negative health effects of international air travel are well documented but now it seems that the common elderberry can provide some relief.

Associate Professor Evelin Tiralongo and Dr Shirley Wee from Griffith’s Menzies Health Institute Queensland (MHIQ) have completed a clinical trial showing that an elderberry supplement can provide some protection from cold and flu-like symptoms following long-haul flights.

Intercontinental air travel can be stressful and affect a passenger’s physical and psychological wellbeing. Whilst jet lag and fatigue remain the best known problems, holidaymakers also often experience upper respiratory symptoms.

The randomised, double-blind placebo controlled clinical trial was conducted with 312 economy class passengers travelling from Australia to an overseas destination. Cold episodes, cold duration and symptoms were recorded in a daily diary and participants also completed surveys before, during and after travel.

“We found that most cold episodes occurred in the placebo group. However, the placebo group had a significantly higher number of cold episode days, and the symptom score in the placebo group over these days was also significantly higher,” says Associate Professor Tiralongo.

The trial used capsules containing 300mg of a standardised, proprietary membrane-filtered elderberry extract which has shown to be effective in working against respiratory bacteria and influenza viruses.

The Gary Null Show - 07.26.22

The Gary Null Show - 07.26.22

July 26, 2022

First trial to prove a diet supplement can prevent hereditary cancer

Newcastle University (UK), July 25, 2022

A trial in people with high hereditary risk of a wide range of cancers has shown a major preventive effect from resistant starch, found in a wide range of foods such as oats, breakfast cereal, cooked and cooled pasta or rice, peas and beans, and slightly green bananas.

An international trial—known as CAPP2—involved almost 1000 patients with Lynch syndrome from around the world, and revealed that a regular dose of resistant starch, also known as fermentable fiber, taken for an average of two years, did not affect cancers in the bowel but did reduce cancers in other parts of the body by more than half. This effect was particularly pronounced for upper gastrointestinal cancers including esophageal, gastric, biliary tract, pancreatic and duodenum cancers.

The astonishing effect was seen to last for 10 years after stopping taking the supplement.

"We found that resistant starch reduces a range of cancers by over 60%. The effect was most obvious in the upper part of the gut," explained Professor John Mathers, professor of Human Nutrition at Newcastle University. "This is important as cancers of the upper GI tract are difficult to diagnose and often are not caught early on.

"Resistant starch can be taken as a powder supplement and is found naturally in peas, beans, oats and other starchy foods. The dose used in the trial is equivalent to eating a daily banana; before they become too ripe and soft, the starch in bananas resists breakdown and reaches the bowel where it can change the type of bacteria that live there.

"Resistant starch is a type of carbohydrate that isn't digested in your small intestine; instead it ferments in your large intestine, feeding beneficial gut bacteria—it acts, in effect, like dietary fiber in your digestive system. This type of starch has several health benefits and fewer calories than regular starch. We think that resistant starch may reduce cancer development by changing the bacterial metabolism of bile acids and to reduce those types of bile acids that can damage our DNA and eventually cause cancer. However, this needs further research."


New study finds lowest risk of death was among adults who exercised 150-600 minutes/week

Harvard School of Public Health, July 25, 2022

An analysis of more than 100,000 participants over a 30-year follow-up period found that adults who perform two to four times the currently recommended amount of moderate or vigorous physical activity per week have a significantly reduced risk of mortality, according to new research published today in the American Heart Association's journal Circulation. The reduction was 21-23% for people who engaged in two to four times the recommended amount of vigorous physical activity, and 26-31% for people who engaged in two to four times the recommended amount of moderate physical activity each week.

In 2018, the United States Department of Health and Human Services' Physical Activity Guidelines for Americans recommended that adults engage in at least 150-300 minutes/week of moderate physical activity or 75-150 minutes/week of vigorous physical activity, or an equivalent combination of both intensities. 

The analysis also found:

  • Participants who met the guidelines for vigorous physical activity had an observed 31% lower risk of CVD mortality and 15% lower risk of non-CVD mortality, for an overall 19% lower risk of death from all causes.
  • Participants who met the guidelines for moderate physical activity had an observed 22-25% lower risk of CVD mortality and 19-20% lower risk of non-CVD mortality, for an overall 20-21% lower risk of death from all causes.
  • Participants who performed two to four times above the recommended amount of long-term vigorous physical activity (150-300 min/week) had an observed 27-33% lower risk of CVD mortality and 19% non-CVD mortality, for an overall 21-23% lower risk of death from all causes.
  • Participants who performed two to four times above the recommended amount of moderate physical activity (300-600 min/week) had an observed 28-38% lower risk of CVD mortality and 25-27% non-CVD mortality, for an overall 26-31% lower risk of mortality from all causes.

In addition, no harmful cardiovascular health effects were found among the adults who reported engaging in more than four times the recommended minimum activity levels. Previous studies have found evidence that long-term, high-intensity, endurance exercise, such as marathons, triathlons and long-distance bicycle races, may increase the risk of adverse cardiovascular events, including myocardial fibrosis, coronary artery calcification, atrial fibrillation and sudden cardiac death.


Treating dementia with the healing waves of sound

Ultrasound applied to the brain could help treat patients with dementia.

Tohoku University (Japan), July 20, 2022

Ultrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease. The research, conducted by scientists at Tohoku University in Japan, suggests that this type of therapy may also benefit humans.

The team, led by cardiologist Hiroaki Shimokawa, found that applying low-intensity pulsed ultrasound (LIPUS) to the whole brain of the mice improved blood vessel formation and nerve cell regeneration without having obvious side effects.

"The LIPUS therapy is a non-invasive physiotherapy that could apply to high-risk elderly patients without the need for surgery or anaesthesia, and could be used repeatedly," says Shimokawa.

The Tohoku University team found that cognitive impairment markedly improved in mice with conditions similar to vascular dementia and Alzheimer's disease when LIPUS was applied to the whole brain three times a day for 20 minutes each time. 


Study: ADHD drugs do not improve cognition in healthy college students

University of Rhode Island, July 19, 2022

Contrary to popular belief across college campuses, attention deficit hyperactivity disorder (ADHD) medications may fail to improve cognition in healthy students and actually can impair functioning, according to a study by researchers at the University of Rhode Island and Brown University.

Study co-investigators Lisa Weyandt, professor of psychology and a faculty member with URI's George and Anne Ryan Institute for Neuroscience, and Tara White, assistant professor of research in behavioral and social sciences at Brown University, had anticipated different findings. "We hypothesized that Adderall would enhance cognition in the healthy students, but instead, the medication did not improve reading comprehension or fluency, and it impaired working memory," she said. "Not only are they not benefitting from it academically, but it could be negatively affecting their performance."

This first-ever multisite pilot study of the impact of so-called "study drugs" on college students who do not have ADHD comes at a time when use of prescription stimulants such as Adderall, Ritalin and Vyvanse is common among young adults who believe the drugs will improve their academic performance. 

Results of the study, published in the journal Pharmacy, show that the standard 30 mg dose of Adderall did improve attention and focus -- a typical result from a stimulant -- but that effect failed to translate to better performance on a battery of neurocognitive tasks that measured short-term memory, reading comprehension and fluency.

Weyandt has a theory about why working memory would be adversely affected by the medication. Brain scan research shows that a person with ADHD often has less neural activity in the regions of the brain that control executive function -- working memory, attention, self-control. For people with ADHD, Adderall and similar medications increase activity in those regions and appear to normalize functioning. "If your brain is functioning normally in those regions, the medication is unlikely to have a positive effect on cognition and my actually impair cognition. In other words, you need to have a deficit to benefit from the medicine," Weyandt said.





Guanabana: the cancer killer big pharma doesn't want you to know about

Northeastern University, July 16, 2022 

Guanabana is known by a variety of names -- including soursop, cherimoya, custard apple, Brazilian paw paw and graviola.

As far back as the 1970s, the National Cancer Institute (NCI) investigated the merits of guanabana, and discovered the stems and leaves of the tree were successful in destroying cancer cells. "Inexplicably, the results [of the NCI research] were published in an internal report and never released to the public. Since 1976, guanabana has proven to be an immensely potent cancer killer in 20 independent laboratory tests, but as of now, no double-blind clinical trials," reports Christopher Lane, Ph.D., in Psychology Today.

Moreover, this study found that a compound derived from the leaves of guanabana was "selectively cytotoxic for the lung (A-549), colon (HT-29), and pancreatic (PACA-2) cell lines with potencies equal to or exceeding those of Adriamycin." And research in the Journal of Natural Products discovered that extracts of guanabana demonstrated pesticidal, antimalarial, antiviral and antimicrobial properties. Likewise, Memorial Sloan Kettering Cancer Center states that guanabana shows anti-inflammatory and anticancer effects in vitro and in vivo.

Revered for centuries in South America and Southeast Asia, the bark, leaves, root, seeds and fruit have been used to tame heart disease, asthma, liver issues and arthritis. Guanabana is also helpful for treating sleep disorders, fevers and cough. According to the article, "Guanabana--Medicinal Uses?" extracts of the plant:

  • Attack cancer safely and effectively with an all-natural therapy that does not cause extreme nausea, weight loss and hair loss.
  • Protect the immune system.
  • Boost energy and outlook on life.
  • Effectively target and kill malignant cells in 12 types of cancer -- including colon, breast, prostate, lung and pancreatic cancer.
  • Proved to be up to 10,000 times stronger in slowing the growth of cancer cells than Adriamycin, a commonly used chemotherapeutic drug.
  • Selectively kill only cancer cells, unlike traditional chemotherapy treatments. 

*A word of caution: Excessive consumption of guanabana can lead to neuronal dysfunction and degeneration with symptoms similar to Parkinson's disease. Consult with a qualified practitioner before taking guanabana on a daily basis.



High-strength cannabis linked to addiction and mental health problems

University of Bath (UK), July 25, 2022

As the strength or potency of cannabis products has increased internationally over the years, so have rates of people being treated for cannabis addiction, say the authors of a new study.

Researchers from the Addiction and Mental Health Group at the University of Bath (UK) have systematically analyzed the relationship between the types of cannabis people use and their addiction and mental health problems. Their work draws on 20 studies involving almost 120,000 people.

The new study, published in The Lancet Psychiatry, suggests that people who use high-potency cannabis are more likely to experience addiction than those using low-potency products. It also suggests that people using high-potency cannabis are more likely to experience a psychotic disorder, such as schizophrenia.

These findings may help to explain why more people have received treatment for cannabis problems over recent years. Data from the European Monitoring Centre for Drugs and Drug Addiction show a 76% increase in people entering treatment for cannabis addiction in the past decade.

The Gary Null Show - 07.22.22

The Gary Null Show - 07.22.22

July 22, 2022

Antihypertensive and antioxidant activity in black beans

National Polytechnic Institute (Mexico)   16 July 2022 


Beans are one of the most important crops for the Mexican population due to its nutritional qualities. In fact, the country is one of the top 10 producers of this legume in the world, and several studies have reflected the correlation between consumption and decreased chronic degenerative diseases, cardiovascular diseases, obesity and diabetes.


Therefore, the National School of Biological Sciences of the National Polytechnic Institute (IPN-ENCB), conducted an investigation to evaluate the antioxidant and antihypertensive activity in black beans, and found that in addition to these qualities, proteins in the bean can remove heavy metals from the body. 


The polytechnic research identified bioactive peptides in the legume that have a beneficial effect as antihypertensive and antioxidant, which could favor the prevention and treatment of cardiovascular diseases, with a specific effect on blood pressure and oxidative stress. 


It was determined that fasolina and lectin hydrolysates (main proteins in the Jamapa black bean) had chelating activity (removal of heavy metals in the body) and, when hydrolyzed with pepsin-pancratin, they release peptides (amino acids) with antihypertensive and antioxidant effects. 


Could Eating Fruit More Often Keep Depression At Bay?

Aston University (UK), July 15, 2022
People who frequently eat fruit are more likely to report greater positive mental well-being and are less likely to report symptoms of depression than those who do not, according to new research from the College of Health and Life Sciences, Aston University
  • The study found frequent fruit eaters had greater positive mental wellbeing
  • The study surveyed 428 adults and looked at the relationship between their consumption of fruit, vegetables, sweet and savoury food snacks and their psychological health
  • The more often people ate fruit, the lower they scored for depression and the higher for mental well-being.
Published in the British Journal of Nutrition, the study surveyed 428 adults from across the UK and looked at the relationship between their consumption of fruit, vegetables, sweet and savoury food snacks, and their psychological health.
People who frequently snacked on nutrient-poor savoury foods (such as crisps) were more likely to experience 'everyday mental lapses' (known as subjective cognitive failures) and report lower mental wellbeing. A greater number of lapses, was associated with higher reported symptoms of anxiety, stress and depression, and lower mental wellbeing scores.

Effect of Short-term Quercetin, Caloric Restriction in Late Life Effective to Counter Age-Related Oxidative Macromolecular Damage.

Pondicherry University (India), July 13, 2022


According to news from Pondicherry, India, research stated, "Aging is characterized by gradual accumulation of macromolecular damage leading to progressive loss of physiological function and increased susceptibility to diverse diseases. Effective anti-aging strategies involving caloric restriction or antioxidant supplementation are receiving growing attention to attenuate macromolecular damage in age associated pathology."

Research from Pondicherry University, "In the present study, we for the first time investigated the effect of quercetin, caloric restriction and combined treatment (caloric restriction with quercetin) on oxidative stress parameters, acetylcholinesterase and ATPases enzyme activities in the cerebral cortex of aged male Wistar rats. 

Our results demonstrate that combined treatment of caloric restriction and quercetin significantly improved the age associated decline in the activities of endogenous antioxidant enzymes [such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and glutathione (GSH), and nitric oxide (NO). 

According to the news reporters, the research concluded: "Finally, we conclude that combined treatment of caloric restriction and quercetin in late life is an effective anti-aging therapy to counteract the age related accumulation of oxidative macromolecular damage."


How Drinking Soda on a Hot Day Can Damage Kidneys, Leading to Diabetes, Heart Disease

University of Buffalo, July 18, 2022

  • Research demonstrates the acute deleterious effects soda can have on your kidney function when used to quench your thirst during exertion on a hot day.
  • Drinking soda causes dehydration and raises markers for kidney disease when consumed after performing manual labor or exercise in 95-degree Fahrenheit weather.
  • When you exert yourself in a hot environment, your body regulates blood pressure and conserves water by reducing blood flow to your kidneys. A sudden and steep drop in blood flow through your kidneys can cause acute kidney injury due to the fact that it reduces the amount of oxygen being delivered to your kidneys.
  • Your diet has an overriding influence over the health of your kidneys, with sugar and excess protein topping the list of food components known to cause problems when consumed regularly.
  • The study, published in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, found soda caused dehydration and raised markers for kidney disease when consumed after performing manual labor in 95-degree F. weather.

“The volunteers completed … a 30-minute treadmill workout followed by three different five-minute lifting, dexterity and sledgehammer swinging activities. After 45 minutes of exercise, the volunteers rested for 15 minutes … while drinking 16 ounces of either a high-fructose, caffeinated soft drink or water. After the break, they repeated the cycle three more times for a total of four hours. Before leaving the laboratory, the volunteers were given more of their assigned beverages to drink before consuming any further fluids. The volume was either 1 liter or a volume equal to 115% of their body weight lost through sweating if that amount was greater.”

When volunteers drank soda, 75% of them had elevated levels of creatinine in their blood, a marker for kidney injury. Only 8% of participants in the water trial had elevated creatinine. When drinking soda, volunteers also had:

  • A lower glomerular filtration rate, another marker for kidney injury
  • Higher uric acid levels
  • Mild dehydration
  • Higher levels of vasopressin, an antidiuretic hormone that raises blood pressure

Black Seed Oil Extract Causes Oral Cancer Cells To Self-Destruct

Institute of Biochemistry and Biotechnology (Taiwan), July 20, 2022 



A range of chemotherapeutic options for treating cancer are available, however many of the treatments are themselves associated with significant morbidity and mortality. Today many cancer sufferers search for alternatives to conventional chemotherapy.

Increasingly natural alternative options are becoming available, often with little or no side-effects and concrete science is proving the effects of many natural substances against cancer.


One substance which is increasingly making the headlines is thymoquinone, an active component of Nigella sativa or black seed oil. Scientists from the Institute of Biochemistry and Biotechnology, Taiwan, have found that this remarkable compound elicits cytotoxic effects on various squamous cancer cell lines through various mechanisms.  The study examined a highly malignant strain of squamous cell carcinoma, which was taken from various patients with oral cancer; this particular cancer type also causes many other cancers of the head and neck.


The cell lines were grown in a lab and treated with different concentrations of thymoquinone. The results showed that after just 24 hours of treatment there was a significant concentration-dependent cytotoxic effect on these cells. The study further examined why this was happening. Their findings are quite remarkable as they were able to demonstrate that thymoquinone was a potent inhibitor of oral cancer cell viability via two distinct anti-neoplastic mechanisms.



No bones about it: Cannabis may be used to treat fractures

Tel Aviv University researcher finds non-psychotropic compound in marijuana can help heal bone fissures

Tel Aviv University (Israel), July 19, 2022

A study published in the Journal of Bone and Mineral Research by Tel Aviv University and Hebrew University researchers explores another promising new medical application for marijuana. According to the research, the administration of the non-psychotropic component cannabinoid cannabidiol (CBD) significantly helps heal bone fractures. The study, conducted on rats with mid-femoral fractures, found that CBD -- even when isolated from tetrahydrocannabinol (THC), the major psychoactive component of cannabis -- markedly enhanced the healing process of the femora after just eight weeks.

Undeniable clinical potential

The same team, in earlier research, discovered that cannabinoid receptors within our bodies stimulated bone formation and inhibited bone loss. This paves the way for the future use of cannabinoid drugs to combat osteoporosis and other bone-related diseases.

"We found that CBD alone makes bones stronger during healing, enhancing the maturation of the collagenous matrix, which provides the basis for new mineralization of bone tissue," said Dr. Gabet. "After being treated with CBD, the healed bone will be harder to break in the future."

The researchers injected one group of rats with CBD alone and another with a combination of CBD and THC. After evaluating the administration of THC and CBD together in the rats, they found CBD alone provided the necessary therapeutic stimulus.



Saturday, July 23 -- 2:00 pm

Kingston, NY (at the historical 4 corners -- Crown and John Streets)


Gerald Celente

Judge Andrew Napolitano

Gary Null

Scott Ritter

Phil Giraldi (former CIA official)

Live music, food and drink

The Gary Null Show - 07.21.22

The Gary Null Show - 07.21.22

July 21, 2022







·  Valuing your time more than money is linked to happiness


Mary Grant

Mary Grant is the Public Water for All Campaign Director at Food & Water Watch. Food & Water Watch is a national nonprofit organization that mobilizes regular people to build political power to move bold and uncompromised solutions to the most pressing food, water, and climate problems of our time.Since 2015, Mary has overseen Food & Water Watch’s campaigns across the country to support universal access to safe water in the United States by promoting responsible and affordable public provision of water and sewer service. Prior to becoming the organization's campaign director, she was a researcher for Food & Water Watch. Her research has been featured in the Washington Post, the Associated Press, the New York Times, the Guardian, and other news outlets. She has also co-written peer reviewed studies dealing with the privatization of water and  public health risks due to lack of water access.  Food and Water Watch's website is

The Gary Null Show - 07.20.22

The Gary Null Show - 07.20.22

July 20, 2022

1. The (evil?) architect of The Great Reset - Sorelle Amore Finance (10:46)

*Who is Klaus Schwab, really? I'll be trying to bring a more balanced perspective to the answer to that question. Because when it comes to the leader of the WEF, it seems like most of the information that's out there is pushing a very one-sided view.

2. United Nations announces Klaus Schwab of the World Economic Forum and UN General Secretary Antonio Guterres have signed an agreement to ‘accelerate’ Agenda 2030 (0:30)

3. World Economic Forum | Strategic Intelligence

4. If I Were the Devil: Paul Harvey (2:47)

* Paul Harvey Aurandt was an American radio broadcaster for ABC News Radio. He broadcast News and Comment on mornings and mid-days on weekdays and at noon on Saturdays and also his famous The Rest of the Story segments. From 1951 to 2008, his programs reached as many as 24 million people per week. 

5. Gun Control and The Vaule Of Life (8:09)


Vitamin B6 Supplements In High Doses Can Calm Anxiety, Depression


University of Reading (UK), July 18, 2022

Taking high-dose vitamin B6 supplements may help to reduce feelings of anxiety and depression, a new study reveals. Researchers from the University of Reading in England report that young adults taking a dose 50 times the recommended daily dose reported feeling less anxious and depressed after a month.

Vitamin B6 increases the body’s production of GABA (Gamma-Aminobutyric Acid), a chemical that blocks impulses between nerve cells in the brain. Vitamin B6 is found naturally in a variety of foods, including salmon, tuna, chickpeas, and bananas.  Vitamin B6 helps the body produce a specific chemical messenger that inhibits impulses in the brain, and this study links this calming effect with reduced anxiety among the participants.”

The study provides evidence lacking in previous studies as to what exactly drives the stress-reducing effects of marmite and multivitamins.

More than 300 participants took either a placebo or Vitamin B6 or B12 supplements at 50 times the recommended amount – around 70mg. Each participant took one tablet a day with food. Vitamin B12 had little effect compared to the placebo, but B6 showed a statistically reliable difference.

The team also detected subtle but harmless changes in visual performance, consistent with controlled levels of brain activity. Health officials in the United Kingdom recommend that people do not take too high a dose – more than 200mg a day – as it can lead to a loss of feeling in the arms and legs. In a few cases, this has become permanent in people who have taken very large doses for several months.


“Many foods, including tuna, chickpeas and many fruits and vegetables, contain Vitamin B6. However, the high doses used in this trial suggest that supplements would be necessary to have a positive effect on mood,” Dr. Field continues. “It is important to acknowledge that this research is at an early stage and the effect of Vitamin B6 on anxiety in our study was quite small compared to what you would expect from medication. However, nutrition-based interventions produce far fewer unpleasant side effects than drugs, and so in the future people might prefer them as an intervention.


Study Ranks Healthiest ‘Powerhouse’ Vegetables, Which is #1? 

William Paterson University, July 14


Research from William Paterson University attempted to rank fruits and vegetables according to the amount of nutrition within. In all, they list 41 “powerhouse” vegetables and fruits, scoring them according to the presence of 17 nutrients.

The produce was scored by the presence of: fiber, potassium, protein, calcium, folate, vitamin D, vitamin A, vitamin B12, and more.


To make the study’s “powerhouse” list, the researchers calculated each fruit or vegetable’s “nutrient density” score based on the percentage of your daily need for each nutrient the food provides. (The study assumed a 2,000 calorie per day diet and 100 grams of each food.) The scores were capped to ensure that a fruit or vegetable that provides a huge amount of just a single nutrient wouldn’t receive a disproportionately high overall score.”

So, which earned the top spot? Super easy-to-grow watercress.

Watercress scored an even 100, with Chinese cabbage closest behind with a score of 91.99. In third place was chard (89.27), followed by beet greens (87.08), spinach (86.43), and chicory (73.36). 

Fruits scored lower, with red pepper at the top (41.26), followed by pumpkin (32.23), tomatoes (20.37), and lemons (18.72). Many of these are surprising considering they aren’t the “superfruits” we are accustomed to hearing about. But, that’s largely because of the nutrients measured in this study.

Fruits like blueberries, that are considered healthiest by many, earn that spot because of their antioxidant levels. This study didn’t capture the concentration of antioxidants, however.


Can listening to the Beatles improve your memory? New research says music just might stir the brain

Northeastern University, July 19, 2022

When Paul McCartney wrote "Get Back," he never would have predicted how useful or relevant the song would become for music therapists.

The song's refrain—"Get back to where you once belonged"—might as well be a therapist encouraging a dementia patient to recall a distant memory. In new research, Psyche Loui, an associate professor of music, is attempting to do exactly that.

Published in Scientific Reports, Loui found that for older adults who listened to some of their favorite music, including The Beatles, connectivity in the brain increased. Specifically, Loui—and her multi-disciplinary team of music therapists, neurologists and geriatric psychiatrists—discovered that music bridged the gap between the brain's auditory system and reward system, the area that governs motivation.

The researchers had a group of older adults between the ages of 54 and 89 from the Boston area listen to a playlist for an hour every day for eight weeks and journal about their response to the music afterward. Loui and the team would scan the participants' brains before and after listening in order to measure their neurological response.

Playlists were highly personalized and featured a combination of the participants' self-selected songs, which ranged from The Beatles to Bruce Springsteen, and a preselected mix of classical pieces, pop and rock songs and new compositions.The most important lesson that we learned from the music therapist was that there is no one-size-fits-all for what kind of music works best," Loui said.

What the researchers found was striking: Music was essentially creating an auditory channel directly to the medial prefrontal cortex, the brain's reward center. Notably, the medial prefrontal cortex "is one of the areas to lose its activity and functional connectivity in aging adults, especially in folks with dementia," Loui said.

Music that was both familiar and well-liked tended to activate the auditory and reward areas more. However, the music that participants selected themselves provided an even stronger connection between these two areas of the brain.


DHA omega-3 linked to ‘significantly improved periodontal outcomes’: Harvard data

Harvard University, July 14 ,2022

Scientists from Harvard report that supplementation with DHA (docosahexaenoic acid) omega-3 may improve periodontal outcomes in people with periodontitis.

Periodontitis is a serious gum infection that destroys the soft tissue and bone supporting the teeth. It is reportedly the second most common disease worldwide, with 30–50% of the US population suffering from it.

Data published in the Journal of Dental Research indicated that DHA supplementation was associated with a decreased the average depth of the pockets between the teeth and the gums, and the gingival index, which is used to assess the extent of gum disease.

In addition, inflammatory biomarkers in the gum tissue were significantly reduced.

Participants were randomly assigned to receive either 2,000 mg per day of DHA or placebo (soy/corn oil) for three months. All of the participants also received 81 mg per day of aspirin.

Results showed DHA levels in red blood cell membranes increased between 3.6% to 6.2%, whereas no such increases were observed in the placebo group. In addition to the improvements in pocket depth and gingival index, the researchers reported that levels of the inflammatory biomarkers C-reactive protein (CRP) and interleukin-1 beta (IL-1beta) decreased significantly in the DHA group. 



This “Holy Herb’ Shows Promise in Treating Alzheimer’s Disease

Yerba santa may also treat brain swelling in dementia patients

Salk Institute, July 14, 2022

A shrub known as Yerba santa, dubbed “holy herb” in Spanish, appears to show promise in treating Alzheimer’s disease, researchers say. It has the potential to reduce brain swelling in people with dementia. 

Native to California, Yerba santa has long been used as a treatment for fevers, headaches, and other common ailments. But researchers at Salk’s Cellular Neurobiology Laboratory believe it could be used to treat much more serious health problems. In fact, millions of dementia patients stand to benefit from the natural treatment, they claim.

A molecule in the shrub called sterubin – the plant’s most active component – could be the key to transforming millions of lives. The team found that sterubin had a significant anti-inflammatory effect on brain cells called microglia, which are involved in the development of Alzheimer’s disease, among other ailments.

The researchers further found that sterubin effectively removes iron. This is an important discovery, as iron contributes to nerve cell damage in the aging brain and neurodegenerative diseases.

Sterubin was found to effectively reduce numerous causes of cell death in the nerve cells.


An inflammatory diet correlates with colorectal cancer risk

The risk of developing colorectal cancer for individuals that follow a pro-inflammatory diet is two times higher than usual

Bellvitge Biomedical Research Institute (Spain), July 15, 2022 

Researchers from the Molecular Mechanisms and Experimental Therapy in Oncology program (Oncobell) of the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO) published in Nutrients the results of a multicenter study that unveils a correlation between inflammatory and antioxidant diets and the risk of developing colorectal and breast cancer. 

"We have observed an association between the risk of developing colorectal cancer and the inflammatory potential of the diet. That is, the participants who followed an inflammatory diet had almost twice the risk of developing colorectal cancer, which is the 4th most frequent cancer worldwide", explains Dr. Mireia Obón.

An inflammatory diet is usually characterized by the consumption of refined carbohydrates, red and processed meat, and saturated or trans fats. In an antioxidant diet, the consumption of vegetables, legumes, fruits and nuts predominates. "In this study we have focused on the role of diet, and specifically on its inflammatory and antioxidant capacity, as there is evidence that both chronic inflammation and oxidative stress influence the development of these two types of cancer", says Dr. Víctor Moreno.

"Following a pro-inflammatory and pro-oxidant diet is a very important risk factor for colon cancer.  We should reorient our eating habits towards a Mediterranean diet, rich in fruits and vegetables, nuts, whole grains and healthy oils, such as olive oil and move away from a more pro-inflammatory diet", she argues.



Saturday, July 23 -- 2:00 pm

Kingston, NY (at the historical 4 corners -- Crown and John Streets)


Gerald Celente

Judge Andrew Napolitano

Gary Null

Scott Ritter

Phil Giraldi (former CIA official)

Live music, food and drink

The Gary Null Show - 07.19.22

The Gary Null Show - 07.19.22

July 19, 2022


1. There was an unexpected 40% increase in 'all cause deaths' in 2021 (8:28)

2.Dr. Mike Yeadon: The Reason Why They Had to Use Genetic Vaccines

3. [PROOF] The Great Reset Is HAPPENING!- Russell Brand

4. Dr. Peter McCullough, MD, MPH, Jun 27, 2022 Texas Senate HHS Testimony

5. If I Were the Devil: Paul Harvey (Clean Audio Version)

6. A few highlights of a recent speech of mine that went slightly viral - Simon O'Connor 

(Simon David O'Connor MP is a New Zealand politician and a member of the New Zealand House of Representatives. He is a member of the National Party. He has represented the Tāmaki electorate since 2011. He is a member of the Foreign Affairs, Defence, and Trade committee).

7. Gun Control and The Vaule Of Life

Health News:

  • Cinnamon could stop Parkinson’s in its tracks 
  • Leucine-rich protein supplements could benefit adults with sarcopenia 
  • Nutrients for the bones
  • Searching for meaning? Try appreciating the small things
  • Want a higher GPA in college? Join a gym
  • Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about



Cinnamon could stop Parkinson’s in its tracks 

Rush University Medical Center, July 14, 2022

In an article appearing in the Journal of Neuroimmune Pharmacology indicates that cinnamon could one day be used by Parkinson’s disease patients to prevent the disease from progressing.

Saurabh Khasnavis and Kalipada Pahan, PhD, of Rush University Medical Center studied the effects of the spice in a mouse model of Parkinson’s disease. They found that when cinnamon is metabolized into sodium benzoate in the blood and brain, the loss of beneficial proteins known as Parkin and DJ-1 is halted, while neurons that produce dopamine, a neurotransmitter that is reduced in Parkinson’s, are protected. Motor function, which can be significantly impaired by the disease, was improved in animals that received cinnamon.

"Cinnamon is metabolized in the liver to sodium benzoate, which is an FDA-approved drug used in the treatment for hepatic metabolic defects associated with hyperammonemia," explained lead researcher Dr Pahan

"Cinnamon has been used widely as a spice throughout the world for centuries,” he noted. “This could potentially be one of the safest approaches to halt disease progression in Parkinson's patients."


Leucine-rich protein supplements could benefit adults with sarcopenia

Seoul National University College of Medicine, July 15 2022. 

Sarcopenia is a condition characterized by muscle wasting that contributes to frailty in aging men and women. Results from a meta-analysis of randomized trials reported in the Archives of Gerontology and Geriatrics concluded that protein supplements rich in the essential branched-chain amino acid leucine could improve muscle strength in sarcopenic individuals.

“The treatment of choice for sarcopenia is still resistance exercise with nutritional supplementation because no pharmacological agents to treat sarcopenia have become available yet,” Sang Yoon Lee, MD, PhD, and colleagues at Seoul National University College of Medicine noted. 

The meta-analysis included 6 randomized, controlled trials that involved a total of 699 men and women with sarcopenia. Three hundred forty-six trial participants received a daily protein supplement containing 3 to 6 grams of leucine and 353 participants received a placebo or no leucine for 8 to 13 weeks. Muscle strength, muscle mass and physical performance were evaluated before and after the treatment periods.

Muscle strength significantly improved in leucine-supplemented participants as a primary outcome in comparison with the control groups. There was also a trend toward improvement in muscle mass and physical performance in the groups that received leucine. There was no significant difference in response between lower and higher amounts of leucine. No serious adverse events were reported.



Nutrients for the bones

Catalytic Longevity Foundation, July 13 2022. 

A review appearing in the International Journal of Molecular Sciences describes how specific nutrients activate bone-preserving mechanisms.

Osteoclasts are bone cells that break down bone tissue while osteoblasts synthesize bone. With respect to osteoblasts, the RUNX2 transcription factor is the master regulator of osteoblast formation and function, driving the transcription of a number of genes essential for the bone forming process.

Signaling pathways that drive RUNX2 gene transcription are triggered by bone morphogenetic proteins (BMP) 2 and 4. AMPK, which is activated by G. pentaphyllum, hesperidin and metformin, promotes BMP 2 and 4 expression in osteoblasts. 

The protein Sirt1 promotes RUNX2 activity. Sirt1 activation is increased by melatonin, nicotinamide riboside, glucosamine and thymoquinone, found in Nigella sativa

Activation of soluble guanylate cyclase (sGC), the only known nitric oxide receptor, also leads to the promotion of RUNX2. High doses of biotin activate sGC.

Nrf2 regulates the cells’ defense against oxidative stress, as well as enhancing the activation of RUNX2 in osteoblasts and osteocytes. Lipoic acid, melatonin, thymoquinone, astaxanthin and sulforaphane can promote Nrf2 activity. 

Activation of these mechanisms also promotes autophagy, a process in which the cells consume their own damaged cellular components, which helps to prevent apoptosis (programmed cell death) and senescence in osteoblasts and osteocytes.

“Regimens providing a selection of these nutraceuticals in clinically meaningful doses may have an important potential for preserving bone health,” the authors concluded. “Concurrent supplementation with taurine, N-acetylcysteine, vitamins D and K2, and minerals, including magnesium, zinc, and manganese, plus a diet naturally high in potassium, may also be helpful in this regard.”




Searching for meaning? Try appreciating the small things

Texas A&M University, July 18, 2022

Appreciating the intrinsic beauty in life's everyday moments can contribute to a more meaningful existence, according to new research.

In a paper recently published in Nature Human Behavior, Joshua Hicks, a professor in the Texas A&M University Department of Psychological and Brain Sciences, says this may be a previously unaccounted for factor tied to perceptions of meaning.

"It might not relate to whether you matter in the grand scheme of things, but we've shown people who value the little things, like your cup of coffee in the morning or being mindful in conversations with others, tend to have a high sense of meaning in life," he said.

Hicks studies existential psychology. Put simply, he aims to understand the "big questions" in life. He describes his main focus as the experience of life—studying people's subjective feeling that their life has meaning.

Scholars like Hicks generally agree there are three main sources of a subjectively meaningful existence: coherence, or the feeling that one's life "makes sense"; the possession of clear, long-term goals and sense of purpose; and existential mattering. This last factor, he says, is the belief that one's actions matter to others.

What Hicks and his co-authors argue in their latest research is that appreciating and finding value in experiences, referred to as experiential appreciation, is a fourth fundamental pathway toward finding meaning in life.


Want a higher GPA in college? Join a gym

Michigan State University, July 10, 2022


For those students looking to bump up their grade point averages during college, the answer may not be spending more time in a library or study hall, but in a gym.


New Michigan State University research shows that students who were members of the recreational sports and fitness centers on MSU's campus during their freshman and sophomore years had higher GPAs than those who weren't.


The research also indicated that students with memberships stayed in school longer. An increase of 3.5 percent in two-year retention rates was seen among this group.


The research supports previous theories suggesting that by creating an environment that connects students to an institution, in this case a university recreational facility, an increase in academic success and retention can occur. During the project, Pivarnik's team analyzed data from a sample of freshmen and sophomores, totaling 4,843 students, and compared the GPAs of those who purchased a fitness facility membership and those who did not. Results showed that after four consecutive semesters, the students with memberships obtained higher cumulative GPAs. They also had more credits completed by the end of their first year in college.



Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about

Baylor University, July 10, 2022

Men who experience hot flashes are unlikely to talk much about it, but they may find relief from their silent suffering if they are willing to try an unusual treatment, according to findings from a Baylor University case study.

After seven weeks of hypnotic relaxation therapy, a 69-year-old man who had uncontrolled hot flashes following prostate cancer surgery showed a drastic decrease not only in hot flashes but also an impressive improvement in sleep quality, according to the study.

Men's hot flashes are, of course, not related to estrogen, the primary female sex hormone. They occur in men with a history of prostate cancer — the second most common malignancy in men — or another disorder causing a testosterone deficiency.

Up to 80 percent of prostate survivors experience hot flashes, and about 50 percent of those experience them as severe and needing treatment. What's more, hot flashes due to prostate cancer tend to be more frequent, more severe and more prolonged than those women experience.

The new research follows previous published studies by Elkins that found a marked decrease in hot flashes among postmenopausal women and also among breast cancer survivors who have undergone hypnotic relaxation therapy. It reduced hot flashes by as much as 80 percent, and research findings by clinically trained therapists show it also improved participants' quality of life and lessened anxiety and depression. (Quality of life included such issues as work, sexuality, social and leisure activities, mood and concentration.)

The Gary Null Show - 07.18.22
The Gary Null Show - 07.15.22

The Gary Null Show - 07.15.22

July 15, 2022

Lutein and zeaxanthin isomers benefits during high screen exposure

University of Georgia, July 10, 2022

An exciting new peer reviewed publication based on ongoing research on macular carotenoids from the University of Georgia demonstrates that supplementation with lutein and zeaxanthin isomers can protect against a growing issue among the general population -- the undesirable effects of prolonged exposure to high-energy blue light emitted from digital screens of computers, tablets and smartphones. Lutein and zeaxanthin isomers -- known as the macular carotenoids -- are natural filters of high-energy blue light. High-energy blue light reaches deep into the eye and can harm the macula -- the region of the eye responsible for highest visual acuity- by promoting the production of free radicals. Short-term effects can cause eye fatigue while long-term exposure can lead to a progressive loss of visual function.

This is the first study to examine the impact of macular carotenoids supplementation to protect visual health and performance, improve sleep quality and reduce eye strain and fatigue during prolonged exposure to blue light emitting digital screens.

The study was a 6-month randomized, double-blind, placebo-controlled supplementation trial with 48 healthy, young adults with screen time exposure of at least 6 hours daily. Subjects were evaluated at baseline, 3-months and 6-months for MPOD (Macular Pigment Optical Density) and markers of visual performance including contrast sensitivity, photostress recovery and disability glare. Sleep quality, which is affected by blue light exposure, and physical indicators of excessive screen use were also measured. The results show that supplementing with lutein and zeaxanthin significantly improved macular pigment optical density, visual performance and indicators of excessive screen use, including eye strain and fatigue and headache frequency. Sleep quality also improved significantly.


Study explores the effects of eating dark chocolate on the brain

Isfahan University of Medical Science (Iran), July 14, 2022

Elham Kalantarzedeh, Maryam Radahmadi and Parham Reisi, three researchers at Isfahan University of Medical Science in Iran have recently carried out a study on rats investigating the impact of different dark chocolate dietary patterns on synapses in a specific region of the brain, known as the hippocampal CA1 area. Their findings, published in Nutritional Neuroscience, suggest that dark chocolate consumption could have beneficial effects on the brain of individuals exhibiting chronic isolation stress.

"Although stress causes brain dysfunction, consumption of dark chocolate (DC) has positive effects on brain functions," the researchers wrote in their paper. "The current study investigated the impact of different DC dietary patterns on synaptic potency and plasticity in the hippocampal CA1 area, as well as food intake and body weight in rats under chronic isolation stress."

Overall, the experiments carried out by this team of researchers suggest that the systematic consumption of dark chocolate could reverse the adverse effects of chronic isolation stress on the synaptic potency and plasticity of the hippocampal CA1 area. This would in turn have beneficial effects on both memory and learning.


Vitamin C found to block growth of cancer stem cells, says peer reviewed study

University of Salford (UK),  July 8, 2022


Increasingly, researchers are discovering the role played by cancer stem cells in the growth and spread of the disease. In groundbreaking new research, vitamin C showed its ability to target cancer stem cells and stop their growth – preventing the recurrence of tumors.

In a newly-published study conducted at the University of Salford in Manchester, vitamin C demonstrated its power to stop tumors in their tracks by interfering with cancer stem cell metabolism – suppressing their ability to process energy for survival and growth.

The study explored the effects of vitamin C on cancer stem cells – and provided evidence that vitamin C, in the form of ascorbic acid, can target and kill them.

The team investigated the impact on cancer stem cells of seven different substances. Three were natural substances, three were experimental drugs, and one was an FDA-approved clinical drug that is widely used.

The natural products studied, along with vitamin C, were silibinin – derived from milk thistle seeds – and caffeic acid phenyl ester – or CAPE – derived from honeybee propolis. The experimental drugs were actinonin, FK866 and 2-DG, and the clinical drug was stiripentol.

Researchers noted that vitamin C destroyed cancer stem cells by inducing oxidative stress. And, the vitamin performed this process ten times more effectively than 2-DG.\

By inhibiting glycolysis, vitamin C inhibited mitrochondrial protein synthesis in cancer stem cells – while leaving healthy cells unaffected.

All seven of the substances tested inhibited the growth of cancer cells to varying degrees – including the non-toxic natural substances. But researchers said the most “exciting” results were with vitamin C.

Again, vitamin C was 1,000 percent more effective than 2-DG, an experimental pharmaceutical drug – in targeting cancer stem cells. 



Preterm birth more likely with exposure to phthalates 

National Institute of Environmental Health Sciences, July 11 2022

Pregnant women who were exposed to multiple phthalates during pregnancy had an increased risk of preterm birth, according to new research by the National Institutes of Health. Phthalates are chemicals used in personal care products, such as cosmetics, as well as in solvents, detergents, and food packaging.

After analyzing data from more than 6,000 pregnant women in the United States, researchers found that women with higher concentrations of several phthalate metabolites in their urine were more likely to deliver their babies preterm, which is delivering three or more weeks before a mother’s due date.

“Having a preterm birth can be dangerous for both baby and mom, so it is important to identify risk factors that could prevent it,” said Kelly Ferguson, Ph.D., an epidemiologist at the National Institute of Environmental Health Sciences (NIEHS), part of NIH, and the senior author on the study published in the journal JAMA Pediatrics.

Higher concentrations of most phthalate metabolites examined were associated with slightly higher odds of preterm birth. Exposure to four of the 11 phthalates found in the pregnant women was associated with a 14-16% greater probability of having a preterm birth. The most consistent findings were for exposure to a phthalate that is used commonly in personal care products like nail polish and cosmetics.

The researchers also used statistical models to simulate interventions that reduce phthalate exposures. They found that reducing the mixture of phthalate metabolite levels by 50% could prevent preterm births by 12% on average. 


Study finds vitamin A directs immune cells to the intestines

Purdue University, July 9, 2022

A key set of immune cells that protect the body from infection would be lost without directions provided by vitamin A, according to a recent study.

A team of researchers from Purdue University found retinoic acid, a metabolite that comes from digested vitamin A, is necessary for two of the three types of innate immune cells that reside in the intestine to find their proper place.

"It is known that vitamin A deficiencies lead to increased susceptibility to disease and low concentrations of immune cells in the mucosal barrier that lines the intestines," said Chang Kim, the professor and section head of microbiology and immunology in Purdue's College of Veterinary Medicine who led the research. "We wanted to find the specific role the vitamin plays in the immune system and how it influences the cells and biological processes. The more we understand the details of how the immune system works, the better we will be able to design treatments for infection, and autoimmune and inflammatory diseases."

Within the immune system there are two categories of cells that work together to rid the body of infection: innate immune cells, the innate lymphoid cells and leukocytes that are fast acting and immediately present to eliminate infection; and adaptive immune cells, the T-cells and B-cells that arrive later, but are specific to the pathogen and more effective at killing or neutralizing it. All innate immune cells are produced in the bone marrow, but eventually populate other areas of the body. 

Innate lymphoid cells first gather in the lymph nodes before traveling to their final destination, and this is where retinoic acid acts upon two of the three subsets destined for the intestines. Kim and his team found that retinoic acid activates specific receptors in the cells that act as homing devices for the intestines.

"It is interesting that both innate and adaptive immune cells share a vitamin A-regulated pathway for migration."


Drinking alcohol while pregnant could have transgenerational effects

University of California, Riverside, July 7, 2022

Soon-to-be mothers have heard the warning – don't drink while pregnant. 

The  study by Kelly Huffman, psychology professor at the University of California, Riverside, was published in the journal Cerebral Cortex.

"Traditionally, prenatal ethanol exposure (PrEE) from maternal consumption of alcohol, was thought to solely impact directly exposed offspring, the embryo or fetus in the womb. However, we now have evidence that the effects of prenatal alcohol exposure could persist transgenerationally and negatively impact the next-generations of offspring who were never exposed to alcohol," Huffman said.

To determine whether the abnormalities in brain and behavior from prenatal ethanol exposure would pass transgenerationally, Huffman generated a mouse model of FASD and tested many aspects of brain and behavioral development across three generations. As expected, the first generation, the directly exposed offspring, showed atypical gene expression, abnormal development of the neural network within the neocortex and behavioral deficits. However, the main discovery of the research lies in the subsequent, non-exposed generations of mice. These animals had neurodevelopmental and behavioral problems similar to the those of the first, directly exposed generation.

"We found that body weight and brain size were significantly reduced in all generations of PrEE animals when compared to controls; all generations of PrEE mice showed increased anxiety-like, depressive-like behaviors and sensory-motor deficits. By demonstrating the strong transgenerational effects of prenatal ethanol exposure in a mouse model of FASD, we suggest that FASD may be a heritable condition in humans," Huffman said.


The Gary Null Show - 07.14.22

The Gary Null Show - 07.14.22

July 14, 2022

Quercetin phytosome reduced allergy symptoms in clinical trial

University of Shizuoka (Japan), July 11 2022. 

A randomized trial described in the European Review for Medical and Pharmacological Sciences revealed a decrease in seasonal allergy symptoms among men and women who were given quercetin, a flavonoid that occurs in fruits, tea, onions and herbs. 

The trial included 60 participants who reported experiencing eye and nasal symptoms related to pollen or house dust exposure. Half of the participants received 200 milligrams quercetin phytosome (a food-grade bioavailable formulation of quercetin) and the remainder received a placebo daily for 4 weeks. Blood samples were analyzed for various factors and quality of life questionnaires that evaluated eye and nasal symptoms were administered before the treatment period and at 2 and 4 weeks. 

At the end of the study, eye itching, sneezing, nasal discharge and sleep disorder scores, were significantly improved among participants who received quercetin in comparison with participants who received a placebo. Severity of sneezing, nasal discharge and disturbance of daily living were lower at the end of various time points among supplemented participants compared to the placebo group. 


Kiwi fruit powder shows gut health benefits

Medicus Research (New Zealand), July 10, 2022

Kiwifruit containing Zyactinase called Kivia may enhance bowel movement frequency and improve other symptoms of occasional constipation, say new data from a randomized clinical trial.

A daily 5.5 gram dose of Kivia powder was associated with a reduction in abdominal pain and flatulence in subjects with occasional constipation, according to findings published in the Nutrition Journal .

While the exact mechanism of action is still to be elucidated, researchers led by Dr Jay Udani at Medicus Research note that kiwifruit extract is rich in enzymes able to aid in digestion, as well as potential prebiotics which may enhance the growth of beneficial bacteria in the gut.

“Improvements were noted in the number of bowel movements, with increased bowel movements in the group using the studied extract,” they wrote. “There were also improvements observed in bowel health and stool formation.

“This suggests that Kivia powder improved bowel habits in this group of subjects.”

Results showed that the Kivia group experienced significant increases in spontaneous bowel movements at every week, compared to data from the start of the study. Significant differences were also observed between the kiwifruit extract group and placebo at weeks 3 and 4.



Lifestyle may be more important than age in determining dementia risk: Study

Baycrest Centre for Geriatric Care, July 13, 2022

Individuals with no dementia risk factors, such as smoking, diabetes or hearing loss, have similar brain health as people who are 10 to 20 years younger than them, according to a new Baycrest study. The study found that a single dementia risk factor could reduce cognition by the equivalent of up to three years of aging.

"Our results suggest lifestyle factors may be more important than age in determining someone's level of cognitive functioning. This is great news, since there's a lot you can do to modify these factors, such as managing diabetes, addressing hearing loss, and getting the support you need to quit smoking," says Dr. Annalise LaPlume, Postdoctoral Fellow at Baycrest's Rotman Research Institute (RRI) and the study's lead author.

The study is one of the first to look at lifestyle risk factors for dementia across the entire lifespan.

The study, published in the journal Alzheimer's & Dementia: Diagnosis, Assessment, and Disease Monitoring, a journal of the Alzheimer's Association, included data from 22,117 people aged 18 to 89.

The researchers looked at participants' performance on memory and attention tests, and how this was impacted by eight modifiable risk factors for dementia: low education (less than a high school diploma), hearing loss, traumatic brain injury, alcohol or substance abuse, hypertension, smoking (currently or in the past four years), diabetes and depression.

Each factor led to a decrease in cognitive performance by as much as three years of aging, with each additional factor contributing the same amount of decline. For example, having three risk factors could lead to a decrease in cognitive performance equivalent to as much as nine years of aging. The effects of the risk factors increased with age, as did the number of risk factors people had.


Research shows that drinking Matcha tea can reduce anxiety

Kumamoto University (Japan), July 9, 2022

Many different countries have a tea culture, and Japanese Matcha tea is growing in popularity around the world. A group of Japanese researchers from Kumamoto University has shown that anxious behavior in mice is reduced after consuming Matcha powder or Matcha extract. Its calming effects appear to be due to mechanisms that activate dopamine D1 receptors and serotonin 5-HT1A receptors, both of which are closely related to anxious behavior.

Matcha is the finely ground powder of new leaves from shade-grown (90% shade) Camellia sinensis green tea bushes.  In Japan, historical medicinal uses for Matcha included helping people relax, preventing obesity, and treatment of skin conditions. The researchers, therefore, sought to determine its various beneficial effects.

The "elevated plus maze" test is an elevated, plus-shaped, narrow platform with two walled arms that provide safety for the test subject, typically a mouse. It is used as an anxiety test for rodents with the idea that animals experiencing higher anxiety will spend more time in the safer walled-off areas. Using this test, researchers found that mouse anxiety was reduced after consuming Matcha powder or Matcha extract. 


Spirituality linked with better health outcomes, patient care

Harvard School of Public Health, July 13 2022

Spirituality should be incorporated into care for both serious illness and overall health, according to a study led by researchers at Harvard T.H. Chan School of Public Health and Brigham and Women's Hospital.

"This study represents the most rigorous and comprehensive systematic analysis of the modern day literature regarding health and spirituality to date," said Tracy Balboni, lead author and senior physician at Harvard Medical School. "Our findings indicate that attention to spirituality in serious illness and in health should be a vital part of future whole person-centered care, and the results should stimulate more national discussion and progress on how spirituality can be incorporated into this type of value-sensitive care." 

According to the International Consensus Conference on Spiritual Care in Health Care, spirituality is "the way individuals seek ultimate meaning, purpose, connection, value, or transcendence." This could include organized religion but extends well beyond to include ways of finding ultimate meaning by connecting, for example, to family, community, or nature. 

According to the researchers, the simple act of asking about a patient's spirituality can and should be part of patient-centered, value-sensitive care. The information gleaned from the conversation can guide further medical decision-making, including but not limited to notifying a spiritual care specialist.  "Overlooking spirituality leaves patients feeling disconnected from the health care system and the clinicians trying to care for them," said Koh. "Integrating spirituality into care can help each person have a better chance of reaching complete well-being and their highest attainable standard of health." 


Kids Who Play Sports Are Happier, Healthier Than Those Who Go Straight To Their Screens

University of South Australia, July 11, 2022


Kids who go straight onto their screens after school are more miserable and feel less healthy than those who do homework or play outside, a new study reveals.

Researchers from the University of South Australia say those who meet up with friends, practice sports, or take music lessons feel much better about themselves. They also found that kids didn’t have to get out and exercise to feel more positive than those on screens, as doing their homework or reading also contributed to better well-being.

The team analyzed data from 61,759 school students in fourth through ninth grade to see what they did between 3 p.m. and 6 p.m. each day. Results show most students watched TV about four days a week and spent time on social media about three times a week.

Researchers measured the activities against well-being factors such as happiness, sadness, worry, engagement, perseverance, optimism, emotion regulation, and life satisfaction.

Overall, the study found that children’s well-being improves when they participate in extracurricular activities but drops when they spend time on social media or using screens. Lead researcher Dr. Rosa Virgara says the research highlights an acute need to encourage children to participate in activities and cut down on screen time.

“Our study highlights how some out-of-school activities can boost children’s well-being, while others – particularly screens – can chip away at their mental and physical health,” Virgara says in a university release. “Screens are a massive distraction for children of all ages. Most parents will attest to this. And whether children are gaming, watching TV or on social media, there’s something about all screens that’s damaging to their well-being.”

The study, published in the journal BMC Pediatrics, shows that students in lower socioeconomic backgrounds who frequently played sport were 15 percent more likely to be optimistic, 14 percent more likely to be happy and satisfied with their life, and 10 percent more likely to be able to regulate their emotions.


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